Mutagenetix > Incidental Mutation

Incidental Mutation 'R4710:Lrrk2'

353232

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

4921513O20Rik, cI-46, D630001M17Rik, 9330188B09Rik, LOC381026

MMRRC Submission

042019-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.451) question?

Stock #

R4710 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

91557378-91700323 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 91584130 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 297 (V297M)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060642
AA Change: V297M

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: V297M

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Meta Mutation Damage Score

0.1100

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.9%
20x: 94.5%

Validation Efficiency

99% (75/76)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	T	6: 121,618,262 (GRCm39)	Q185L	probably benign	Het
Acaca	T	A	11: 84,283,163 (GRCm39)	I2243N	possibly damaging	Het
Adamts18	A	G	8: 114,433,558 (GRCm39)	S1059P	probably damaging	Het
Aox4	A	T	1: 58,294,797 (GRCm39)	K1002M	probably damaging	Het
Ap1b1	A	G	11: 4,981,664 (GRCm39)	Y524C	probably damaging	Het
Bag4	C	T	8: 26,259,516 (GRCm39)	A228T	probably benign	Het
Bpifb6	T	A	2: 153,750,436 (GRCm39)	I309N	possibly damaging	Het
Cd209b	T	C	8: 3,974,215 (GRCm39)	E99G	probably damaging	Het
Cntn2	T	A	1: 132,455,963 (GRCm39)	H185L	possibly damaging	Het
Col4a2	C	A	8: 11,459,462 (GRCm39)	P299Q	probably benign	Het
Commd3	A	G	2: 18,679,093 (GRCm39)	N106S	probably benign	Het
Coro7	T	G	16: 4,452,797 (GRCm39)		probably benign	Het
Ctf1	C	A	7: 127,316,252 (GRCm39)	P66Q	probably damaging	Het
Dclre1c	T	C	2: 3,441,898 (GRCm39)		probably null	Het
Dnaaf3	A	T	7: 4,529,493 (GRCm39)	L317Q	probably damaging	Het
Dnah2	A	G	11: 69,368,903 (GRCm39)	L1667P	probably damaging	Het
Dpp4	A	G	2: 62,190,659 (GRCm39)	I399T	probably benign	Het
Dysf	C	A	6: 84,074,697 (GRCm39)	D499E	probably damaging	Het
Erg	T	C	16: 95,190,893 (GRCm39)	D90G	possibly damaging	Het
F11	T	C	8: 45,703,183 (GRCm39)	Y169C	probably damaging	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Fcgbp	A	T	7: 27,794,386 (GRCm39)	M1197L	probably benign	Het
Gimd1	T	C	3: 132,340,609 (GRCm39)	S42P	possibly damaging	Het
Gm5526	T	A	1: 45,896,579 (GRCm39)		noncoding transcript	Het
Gnl2	T	A	4: 124,947,252 (GRCm39)	S625T	probably benign	Het
H2-Q2	A	G	17: 35,562,278 (GRCm39)	E175G	probably damaging	Het
Hmgxb3	G	A	18: 61,270,547 (GRCm39)	P926S	probably damaging	Het
Ifi213	G	A	1: 173,394,738 (GRCm39)		probably benign	Het
Inhba	T	C	13: 16,201,068 (GRCm39)	V210A	probably benign	Het
Kansl1l	G	A	1: 66,840,655 (GRCm39)	A215V	possibly damaging	Het
Kcnk1	T	A	8: 126,756,267 (GRCm39)	V263D	probably damaging	Het
Kcnk9	A	G	15: 72,384,824 (GRCm39)	I118T	probably damaging	Het
Lamb1	A	G	12: 31,332,582 (GRCm39)	I283V	probably benign	Het
Larp7-ps	T	C	4: 92,079,212 (GRCm39)	E203G	possibly damaging	Het
Lias	A	G	5: 65,555,070 (GRCm39)	D88G	probably benign	Het
Maea	C	T	5: 33,526,034 (GRCm39)	R237C	probably benign	Het
Mdfi	T	A	17: 48,135,511 (GRCm39)	N73I	probably damaging	Het
Mphosph6	T	A	8: 118,528,641 (GRCm39)	M1L	probably damaging	Het
Mta2	T	A	19: 8,926,517 (GRCm39)	I486N	probably damaging	Het
Nbr1	C	T	11: 101,466,101 (GRCm39)	P769L	probably damaging	Het
Ncam2	T	A	16: 81,262,594 (GRCm39)		probably null	Het
Ndel1	A	G	11: 68,736,163 (GRCm39)	Y26H	probably damaging	Het
Neb	T	C	2: 52,150,610 (GRCm39)	R2473G	probably benign	Het
Or10ag53	T	A	2: 87,082,384 (GRCm39)	D34E	possibly damaging	Het
Or2t46	A	T	11: 58,472,548 (GRCm39)	I293F	probably damaging	Het
Or4c3d	T	C	2: 89,882,494 (GRCm39)	Y58C	probably damaging	Het
Or5h19	T	A	16: 58,856,638 (GRCm39)	H154L	possibly damaging	Het
Or6d13	T	C	6: 116,517,611 (GRCm39)	Y66H	possibly damaging	Het
Or9a2	G	T	6: 41,748,442 (GRCm39)	Q264K	probably benign	Het
Prkn	A	C	17: 12,073,720 (GRCm39)	Q346P	possibly damaging	Het
Prrc2b	T	A	2: 32,083,869 (GRCm39)	S236R	possibly damaging	Het
Rae1	G	T	2: 172,857,185 (GRCm39)		probably benign	Het
Rnf112	T	C	11: 61,340,657 (GRCm39)	D491G	probably damaging	Het
Rnf220	C	T	4: 117,146,411 (GRCm39)		probably benign	Het
Ryr3	G	A	2: 112,596,646 (GRCm39)	L2483F	probably damaging	Het
Sema6a	T	C	18: 47,403,750 (GRCm39)	N624S	probably benign	Het
Sgms1	C	T	19: 32,137,537 (GRCm39)	V10M	probably damaging	Het
Slc23a2	T	C	2: 131,898,629 (GRCm39)	N636S	probably benign	Het
Slc25a48	C	T	13: 56,611,379 (GRCm39)	T162I	probably damaging	Het
Smtn	G	A	11: 3,474,663 (GRCm39)	S716F	probably damaging	Het
Snrnp200	T	C	2: 127,068,053 (GRCm39)	L850P	probably damaging	Het
Sost	G	A	11: 101,857,670 (GRCm39)	P44S	probably damaging	Het
Sox18	A	G	2: 181,312,688 (GRCm39)	Y148H	probably damaging	Het
Stk-ps1	A	G	17: 36,708,562 (GRCm39)		noncoding transcript	Het
Tas2r104	T	A	6: 131,662,407 (GRCm39)	T101S	probably damaging	Het
Traf3ip2	C	T	10: 39,515,256 (GRCm39)	P345S	possibly damaging	Het
Ttn	A	G	2: 76,582,428 (GRCm39)	Y22822H	probably damaging	Het
Vmn2r4	A	G	3: 64,317,201 (GRCm39)		probably null	Het
Vmn2r53	T	A	7: 12,335,129 (GRCm39)	H177L	probably benign	Het
Zbtb20	G	T	16: 43,431,039 (GRCm39)	A517S	probably damaging	Het
Zfat	A	T	15: 68,052,131 (GRCm39)	D554E	probably benign	Het
