Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02861:Cdon'

362146

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdon

Ensembl Gene

ENSMUSG00000038119

Gene Name

cell adhesion molecule-related/down-regulated by oncogenes

Synonyms

CAM-related/down-regulated by oncogenes, CDO

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.351) question?

Stock #

IGL02861

Quality Score

Status

Chromosome

Chromosomal Location

35332836-35418948 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 35398253 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 990 (Q990L)

Ref Sequence

ENSEMBL: ENSMUSP00000113977 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129]

AlphaFold

Q32MD9

Predicted Effect

probably damaging
Transcript: ENSMUST00000042842
AA Change: Q990L

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: Q990L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IGc2	40	103	1.35e-9	SMART
IG	125	212	7.25e-1	SMART
IGc2	233	296	1.38e-6	SMART
IGc2	323	386	4.62e-17	SMART
IGc2	416	506	5e-13	SMART
FN3	573	660	2.18e-2	SMART
FN3	717	800	1.89e-11	SMART
FN3	822	909	7.01e-6	SMART
transmembrane domain	962	984	N/A	INTRINSIC
low complexity region	1101	1111	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000119129
AA Change: Q990L

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: Q990L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IGc2	40	103	1.35e-9	SMART
IG	125	212	7.25e-1	SMART
IGc2	233	296	1.38e-6	SMART
IGc2	323	386	4.62e-17	SMART
IGc2	416	506	5e-13	SMART
FN3	573	660	2.18e-2	SMART
FN3	717	800	1.89e-11	SMART
FN3	822	909	7.01e-6	SMART
transmembrane domain	962	984	N/A	INTRINSIC
low complexity region	1101	1111	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930486L24Rik	A	T	13: 61,001,146 (GRCm39)		probably benign	Het
6430548M08Rik	G	A	8: 120,876,863 (GRCm39)	R157H	probably damaging	Het
Amer3	A	G	1: 34,627,206 (GRCm39)	K482E	probably damaging	Het
Ankrd11	A	T	8: 123,622,566 (GRCm39)	S429T	probably damaging	Het
Ano3	T	A	2: 110,569,157 (GRCm39)	N125I	probably damaging	Het
BC106179	T	A	16: 23,042,746 (GRCm39)		probably benign	Het
Bclaf3	T	C	X: 158,338,524 (GRCm39)	I457T	possibly damaging	Het
Cbr3	T	G	16: 93,482,007 (GRCm39)	V121G	probably damaging	Het
Cd44	A	G	2: 102,662,826 (GRCm39)		probably null	Het
Cd72	G	A	4: 43,448,332 (GRCm39)	A316V	probably benign	Het
Cdc27	A	T	11: 104,413,657 (GRCm39)		probably benign	Het
Clk2	T	C	3: 89,080,706 (GRCm39)	W231R	probably damaging	Het
Cpsf2	G	A	12: 101,965,825 (GRCm39)	V597I	probably benign	Het
D630003M21Rik	A	G	2: 158,042,918 (GRCm39)	V874A	probably benign	Het
Daam2	A	G	17: 49,776,455 (GRCm39)	F811L	probably damaging	Het
Ddx54	T	C	5: 120,756,195 (GRCm39)		probably benign	Het
Dysf	T	A	6: 84,016,519 (GRCm39)	L59Q	probably damaging	Het
Eps8	A	G	6: 137,476,597 (GRCm39)	Y601H	probably damaging	Het
Faf2	T	C	13: 54,796,235 (GRCm39)	Y131H	probably damaging	Het
Hectd4	T	A	5: 121,445,067 (GRCm39)	D101E	possibly damaging	Het
Hk2	T	C	6: 82,737,139 (GRCm39)	T30A	possibly damaging	Het
Il27	A	T	7: 126,191,821 (GRCm39)	L77Q	probably damaging	Het
Klhdc1	T	A	12: 69,298,225 (GRCm39)	V83D	possibly damaging	Het
Manba	T	G	3: 135,276,024 (GRCm39)	S822A	probably benign	Het
Mterf2	A	C	10: 84,956,195 (GRCm39)	V143G	probably damaging	Het
Ncapd3	A	G	9: 26,981,195 (GRCm39)	D895G	probably benign	Het
Or4c115	T	A	2: 88,927,801 (GRCm39)	I157L	probably benign	Het
Or6n1	T	A	1: 173,916,602 (GRCm39)		probably benign	Het
Panx1	T	C	9: 14,919,101 (GRCm39)	K253E	probably benign	Het
Phc1	T	A	6: 122,300,748 (GRCm39)		probably benign	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Ptchd4	A	G	17: 42,688,208 (GRCm39)	E250G	probably damaging	Het
Rp1	G	T	1: 4,416,375 (GRCm39)	S1579*	probably null	Het
Rrp1	A	G	10: 78,245,056 (GRCm39)		probably benign	Het
Ryr3	A	G	2: 112,483,186 (GRCm39)	L4187P	possibly damaging	Het
Serpinc1	A	T	1: 160,827,561 (GRCm39)	I387F	probably damaging	Het
Slc2a7	G	A	4: 150,252,836 (GRCm39)	C492Y	probably benign	Het
Slf1	A	G	13: 77,274,478 (GRCm39)		probably benign	Het
Spta1	T	A	1: 174,039,164 (GRCm39)	L1169Q	probably damaging	Het
Stap1	T	A	5: 86,219,824 (GRCm39)		probably benign	Het
Taf6	A	G	5: 138,182,147 (GRCm39)	L66P	probably damaging	Het
Ttn	T	C	2: 76,632,841 (GRCm39)	E14071G	probably damaging	Het
Unk	A	G	11: 115,947,125 (GRCm39)	H586R	possibly damaging	Het
Zfpm2	A	C	15: 40,966,662 (GRCm39)	K917T	probably damaging	Het

