Mutagenetix > Incidental Mutation

Incidental Mutation 'R4421:Vmn2r72'

327100

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

EG244114, Vmn2r72-ps

MMRRC Submission

041142-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R4421 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85386992-85404189 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 85387708 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 619 (N619D)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: N619D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: N619D

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acy1	G	C	9: 106,312,912 (GRCm39)		probably null	Het
Adgrv1	T	C	13: 81,714,421 (GRCm39)	E234G	probably damaging	Het
Aga	T	C	8: 53,964,861 (GRCm39)	S8P	probably benign	Het
C1s2	T	C	6: 124,602,174 (GRCm39)	D673G	probably benign	Het
Capza3	G	A	6: 139,987,768 (GRCm39)	M122I	probably benign	Het
Cfap44	T	C	16: 44,242,800 (GRCm39)	S735P	probably damaging	Het
Cntn3	A	G	6: 102,441,508 (GRCm39)	F13L	probably damaging	Het
Col6a5	A	T	9: 105,805,672 (GRCm39)	M1078K	unknown	Het
Colgalt2	A	T	1: 152,360,763 (GRCm39)	I267F	probably damaging	Het
Cpped1	T	C	16: 11,623,221 (GRCm39)	*299W	probably null	Het
Cyp3a59	A	G	5: 146,041,713 (GRCm39)		probably null	Het
Ddx42	T	A	11: 106,121,964 (GRCm39)	Y160N	probably damaging	Het
Dhx35	A	T	2: 158,648,321 (GRCm39)	R60W	probably damaging	Het
Gbp10	T	C	5: 105,372,517 (GRCm39)		probably null	Het
Gtf2i	T	C	5: 134,283,891 (GRCm39)	T467A	possibly damaging	Het
Hip1r	G	C	5: 124,135,925 (GRCm39)	G542A	possibly damaging	Het
Hspg2	G	A	4: 137,275,433 (GRCm39)	A2748T	probably benign	Het
Kcnq3	T	C	15: 65,867,360 (GRCm39)	Y761C	probably benign	Het
Krt13	T	G	11: 100,009,761 (GRCm39)	T340P	possibly damaging	Het
Map2k5	A	G	9: 63,071,412 (GRCm39)	C435R	probably damaging	Het
Ms4a4c	T	A	19: 11,393,739 (GRCm39)	I53K	probably damaging	Het
Myh15	T	A	16: 48,929,707 (GRCm39)	F544L	probably damaging	Het
Neurod2	G	T	11: 98,219,026 (GRCm39)	S46*	probably null	Het
Nsd3	T	A	8: 26,131,288 (GRCm39)	S218T	probably damaging	Het
Or2ag2	G	T	7: 106,485,660 (GRCm39)	D121E	probably damaging	Het
Or4p22	A	T	2: 88,317,585 (GRCm39)	N170Y	probably damaging	Het
Prrc2c	TTGCTGCTGCTGCTGCTGCTGCTGCTGC	TTGCTGCTGCTGCTGCTGCTGCTGC	1: 162,536,630 (GRCm39)		probably benign	Het
Prrg3	A	T	X: 71,010,915 (GRCm39)	S141C	probably damaging	Het
Ranbp17	A	T	11: 33,425,056 (GRCm39)	D433E	probably benign	Het
Rbm28	T	C	6: 29,154,836 (GRCm39)	D278G	probably damaging	Het
Sbpl	A	G	17: 24,173,860 (GRCm39)	L8P	unknown	Het
Spopl	C	T	2: 23,407,957 (GRCm39)	V241M	probably damaging	Het
Tdrd3	A	G	14: 87,723,719 (GRCm39)	E311G	probably damaging	Het
Tma16	C	T	8: 66,936,823 (GRCm39)		probably null	Het
Ubr4	A	G	4: 139,189,167 (GRCm39)	N3917D	possibly damaging	Het
Vmn2r68	TCC	TC	7: 84,870,758 (GRCm39)		probably null	Het
Xab2	C	A	8: 3,664,244 (GRCm39)		probably null	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,387,542 (GRCm39)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,387,575 (GRCm39)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,399,919 (GRCm39)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,387,170 (GRCm39)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,399,901 (GRCm39)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,387,907 (GRCm39)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,387,391 (GRCm39)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,387,879 (GRCm39)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,401,021 (GRCm39)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,401,249 (GRCm39)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,400,384 (GRCm39)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,404,162 (GRCm39)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,400,075 (GRCm39)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,401,044 (GRCm39)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,404,084 (GRCm39)	missense	probably benign
R0655:Vmn2r72	UTSW	7	85,387,319 (GRCm39)	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85,398,947 (GRCm39)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,400,517 (GRCm39)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,398,396 (GRCm39)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,387,465 (GRCm39)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,398,419 (GRCm39)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,401,000 (GRCm39)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,387,378 (GRCm39)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,398,369 (GRCm39)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,387,444 (GRCm39)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,387,549 (GRCm39)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,400,161 (GRCm39)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,400,477 (GRCm39)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85,398,850 (GRCm39)	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,398,943 (GRCm39)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,400,339 (GRCm39)	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85,399,017 (GRCm39)	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85,387,708 (GRCm39)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,387,036 (GRCm39)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,387,119 (GRCm39)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,387,069 (GRCm39)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,399,806 (GRCm39)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,400,317 (GRCm39)	missense	probably benign
R4991:Vmn2r72	UTSW	7	85,400,338 (GRCm39)	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85,387,693 (GRCm39)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,387,061 (GRCm39)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,387,048 (GRCm39)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,387,462 (GRCm39)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,400,105 (GRCm39)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,401,150 (GRCm39)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,387,058 (GRCm39)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,399,747 (GRCm39)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,400,382 (GRCm39)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,398,892 (GRCm39)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,387,204 (GRCm39)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,399,011 (GRCm39)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,404,125 (GRCm39)	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85,387,482 (GRCm39)	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85,399,771 (GRCm39)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,400,348 (GRCm39)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,400,362 (GRCm39)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,401,146 (GRCm39)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,404,098 (GRCm39)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,399,834 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,398,838 (GRCm39)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,400,441 (GRCm39)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,400,227 (GRCm39)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,401,168 (GRCm39)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,387,383 (GRCm39)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,404,134 (GRCm39)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,398,388 (GRCm39)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,400,411 (GRCm39)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,404,022 (GRCm39)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,404,075 (GRCm39)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,398,399 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- AAGCAGCCACCTCATTCTTC -3'
(R):5'- TGAAGTGTCGAGAAGATCAATATGC -3'

Sequencing Primer
(F):5'- GAATGCTAGTAGAACAGTAATCGTC -3'
(R):5'- TGCAAATGAAGACCATACTCTCTTC -3'

Posted On

2015-07-07