Incidental Mutation 'R4707:Ubr3'
| ID |
355284 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ubr3
|
| Ensembl Gene |
ENSMUSG00000044308 |
| Gene Name |
ubiquitin protein ligase E3 component n-recognin 3 |
| Synonyms |
1110059H15Rik, 4833421P10Rik, A130030D10Rik, Zfp650 |
| MMRRC Submission |
041955-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4707 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
69727590-69854357 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
A to G
at 69768714 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107870
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055758]
[ENSMUST00000112251]
|
| AlphaFold |
Q5U430 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055758
|
| SMART Domains |
Protein: ENSMUSP00000060159
Gene: ENSMUSG00000044308
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
88 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
118 |
188 |
1.6e-19 |
PFAM |
|
low complexity region
|
339 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
570 |
580 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1082 |
1101 |
N/A |
INTRINSIC |
|
coiled coil region
|
1167 |
1199 |
N/A |
INTRINSIC |
|
Blast:RING
|
1289 |
1363 |
8e-39 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112251
|
| SMART Domains |
Protein: ENSMUSP00000107870
Gene: ENSMUSG00000044308
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
88 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
119 |
187 |
1.7e-21 |
PFAM |
|
low complexity region
|
338 |
353 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
579 |
N/A |
INTRINSIC |
|
low complexity region
|
1015 |
1026 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1100 |
N/A |
INTRINSIC |
|
coiled coil region
|
1166 |
1198 |
N/A |
INTRINSIC |
|
Blast:RING
|
1288 |
1362 |
8e-39 |
BLAST |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000131553
AA Change: N504S
|
| SMART Domains |
Protein: ENSMUSP00000121401
Gene: ENSMUSG00000044308
AA Change: N504S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
11 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
65 |
86 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
117 |
185 |
1.2e-21 |
PFAM |
|
low complexity region
|
336 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142563
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 115 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
A |
G |
17: 9,224,544 (GRCm39) |
K450R |
probably damaging |
Het |
| Abcd2 |
T |
C |
15: 91,043,385 (GRCm39) |
D601G |
probably benign |
Het |
| Abcf3 |
A |
G |
16: 20,367,808 (GRCm39) |
K56E |
possibly damaging |
Het |
| Acaca |
T |
C |
11: 84,203,680 (GRCm39) |
V1477A |
probably damaging |
Het |
| Adamts20 |
G |
A |
15: 94,231,528 (GRCm39) |
P887L |
possibly damaging |
Het |
| Ahnak |
T |
G |
19: 8,994,099 (GRCm39) |
S5128A |
probably benign |
Het |
| Ahsa2 |
C |
A |
11: 23,443,162 (GRCm39) |
V197F |
probably benign |
Het |
| Ak9 |
C |
A |
10: 41,221,456 (GRCm39) |
H402N |
probably benign |
Het |
| Alpk1 |
G |
T |
3: 127,481,241 (GRCm39) |
N175K |
possibly damaging |
Het |
| Als2 |
A |
G |
1: 59,254,472 (GRCm39) |
V295A |
probably benign |
Het |
| Ankrd16 |
A |
G |
2: 11,783,608 (GRCm39) |
D70G |
probably damaging |
Het |
| Apob |
A |
T |
12: 8,056,205 (GRCm39) |
K1562N |
probably damaging |
Het |
| Arfgap2 |
C |
A |
2: 91,100,316 (GRCm39) |
S250R |
probably damaging |
Het |
| Arhgef10l |
C |
T |
4: 140,264,194 (GRCm39) |
M671I |
possibly damaging |
Het |
| Atrnl1 |
A |
G |
19: 57,617,590 (GRCm39) |
I122V |
probably damaging |
Het |
| B4galnt2 |
C |
T |
11: 95,766,923 (GRCm39) |
|
probably null |
Het |
| C8a |
A |
G |
4: 104,713,618 (GRCm39) |
Y171H |
probably damaging |
Het |
| Cacnb4 |
A |
G |
2: 52,364,927 (GRCm39) |
V112A |
probably benign |
Het |
| Capn9 |
G |
T |
8: 125,340,195 (GRCm39) |
C566F |
possibly damaging |
Het |
| Ccdc88a |
T |
A |
11: 29,397,956 (GRCm39) |
S230T |
probably benign |
Het |
| Cd300c2 |
A |
T |
11: 114,887,811 (GRCm39) |
F197Y |
probably benign |
Het |
| Chd5 |
A |
G |
4: 152,445,039 (GRCm39) |
Y340C |
probably damaging |
Het |
| Chrd |
A |
T |
16: 20,557,558 (GRCm39) |
I726F |
possibly damaging |
Het |
| Chrna10 |
G |
A |
7: 101,762,426 (GRCm39) |
P255S |
possibly damaging |
Het |
| Clasp1 |
T |
A |
1: 118,470,927 (GRCm39) |
Y197* |
probably null |
Het |
| Cyp2c69 |
C |
G |
19: 39,837,852 (GRCm39) |
G410A |
probably benign |
Het |
| Cyp2e1 |
G |
A |
7: 140,343,821 (GRCm39) |
V20I |
possibly damaging |
Het |
| Dapp1 |
T |
C |
3: 137,638,928 (GRCm39) |
D225G |
probably benign |
Het |
| Dnah5 |
A |
T |
15: 28,372,521 (GRCm39) |
D2924V |
probably damaging |
Het |
| Efcab12 |
A |
T |
6: 115,791,510 (GRCm39) |
L554Q |
possibly damaging |
Het |
| Emsy |
T |
C |
7: 98,246,311 (GRCm39) |
T228A |
possibly damaging |
Het |
| Evc2 |
G |
A |
5: 37,579,204 (GRCm39) |
V1106I |
probably benign |
Het |
| Exoc8 |
G |
T |
8: 125,624,209 (GRCm39) |
Q53K |
possibly damaging |
Het |
| Fbn2 |
A |
T |
18: 58,189,344 (GRCm39) |
V1594D |
probably damaging |
Het |
| Fer1l4 |
T |
C |
2: 155,887,543 (GRCm39) |
Y551C |
possibly damaging |
Het |
| Fhip1a |
G |
T |
3: 85,595,877 (GRCm39) |
T115K |
probably damaging |
Het |
| Fmnl3 |
A |
G |
15: 99,221,362 (GRCm39) |
M481T |
probably benign |
Het |
| Fras1 |
A |
G |
5: 96,883,097 (GRCm39) |
N2543S |
probably damaging |
Het |
| Fsd2 |
T |
C |
7: 81,209,428 (GRCm39) |
D138G |
probably damaging |
Het |
| Gda |
C |
T |
19: 21,405,992 (GRCm39) |
V5I |
probably benign |
Het |
| Glt8d2 |
A |
T |
10: 82,496,583 (GRCm39) |
D158E |
probably damaging |
Het |
| Gpx6 |
C |
T |
13: 21,496,434 (GRCm39) |
Q3* |
probably null |
Het |
| Greb1l |
A |
G |
18: 10,532,922 (GRCm39) |
M830V |
probably benign |
Het |
| Hnrnpul1 |
A |
C |
7: 25,426,258 (GRCm39) |
V531G |
probably damaging |
Het |
| Ifi206 |
A |
T |
1: 173,308,432 (GRCm39) |
H521Q |
probably benign |
Het |
| Igsf3 |
G |
C |
3: 101,365,410 (GRCm39) |
R1127P |
probably benign |
Het |
| Il1rl1 |
A |
G |
1: 40,489,348 (GRCm39) |
R367G |
probably damaging |
Het |
| Islr |
T |
C |
9: 58,064,970 (GRCm39) |
D179G |
possibly damaging |
Het |
| Jcad |
G |
T |
18: 4,649,338 (GRCm39) |
E70* |
probably null |
Het |
| Kcnd2 |
T |
C |
6: 21,723,211 (GRCm39) |
I467T |
probably benign |
Het |
| Lrrc27 |
A |
G |
7: 138,822,614 (GRCm39) |
T502A |
probably benign |
Het |
| Lrrtm3 |
T |
A |
10: 63,923,781 (GRCm39) |
H462L |
probably benign |
Het |
| Mbd5 |
T |
C |
2: 49,140,168 (GRCm39) |
L44S |
probably damaging |
Het |
| Mccc1 |
C |
A |
3: 36,030,022 (GRCm39) |
M429I |
probably damaging |
Het |
| Mgam |
A |
T |
6: 40,691,566 (GRCm39) |
|
probably null |
Het |
| Mipep |
T |
A |
14: 61,109,552 (GRCm39) |
I643N |
probably damaging |
Het |
| Mmrn1 |
A |
T |
6: 60,965,457 (GRCm39) |
I1162L |
probably benign |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Mug1 |
G |
A |
6: 121,861,600 (GRCm39) |
C1354Y |
probably damaging |
Het |
| Nbeal2 |
A |
T |
9: 110,461,123 (GRCm39) |
S1647T |
probably benign |
Het |
| Ndufaf2 |
C |
G |
13: 108,189,314 (GRCm39) |
A145P |
probably damaging |
Het |
| Nedd9 |
A |
T |
13: 41,492,051 (GRCm39) |
|
probably null |
Het |
| Nr4a2 |
T |
A |
2: 57,002,105 (GRCm39) |
H116L |
probably benign |
Het |
| Nwd2 |
A |
G |
5: 63,951,665 (GRCm39) |
Y232C |
probably damaging |
