Incidental Mutation 'R0554:Tiam2'
| ID |
45413 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
STEF, 3000002F19Rik |
| MMRRC Submission |
038746-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0554 (G1)
|
| Quality Score |
218 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
3376675-3569672 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 3488956 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 755
(R755*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072156]
[ENSMUST00000169838]
|
| AlphaFold |
Q6ZPF3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000072156
AA Change: R755*
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: R755*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000169838
AA Change: R755*
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: R755*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226748
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226905
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700018F24Rik |
T |
A |
5: 144,982,181 (GRCm39) |
Y255* |
probably null |
Het |
| 1810024B03Rik |
A |
G |
2: 127,029,196 (GRCm39) |
M1T |
probably null |
Het |
| 4930503L19Rik |
T |
C |
18: 70,600,451 (GRCm39) |
D386G |
probably damaging |
Het |
| Ace2 |
T |
A |
X: 162,958,947 (GRCm39) |
N601K |
probably benign |
Het |
| Adam4 |
A |
C |
12: 81,468,198 (GRCm39) |
I141R |
probably damaging |
Het |
| Adcy10 |
G |
A |
1: 165,340,699 (GRCm39) |
G235S |
probably benign |
Het |
| Adcy5 |
G |
A |
16: 35,114,387 (GRCm39) |
V997I |
probably benign |
Het |
| Aff2 |
T |
G |
X: 68,907,680 (GRCm39) |
W1221G |
possibly damaging |
Het |
| Ankrd44 |
T |
C |
1: 54,802,917 (GRCm39) |
N194D |
probably benign |
Het |
| Apba2 |
T |
G |
7: 64,395,528 (GRCm39) |
L668R |
probably damaging |
Het |
| Asph |
T |
C |
4: 9,604,581 (GRCm39) |
D152G |
probably damaging |
Het |
| Bcl3 |
C |
G |
7: 19,553,991 (GRCm39) |
V126L |
probably benign |
Het |
| Cd163 |
A |
G |
6: 124,289,619 (GRCm39) |
T446A |
probably benign |
Het |
| Cd209g |
C |
T |
8: 4,184,995 (GRCm39) |
|
probably benign |
Het |
| Cdadc1 |
A |
T |
14: 59,823,901 (GRCm39) |
V197E |
probably damaging |
Het |
| CN725425 |
T |
C |
15: 91,144,966 (GRCm39) |
C610R |
possibly damaging |
Het |
| Col6a2 |
A |
G |
10: 76,446,995 (GRCm39) |
|
probably null |
Het |
| Coro7 |
A |
G |
16: 4,450,121 (GRCm39) |
L576P |
possibly damaging |
Het |
| Dgkb |
T |
A |
12: 38,266,030 (GRCm39) |
V503E |
probably benign |
Het |
| Dhx57 |
A |
T |
17: 80,567,665 (GRCm39) |
L806* |
probably null |
Het |
| Dlec1 |
T |
C |
9: 118,944,070 (GRCm39) |
V373A |
probably benign |
Het |
| Dnah11 |
G |
T |
12: 117,894,913 (GRCm39) |
R3645S |
probably benign |
Het |
| Dnhd1 |
T |
C |
7: 105,343,602 (GRCm39) |
S1649P |
probably benign |
Het |
| Draxin |
T |
G |
4: 148,192,420 (GRCm39) |
K297N |
probably damaging |
Het |
| Epha7 |
T |
C |
4: 28,951,401 (GRCm39) |
S841P |
probably damaging |
Het |
| Esp8 |
T |
G |
17: 40,841,166 (GRCm39) |
D142E |
unknown |
Het |
| F5 |
T |
G |
1: 164,007,018 (GRCm39) |
V274G |
probably damaging |
Het |
| Fancc |
T |
C |
13: 63,465,283 (GRCm39) |
S475G |
probably benign |
Het |
| Fmo3 |
T |
C |
1: 162,781,901 (GRCm39) |
N484S |
probably benign |
Het |
| Focad |
T |
C |
4: 88,267,126 (GRCm39) |
Y1046H |
unknown |
Het |
| Furin |
C |
T |
7: 80,041,032 (GRCm39) |
G602D |
probably damaging |
Het |
| Fut8 |
A |
T |
12: 77,411,744 (GRCm39) |
I69L |
probably benign |
Het |
| Gnai3 |
A |
G |
3: 108,030,928 (GRCm39) |
I78T |
probably benign |
Het |
| Gpr182 |
T |
C |
10: 127,586,940 (GRCm39) |
I4V |
probably benign |
Het |
| Gpr63 |
T |
C |
4: 25,007,447 (GRCm39) |
M57T |
probably benign |
Het |
| Grm1 |
T |
A |
10: 10,595,667 (GRCm39) |
T654S |
probably benign |
Het |
| Gtf2h4 |
T |
C |
17: 35,979,531 (GRCm39) |
T371A |
probably benign |
Het |
| Helq |
T |
C |
5: 100,938,066 (GRCm39) |
N460S |
probably benign |
Het |
| Hmcn1 |
T |
C |
1: 150,594,868 (GRCm39) |
N1867S |
probably benign |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Iigp1c |
G |
A |
18: 60,378,489 (GRCm39) |
R8H |
probably benign |
Het |
| Inpp5j |
A |
G |
11: 3,449,644 (GRCm39) |
Y713H |
probably damaging |
Het |
| Ints6 |
A |
T |
14: 62,942,200 (GRCm39) |
V511D |
possibly damaging |
Het |
| Irag2 |
G |
A |
6: 145,111,013 (GRCm39) |
A237T |
probably benign |
Het |
| Itga4 |
A |
G |
2: 79,109,461 (GRCm39) |
Y220C |
probably damaging |
Het |
| Itgav |
T |
G |
2: 83,624,614 (GRCm39) |
S735A |
possibly damaging |
Het |
| Kctd16 |
A |
G |
18: 40,391,492 (GRCm39) |
I27V |
probably benign |
Het |
| Klhl6 |
T |
C |
16: 19,772,343 (GRCm39) |
E334G |
probably damaging |
Het |
| Ltbp1 |
T |
A |
17: 75,532,274 (GRCm39) |
L116H |
probably damaging |
Het |
| Magohb |
T |
A |
6: 131,262,660 (GRCm39) |
H98L |
probably benign |
Het |
| Mgat2 |
A |
G |
12: 69,232,166 (GRCm39) |
T247A |
probably benign |
Het |
| Mtif2 |
G |
A |
11: 29,483,398 (GRCm39) |
|
probably null |
Het |
| Myrfl |
T |
C |
10: 116,664,878 (GRCm39) |
E384G |
probably damaging |
Het |
| Nfam1 |
G |
T |
15: 82,917,410 (GRCm39) |
R8S |
probably benign |
Het |
| Numa1 |
T |
C |
7: 101,644,731 (GRCm39) |
S236P |
possibly damaging |
Het |
| Or14c46 |
A |
T |
7: 85,918,865 (GRCm39) |
I44N |
probably damaging |
Het |
| Or2w3b |
T |
C |
11: 58,623,865 (GRCm39) |
N42S |
probably damaging |
Het |
| Or5m10b |
T |
C |
2: 85,699,863 (GRCm39) |
F309S |
probably benign |
Het |
| Or6c207 |
T |
C |
10: 129,104,368 (GRCm39) |
T275A |
probably benign |
Het |
| Orc4 |
C |
T |
2: 48,795,433 (GRCm39) |
S431N |
probably benign |
Het |
| Pax2 |
T |
C |
19: 44,750,300 (GRCm39) |
V129A |
probably damaging |
Het |
| Pcdhb15 |
A |
G |
18: 37,607,572 (GRCm39) |
D268G |
probably damaging |
Het |
| Pdcd1 |
G |
A |
1: 93,967,107 (GRCm39) |
R264C |
probably damaging |
Het |
| Pi15 |
T |
A |
1: 17,691,872 (GRCm39) |
M187K |
probably benign |
Het |
| Plag1 |
C |
T |
4: 3,904,546 (GRCm39) |
C215Y |
probably damaging |
Het |
| Plagl1 |
A |
G |
10: 13,002,926 (GRCm39) |
T65A |
probably benign |
Het |
| Pramel51 |
T |
C |
12: 88,144,328 (GRCm39) |
T162A |
probably benign |
Het |
| Prss48 |
T |
A |
3: 85,908,228 (GRCm39) |
Q18L |
probably benign |
Het |
| Prune2 |
T |
A |
19: 17,102,582 (GRCm39) |
C2580* |
probably null |
Het |
| Rab40b |
T |
A |
11: 121,250,432 (GRCm39) |
Q74L |
probably damaging |
Het |
| Raf1 |
A |
G |
6: 115,600,491 (GRCm39) |
I376T |
probably benign |
Het |
| Rbm46 |
A |
T |
3: 82,772,575 (GRCm39) |
F186I |
probably damaging |
Het |
| Reps1 |
C |
T |
10: 17,998,867 (GRCm39) |
T720M |
possibly damaging |
Het |
| Rgs22 |
A |
G |
15: 36,054,855 (GRCm39) |
M649T |
probably benign |
Het |
| Rhot1 |
C |
T |
11: 80,134,264 (GRCm39) |
R47* |
probably null |
Het |
| Rhox2f |
A |
G |
X: 36,753,124 (GRCm39) |
Y8C |
possibly damaging |
Het |
| Rnf17 |
A |
G |
14: 56,760,007 (GRCm39) |
Y1604C |
probably damaging |
Het |
| Rnf40 |
T |
C |
7: 127,201,756 (GRCm39) |
C943R |
probably damaging |
Het |
| Ropn1l |
A |
T |
15: 31,451,295 (GRCm39) |
M63K |
probably benign |
Het |
| Sbf2 |
C |
A |
7: 110,027,494 (GRCm39) |
V501F |
probably damaging |
Het |
| Sh3bp1 |
T |
A |
15: 78,791,467 (GRCm39) |
M354K |
probably damaging |
Het |
| Sipa1l3 |
T |
C |
7: 29,087,455 (GRCm39) |
H590R |
possibly damaging |
Het |
| Slco6d1 |
T |
A |
1: 98,394,422 (GRCm39) |
C369S |
probably benign |
Het |
| Sulf1 |
T |
C |
1: 12,875,418 (GRCm39) |
Y143H |
probably damaging |
Het |
| Trim12c |
C |
A |
7: 103,994,169 (GRCm39) |
L228F |
probably damaging |
Het |
| Ttc23l |
G |
T |
15: 10,530,743 (GRCm39) |
Q290K |
probably benign |
Het |
| Uba3 |
T |
C |
6: 97,168,221 (GRCm39) |
|
probably null |
Het |
| Ugt1a10 |
A |
G |
1: 87,983,817 (GRCm39) |
E205G |
probably damaging |
Het |
| Ugt3a1 |
T |
A |
15: 9,351,206 (GRCm39) |
S72T |
probably benign |
Het |
| Upk3bl |
C |
T |
5: 136,088,648 (GRCm39) |
T113I |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,124,644 (GRCm39) |
D20E |
probably damaging |
Het |
| Vmn2r19 |
G |
A |
6: 123,313,102 (GRCm39) |
G724E |
probably damaging |
Het |
| Vmn2r63 |
T |
A |
7: 42,583,129 (GRCm39) |
K29* |
probably null |
Het |
| Vwf |
C |
T |
6: 125,619,744 (GRCm39) |
A1474V |
probably benign |
Het |
| Xpc |
C |
T |
6: 91,468,208 (GRCm39) |
A860T |
probably benign |
Het |
| Zfp462 |
A |
G |
4: 55,013,689 (GRCm39) |
H737R |
probably damaging |
Het |
| Zfp536 |
T |
C |
7: 37,180,244 (GRCm39) |
D787G |
probably damaging |
Het |
| Zfp692 |
A |
G |
11: 58,205,053 (GRCm39) |
H434R |
probably damaging |
Het |
| Zp1 |
C |
A |
19: 10,897,926 (GRCm39) |
C5F |
probably benign |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,465,303 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,556,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,477,477 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,504,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,477,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,471,756 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,489,971 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,559,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,488,983 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,501,088 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,553,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,561,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Tiam2
|
UTSW |
17 |
3,471,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,479,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Tiam2
|
UTSW |
17 |
3,564,973 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0726:Tiam2
|
UTSW |
17 |
3,563,108 (GRCm39) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,527,542 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,566,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,557,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,568,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1759:Tiam2
|
UTSW |
17 |