Other mutations in Cdon

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00832:Cdon	APN	9	35,389,412 (GRCm39)	missense	probably damaging	1.00
IGL01307:Cdon	APN	9	35,368,860 (GRCm39)	missense	probably benign	0.01
IGL01528:Cdon	APN	9	35,381,403 (GRCm39)	missense	possibly damaging	0.95
IGL01663:Cdon	APN	9	35,394,510 (GRCm39)	missense	possibly damaging	0.57
IGL01723:Cdon	APN	9	35,414,634 (GRCm39)	missense	probably benign	0.05
IGL02200:Cdon	APN	9	35,394,405 (GRCm39)	missense	probably benign	0.28
IGL02444:Cdon	APN	9	35,384,744 (GRCm39)	missense	probably benign	0.09
IGL02547:Cdon	APN	9	35,389,950 (GRCm39)	missense	probably damaging	1.00
IGL02620:Cdon	APN	9	35,364,095 (GRCm39)	missense	probably benign	0.00
IGL02894:Cdon	APN	9	35,366,722 (GRCm39)	missense	probably benign	0.01
IGL03153:Cdon	APN	9	35,389,255 (GRCm39)	missense	probably damaging	1.00
IGL03206:Cdon	APN	9	35,414,602 (GRCm39)	missense	probably benign
IGL03374:Cdon	APN	9	35,389,299 (GRCm39)	missense	possibly damaging	0.46
corleone	UTSW	9	35,398,252 (GRCm39)	nonsense	probably null
indentured	UTSW	9	35,363,402 (GRCm39)	start codon destroyed	probably null	1.00
Molar	UTSW	9	35,375,191 (GRCm39)	missense	probably benign	0.15
Servitude	UTSW	9	35,388,244 (GRCm39)	missense	probably damaging	1.00
PIT4280001:Cdon	UTSW	9	35,398,231 (GRCm39)	missense	probably damaging	1.00
R0045:Cdon	UTSW	9	35,398,103 (GRCm39)	missense	probably benign
R0045:Cdon	UTSW	9	35,398,103 (GRCm39)	missense	probably benign
R0064:Cdon	UTSW	9	35,400,523 (GRCm39)	missense	probably benign	0.03
R0396:Cdon	UTSW	9	35,381,426 (GRCm39)	missense	probably damaging	1.00
R0403:Cdon	UTSW	9	35,384,796 (GRCm39)	missense	probably benign	0.00
R0490:Cdon	UTSW	9	35,363,978 (GRCm39)	missense	probably damaging	1.00
R0547:Cdon	UTSW	9	35,368,794 (GRCm39)	missense	possibly damaging	0.88
R0609:Cdon	UTSW	9	35,389,907 (GRCm39)	missense	probably damaging	1.00
R0645:Cdon	UTSW	9	35,388,379 (GRCm39)	splice site	probably null
R0781:Cdon	UTSW	9	35,367,733 (GRCm39)	splice site	probably benign
R1110:Cdon	UTSW	9	35,367,733 (GRCm39)	splice site	probably benign
R1391:Cdon	UTSW	9	35,415,485 (GRCm39)	missense	possibly damaging	0.51
R1574:Cdon	UTSW	9	35,364,233 (GRCm39)	splice site	probably benign
R1851:Cdon	UTSW	9	35,394,454 (GRCm39)	missense	probably damaging	1.00
R2031:Cdon	UTSW	9	35,415,370 (GRCm39)	missense	probably damaging	0.96
R2230:Cdon	UTSW	9	35,403,222 (GRCm39)	critical splice donor site	probably null
R3683:Cdon	UTSW	9	35,400,328 (GRCm39)	missense	possibly damaging	0.89
R3684:Cdon	UTSW	9	35,400,328 (GRCm39)	missense	possibly damaging	0.89
R3685:Cdon	UTSW	9	35,400,328 (GRCm39)	missense	possibly damaging	0.89
R3941:Cdon	UTSW	9	35,375,467 (GRCm39)	missense	probably benign	0.09
R4030:Cdon	UTSW	9	35,403,202 (GRCm39)	missense	probably damaging	1.00
R4084:Cdon	UTSW	9	35,389,427 (GRCm39)	missense	probably damaging	0.98
R4462:Cdon	UTSW	9	35,368,876 (GRCm39)	missense	probably damaging	0.97
R4569:Cdon	UTSW	9	35,388,265 (GRCm39)	missense	probably damaging	1.00
R4677:Cdon	UTSW	9	35,389,901 (GRCm39)	missense	probably damaging	1.00
R4869:Cdon	UTSW	9	35,364,200 (GRCm39)	missense	possibly damaging	0.71
R5032:Cdon	UTSW	9	35,400,330 (GRCm39)	missense	probably damaging	1.00
R5047:Cdon	UTSW	9	35,389,935 (GRCm39)	missense	probably damaging	1.00
R5214:Cdon	UTSW	9	35,394,504 (GRCm39)	missense	probably damaging	1.00
R5341:Cdon	UTSW	9	35,381,431 (GRCm39)	missense	probably damaging	1.00
R5410:Cdon	UTSW	9	35,381,331 (GRCm39)	missense	probably damaging	0.99
R5581:Cdon	UTSW	9	35,415,377 (GRCm39)	missense	probably benign	0.01
R5696:Cdon	UTSW	9	35,403,162 (GRCm39)	missense	possibly damaging	0.69
R5757:Cdon	UTSW	9	35,364,068 (GRCm39)	missense	probably damaging	0.98
R5802:Cdon	UTSW	9	35,365,716 (GRCm39)	missense	probably damaging	0.99
R5845:Cdon	UTSW	9	35,368,762 (GRCm39)	missense	probably damaging	1.00
R5949:Cdon	UTSW	9	35,398,247 (GRCm39)	missense	probably benign	0.32
R6106:Cdon	UTSW	9	35,366,704 (GRCm39)	nonsense	probably null
R6245:Cdon	UTSW	9	35,388,235 (GRCm39)	missense	probably damaging	1.00
R6845:Cdon	UTSW	9	35,398,252 (GRCm39)	nonsense	probably null
R6896:Cdon	UTSW	9	35,363,402 (GRCm39)	start codon destroyed	probably null	1.00
R7060:Cdon	UTSW	9	35,398,205 (GRCm39)	missense	probably damaging	1.00
R7076:Cdon	UTSW	9	35,415,446 (GRCm39)	missense	probably benign	0.00
R7184:Cdon	UTSW	9	35,375,191 (GRCm39)	missense	probably benign	0.15
R7382:Cdon	UTSW	9	35,389,944 (GRCm39)	missense	probably damaging	1.00
R7763:Cdon	UTSW	9	35,365,711 (GRCm39)	nonsense	probably null
R7857:Cdon	UTSW	9	35,367,908 (GRCm39)	missense	possibly damaging	0.79
R7885:Cdon	UTSW	9	35,367,818 (GRCm39)	missense	probably benign	0.01
R7894:Cdon	UTSW	9	35,388,244 (GRCm39)	missense	probably damaging	1.00
R7984:Cdon	UTSW	9	35,414,598 (GRCm39)	missense	probably benign	0.00
R8287:Cdon	UTSW	9	35,375,225 (GRCm39)	missense	probably benign
R8428:Cdon	UTSW	9	35,403,163 (GRCm39)	missense	probably benign	0.21
R8519:Cdon	UTSW	9	35,389,950 (GRCm39)	missense	probably damaging	1.00
R8698:Cdon	UTSW	9	35,398,269 (GRCm39)	critical splice donor site	probably null
R8797:Cdon	UTSW	9	35,389,931 (GRCm39)	missense	probably damaging	1.00
R8995:Cdon	UTSW	9	35,398,093 (GRCm39)	missense	probably damaging	1.00
R9090:Cdon	UTSW	9	35,403,175 (GRCm39)	missense	probably damaging	0.98
R9177:Cdon	UTSW	9	35,381,230 (GRCm39)	missense	probably benign	0.00
R9200:Cdon	UTSW	9	35,414,617 (GRCm39)	missense	probably benign	0.00
R9271:Cdon	UTSW	9	35,403,175 (GRCm39)	missense	probably damaging	0.98
R9330:Cdon	UTSW	9	35,400,275 (GRCm39)	nonsense	probably null
R9477:Cdon	UTSW	9	35,403,201 (GRCm39)	missense	probably damaging	1.00
R9612:Cdon	UTSW	9	35,398,201 (GRCm39)	missense	probably damaging	1.00
R9730:Cdon	UTSW	9	35,398,263 (GRCm39)	missense	probably benign	0.00
Z1177:Cdon	UTSW	9	35,403,196 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18