Het |
| Odf4 |
A |
G |
11: 68,817,514 (GRCm39) |
L58P |
probably damaging |
Het |
| Or2a20 |
T |
A |
6: 43,193,883 (GRCm39) |
V12D |
probably benign |
Het |
| Or4a27 |
T |
A |
2: 88,559,056 (GRCm39) |
M296L |
possibly damaging |
Het |
| Or4c116 |
A |
T |
2: 88,942,576 (GRCm39) |
F93L |
probably damaging |
Het |
| Or4g17 |
T |
A |
2: 111,209,990 (GRCm39) |
L215H |
probably damaging |
Het |
| Or7e165 |
C |
T |
9: 19,694,596 (GRCm39) |
H18Y |
probably damaging |
Het |
| Or8g24 |
A |
G |
9: 38,989,558 (GRCm39) |
V161A |
probably benign |
Het |
| Or8s5 |
G |
T |
15: 98,238,659 (GRCm39) |
H70Q |
possibly damaging |
Het |
| Orc6 |
T |
A |
8: 86,029,579 (GRCm39) |
I41K |
probably damaging |
Het |
| Pikfyve |
A |
G |
1: 65,307,005 (GRCm39) |
T1798A |
probably benign |
Het |
| Prdx6b |
T |
C |
2: 80,123,404 (GRCm39) |
L71P |
probably damaging |
Het |
| Prmt2 |
A |
G |
10: 76,062,055 (GRCm39) |
I50T |
probably damaging |
Het |
| Ptdss1 |
T |
C |
13: 67,143,482 (GRCm39) |
|
probably null |
Het |
| Pygl |
T |
C |
12: 70,254,532 (GRCm39) |
T138A |
possibly damaging |
Het |
| Rab3c |
T |
C |
13: 110,198,434 (GRCm39) |
E198G |
probably benign |
Het |
| Rbl2 |
A |
G |
8: 91,812,196 (GRCm39) |
Y255C |
probably damaging |
Het |
| Rev3l |
T |
A |
10: 39,699,393 (GRCm39) |
S1297T |
probably damaging |
Het |
| Rgma |
C |
A |
7: 73,067,564 (GRCm39) |
T367K |
probably damaging |
Het |
| Rps6ka5 |
C |
T |
12: 100,564,144 (GRCm39) |
|
probably null |
Het |
| Rslcan18 |
A |
T |
13: 67,246,590 (GRCm39) |
C217S |
probably damaging |
Het |
| Rtp3 |
A |
G |
9: 110,815,279 (GRCm39) |
|
probably benign |
Het |
| Ryr1 |
A |
T |
7: 28,745,087 (GRCm39) |
N3848K |
probably damaging |
Het |
| Sema6a |
T |
A |
18: 47,381,779 (GRCm39) |
T923S |
probably benign |
Het |
| Serpinb6d |
A |
T |
13: 33,855,336 (GRCm39) |
T337S |
possibly damaging |
Het |
| Sf3b1 |
G |
A |
1: 55,029,666 (GRCm39) |
T1112M |
probably damaging |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Sidt1 |
A |
T |
16: 44,090,221 (GRCm39) |
Y369* |
probably null |
Het |
| Slc16a6 |
A |
G |
11: 109,354,193 (GRCm39) |
S59P |
probably benign |
Het |
| Slc25a17 |
A |
C |
15: 81,211,527 (GRCm39) |
L163W |
probably damaging |
Het |
| Slc44a3 |
T |
C |
3: 121,320,723 (GRCm39) |
T93A |
possibly damaging |
Het |
| Sptbn1 |
T |
C |
11: 30,087,197 (GRCm39) |
T1081A |
possibly damaging |
Het |
| Sptbn4 |
T |
C |
7: 27,116,431 (GRCm39) |
D456G |
probably benign |
Het |
| Sycp1 |
C |
A |
3: 102,760,805 (GRCm39) |
A703S |
possibly damaging |
Het |
| Tas2r118 |
T |
A |
6: 23,969,225 (GRCm39) |
M279L |
probably benign |
Het |
| Tc2n |
T |
G |
12: 101,660,832 (GRCm39) |
Q133H |
probably benign |
Het |
| Tctn1 |
A |
G |
5: 122,399,468 (GRCm39) |
|
probably null |
Het |
| Tenm4 |
A |
C |
7: 96,423,253 (GRCm39) |
K683Q |
probably damaging |
Het |
| Tex10 |
A |
T |
4: 48,468,984 (GRCm39) |
S64T |
probably benign |
Het |
| Tex15 |
A |
G |
8: 34,072,525 (GRCm39) |
T2691A |
probably benign |
Het |
| Tmem175 |
A |
T |
5: 108,790,016 (GRCm39) |
T123S |
probably damaging |
Het |
| Tsc1 |
C |
A |
2: 28,562,419 (GRCm39) |
S348R |
probably damaging |
Het |
| Ttll4 |
A |
T |
1: 74,718,166 (GRCm39) |
T6S |
possibly damaging |
Het |
| Ttll8 |
A |
T |
15: 88,801,293 (GRCm39) |
I465N |
probably damaging |
Het |
| Ugdh |
A |
T |
5: 65,580,695 (GRCm39) |
|
probably null |
Het |
| Usp34 |
T |
C |
11: 23,437,215 (GRCm39) |
L3326S |
probably damaging |
Het |
| Vmn2r125 |
A |
T |
4: 156,702,276 (GRCm39) |
I21F |
probably damaging |
Het |
| Vps9d1 |
G |
A |
8: 123,975,351 (GRCm39) |
|
probably benign |
Het |
| Xab2 |
G |
A |
8: 3,668,117 (GRCm39) |
R154C |