3,566,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,487,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1932:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1993:Tiam2
|
UTSW |
17 |
3,465,401 (GRCm39) |
nonsense |
probably null |
|
|
R2211:Tiam2
|
UTSW |
17 |
3,465,193 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,465,389 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,477,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,527,536 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,503,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,568,525 (GRCm39) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,471,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,489,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,471,959 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,471,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,479,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,479,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,501,120 (GRCm39) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,501,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,464,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,464,242 (GRCm39) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,564,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,568,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,504,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,500,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,555,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,488,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,465,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,498,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,487,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,488,915 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,465,084 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,464,396 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,503,613 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,559,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,488,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,557,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,557,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,568,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,568,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,464,655 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,558,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,568,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,498,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,498,660 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,568,687 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,503,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,553,283 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,532,880 (GRCm39) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,568,431 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,471,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,559,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,487,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,568,399 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,568,524 (GRCm39) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,498,671 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,568,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,568,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,557,142 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,558,065 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,568,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,501,087 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,479,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,527,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,561,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,464,519 (GRCm39) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,498,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9271:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9347:Tiam2
|
UTSW |
17 |
3,471,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,558,074 (GRCm39) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,553,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,487,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,559,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,561,440 (GRCm39) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,464,275 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,500,629 (GRCm39) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,555,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,465,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,556,051 (GRCm39) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,477,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCGTGTGAACTATGCAGCAGAC -3'
(R):5'- ACACTGAGGCAGACAGTAAGGCTC -3'
Sequencing Primer
(F):5'- TGAACTATGCAGCAGACTCAAG -3'
(R):5'- TGGATTACAGTTAACCGCTACC -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation