Incidental Mutation 'R6210:Vmn2r105'
| ID |
503425 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r105
|
| Ensembl Gene |
ENSMUSG00000091670 |
| Gene Name |
vomeronasal 2, receptor 105 |
| Synonyms |
EG627743 |
| MMRRC Submission |
044344-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6210 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20428492-20455134 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 20448758 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 140
(N140Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167382]
|
| AlphaFold |
E9Q3A5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167382
AA Change: N140Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: N140Y
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
85 |
469 |
6.5e-42 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
3.2e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.5e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.4%
|
| Validation Efficiency |
95% (52/55) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd3 |
T |
A |
18: 10,706,032 (GRCm39) |
I94F |
probably damaging |
Het |
| Bbox1 |
A |
T |
2: 110,100,422 (GRCm39) |
D258E |
probably benign |
Het |
| Catsperb |
A |
G |
12: 101,378,827 (GRCm39) |
|
probably null |
Het |
| Ccdc127 |
T |
C |
13: 74,505,040 (GRCm39) |
V196A |
probably benign |
Het |
| Cd101 |
A |
T |
3: 100,925,959 (GRCm39) |
D253E |
probably damaging |
Het |
| Ceacam15 |
T |
C |
7: 16,407,214 (GRCm39) |
Y101C |
probably damaging |
Het |
| Cep135 |
C |
T |
5: 76,772,570 (GRCm39) |
L652F |
probably benign |
Het |
| Col5a1 |
G |
T |
2: 27,922,633 (GRCm39) |
V234L |
probably benign |
Het |
| Cxcr6 |
T |
C |
9: 123,639,073 (GRCm39) |
S25P |
possibly damaging |
Het |
| Dctn4 |
C |
T |
18: 60,679,865 (GRCm39) |
Q258* |
probably null |
Het |
| Fmnl2 |
A |
T |
2: 53,020,457 (GRCm39) |
N1067I |
possibly damaging |
Het |
| Frrs1 |
A |
T |
3: 116,672,080 (GRCm39) |
K59N |
probably benign |
Het |
| Gpr157 |
T |
C |
4: 150,186,055 (GRCm39) |
Y206H |
probably damaging |
Het |
| Hephl1 |
A |
G |
9: 15,001,860 (GRCm39) |
Y161H |
possibly damaging |
Het |
| Hinfp |
C |
T |
9: 44,210,169 (GRCm39) |
|
probably null |
Het |
| Igf2r |
A |
T |
17: 12,933,838 (GRCm39) |
N805K |
probably damaging |
Het |
| Ilrun |
A |
T |
17: 27,986,960 (GRCm39) |
D255E |
probably benign |
Het |
| Itga3 |
T |
C |
11: 94,959,717 (GRCm39) |
|
probably benign |
Het |
| Itga6 |
A |
G |
2: 71,664,351 (GRCm39) |
|
probably null |
Het |
| Kcnip1 |
G |
A |
11: 33,595,600 (GRCm39) |
T30I |
possibly damaging |
Het |
| Lig4 |
T |
C |
8: 10,021,585 (GRCm39) |
T732A |
probably benign |
Het |
| Lmod3 |
T |
A |
6: 97,224,262 (GRCm39) |
T520S |
probably damaging |
Het |
| Megf8 |
G |
A |
7: 25,043,145 (GRCm39) |
V1356I |
possibly damaging |
Het |
| Mical3 |
C |
T |
6: 121,017,478 (GRCm39) |
|
probably null |
Het |
| Msi1 |
T |
C |
5: 115,573,535 (GRCm39) |
I8T |
probably damaging |
Het |
| Mug4-ps |
A |
T |
6: 121,927,276 (GRCm39) |
|
noncoding transcript |
Het |
| Myo1f |
T |
A |
17: 33,820,044 (GRCm39) |
I783N |
probably damaging |
Het |
| Nr6a1 |
A |
C |
2: 38,619,509 (GRCm39) |
I462S |
probably damaging |
Het |
| Or2t48 |
C |
T |
11: 58,420,090 (GRCm39) |
A241T |
probably damaging |
Het |
| Or8k23 |
A |
G |
2: 86,186,702 (GRCm39) |
V8A |
probably benign |
Het |
| Pah |
C |
A |
10: 87,419,423 (GRCm39) |
Q449K |
probably benign |
Het |
| Pced1a |
A |
G |
2: 130,263,839 (GRCm39) |
V271A |
probably damaging |
Het |
| Pdzrn4 |
A |
T |
15: 92,655,562 (GRCm39) |
E485V |
probably damaging |
Het |
| Psg21 |
A |
G |
7: 18,386,270 (GRCm39) |
Y239H |
probably damaging |
Het |
| Ptprt |
T |
C |
2: 162,109,949 (GRCm39) |
Y180C |
probably damaging |
Het |
| Raet1d |
T |
A |
10: 22,246,849 (GRCm39) |
I59N |
probably damaging |
Het |
| Rfx1 |
T |
C |
8: 84,819,647 (GRCm39) |
L653P |
probably damaging |
Het |
| Rnase2a |
A |
G |
14: 51,493,131 (GRCm39) |
V78A |
possibly damaging |
Het |
| Rsf1 |
ATGGCG |
ATGGCGACGGTGGCG |
7: 97,229,111 (GRCm39) |
|
probably benign |
Homo |
| Serbp1 |
T |
C |
6: 67,249,851 (GRCm39) |
|
probably benign |
Het |
| Tlr1 |
A |
T |
5: 65,082,629 (GRCm39) |
H649Q |
probably damaging |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Trpc6 |
T |
A |
9: 8,656,731 (GRCm39) |
D719E |
probably benign |
Het |
| Ttc21b |
A |
T |
2: 66,066,698 (GRCm39) |
S318R |
probably benign |
Het |
| Ttn |
G |
A |
2: 76,579,673 (GRCm39) |
T23740M |
probably damaging |
Het |
| Uhmk1 |
T |
C |
1: 170,039,806 (GRCm39) |
Q187R |
probably damaging |
Het |
| Ung |
C |
T |
5: 114,269,438 (GRCm39) |
A50V |
probably benign |
Het |
| Upk3bl |
C |
T |
5: 136,088,674 (GRCm39) |
Q103* |
probably null |
Het |
| Usp17le |
C |
A |
7: 104,418,350 (GRCm39) |
C264F |
probably damaging |
Het |
| Vmn2r84 |
C |
T |
10: 130,222,114 (GRCm39) |
C702Y |
probably damaging |
Het |
| Zfp709 |
TCGACG |
TCG |
8: 72,644,552 (GRCm39) |
|
probably benign |
Het |
| Zfp748 |
G |
A |
13: 67,688,923 (GRCm39) |