possibly damaging |
Het |
| Zbtb12 |
T |
C |
17: 35,114,475 (GRCm39) |
S87P |
probably damaging |
Het |
| Zc3h12a |
A |
G |
4: 125,014,686 (GRCm39) |
M266T |
probably damaging |
Het |
| Zfp108 |
G |
A |
7: 23,959,837 (GRCm39) |
A143T |
probably benign |
Het |
|
| Other mutations in Ubr3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Ubr3
|
APN |
2 |
69,819,154 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL00985:Ubr3
|
APN |
2 |
69,833,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01061:Ubr3
|
APN |
2 |
69,813,569 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01325:Ubr3
|
APN |
2 |
69,747,441 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01398:Ubr3
|
APN |
2 |
69,789,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01484:Ubr3
|
APN |
2 |
69,851,888 (GRCm39) |
nonsense |
probably null |
|
|
IGL01599:Ubr3
|
APN |
2 |
69,768,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01616:Ubr3
|
APN |
2 |
69,850,828 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01634:Ubr3
|
APN |
2 |
69,803,916 (GRCm39) |
missense |
probably benign |
|
|
IGL01684:Ubr3
|
APN |
2 |
69,846,502 (GRCm39) |
nonsense |
probably null |
|
|
IGL01810:Ubr3
|
APN |
2 |
69,833,809 (GRCm39) |
splice site |
probably null |
|
|
IGL01813:Ubr3
|
APN |
2 |
69,781,914 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL01994:Ubr3
|
APN |
2 |
69,851,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02188:Ubr3
|
APN |
2 |
69,789,955 (GRCm39) |
nonsense |
probably null |
|
|
IGL02318:Ubr3
|
APN |
2 |
69,809,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02379:Ubr3
|
APN |
2 |
69,778,832 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02635:Ubr3
|
APN |
2 |
69,850,827 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02858:Ubr3
|
APN |
2 |
69,783,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03140:Ubr3
|
APN |
2 |
69,800,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Ubr3
|
APN |
2 |
69,803,490 (GRCm39) |
splice site |
probably benign |
|
|
Hyrax
|
UTSW |
2 |
69,783,212 (GRCm39) |
missense |
probably benign |
0.32 |
|
manatee
|
UTSW |
2 |
69,809,730 (GRCm39) |
nonsense |
probably null |
|
|
sea_cow
|
UTSW |
2 |
69,790,013 (GRCm39) |
splice site |
probably null |
|
|
R0094:Ubr3
|
UTSW |
2 |
69,781,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0094:Ubr3
|
UTSW |
2 |
69,781,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0122:Ubr3
|
UTSW |
2 |
69,809,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Ubr3
|
UTSW |
2 |
69,781,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Ubr3
|
UTSW |
2 |
69,783,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0787:Ubr3
|
UTSW |
2 |
69,781,765 (GRCm39) |
splice site |
probably benign |
|
|
R1137:Ubr3
|
UTSW |
2 |
69,768,659 (GRCm39) |
splice site |
probably benign |
|
|
R1191:Ubr3
|
UTSW |
2 |
69,851,525 (GRCm39) |
nonsense |
probably null |
|
|
R1416:Ubr3
|
UTSW |
2 |
69,775,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1623:Ubr3
|
UTSW |
2 |
69,808,067 (GRCm39) |
nonsense |
probably null |
|
|
R1735:Ubr3
|
UTSW |
2 |
69,839,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Ubr3
|
UTSW |
2 |
69,846,711 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1793:Ubr3
|
UTSW |
2 |
69,830,895 (GRCm39) |
splice site |
probably benign |
|
|
R1932:Ubr3
|
UTSW |
2 |
69,783,820 (GRCm39) |
splice site |
probably null |
|
|
R2042:Ubr3
|
UTSW |
2 |
69,808,118 (GRCm39) |
nonsense |
probably null |
|
|
R2085:Ubr3
|
UTSW |
2 |
69,784,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2090:Ubr3
|
UTSW |
2 |
69,766,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Ubr3
|
UTSW |
2 |
69,808,136 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2173:Ubr3
|
UTSW |
2 |
69,727,743 (GRCm39) |
missense |
probably benign |
|
|
R2215:Ubr3
|
UTSW |
2 |
69,809,661 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2273:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2274:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2275:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2292:Ubr3
|
UTSW |
2 |
69,727,604 (GRCm39) |
unclassified |
probably benign |
|
|
R2447:Ubr3
|
UTSW |
2 |
69,833,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Ubr3
|
UTSW |
2 |
69,768,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2517:Ubr3
|
UTSW |
2 |
69,766,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2901:Ubr3
|
UTSW |
2 |
69,846,536 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3109:Ubr3
|
UTSW |
2 |
69,819,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3737:Ubr3
|
UTSW |
2 |
69,801,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3793:Ubr3
|
UTSW |
2 |
69,747,525 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3821:Ubr3
|
UTSW |
2 |
69,824,157 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3918:Ubr3
|
UTSW |
2 |
69,846,474 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4157:Ubr3
|
UTSW |
2 |
69,790,013 (GRCm39) |
splice site |
probably null |
|
|
R4235:Ubr3
|
UTSW |
2 |
69,846,729 (GRCm39) |
nonsense |
probably null |
|
|
R4276:Ubr3
|
UTSW |
2 |
69,768,731 (GRCm39) |
nonsense |
probably null |
|
|
R4544:Ubr3
|
UTSW |
2 |
69,786,437 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4678:Ubr3
|
UTSW |
2 |
69,766,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Ubr3
|
UTSW |
2 |
69,789,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4872:Ubr3
|
UTSW |
2 |
69,800,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Ubr3
|
UTSW |
2 |
69,843,475 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4920:Ubr3
|
UTSW |
2 |
69,783,212 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4989:Ubr3
|
UTSW |
2 |
69,850,790 (GRCm39) |
splice site |
probably benign |
|
|
R5104:Ubr3
|
UTSW |
2 |
69,768,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5134:Ubr3
|
UTSW |
2 |
69,850,790 (GRCm39) |
splice site |
probably benign |
|
|
R5137:Ubr3
|
UTSW |
2 |
69,803,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Ubr3
|
UTSW |
2 |
69,839,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Ubr3
|
UTSW |
2 |
69,786,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5437:Ubr3
|
UTSW |
2 |
69,774,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5539:Ubr3
|
UTSW |
2 |
69,850,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5781:Ubr3
|
UTSW |
2 |
69,846,588 (GRCm39) |
splice site |
probably null |
|
|
R5809:Ubr3
|
UTSW |
2 |
69,795,855 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5913:Ubr3
|
UTSW |
2 |
69,851,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5969:Ubr3
|
UTSW |
2 |
69,809,730 (GRCm39) |
nonsense |
probably null |
|
|
R6136:Ubr3
|
UTSW |
2 |
69,824,107 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6140:Ubr3
|
UTSW |
2 |
69,803,673 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6185:Ubr3
|
UTSW |
2 |
69,768,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6220:Ubr3
|
UTSW |
2 |
69,850,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6258:Ubr3
|
UTSW |
2 |
69,813,208 (GRCm39) |
splice site |
probably null |
|
|
R6319:Ubr3
|
UTSW |
2 |
69,803,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6322:Ubr3
|
UTSW |
2 |
69,786,429 (GRCm39) |
nonsense |
probably null |
|
|
R6470:Ubr3
|
UTSW |
2 |
69,795,804 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6477:Ubr3