Zfp719	C	T	7: 43,239,656 (GRCm39)	H415Y	probably damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,632,002 (GRCm39)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,584,146 (GRCm39)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,686,036 (GRCm39)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,686,036 (GRCm39)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,664,044 (GRCm39)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,639,993 (GRCm39)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,641,261 (GRCm39)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,623,035 (GRCm39)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,610,340 (GRCm39)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,567,345 (GRCm39)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,651,542 (GRCm39)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,584,772 (GRCm39)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,613,128 (GRCm39)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,696,516 (GRCm39)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,584,192 (GRCm39)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,659,191 (GRCm39)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,664,149 (GRCm39)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,615,694 (GRCm39)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,610,511 (GRCm39)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,570,025 (GRCm39)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,634,480 (GRCm39)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,631,958 (GRCm39)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,584,781 (GRCm39)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,681,617 (GRCm39)	splice site	probably null
horned	UTSW	15	91,657,061 (GRCm39)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,584,098 (GRCm39)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,584,130 (GRCm39)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,680,292 (GRCm39)	missense	probably damaging	1.00
spree	UTSW	15	91,586,450 (GRCm39)	missense	probably benign	0.00
Spur	UTSW	15	91,659,198 (GRCm39)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,686,137 (GRCm39)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,651,542 (GRCm39)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,557,561 (GRCm39)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,557,561 (GRCm39)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,698,863 (GRCm39)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,686,248 (GRCm39)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,686,248 (GRCm39)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,618,212 (GRCm39)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,629,999 (GRCm39)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,662,617 (GRCm39)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,593,508 (GRCm39)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,634,478 (GRCm39)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,699,619 (GRCm39)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,636,481 (GRCm39)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,680,231 (GRCm39)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,657,199 (GRCm39)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,671,219 (GRCm39)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,641,273 (GRCm39)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,659,249 (GRCm39)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,584,098 (GRCm39)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,640,165 (GRCm39)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,613,284 (GRCm39)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,613,372 (GRCm39)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,557,892 (GRCm39)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,584,671 (GRCm39)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,557,838 (GRCm39)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,696,563 (GRCm39)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,613,123 (GRCm39)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,584,098 (GRCm39)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,618,261 (GRCm39)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,664,184 (GRCm39)	missense	possibly damaging	0.96
R1809:Lrrk2	UTSW	15	91,584,095 (GRCm39)	missense	possibly damaging	0.86
R1839:Lrrk2	UTSW	15	91,567,337 (GRCm39)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,620,864 (GRCm39)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,680,263 (GRCm39)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,648,919 (GRCm39)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,681,729 (GRCm39)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,640,130 (GRCm39)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,698,898 (GRCm39)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,698,898 (GRCm39)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,621,314 (GRCm39)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,640,119 (GRCm39)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,631,904 (GRCm39)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,631,903 (GRCm39)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,651,664 (GRCm39)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,662,707 (GRCm39)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,662,707 (GRCm39)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,596,983 (GRCm39)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,593,487 (GRCm39)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,699,686 (GRCm39)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,639,997 (GRCm39)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,584,098 (GRCm39)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,632,023 (GRCm39)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,607,391 (GRCm39)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,589,323 (GRCm39)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,613,345 (GRCm39)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,649,884 (GRCm39)	missense	probably damaging	0.96
R4722:Lrrk2	UTSW	15	91,573,104 (GRCm39)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,648,962 (GRCm39)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,649,950 (GRCm39)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,573,052 (GRCm39)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,649,950 (GRCm39)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,573,052 (GRCm39)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,597,031 (GRCm39)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,689,123 (GRCm39)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,687,592 (GRCm39)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,634,081 (GRCm39)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,584,822 (GRCm39)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,649,993 (GRCm39)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,680,292 (GRCm39)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,657,061 (GRCm39)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,698,847 (GRCm39)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,696,553 (GRCm39)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,671,219 (GRCm39)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,649,948 (GRCm39)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,687,504 (GRCm39)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,586,425 (GRCm39)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,659,177 (GRCm39)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,586,386 (GRCm39)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,648,851 (GRCm39)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,593,593 (GRCm39)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,640,152 (GRCm39)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,618,249 (GRCm39)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,630,034 (GRCm39)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,657,148 (GRCm39)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,607,338 (GRCm39)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,632,029 (GRCm39)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,586,450 (GRCm39)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,626,469 (GRCm39)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,696,549 (GRCm39)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,696,549 (GRCm39)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,607,421 (GRCm39)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,659,198 (GRCm39)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,686,123 (GRCm39)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,648,985 (GRCm39)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,686,088 (GRCm39)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,618,258 (GRCm39)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,641,204 (GRCm39)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,584,644 (GRCm39)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,622,947 (GRCm39)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,615,858 (GRCm39)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,584,207 (GRCm39)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,651,543 (GRCm39)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,696,528 (GRCm39)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,657,061 (GRCm39)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,696,526 (GRCm39)	missense	probably damaging	1.00
R7658:Lrrk2	UTSW	15	91,584,561 (GRCm39)	missense	possibly damaging	0.91
R7679:Lrrk2	UTSW	15	91,610,389 (GRCm39)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,699,649 (GRCm39)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,584,816 (GRCm39)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,651,527 (GRCm39)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,610,355 (GRCm39)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,557,443 (GRCm39)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,584,194 (GRCm39)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,615,680 (GRCm39)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,636,400 (GRCm39)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,586,473 (GRCm39)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,634,469 (GRCm39)	missense
R9086:Lrrk2	UTSW	15	91,640,051 (GRCm39)	missense	probably benign	0.01
R9096:Lrrk2	UTSW	15	91,557,459 (GRCm39)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,557,459 (GRCm39)	start gained	probably benign
R9267:Lrrk2	UTSW	15	91,584,629 (GRCm39)	missense	probably damaging	0.99
R9285:Lrrk2	UTSW	15	91,662,686 (GRCm39)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,584,618 (GRCm39)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,584,618 (GRCm39)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,607,407 (GRCm39)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,636,388 (GRCm39)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,621,420 (GRCm39)	missense	probably benign	0.37
R9502:Lrrk2	UTSW	15	91,607,365 (GRCm39)	missense	probably damaging	0.98
R9563:Lrrk2	UTSW	15	91,634,043 (GRCm39)	missense	possibly damaging	0.90
R9576:Lrrk2	UTSW	15	91,636,388 (GRCm39)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,621,420 (GRCm39)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,696,527 (GRCm39)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,671,251 (GRCm39)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,618,228 (GRCm39)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,649,884 (GRCm39)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,634,482 (GRCm39)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,618,228 (GRCm39)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,695,229 (GRCm39)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,620,836 (GRCm39)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,623,054 (GRCm39)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,610,443 (GRCm39)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- GTCTCTTGCATTTAATGTACACCAC -3'
(R):5'- CAGGGAGATGCCAACACTTG -3'

Sequencing Primer
(F):5'- CACCACTATGTTGTAAAGAGCG -3'
(R):5'- GACTGGAAGAAGGTCCTT -3'

Posted On

2015-10-21