Incidental Mutation 'R5342:Or2r3'
ID 422380
Institutional Source Beutler Lab
Gene Symbol Or2r3
Ensembl Gene ENSMUSG00000091983
Gene Name olfactory receptor family 2 subfamily R member 3
Synonyms GA_x6K02T2P3E9-5088893-5089834, Olfr457, MOR257-1
MMRRC Submission 042921-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R5342 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 42448169-42449110 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 42448836 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 92 (I92T)
Ref Sequence ENSEMBL: ENSMUSP00000144914 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170504] [ENSMUST00000203396] [ENSMUST00000204324]
AlphaFold Q8VGP5
Predicted Effect probably damaging
Transcript: ENSMUST00000170504
AA Change: I92T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127348
Gene: ENSMUSG00000091983
AA Change: I92T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203396
AA Change: I92T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145162
Gene: ENSMUSG00000091983
AA Change: I92T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204324
AA Change: I92T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144914
Gene: ENSMUSG00000091983
AA Change: I92T

DomainStartEndE-ValueType
Pfam:7tm_4 31 125 2.4e-19 PFAM
Pfam:7tm_1 41 125 3.1e-14 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adrb3 A C 8: 27,716,809 (GRCm39) Y392* probably null Het
Arap1 G A 7: 101,054,167 (GRCm39) E1330K probably benign Het
Atg2b G T 12: 105,625,175 (GRCm39) D600E possibly damaging Het
Atp1b2 C T 11: 69,493,654 (GRCm39) V142I probably damaging Het
AW551984 A T 9: 39,505,847 (GRCm39) M450K probably damaging Het
Bcar3 A G 3: 122,220,298 (GRCm39) D65G probably damaging Het
Ccnt2 T C 1: 127,719,470 (GRCm39) silent Het
Cdca7l A G 12: 117,840,768 (GRCm39) Y430C probably damaging Het
Ces4a A G 8: 105,872,775 (GRCm39) T343A probably benign Het
Clec2g C T 6: 128,925,714 (GRCm39) A41V probably benign Het
Crybg3 A T 16: 59,342,512 (GRCm39) Y2708N probably damaging Het
Cspg4b T C 13: 113,502,803 (GRCm39) probably null Het
Dmxl1 A T 18: 50,084,302 (GRCm39) E2758V probably damaging Het
Eci2 C T 13: 35,162,707 (GRCm39) E283K probably benign Het
Edrf1 T A 7: 133,253,639 (GRCm39) probably null Het
Eif3b T C 5: 140,411,035 (GRCm39) L162P probably damaging Het
Ercc3 A G 18: 32,378,648 (GRCm39) I210V probably benign Het
Exoc1 A G 5: 76,714,861 (GRCm39) N739S probably damaging Het
Gm7334 A G 17: 51,005,782 (GRCm39) K23E probably benign Het
Gm7356 T G 17: 14,221,360 (GRCm39) D223A possibly damaging Het
Klhl26 A G 8: 70,908,215 (GRCm39) L47P probably damaging Het
Klhl42 C T 6: 146,993,784 (GRCm39) T252I possibly damaging Het
Morc1 G T 16: 48,438,872 (GRCm39) G756W probably damaging Het
Mroh2b G T 15: 4,943,615 (GRCm39) E384* probably null Het
Nol10 G A 12: 17,419,621 (GRCm39) probably null Het
Nxpe5 T C 5: 138,237,503 (GRCm39) L9P probably damaging Het
Or52z12 C T 7: 103,234,035 (GRCm39) R269C probably benign Het
