Mutagenetix > Incidental Mutation

Incidental Mutation 'R2862:Vmn2r72'

252931

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

EG244114, Vmn2r72-ps

MMRRC Submission

040452-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R2862 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85386992-85404189 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 85400044 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 335 (I335N)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: I335N

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: I335N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,259,057 (GRCm39)	S2928G	probably damaging	Het
Abcd1	T	A	X: 72,781,064 (GRCm39)	L713H	probably damaging	Het
Actg1	T	C	11: 120,237,627 (GRCm39)	I52V	probably benign	Het
Ahi1	T	A	10: 20,857,307 (GRCm39)	V634E	probably damaging	Het
Ang	G	T	14: 51,339,275 (GRCm39)	D139Y	probably damaging	Het
Apoe	T	C	7: 19,431,479 (GRCm39)	Y46C	probably damaging	Het
Aqr	A	T	2: 113,967,398 (GRCm39)	V539D	probably damaging	Het
Btg3	A	G	16: 78,161,868 (GRCm39)	V114A	probably damaging	Het
Cap1	A	T	4: 122,758,518 (GRCm39)	S221T	probably benign	Het
Ccdc121	G	A	5: 31,643,255 (GRCm39)		probably benign	Het
Cdca2	T	C	14: 67,935,539 (GRCm39)	E392G	probably damaging	Het
Col1a2	G	A	6: 4,518,822 (GRCm39)		probably benign	Het
Col22a1	A	G	15: 71,687,792 (GRCm39)		probably null	Het
Cyp2c38	G	A	19: 39,449,138 (GRCm39)	R72W	probably benign	Het
Dnah1	C	T	14: 31,006,719 (GRCm39)	G2199S	probably benign	Het
Dnhd1	A	G	7: 105,361,766 (GRCm39)	E3608G	probably benign	Het
Ears2	A	T	7: 121,662,163 (GRCm39)	L95Q	probably damaging	Het
F5	A	T	1: 164,012,533 (GRCm39)	K482N	probably damaging	Het
Gata5	C	T	2: 179,976,129 (GRCm39)	G12S	possibly damaging	Het
Gm11938	C	A	11: 99,493,972 (GRCm39)	R41L	probably damaging	Het
Grap2	A	T	15: 80,532,165 (GRCm39)	Q260L	probably damaging	Het
Greb1	A	G	12: 16,761,746 (GRCm39)	S545P	probably benign	Het
Iglc1	T	C	16: 18,880,660 (GRCm39)		probably benign	Het
Il18r1	T	C	1: 40,537,717 (GRCm39)	V494A	possibly damaging	Het
Kdf1	G	A	4: 133,255,852 (GRCm39)	E190K	probably damaging	Het
Lama2	G	A	10: 27,298,608 (GRCm39)	Q163*	probably null	Het
Lama3	G	T	18: 12,586,807 (GRCm39)	L723F	probably damaging	Het
Lamp5	A	T	2: 135,900,866 (GRCm39)	H22L	probably benign	Het
Maged1	G	A	X: 93,582,530 (GRCm39)	P366S	probably damaging	Het
Med14	A	G	X: 12,585,936 (GRCm39)	I521T	probably benign	Het
Mia2	A	G	12: 59,201,196 (GRCm39)	K841E	probably damaging	Het
Mrgbp	G	A	2: 180,225,203 (GRCm39)	R53Q	possibly damaging	Het
Mrps18b	G	A	17: 36,221,746 (GRCm39)	S101L	probably benign	Het
Nmnat2	G	A	1: 152,988,171 (GRCm39)	V267I	probably benign	Het
Noc2l	A	G	4: 156,321,907 (GRCm39)	D102G	probably benign	Het
Ntn1	T	C	11: 68,276,690 (GRCm39)	E86G	probably benign	Het
Opn4	A	G	14: 34,315,785 (GRCm39)		probably null	Het
Or2d2b	T	A	7: 106,705,675 (GRCm39)	H131L	probably benign	Het
Or4c109	A	T	2: 88,817,664 (GRCm39)	I294K	probably benign	Het
Or52n1	A	G	7: 104,383,425 (GRCm39)	F49L	probably benign	Het
Or6k6	A	G	1: 173,945,298 (GRCm39)	Y95H	probably damaging	Het
Pate3	T	A	9: 35,559,415 (GRCm39)	M1L	possibly damaging	Het
Pex2	A	G	3: 5,626,240 (GRCm39)	Y190H	probably damaging	Het
Pkhd1l1	A	C	15: 44,404,267 (GRCm39)	T2299P	probably damaging	Het
Ppp6r3	A	C	19: 3,571,782 (GRCm39)	S122R	possibly damaging	Het
Pwwp3b	G	A	X: 138,137,429 (GRCm39)	G656S	possibly damaging	Het
Rnf113a1	A	G	X: 36,455,736 (GRCm39)	E231G	probably damaging	Het
Rnf41	T	C	10: 128,274,023 (GRCm39)	L225P	possibly damaging	Het
Rreb1	G	C	13: 38,116,429 (GRCm39)	A1263P	probably benign	Het
Rxfp1	A	G	3: 79,589,778 (GRCm39)	V121A	possibly damaging	Het
Slc35e4	A	T	11: 3,862,796 (GRCm39)	V131D	probably damaging	Het
Smyd4	T	A	11: 75,280,962 (GRCm39)	M145K	probably benign	Het
Snx13	T	A	12: 35,188,116 (GRCm39)	I798N	probably benign	Het
Srgap3	A	T	6: 112,699,933 (GRCm39)	F1015Y	probably damaging	Het
Synj1	T	C	16: 90,766,217 (GRCm39)	Y567C	probably damaging	Het
Tbc1d8	G	A	1: 39,441,777 (GRCm39)	Q272*	probably null	Het
Tinf2	T	C	14: 55,918,088 (GRCm39)	D127G	probably damaging	Het
Ube2v1	G	A	2: 167,459,885 (GRCm39)	P39L	probably damaging	Het
Vegfd	A	G	X: 163,168,879 (GRCm39)	E57G	probably damaging	Het
Zc3h6	A	G	2: 128,857,380 (GRCm39)	H633R	probably benign	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,387,542 (GRCm39)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,387,575 (GRCm39)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,399,919 (GRCm39)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,387,170 (GRCm39)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,399,901 (GRCm39)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,387,907 (GRCm39)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,387,391 (GRCm39)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,387,879 (GRCm39)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,401,021 (GRCm39)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,401,249 (GRCm39)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,400,384 (GRCm39)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,404,162 (GRCm39)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,400,075 (GRCm39)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,401,044 (GRCm39)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,404,084 (GRCm39)	missense	probably benign
R0655:Vmn2r72	UTSW	7	85,387,319 (GRCm39)	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85,398,947 (GRCm39)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,400,517 (GRCm39)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,398,396 (GRCm39)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,387,465 (GRCm39)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,398,419 (GRCm39)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,401,000 (GRCm39)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,387,378 (GRCm39)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,398,369 (GRCm39)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,387,444 (GRCm39)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,387,549 (GRCm39)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,400,161 (GRCm39)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,400,477 (GRCm39)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85,398,850 (GRCm39)	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,398,943 (GRCm39)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,400,339 (GRCm39)	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85,399,017 (GRCm39)	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85,387,708 (GRCm39)	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85,387,708 (GRCm39)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,387,036 (GRCm39)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,387,119 (GRCm39)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,387,069 (GRCm39)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,399,806 (GRCm39)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,400,317 (GRCm39)	missense	probably benign
R4991:Vmn2r72	UTSW	7	85,400,338 (GRCm39)	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85,387,693 (GRCm39)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,387,061 (GRCm39)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,387,048 (GRCm39)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,387,462 (GRCm39)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,400,105 (GRCm39)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,401,150 (GRCm39)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,387,058 (GRCm39)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,399,747 (GRCm39)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,400,382 (GRCm39)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,398,892 (GRCm39)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,387,204 (GRCm39)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,399,011 (GRCm39)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,404,125 (GRCm39)	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85,387,482 (GRCm39)	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85,399,771 (GRCm39)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,400,348 (GRCm39)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,400,362 (GRCm39)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,401,146 (GRCm39)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,404,098 (GRCm39)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,399,834 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,398,838 (GRCm39)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,400,441 (GRCm39)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,400,227 (GRCm39)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,401,168 (GRCm39)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,387,383 (GRCm39)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,404,134 (GRCm39)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,398,388 (GRCm39)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,400,411 (GRCm39)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,404,022 (GRCm39)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,404,075 (GRCm39)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,398,399 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- ATAGCATGTATCACTCATGGCC -3'
(R):5'- AAGGTCATCAGCAAAAGTTGTG -3'

Sequencing Primer
(F):5'- CATTCCAAGTGGTGTCCTGAATAACC -3'
(R):5'- GGAGACTATGCCTCTCCCATAG -3'

Posted On

2014-12-04