Incidental Mutation 'R4171:Or6c204'
ID 318139
Institutional Source Beutler Lab
Gene Symbol Or6c204
Ensembl Gene ENSMUSG00000096000
Gene Name olfactory receptor family 6 subfamily C member 204
Synonyms Olfr773-ps1, GA_x6K02T2PULF-10872859-10871923, MOR114-15, Olfr773
MMRRC Submission 041011-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R4171 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129022353-129023288 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 129022453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 279 (A279V)
Ref Sequence ENSEMBL: ENSMUSP00000072743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072976]
AlphaFold F6VS78
Predicted Effect probably benign
Transcript: ENSMUST00000072976
AA Change: A279V

PolyPhen 2 Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000072743
Gene: ENSMUSG00000096000
AA Change: A279V

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.6e-48 PFAM
Pfam:7tm_1 38 287 4.4e-22 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
2310022A10Rik A G 7: 27,265,109 (GRCm39) N87S probably benign Het
Apmap A G 2: 150,425,987 (GRCm39) V387A probably benign Het
B130024G19Rik C T 7: 70,038,454 (GRCm39) noncoding transcript Het
Cd200r1 A G 16: 44,613,127 (GRCm39) I244M probably damaging Het
Clic6 T C 16: 92,293,949 (GRCm39) probably benign Het
Col11a1 A G 3: 114,001,863 (GRCm39) D429G probably damaging Het
Dsg4 T A 18: 20,591,636 (GRCm39) Y458* probably null Het
Elapor1 G T 3: 108,368,259 (GRCm39) Q885K probably benign Het
Fbxl13 A G 5: 21,748,786 (GRCm39) Y378H probably benign Het
Ifi203 A C 1: 173,761,341 (GRCm39) probably benign Het
Ifna6 T C 4: 88,746,038 (GRCm39) V129A probably benign Het
Igkv3-4 G A 6: 70,649,324 (GRCm39) A108T probably damaging Het
Itga1 G A 13: 115,167,422 (GRCm39) Q165* probably null Het
Kdm4c T A 4: 74,199,135 (GRCm39) Y108N possibly damaging Het
Lap3 T C 5: 45,666,833 (GRCm39) S412P probably benign Het
Lrfn5 G A 12: 61,890,168 (GRCm39) V486I probably damaging Het
Mep1b A T 18: 21,228,163 (GRCm39) probably null Het
Mettl6 T C 14: 31,215,624 (GRCm39) N52S probably damaging Het
Nup54 A G 5: 92,565,343 (GRCm39) I458T possibly damaging Het
Or1e16 A C 11: 73,286,365 (GRCm39) L161R probably damaging Het
Pecr A T 1: 72,315,428 (GRCm39) N107K probably damaging Het
Pnpla6 A G 8: 3,593,997 (GRCm39) Q1307R probably benign Het
Poll T C 19: 45,544,492 (GRCm39) K310E probably damaging Het
Rab29 A G 1: 131,795,475 (GRCm39) Q29R probably benign Het
Reg2 G A 6: 78,383,574 (GRCm39) G99D probably damaging Het
Rftn2 G A 1: 55,253,429 (GRCm39) S58L probably damaging Het
Rps6kb1 T C 11: 86,435,405 (GRCm39) E43G possibly damaging Het
Sdk2 T C 11: 113,757,815 (GRCm39) probably null Het
Slc38a6 T A 12: 73,397,326 (GRCm39) Y323N probably benign Het
Sp100 T C 1: 85,634,562 (GRCm39) S152P probably benign Het
Tmc5 A G 7: 118,248,810 (GRCm39) Y605C probably damaging Het
Txndc17 T C 11: 72,098,537 (GRCm39) Y30H probably damaging Het
Vmn1r44 T A 6: 89,870,996 (GRCm39) F247L probably damaging Het
Zbtb39 C T 10: 127,578,236 (GRCm39) T270I possibly damaging Het
Zfp512b G A 2: 181,232,391 (GRCm39) probably null Het
Zwilch T A 9: 64,065,997 (GRCm39) R255* probably null Het
Other mutations in Or6c204
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01539:Or6c204 APN 10 129,022,804 (GRCm39) missense probably benign 0.04
R1924:Or6c204 UTSW 10 129,023,044 (GRCm39) missense possibly damaging 0.78
R4688:Or6c204 UTSW 10 129,022,514 (GRCm39) missense probably damaging 0.99
R4952:Or6c204 UTSW 10 129,022,466 (GRCm39) missense probably benign 0.12
R5066:Or6c204 UTSW 10 129,022,433 (GRCm39) missense possibly damaging 0.88
R5610:Or6c204 UTSW 10 129,022,426 (GRCm39) missense probably damaging 0.96
R5633:Or6c204 UTSW 10 129,022,718 (GRCm39) missense probably benign 0.02
R6953:Or6c204 UTSW 10 129,022,474 (GRCm39) missense probably benign 0.01
R9644:Or6c204 UTSW 10 129,022,738 (GRCm39) missense possibly damaging 0.94
RF007:Or6c204 UTSW 10 129,022,562 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAACCACAATGAGAAAGAGTGTTC -3'
(R):5'- GCAGACAGTTCTCATCTGTGC -3'

Sequencing Primer
(F):5'- TGTTCAGGGAAAGTCAACTGG -3'
(R):5'- CTGACACTCATTATAACGCTGGTGTG -3'
Posted On 2015-06-10