Or7e166 A G 9: 19,624,333 (GRCm39) D70G probably damaging Het
Pak2 T C 16: 31,863,306 (GRCm39) E94G probably damaging Het
Pcdha7 A G 18: 37,107,724 (GRCm39) K250E possibly damaging Het
Pde8b T C 13: 95,178,498 (GRCm39) T541A probably damaging Het
Peg3 A T 7: 6,712,969 (GRCm39) I751N probably damaging Het
Prpsap2 T C 11: 61,622,396 (GRCm39) D269G probably damaging Het
Raver2 C A 4: 100,959,889 (GRCm39) T123K possibly damaging Het
Rpgrip1 G A 14: 52,382,666 (GRCm39) D600N possibly damaging Het
Scn2b A G 9: 45,036,816 (GRCm39) Y108C probably damaging Het
Sdr16c6 T C 4: 4,069,923 (GRCm39) E139G probably damaging Het
Sgpp2 A G 1: 78,336,825 (GRCm39) I68V probably benign Het
Sorbs2 T A 8: 46,249,050 (GRCm39) I687N probably damaging Het
Sorcs3 G A 19: 48,784,911 (GRCm39) probably null Het
Stk16 T A 1: 75,189,609 (GRCm39) C174S probably benign Het
Styxl2 T C 1: 165,937,819 (GRCm39) E80G probably benign Het
Ttll9 C A 2: 152,833,572 (GRCm39) N198K possibly damaging Het
Unc13c A T 9: 73,838,105 (GRCm39) D915E probably benign Het
Unc5b T A 10: 60,614,046 (GRCm39) K268* probably null Het
Vim T A 2: 13,584,824 (GRCm39) probably null Het
Xirp2 T A 2: 67,343,805 (GRCm39) N2015K probably damaging Het
Zfp160 T G 17: 21,240,995 (GRCm39) M21R possibly damaging Het
Other mutations in Or2r3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01417:Or2r3 APN 6 42,449,046 (GRCm39) missense probably benign 0.00
IGL01915:Or2r3 APN 6 42,448,223 (GRCm39) missense probably benign 0.01
IGL02006:Or2r3 APN 6 42,449,025 (GRCm39) missense probably benign 0.37
IGL02440:Or2r3 APN 6 42,449,100 (GRCm39) missense probably benign
R0024:Or2r3 UTSW 6 42,448,194 (GRCm39) missense probably benign
R0662:Or2r3 UTSW 6 42,448,708 (GRCm39) missense possibly damaging 0.75
R1599:Or2r3 UTSW 6 42,448,176 (GRCm39) missense probably damaging 1.00
R2087:Or2r3 UTSW 6 42,448,985 (GRCm39) missense probably damaging 1.00
R5002:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R5022:Or2r3 UTSW 6 42,448,221 (GRCm39) missense possibly damaging 0.92
R5288:Or2r3 UTSW 6 42,448,186 (GRCm39) missense probably benign
R5823:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R5824:Or2r3 UTSW 6 42,448,906 (GRCm39) missense probably benign 0.18
R6378:Or2r3 UTSW 6 42,448,687 (GRCm39) missense probably benign 0.01
R7384:Or2r3 UTSW 6 42,448,257 (GRCm39) missense possibly damaging 0.89
R7442:Or2r3 UTSW 6 42,448,434 (GRCm39) missense probably benign 0.02
R7631:Or2r3 UTSW 6 42,448,870 (GRCm39) missense probably benign 0.01
R7811:Or2r3 UTSW 6 42,448,635 (GRCm39) missense probably damaging 1.00
R7896:Or2r3 UTSW 6 42,449,100 (GRCm39) missense probably benign 0.22
R9244:Or2r3 UTSW 6 42,448,537 (GRCm39) missense possibly damaging 0.88
R9579:Or2r3 UTSW 6 42,448,574 (GRCm39) nonsense probably null
X0017:Or2r3 UTSW 6 42,448,752 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGACACCTGCTAGACCCATG -3'
(R):5'- ATCCTCATGGGTCTCTCCAG -3'

Sequencing Primer
(F):5'- CATGCAGAGCCTTGGGTTCATC -3'
(R):5'- TGGGTCTCTCCAGTGACAAAC -3'
Posted On 2016-08-04