P779L |
possibly damaging |
Het |
|
| Other mutations in Vmn2r105 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01433:Vmn2r105
|
APN |
17 |
20,448,817 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01909:Vmn2r105
|
APN |
17 |
20,444,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01925:Vmn2r105
|
APN |
17 |
20,428,973 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02021:Vmn2r105
|
APN |
17 |
20,448,157 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02828:Vmn2r105
|
APN |
17 |
20,429,345 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02838:Vmn2r105
|
APN |
17 |
20,447,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Vmn2r105
|
APN |
17 |
20,446,631 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0212:Vmn2r105
|
UTSW |
17 |
20,428,827 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0268:Vmn2r105
|
UTSW |
17 |
20,428,938 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0271:Vmn2r105
|
UTSW |
17 |
20,454,965 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0613:Vmn2r105
|
UTSW |
17 |
20,428,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,448,119 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1162:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1263:Vmn2r105
|
UTSW |
17 |
20,428,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1363:Vmn2r105
|
UTSW |
17 |
20,428,932 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1464:Vmn2r105
|
UTSW |
17 |
20,449,004 (GRCm39) |
splice site |
probably benign |
|
|
R2029:Vmn2r105
|
UTSW |
17 |
20,444,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2421:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2422:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2570:Vmn2r105
|
UTSW |
17 |
20,447,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3847:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3848:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4030:Vmn2r105
|
UTSW |
17 |
20,429,016 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4275:Vmn2r105
|
UTSW |
17 |
20,448,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4551:Vmn2r105
|
UTSW |
17 |
20,446,613 (GRCm39) |
missense |
probably benign |
|
|
R4801:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4802:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4816:Vmn2r105
|
UTSW |
17 |
20,428,953 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4929:Vmn2r105
|
UTSW |
17 |
20,448,280 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5022:Vmn2r105
|
UTSW |
17 |
20,428,676 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5475:Vmn2r105
|
UTSW |
17 |
20,455,044 (GRCm39) |
missense |
probably benign |
|
|
R5576:Vmn2r105
|
UTSW |
17 |
20,444,836 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5795:Vmn2r105
|
UTSW |
17 |
20,448,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5895:Vmn2r105
|
UTSW |
17 |
20,448,929 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6017:Vmn2r105
|
UTSW |
17 |
20,428,889 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6491:Vmn2r105
|
UTSW |
17 |
20,447,992 (GRCm39) |
nonsense |
probably null |
|
|
R6542:Vmn2r105
|
UTSW |
17 |
20,448,803 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6729:Vmn2r105
|
UTSW |
17 |
20,428,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7020:Vmn2r105
|
UTSW |
17 |
20,429,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Vmn2r105
|
UTSW |
17 |
20,428,874 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7488:Vmn2r105
|
UTSW |
17 |
20,429,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7491:Vmn2r105
|
UTSW |
17 |
20,448,827 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7555:Vmn2r105
|
UTSW |
17 |
20,447,937 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7863:Vmn2r105
|
UTSW |
17 |
20,428,937 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8137:Vmn2r105
|
UTSW |
17 |
20,454,966 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8166:Vmn2r105
|
UTSW |
17 |
20,428,904 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8186:Vmn2r105
|
UTSW |
17 |
20,444,880 (GRCm39) |
nonsense |
probably null |
|
|
R8214:Vmn2r105
|
UTSW |
17 |
20,448,775 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8497:Vmn2r105
|
UTSW |
17 |
20,455,134 (GRCm39) |
start codon destroyed |
probably null |
0.75 |
|
R8850:Vmn2r105
|
UTSW |
17 |
20,428,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8880:Vmn2r105
|
UTSW |
17 |
20,429,229 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9272:Vmn2r105
|
UTSW |
17 |
20,447,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Vmn2r105
|
UTSW |
17 |
20,429,404 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9549:Vmn2r105
|
UTSW |
17 |
20,448,023 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATGTGGATTGATCTCCTCGTG -3'
(R):5'- AAAGCTACCAGTATATTCTCGCTC -3'
Sequencing Primer
(F):5'- ATTGATCTCCTCGTGTTTGAGTC -3'
(R):5'- CTCTGCTATTTGCCATTGAGGAGATC -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation