Incidental Mutation 'R3921:Olig3'
ID 315745
Institutional Source Beutler Lab
Gene Symbol Olig3
Ensembl Gene ENSMUSG00000045591
Gene Name oligodendrocyte transcription factor 3
Synonyms bHLHe20, Bhlhb7
MMRRC Submission 040818-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.605) question?
Stock # R3921 (G1)
Quality Score 149
Status Not validated
Chromosome 10
Chromosomal Location 19232287-19234352 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19232423 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 16 (D16G)
Ref Sequence ENSEMBL: ENSMUSP00000057106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053225]
AlphaFold Q6PFG8
Predicted Effect probably damaging
Transcript: ENSMUST00000053225
AA Change: D16G

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000057106
Gene: ENSMUSG00000045591
AA Change: D16G

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
low complexity region 25 33 N/A INTRINSIC
HLH 90 144 3.68e-13 SMART
low complexity region 165 184 N/A INTRINSIC
low complexity region 186 203 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutant mice exhibit impaired development of class A neurons in the dorsal spinal cord, the alar plate, with reduced numbers of dI1 neurons and misspecified dI2 and dI3 neurons that assume the identity of class B neurons. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm2 T A 3: 59,659,498 (GRCm39) L317Q probably damaging Het
Aebp2 C T 6: 140,579,461 (GRCm39) R11C probably damaging Het
Anxa8 T C 14: 33,816,403 (GRCm39) F201L probably damaging Het
Armh4 A G 14: 50,011,659 (GRCm39) F16S probably benign Het
Bcl7a A G 5: 123,509,136 (GRCm39) N206S probably benign Het
Birc6 A G 17: 74,934,014 (GRCm39) N2542D probably damaging Het
Cubn A G 2: 13,331,488 (GRCm39) Y2562H probably damaging Het
Dnah12 C G 14: 26,493,008 (GRCm39) D1256E probably damaging Het
Dnajb14 A T 3: 137,610,613 (GRCm39) R280S probably damaging Het
Dop1a A T 9: 86,402,324 (GRCm39) I1173F probably benign Het
Fam228a T C 12: 4,781,506 (GRCm39) T118A probably benign Het
Gata2 TGCCATGGGCTAGGCAAGCC TGCC 6: 88,182,464 (GRCm39) probably null Het
Hif3a T C 7: 16,771,097 (GRCm39) D618G possibly damaging Het
Ighv1-43 C A 12: 114,909,772 (GRCm39) G50V probably benign Het
Lrrc37a G T 11: 103,392,296 (GRCm39) T1043N probably benign Het
Masp2 T A 4: 148,690,188 (GRCm39) D232E possibly damaging Het
Ms4a4a A C 19: 11,356,172 (GRCm39) Q19P probably benign Het
Nckipsd A G 9: 108,691,275 (GRCm39) E399G possibly damaging Het
Nnt T A 13: 119,503,030 (GRCm39) T572S probably damaging Het
Or4a74 C T 2: 89,439,853 (GRCm39) V198I probably benign Het
Or5p57 T A 7: 107,665,108 (GRCm39) D299V possibly damaging Het
Polr2b T C 5: 77,474,500 (GRCm39) Y446H probably damaging Het
Prtg T C 9: 72,755,629 (GRCm39) V277A probably damaging Het
Rnf31 T C 14: 55,838,599 (GRCm39) Y857H probably damaging Het
Serac1 T C 17: 6,117,067 (GRCm39) D163G probably damaging Het
Slc22a22 C A 15: 57,119,940 (GRCm39) V197F probably benign Het
Slc2a10 C T 2: 165,357,521 (GRCm39) P394S probably benign Het
Spg7 G C 8: 123,814,112 (GRCm39) R457P probably damaging Het
St7 A G 6: 17,846,244 (GRCm39) N120D probably benign Het
Sult2a6 C T 7: 13,988,668 (GRCm39) V31M possibly damaging Het
Taf3 T C 2: 10,053,109 (GRCm39) T35A probably benign Het
Tmem131l A G 3: 83,847,908 (GRCm39) I319T possibly damaging Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Ttc23l T TTGGATG 15: 10,537,649 (GRCm39) probably benign Het
Ttc23l CT CTTGGATT 15: 10,537,648 (GRCm39) probably benign Het
Vmn2r9 T G 5: 108,996,921 (GRCm39) Y116S probably benign Het
Vstm2l A G 2: 157,777,283 (GRCm39) T54A probably benign Het
Xrn1 T A 9: 95,851,337 (GRCm39) M153K probably benign Het
Zfp106 G A 2: 120,364,097 (GRCm39) P770L probably damaging Het
Other mutations in Olig3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03094:Olig3 APN 10 19,232,878 (GRCm39) missense probably benign 0.21
R1726:Olig3 UTSW 10 19,232,482 (GRCm39) missense probably benign
R6042:Olig3 UTSW 10 19,232,503 (GRCm39) missense probably damaging 1.00
R7382:Olig3 UTSW 10 19,232,413 (GRCm39) missense unknown
R7827:Olig3 UTSW 10 19,232,518 (GRCm39) missense probably benign
R8143:Olig3 UTSW 10 19,232,732 (GRCm39) missense probably damaging 1.00
R9732:Olig3 UTSW 10 19,233,151 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTCTGGTTTTACAACTGGGGAAG -3'
(R):5'- TGATCTTCAGCCGCAACTGC -3'

Sequencing Primer
(F):5'- TACAACTGGGGAAGTGGGTTC -3'
(R):5'- GCAACTGCTGAAGATCCTGCTC -3'
Posted On 2015-05-15