Mutagenetix > Incidental Mutation

Incidental Mutation 'R4504:Taar3'

331933

Institutional Source

Beutler Lab

Gene Symbol

Taar3

Ensembl Gene

ENSMUSG00000069708

Gene Name

trace amine-associated receptor 3

Synonyms

MMRRC Submission

041755-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.125) question?

Stock #

R4504 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23825456-23826487 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23825471 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 6 (I6V)

Ref Sequence

ENSEMBL: ENSMUSP00000036817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045152]

AlphaFold

Q5QD16

Predicted Effect

possibly damaging
Transcript: ENSMUST00000045152
AA Change: I6V

PolyPhen 2 Score 0.844 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000036817
Gene: ENSMUSG00000069708
AA Change: I6V

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	320	1.8e-13	PFAM
Pfam:7tm_1	48	309	1.4e-53	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930503E14Rik	A	G	14: 44,407,899 (GRCm39)	S45P	probably damaging	Het
Adgrg4	C	T	X: 55,961,802 (GRCm39)	R1124C	possibly damaging	Het
Anxa13	T	C	15: 58,228,052 (GRCm39)		noncoding transcript	Het
Arhgap32	C	A	9: 32,093,135 (GRCm39)		probably null	Het
Carm1	T	C	9: 21,480,822 (GRCm39)	F99L	probably damaging	Het
Dennd1b	A	G	1: 139,013,665 (GRCm39)	E253G	possibly damaging	Het
Dsg4	A	G	18: 20,594,493 (GRCm39)	I541V	probably benign	Het
Dstyk	A	G	1: 132,362,127 (GRCm39)	T186A	possibly damaging	Het
Ear1	A	T	14: 44,056,721 (GRCm39)	V49D	probably benign	Het
Epha10	A	G	4: 124,809,480 (GRCm39)		probably benign	Het
Fbh1	A	G	2: 11,753,828 (GRCm39)	V838A	possibly damaging	Het
Fndc8	T	A	11: 82,783,226 (GRCm39)	M69K	probably benign	Het
Golga1	T	C	2: 38,913,466 (GRCm39)	I482V	probably benign	Het
Hivep3	G	A	4: 119,590,990 (GRCm39)		probably benign	Het
Igkv13-85	A	G	6: 68,907,356 (GRCm39)	F82L	probably damaging	Het
Itih1	G	A	14: 30,657,842 (GRCm39)	R410C	probably damaging	Het
Kcnc2	T	C	10: 112,291,699 (GRCm39)	W296R	probably damaging	Het
Kcnq3	A	T	15: 65,867,191 (GRCm39)	Y817*	probably null	Het
Kif3b	T	C	2: 153,165,564 (GRCm39)		probably null	Het
Krtcap2	A	G	3: 89,153,563 (GRCm39)		probably benign	Het
Lhx5	C	A	5: 120,578,073 (GRCm39)	H298N	possibly damaging	Het
Notch1	A	G	2: 26,362,189 (GRCm39)	V1022A	probably benign	Het
Npc1l1	A	G	11: 6,178,741 (GRCm39)	L223S	possibly damaging	Het
Or11m3	T	C	15: 98,396,015 (GRCm39)	F221L	probably benign	Het
Or4c10	C	T	2: 89,760,695 (GRCm39)	P181S	possibly damaging	Het
Or8a1b	C	T	9: 37,622,760 (GRCm39)	V272I	probably benign	Het
Pbxip1	A	G	3: 89,353,690 (GRCm39)	D281G	possibly damaging	Het
Pcdhga8	G	C	18: 37,949,816 (GRCm39)	V411L	probably damaging	Het
Pcsk5	C	T	19: 17,429,319 (GRCm39)	C1553Y	probably damaging	Het
Pdgfc	A	C	3: 81,082,298 (GRCm39)	M164L	probably benign	Het
Pdzd8	T	C	19: 59,333,880 (GRCm39)	Y47C	probably damaging	Het
Pip5k1c	T	A	10: 81,150,945 (GRCm39)	I633N	probably damaging	Het
Pkn1	G	A	8: 84,419,556 (GRCm39)	R16*	probably null	Het
Pole2	A	G	12: 69,269,242 (GRCm39)	V85A	probably benign	Het
Ppp4c	A	C	7: 126,386,637 (GRCm39)	L150R	probably damaging	Het
Pramel25	G	C	4: 143,520,553 (GRCm39)	E102Q	probably benign	Het
Ric8a	A	G	7: 140,438,429 (GRCm39)	I223V	probably benign	Het
Rnf144a	T	A	12: 26,377,302 (GRCm39)	R92S	probably benign	Het
Sbno2	C	A	10: 79,896,326 (GRCm39)	R898L	possibly damaging	Het
Scnn1b	A	C	7: 121,511,698 (GRCm39)	N370T	probably damaging	Het
Vps13a	T	C	19: 16,672,866 (GRCm39)	E1302G	possibly damaging	Het

Other mutations in Taar3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Taar3	APN	10	23,826,330 (GRCm39)	missense	probably damaging	1.00
IGL01777:Taar3	APN	10	23,825,903 (GRCm39)	missense	probably benign	0.39
IGL01940:Taar3	APN	10	23,825,855 (GRCm39)	missense	probably damaging	1.00
IGL02120:Taar3	APN	10	23,826,065 (GRCm39)	missense	probably benign	0.33
PIT4445001:Taar3	UTSW	10	23,825,586 (GRCm39)	missense	possibly damaging	0.85
R0582:Taar3	UTSW	10	23,825,715 (GRCm39)	missense	probably damaging	1.00
R1925:Taar3	UTSW	10	23,826,483 (GRCm39)	missense	probably benign	0.22
R2261:Taar3	UTSW	10	23,826,053 (GRCm39)	missense	probably benign	0.00
R4088:Taar3	UTSW	10	23,825,757 (GRCm39)	missense	possibly damaging	0.46
R4505:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4507:Taar3	UTSW	10	23,825,471 (GRCm39)	missense	possibly damaging	0.84
R4925:Taar3	UTSW	10	23,826,441 (GRCm39)	missense	probably damaging	0.99
R6221:Taar3	UTSW	10	23,825,970 (GRCm39)	missense	possibly damaging	0.92
R6451:Taar3	UTSW	10	23,825,705 (GRCm39)	missense	possibly damaging	0.96
R7290:Taar3	UTSW	10	23,826,298 (GRCm39)	nonsense	probably null
R7414:Taar3	UTSW	10	23,825,715 (GRCm39)	missense	probably damaging	1.00
R8432:Taar3	UTSW	10	23,826,053 (GRCm39)	missense	probably benign	0.11
X0057:Taar3	UTSW	10	23,825,544 (GRCm39)	missense	probably benign	0.13

Predicted Primers

PCR Primer
(F):5'- TGGCAATCTTCCAGTTCACTAC -3'
(R):5'- TGGTTGCCATGGAGAGGATC -3'

Sequencing Primer
(F):5'- GGAAGATCAGCCAGTGTTCTTAACC -3'
(R):5'- TGCCATGGAGAGGATCAGAAAGTTG -3'

Posted On

2015-07-21