Mutagenetix > Incidental Mutation

Incidental Mutation 'R5848:Gm10644'

453719

Institutional Source

Beutler Lab

Gene Symbol

Gm10644

Ensembl Gene

ENSMUSG00000074219

Gene Name

predicted gene 10644

Synonyms

MMRRC Submission

043225-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5848 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

84658956-84681962 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to A at 84660668 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045393] [ENSMUST00000098595] [ENSMUST00000124355] [ENSMUST00000131717] [ENSMUST00000132500] [ENSMUST00000152978] [ENSMUST00000141158]

AlphaFold

no structure available at present

Predicted Effect

silent
Transcript: ENSMUST00000045393

SMART Domains

Protein: ENSMUSP00000048422
Gene: ENSMUSG00000013033

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
Pfam:Gal_Lectin	48	128	6.6e-23	PFAM
OLF	142	398	8.5e-138	SMART
low complexity region	405	441	N/A	INTRINSIC
low complexity region	455	470	N/A	INTRINSIC
HormR	476	541	1.4e-23	SMART
low complexity region	579	591	N/A	INTRINSIC
low complexity region	747	758	N/A	INTRINSIC
GPS	797	849	3.5e-27	SMART
Pfam:7tm_2	856	1092	5.3e-66	PFAM
Pfam:Latrophilin	1112	1470	1.7e-177	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000098595

SMART Domains

Protein: ENSMUSP00000096195
Gene: ENSMUSG00000074219

Domain	Start	End	E-Value	Type
low complexity region	60	72	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124355

SMART Domains

Protein: ENSMUSP00000116064
Gene: ENSMUSG00000013033

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
Pfam:Gal_Lectin	48	128	1.1e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000131018

SMART Domains

Protein: ENSMUSP00000117720
Gene: ENSMUSG00000013033

Domain	Start	End	E-Value	Type
Pfam:Latrophilin	1	213	9.2e-76	PFAM

Predicted Effect

silent
Transcript: ENSMUST00000131717

SMART Domains

Protein: ENSMUSP00000118579
Gene: ENSMUSG00000013033

Domain	Start	End	E-Value	Type
OLF	1	222	4.51e-103	SMART
low complexity region	229	265	N/A	INTRINSIC
low complexity region	279	294	N/A	INTRINSIC
HormR	300	365	2.26e-21	SMART
low complexity region	403	415	N/A	INTRINSIC
low complexity region	571	582	N/A	INTRINSIC
GPS	621	673	5.64e-25	SMART
Pfam:7tm_2	680	916	7.9e-68	PFAM
Pfam:Latrophilin	936	1295	2.7e-181	PFAM

Predicted Effect

silent
Transcript: ENSMUST00000132500

SMART Domains

Protein: ENSMUSP00000119100
Gene: ENSMUSG00000013033

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:Gal_Lectin	48	128	1.6e-25	PFAM
OLF	137	393	1.39e-135	SMART
low complexity region	400	436	N/A	INTRINSIC
low complexity region	450	465	N/A	INTRINSIC
HormR	471	536	2.26e-21	SMART
low complexity region	574	586	N/A	INTRINSIC
low complexity region	742	753	N/A	INTRINSIC
GPS	792	844	5.64e-25	SMART
Pfam:7tm_2	851	1087	3.4e-68	PFAM
Pfam:Latrophilin	1146	1511	6.4e-193	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139575

Predicted Effect

silent
Transcript: ENSMUST00000152978

SMART Domains

Protein: ENSMUSP00000115295
Gene: ENSMUSG00000013033

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:Gal_Lectin	48	128	2.1e-25	PFAM
OLF	142	398	1.39e-135	SMART
low complexity region	405	441	N/A	INTRINSIC
low complexity region	455	470	N/A	INTRINSIC
HormR	476	541	2.26e-21	SMART
Pfam:GAIN	544	773	4.1e-59	PFAM
GPS	797	849	5.64e-25	SMART
Pfam:7tm_2	856	1092	2.3e-69	PFAM
Pfam:Latrophilin	1112	1516	7.3e-136	PFAM

Predicted Effect

silent
Transcript: ENSMUST00000141158

SMART Domains

Protein: ENSMUSP00000118452
Gene: ENSMUSG00000013033

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:Gal_Lectin	48	128	3.4e-25	PFAM
OLF	137	393	1.39e-135	SMART
low complexity region	400	436	N/A	INTRINSIC
low complexity region	450	465	N/A	INTRINSIC
HormR	471	536	2.26e-21	SMART
low complexity region	574	586	N/A	INTRINSIC
low complexity region	742	753	N/A	INTRINSIC
GPS	792	844	5.64e-25	SMART
Pfam:7tm_2	851	1087	4.5e-68	PFAM
Pfam:Latrophilin	1107	1466	1.1e-180	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141661

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150674

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199528

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200106

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930553M12Rik	T	C	4: 88,786,596 (GRCm39)	I7M	unknown	Het
Aadacl4	T	A	4: 144,344,428 (GRCm39)	M68K	probably benign	Het
Abca8b	C	A	11: 109,868,639 (GRCm39)	G175V	probably damaging	Het
Cdcp1	T	A	9: 123,012,770 (GRCm39)	H259L	possibly damaging	Het
Ckap4	T	C	10: 84,369,354 (GRCm39)	Q126R	probably benign	Het
Clec18a	C	T	8: 111,802,093 (GRCm39)	V299I	probably benign	Het
D7Ertd443e	A	G	7: 133,951,451 (GRCm39)	I27T	possibly damaging	Het
Dlg2	T	G	7: 92,093,735 (GRCm39)	D726E	probably benign	Het
Dnah8	T	C	17: 30,947,165 (GRCm39)	I1856T	possibly damaging	Het
Espl1	G	A	15: 102,231,011 (GRCm39)	V1837I	probably benign	Het
Fanca	G	T	8: 124,021,792 (GRCm39)		probably benign	Het
Fer1l5	A	G	1: 36,428,016 (GRCm39)	T437A	probably benign	Het
Katnb1	A	G	8: 95,825,340 (GRCm39)	S635G	probably benign	Het
Map3k12	A	G	15: 102,412,670 (GRCm39)	V234A	possibly damaging	Het
Mks1	A	G	11: 87,747,696 (GRCm39)	N193S	probably benign	Het
Mmp11	T	C	10: 75,763,223 (GRCm39)	E151G	probably damaging	Het
Napg	A	G	18: 63,127,440 (GRCm39)	R265G	possibly damaging	Het
Odad2	T	A	18: 7,268,507 (GRCm39)		probably null	Het
Or5e1	T	A	7: 108,354,781 (GRCm39)	C239*	probably null	Het
Or6e1	A	G	14: 54,520,022 (GRCm39)	F110S	possibly damaging	Het
P3r3urf	T	C	4: 116,030,812 (GRCm39)	I72T	probably damaging	Het
Pcdha7	G	T	18: 37,108,136 (GRCm39)	C387F	probably damaging	Het
Pcdhb3	G	T	18: 37,434,700 (GRCm39)	R222L	probably benign	Het
Phf2	A	G	13: 48,973,546 (GRCm39)	M373T	unknown	Het
Plekha7	T	C	7: 115,739,634 (GRCm39)	T636A	probably damaging	Het
Rictor	G	A	15: 6,823,487 (GRCm39)	E1555K	probably benign	Het
Rnf6	G	A	5: 146,147,959 (GRCm39)	P353L	probably benign	Het
Sel1l3	A	C	5: 53,342,150 (GRCm39)	L357V	possibly damaging	Het
Sh3rf3	T	A	10: 58,819,975 (GRCm39)	M262K	possibly damaging	Het
Sorcs3	A	T	19: 48,776,950 (GRCm39)	H994L	probably damaging	Het
Thsd7a	A	T	6: 12,503,922 (GRCm39)	C411S	probably damaging	Het
Ttn	T	C	2: 76,593,682 (GRCm39)	K20653E	probably damaging	Het
Ttn	A	C	2: 76,708,908 (GRCm39)		probably null	Het
Ttn	A	G	2: 76,611,264 (GRCm39)	W15677R	probably damaging	Het
Ubr2	T	C	17: 47,267,581 (GRCm39)	M1049V	possibly damaging	Het

Other mutations in Gm10644

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0332:Gm10644	UTSW	8	84,660,210 (GRCm39)	missense	possibly damaging	0.92
R1914:Gm10644	UTSW	8	84,660,479 (GRCm39)	intron	probably benign
R1915:Gm10644	UTSW	8	84,660,479 (GRCm39)	intron	probably benign
R2184:Gm10644	UTSW	8	84,660,256 (GRCm39)	missense	possibly damaging	0.66
R5002:Gm10644	UTSW	8	84,660,216 (GRCm39)	missense	possibly damaging	0.90

Predicted Primers

Posted On

2017-02-10