|
UTSW |
2 |
69,809,773 (GRCm39) |
nonsense |
probably null |
|
|
R6702:Ubr3
|
UTSW |
2 |
69,786,393 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6709:Ubr3
|
UTSW |
2 |
69,843,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6803:Ubr3
|
UTSW |
2 |
69,766,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6806:Ubr3
|
UTSW |
2 |
69,786,308 (GRCm39) |
splice site |
probably benign |
|
|
R6834:Ubr3
|
UTSW |
2 |
69,830,825 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6841:Ubr3
|
UTSW |
2 |
69,850,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6847:Ubr3
|
UTSW |
2 |
69,813,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6889:Ubr3
|
UTSW |
2 |
69,774,644 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7065:Ubr3
|
UTSW |
2 |
69,784,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7102:Ubr3
|
UTSW |
2 |
69,728,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Ubr3
|
UTSW |
2 |
69,851,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Ubr3
|
UTSW |
2 |
69,846,478 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7273:Ubr3
|
UTSW |
2 |
69,809,677 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7314:Ubr3
|
UTSW |
2 |
69,821,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7422:Ubr3
|
UTSW |
2 |
69,783,886 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7584:Ubr3
|
UTSW |
2 |
69,821,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7588:Ubr3
|
UTSW |
2 |
69,801,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7597:Ubr3
|
UTSW |
2 |
69,803,812 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7697:Ubr3
|
UTSW |
2 |
69,728,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7737:Ubr3
|
UTSW |
2 |
69,821,910 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7743:Ubr3
|
UTSW |
2 |
69,774,793 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7946:Ubr3
|
UTSW |
2 |
69,781,739 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7991:Ubr3
|
UTSW |
2 |
69,783,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Ubr3
|
UTSW |
2 |
69,819,220 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8136:Ubr3
|
UTSW |
2 |
69,851,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Ubr3
|
UTSW |
2 |
69,784,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R8313:Ubr3
|
UTSW |
2 |
69,775,478 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8675:Ubr3
|
UTSW |
2 |
69,850,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8834:Ubr3
|
UTSW |
2 |
69,833,785 (GRCm39) |
missense |
probably benign |
|
|
R8975:Ubr3
|
UTSW |
2 |
69,752,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9060:Ubr3
|
UTSW |
2 |
69,839,489 (GRCm39) |
nonsense |
probably null |
|
|
R9153:Ubr3
|
UTSW |
2 |
69,795,822 (GRCm39) |
missense |
|
|
|
R9234:Ubr3
|
UTSW |
2 |
69,727,990 (GRCm39) |
missense |
probably benign |
|
|
R9293:Ubr3
|
UTSW |
2 |
69,727,769 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9312:Ubr3
|
UTSW |
2 |
69,784,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9710:Ubr3
|
UTSW |
2 |
69,727,957 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9762:Ubr3
|
UTSW |
2 |
69,839,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Ubr3
|
UTSW |
2 |
69,752,711 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,803,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,728,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,727,805 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGTTGTTCAGCAATGAGGAGC -3'
(R):5'- CATGCACACTGTGATAACACTTG -3'
Sequencing Primer
(F):5'- TGTTCAGCAATGAGGAGCTAGCC -3'
(R):5'- CACACTGTGATAACACTTGTTTAAAG -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation