Mutagenetix > Incidental Mutation

Incidental Mutation 'R4402:Or1e26'

326687

Institutional Source

Beutler Lab

Gene Symbol

Or1e26

Ensembl Gene

ENSMUSG00000095095

Gene Name

olfactory receptor family 1 subfamily E member 26

Synonyms

Olfr385, GA_x6K02T2P1NL-3760313-3759375, MOR135-3

MMRRC Submission

042003-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R4402 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

73479624-73480562 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 73480081 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 161 (V161A)

Ref Sequence

ENSEMBL: ENSMUSP00000149293 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071553] [ENSMUST00000215689]

AlphaFold

Q8VGT1

Predicted Effect

probably benign
Transcript: ENSMUST00000071553
AA Change: V161A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000071484
Gene: ENSMUSG00000095095
AA Change: V161A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	6.1e-55	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.7e-6	PFAM
Pfam:7tm_1	41	290	2.2e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215689
AA Change: V161A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.1%
20x: 94.7%

Validation Efficiency

98% (61/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810021J22Rik	T	A	11: 58,771,020 (GRCm39)	H167Q	probably benign	Het
Adamts20	T	C	15: 94,277,827 (GRCm39)	T212A	probably benign	Het
Ap3b1	C	A	13: 94,554,607 (GRCm39)	L248I	probably damaging	Het
Atl1	T	G	12: 70,005,973 (GRCm39)	D426E	probably benign	Het
Cage1	T	A	13: 38,207,078 (GRCm39)	I256F	probably damaging	Het
Calcr	A	T	6: 3,708,484 (GRCm39)		probably null	Het
Canx	T	C	11: 50,195,265 (GRCm39)	T268A	probably benign	Het
Chd7	A	T	4: 8,866,353 (GRCm39)	M842L	possibly damaging	Het
Clca4a	T	C	3: 144,658,609 (GRCm39)	T787A	probably benign	Het
Clstn3	T	C	6: 124,433,939 (GRCm39)	Y407C	probably damaging	Het
Copa	C	A	1: 171,929,791 (GRCm39)	T286N	probably damaging	Het
Cyb5a	G	A	18: 84,889,718 (GRCm39)	R49Q	possibly damaging	Het
Def6	A	G	17: 28,438,950 (GRCm39)	K219E	probably damaging	Het
Eif4g1	G	T	16: 20,497,593 (GRCm39)		probably benign	Het
Eif5	A	T	12: 111,508,183 (GRCm39)	K161N	probably benign	Het
Fras1	C	A	5: 96,790,479 (GRCm39)	T951K	probably damaging	Het
Gen1	A	T	12: 11,292,363 (GRCm39)	N475K	possibly damaging	Het
Gm14569	T	C	X: 35,697,146 (GRCm39)	Y521C	probably benign	Het
Gm6124	T	A	7: 38,870,529 (GRCm39)		noncoding transcript	Het
Gpt2	A	T	8: 86,252,188 (GRCm39)	D501V	probably benign	Het
Gstm2	T	C	3: 107,893,370 (GRCm39)	K31R	probably benign	Het
Homer3	G	A	8: 70,742,793 (GRCm39)		probably null	Het
Itga1	T	A	13: 115,138,102 (GRCm39)	M428L	probably benign	Het
Kalrn	C	T	16: 33,810,180 (GRCm39)	D2525N	possibly damaging	Het
Kcnn4	T	C	7: 24,076,867 (GRCm39)	W139R	probably benign	Het
Kdm7a	T	A	6: 39,143,602 (GRCm39)	R380W	probably null	Het
Khdrbs1	T	G	4: 129,635,889 (GRCm39)	D22A	possibly damaging	Het
Liph	A	T	16: 21,795,000 (GRCm39)	I204N	probably damaging	Het
Loxhd1	A	G	18: 77,529,456 (GRCm39)	E2033G	possibly damaging	Het
M6pr	C	T	6: 122,291,982 (GRCm39)		probably benign	Het
Mrm1	A	G	11: 84,709,915 (GRCm39)	I95T	probably damaging	Het
Mroh2a	G	T	1: 88,182,657 (GRCm39)	R1195L	possibly damaging	Het
Mug1	C	A	6: 121,856,311 (GRCm39)	F1030L	probably damaging	Het
Naca	C	T	10: 127,879,341 (GRCm39)		probably benign	Het
Nob1	A	T	8: 108,145,120 (GRCm39)		probably benign	Het
Nutm1	A	C	2: 112,080,154 (GRCm39)	I587R	probably damaging	Het
Pcdhb2	A	G	18: 37,428,455 (GRCm39)	K143E	probably benign	Het
Pcnt	T	C	10: 76,228,227 (GRCm39)	Q1646R	probably benign	Het
Piwil2	A	T	14: 70,646,365 (GRCm39)	D390E	probably benign	Het
Pkhd1	A	G	1: 20,309,635 (GRCm39)	L2771P	probably damaging	Het
Pla2g1b	T	A	5: 115,608,947 (GRCm39)	Y47*	probably null	Het
Plekhn1	T	C	4: 156,309,813 (GRCm39)	T135A	probably damaging	Het
Pola1	T	C	X: 92,605,029 (GRCm39)	Y968C	probably damaging	Het
Ppp1r26	C	A	2: 28,341,618 (GRCm39)	T416K	probably benign	Het
Psmd1	A	G	1: 86,003,673 (GRCm39)	I153V	possibly damaging	Het
Rcan2	A	G	17: 44,264,361 (GRCm39)	D7G	probably benign	Het
Rexo5	T	C	7: 119,433,599 (GRCm39)	I326T	possibly damaging	Het
Rps6kc1	A	G	1: 190,530,802 (GRCm39)		probably benign	Het
Shc1	T	C	3: 89,333,985 (GRCm39)	S273P	probably benign	Het
Slc9b2	T	C	3: 135,042,305 (GRCm39)	V528A	probably benign	Het
Tas2r118	T	C	6: 23,969,293 (GRCm39)	K256R	probably benign	Het
Tma16	C	T	8: 66,936,823 (GRCm39)		probably null	Het
Tnfaip2	T	C	12: 111,416,285 (GRCm39)	F516L	probably benign	Het
Ugt1a1	CAGAGAGAGAGAGA	CAGAGAGAGAGA	1: 88,139,706 (GRCm39)		probably benign	Het
Ugt1a10	C	T	1: 88,142,845 (GRCm39)	P113L	probably damaging	Het
Wdr35	A	G	12: 9,039,981 (GRCm39)	D362G	probably damaging	Het
Wwp2	T	C	8: 108,184,610 (GRCm39)	V106A	probably benign	Het
Zfp40	T	A	17: 23,395,693 (GRCm39)	H230L	possibly damaging	Het
Zkscan17	T	A	11: 59,393,848 (GRCm39)	M1L	possibly damaging	Het

Other mutations in Or1e26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01570:Or1e26	APN	11	73,480,209 (GRCm39)	missense	probably benign	0.34
IGL02045:Or1e26	APN	11	73,480,058 (GRCm39)	missense	probably damaging	1.00
IGL02324:Or1e26	APN	11	73,480,081 (GRCm39)	missense	probably benign	0.02
IGL02328:Or1e26	APN	11	73,480,081 (GRCm39)	missense	probably benign	0.02
IGL02562:Or1e26	APN	11	73,480,237 (GRCm39)	missense	probably benign
IGL02715:Or1e26	APN	11	73,479,947 (GRCm39)	missense	probably benign	0.00
IGL03182:Or1e26	APN	11	73,480,268 (GRCm39)	missense	probably benign	0.04
IGL03048:Or1e26	UTSW	11	73,479,831 (GRCm39)	missense	possibly damaging	0.56
R0346:Or1e26	UTSW	11	73,480,283 (GRCm39)	missense	probably damaging	1.00
R0675:Or1e26	UTSW	11	73,480,078 (GRCm39)	missense	probably damaging	1.00
R0751:Or1e26	UTSW	11	73,479,970 (GRCm39)	missense	probably benign	0.02
R1220:Or1e26	UTSW	11	73,480,203 (GRCm39)	nonsense	probably null
R1389:Or1e26	UTSW	11	73,480,369 (GRCm39)	missense	possibly damaging	0.88
R1484:Or1e26	UTSW	11	73,480,187 (GRCm39)	missense	possibly damaging	0.91
R1619:Or1e26	UTSW	11	73,480,118 (GRCm39)	missense	probably damaging	1.00
R2290:Or1e26	UTSW	11	73,479,745 (GRCm39)	missense	probably benign	0.37
R3713:Or1e26	UTSW	11	73,479,731 (GRCm39)	missense	probably damaging	1.00
R3781:Or1e26	UTSW	11	73,480,194 (GRCm39)	nonsense	probably null
R3781:Or1e26	UTSW	11	73,479,839 (GRCm39)	missense	probably damaging	1.00
R3782:Or1e26	UTSW	11	73,480,194 (GRCm39)	nonsense	probably null
R3782:Or1e26	UTSW	11	73,479,839 (GRCm39)	missense	probably damaging	1.00
R4721:Or1e26	UTSW	11	73,480,273 (GRCm39)	missense	probably damaging	1.00
R5157:Or1e26	UTSW	11	73,480,549 (GRCm39)	missense	probably damaging	1.00
R5995:Or1e26	UTSW	11	73,480,076 (GRCm39)	missense	probably benign
R6373:Or1e26	UTSW	11	73,479,724 (GRCm39)	missense	probably benign	0.42
R6658:Or1e26	UTSW	11	73,479,874 (GRCm39)	missense	probably damaging	0.99
R7046:Or1e26	UTSW	11	73,480,558 (GRCm39)	missense	probably benign
R7096:Or1e26	UTSW	11	73,480,463 (GRCm39)	missense	probably benign	0.03
R7238:Or1e26	UTSW	11	73,480,561 (GRCm39)	start codon destroyed	probably null	0.99
R7537:Or1e26	UTSW	11	73,480,094 (GRCm39)	missense	probably benign	0.04
R7548:Or1e26	UTSW	11	73,479,802 (GRCm39)	missense	possibly damaging	0.56
R7888:Or1e26	UTSW	11	73,480,354 (GRCm39)	missense	probably damaging	0.99
R7968:Or1e26	UTSW	11	73,480,154 (GRCm39)	missense	probably benign	0.05
R8923:Or1e26	UTSW	11	73,480,076 (GRCm39)	missense	probably benign
R9006:Or1e26	UTSW	11	73,480,036 (GRCm39)	missense	probably benign	0.40
R9281:Or1e26	UTSW	11	73,480,133 (GRCm39)	missense	probably benign
R9689:Or1e26	UTSW	11	73,479,686 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGCTATTCCCCGTGTAGATG -3'
(R):5'- CCAAGTTGCTGCAGAACATG -3'

Sequencing Primer
(F):5'- GGCTATTCCCCGTGTAGATGAAAAC -3'
(R):5'- GACACAACCATCTCCTATGTAGGTTG -3'

Posted On

2015-07-07