Incidental Mutation 'R0759:Zftraf1'
ID |
474008 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zftraf1
|
Ensembl Gene |
ENSMUSG00000053929 |
Gene Name |
zinc finger TRAF type containing 1 |
Synonyms |
Cyhr1, Chrp, 1110031M01Rik |
MMRRC Submission |
038939-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.274)
|
Stock # |
R0759 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
15 |
Chromosomal Location |
76527586-76541120 bp(-) (GRCm39) |
Type of Mutation |
makesense |
DNA Base Change (assembly) |
A to G
at 76530385 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Stop codon to Glutamine
at position 312
(*312Q)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000080043
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081291]
[ENSMUST00000176274]
[ENSMUST00000229524]
|
AlphaFold |
Q9QXA1 |
Predicted Effect |
probably null
Transcript: ENSMUST00000081291
AA Change: *312Q
|
SMART Domains |
Protein: ENSMUSP00000080043 Gene: ENSMUSG00000053929 AA Change: *312Q
Domain | Start | End | E-Value | Type |
SCOP:d1jm7a_
|
21 |
88 |
3e-5 |
SMART |
Blast:RING
|
27 |
62 |
8e-15 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176274
|
SMART Domains |
Protein: ENSMUSP00000134739 Gene: ENSMUSG00000053929
Domain | Start | End | E-Value | Type |
low complexity region
|
3 |
48 |
N/A |
INTRINSIC |
low complexity region
|
78 |
91 |
N/A |
INTRINSIC |
RING
|
106 |
150 |
1.9e-1 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000229524
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229541
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229552
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.4%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
3425401B19Rik |
A |
T |
14: 32,384,454 (GRCm39) |
F504I |
possibly damaging |
Het |
Amdhd2 |
C |
A |
17: 24,380,587 (GRCm39) |
C119F |
probably benign |
Het |
Arhgef18 |
T |
G |
8: 3,438,822 (GRCm39) |
|
probably benign |
Het |
Bsph2 |
A |
T |
7: 13,290,652 (GRCm39) |
Y76N |
probably damaging |
Het |
C1s1 |
T |
C |
6: 124,508,396 (GRCm39) |
N531S |
probably damaging |
Het |
Ces1c |
G |
A |
8: 93,857,492 (GRCm39) |
Q30* |
probably null |
Het |
Cltc |
A |
C |
11: 86,627,908 (GRCm39) |
I80S |
probably null |
Het |
Colec11 |
A |
G |
12: 28,644,730 (GRCm39) |
S249P |
probably damaging |
Het |
Cxcl16 |
C |
T |
11: 70,349,954 (GRCm39) |
C24Y |
probably damaging |
Het |
Dennd4c |
A |
G |
4: 86,707,066 (GRCm39) |
I348V |
probably damaging |
Het |
Elavl1 |
C |
A |
8: 4,339,815 (GRCm39) |
D256Y |
probably damaging |
Het |
Fubp1 |
TGGCGGCGGCGGCGGCGG |
TGGCGGCGGCGGCGGCGGCGG |
3: 151,916,274 (GRCm39) |
|
probably benign |
Het |
Gm43434 |
T |
G |
14: 54,382,952 (GRCm39) |
|
probably benign |
Het |
Il1a |
T |
A |
2: 129,146,607 (GRCm39) |
D162V |
probably damaging |
Het |
Map3k19 |
A |
G |
1: 127,745,162 (GRCm39) |
Y1227H |
possibly damaging |
Het |
Myb |
C |
T |
10: 21,020,927 (GRCm39) |
V501I |
probably benign |
Het |
Nav1 |
A |
G |
1: 135,382,998 (GRCm39) |
I1238T |
possibly damaging |
Het |
Nr0b2 |
A |
T |
4: 133,281,049 (GRCm39) |
Q105L |
probably damaging |
Het |
Or11g27 |
T |
C |
14: 50,771,159 (GRCm39) |
S97P |
possibly damaging |
Het |
Pdilt |
A |
T |
7: 119,088,707 (GRCm39) |
Y431* |
probably null |
Het |
Plg |
A |
G |
17: 12,629,838 (GRCm39) |
H624R |
probably damaging |
Het |
Ppl |
A |
G |
16: 4,907,641 (GRCm39) |
S885P |
probably benign |
Het |
Ptdss1 |
T |
C |
13: 67,135,868 (GRCm39) |
L375P |
probably damaging |
Het |
Rrm1 |
A |
G |
7: 102,106,768 (GRCm39) |
D347G |
probably benign |
Het |
Sbf1 |
A |
T |
15: 89,188,919 (GRCm39) |
V573E |
probably damaging |
Het |
Slc9a1 |
T |
A |
4: 133,143,714 (GRCm39) |
I400N |
probably damaging |
Het |
Slurp1 |
A |
G |
15: 74,598,808 (GRCm39) |
F61S |
probably damaging |
Het |
Smpd3 |
T |
C |
8: 106,991,860 (GRCm39) |
E231G |
probably benign |
Het |
Sned1 |
C |
T |
1: 93,200,286 (GRCm39) |
T564M |
probably damaging |
Het |
Tril |
G |
T |
6: 53,795,012 (GRCm39) |
R737S |
probably damaging |
Het |
Trim35 |
T |
A |
14: 66,546,236 (GRCm39) |
D334E |
probably benign |
Het |
Trp53i11 |
A |
G |
2: 93,029,303 (GRCm39) |
T101A |
possibly damaging |
Het |
Usp9y |
T |
C |
Y: 1,299,097 (GRCm39) |
N2514D |
probably damaging |
Het |
Xpc |
A |
T |
6: 91,475,124 (GRCm39) |
Y634N |
probably damaging |
Het |
|
Other mutations in Zftraf1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00093:Zftraf1
|
APN |
15 |
76,530,738 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03163:Zftraf1
|
APN |
15 |
76,543,474 (GRCm39) |
missense |
probably damaging |
0.97 |
R0107:Zftraf1
|
UTSW |
15 |
76,530,547 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0445:Zftraf1
|
UTSW |
15 |
76,532,457 (GRCm39) |
missense |
probably damaging |
1.00 |
R1327:Zftraf1
|
UTSW |
15 |
76,533,376 (GRCm39) |
missense |
probably damaging |
0.98 |
R1366:Zftraf1
|
UTSW |
15 |
76,533,169 (GRCm39) |
missense |
probably damaging |
0.96 |
R1950:Zftraf1
|
UTSW |
15 |
76,543,417 (GRCm39) |
critical splice donor site |
probably null |
|
R3416:Zftraf1
|
UTSW |
15 |
76,542,915 (GRCm39) |
splice site |
probably null |
|
R5092:Zftraf1
|
UTSW |
15 |
76,530,512 (GRCm39) |
missense |
probably benign |
0.11 |
R5749:Zftraf1
|
UTSW |
15 |
76,542,844 (GRCm39) |
splice site |
probably null |
|
R5860:Zftraf1
|
UTSW |
15 |
76,540,615 (GRCm39) |
missense |
probably damaging |
1.00 |
R5860:Zftraf1
|
UTSW |
15 |
76,532,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R6032:Zftraf1
|
UTSW |
15 |
76,543,058 (GRCm39) |
missense |
probably damaging |
0.99 |
R6032:Zftraf1
|
UTSW |
15 |
76,543,058 (GRCm39) |
missense |
probably damaging |
0.99 |
R6397:Zftraf1
|
UTSW |
15 |
76,532,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R6481:Zftraf1
|
UTSW |
15 |
76,542,908 (GRCm39) |
splice site |
probably null |
|
R6533:Zftraf1
|
UTSW |
15 |
76,531,930 (GRCm39) |
nonsense |
probably null |
|
R7466:Zftraf1
|
UTSW |
15 |
76,532,386 (GRCm39) |
missense |
probably benign |
0.29 |
R7484:Zftraf1
|
UTSW |
15 |
76,530,435 (GRCm39) |
missense |
probably damaging |
1.00 |
R7629:Zftraf1
|
UTSW |
15 |
76,532,386 (GRCm39) |
missense |
probably benign |
0.29 |
R7732:Zftraf1
|
UTSW |
15 |
76,532,386 (GRCm39) |
missense |
probably benign |
0.29 |
R7763:Zftraf1
|
UTSW |
15 |
76,542,747 (GRCm39) |
missense |
probably damaging |
0.99 |
R7861:Zftraf1
|
UTSW |
15 |
76,532,386 (GRCm39) |
missense |
probably benign |
0.29 |
R9300:Zftraf1
|
UTSW |
15 |
76,530,541 (GRCm39) |
missense |
probably benign |
0.05 |
|
Predicted Primers |
|
Posted On |
2017-04-14 |