Incidental Mutation 'R7365:Myh4'
| ID |
571734 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh4
|
| Ensembl Gene |
ENSMUSG00000057003 |
| Gene Name |
myosin, heavy polypeptide 4, skeletal muscle |
| Synonyms |
MYH-2B, MM, MHC2B, MyHC-IIb, Myhsf, Minimsc, Minmus |
| MMRRC Submission |
045449-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.410)
|
| Stock # |
R7365 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
67128855-67151272 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 67133674 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 238
(T238A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127514
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018632]
[ENSMUST00000170942]
|
| AlphaFold |
Q5SX39 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018632
AA Change: T238A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000018632
Gene: ENSMUSG00000057003
AA Change: T238A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
74 |
4.7e-14 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
847 |
1928 |
2.5e-168 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170942
AA Change: T238A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000127514
Gene: ENSMUSG00000057003
AA Change: T238A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
1.1e-15 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
low complexity region
|
928 |
942 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1072 |
1930 |
N/A |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (96/96) |
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(3) : Targeted, knock-out(1) Targeted, other(2) |
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700123K08Rik |
T |
C |
5: 138,561,198 (GRCm39) |
S155G |
probably benign |
Het |
| Abcc4 |
T |
C |
14: 118,865,066 (GRCm39) |
N320S |
probably damaging |
Het |
| Akr1c19 |
G |
A |
13: 4,287,069 (GRCm39) |
R96H |
probably benign |
Het |
| Ankrd17 |
T |
C |
5: 90,439,010 (GRCm39) |
D451G |
possibly damaging |
Het |
| Ano8 |
T |
A |
8: 71,937,754 (GRCm39) |
D36V |
probably damaging |
Het |
| Aqp3 |
A |
G |
4: 41,098,003 (GRCm39) |
V36A |
probably benign |
Het |
| Atf7ip |
A |
G |
6: 136,537,708 (GRCm39) |
T314A |
probably benign |
Het |
| Atp2c1 |
A |
T |
9: 105,300,198 (GRCm39) |
D700E |
probably damaging |
Het |
| Axin2 |
G |
A |
11: 108,830,202 (GRCm39) |
V341M |
possibly damaging |
Het |
| Bin3 |
A |
G |
14: 70,371,976 (GRCm39) |
Q139R |
probably damaging |
Het |
| Brca2 |
A |
G |
5: 150,455,802 (GRCm39) |
D181G |
probably damaging |
Het |
| Capn3 |
A |
G |
2: 120,325,295 (GRCm39) |
E466G |
probably damaging |
Het |
| Ccdc14 |
T |
A |
16: 34,543,989 (GRCm39) |
Y830* |
probably null |
Het |
| Cdk12 |
T |
C |
11: 98,111,910 (GRCm39) |
F723L |
unknown |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Cip2a |
T |
A |
16: 48,822,016 (GRCm39) |
S215T |
probably benign |
Het |
| Clca3a2 |
T |
A |
3: 144,804,545 (GRCm39) |
I61F |
probably damaging |
Het |
| Clca4b |
T |
C |
3: 144,628,529 (GRCm39) |
T393A |
not run |
Het |
| Cldn5 |
G |
A |
16: 18,595,845 (GRCm39) |
A34T |
probably damaging |
Het |
| Cobll1 |
A |
T |
2: 64,928,717 (GRCm39) |
S870T |
probably damaging |
Het |
| Col12a1 |
T |
C |
9: 79,613,642 (GRCm39) |
K68E |
probably damaging |
Het |
| Crnn |
A |
T |
3: 93,055,841 (GRCm39) |
Q209L |
probably damaging |
Het |
| Cwf19l1 |
A |
T |
19: 44,120,579 (GRCm39) |
F45I |
probably damaging |
Het |
| Cyfip2 |
T |
A |
11: 46,098,267 (GRCm39) |
K1052* |
probably null |
Het |
| D930020B18Rik |
G |
A |
10: 121,503,716 (GRCm39) |
|
probably null |
Het |
| Dcc |
G |
A |
18: 71,959,194 (GRCm39) |
P193S |
probably damaging |
Het |
| Dda1 |
T |
A |
8: 71,927,137 (GRCm39) |
C48S |
probably benign |
Het |
| Disc1 |
A |
G |
8: 125,881,780 (GRCm39) |
R572G |
probably damaging |
Het |
| Dnah7a |
A |
T |
1: 53,536,297 (GRCm39) |
M2582K |
probably benign |
Het |
| Dsel |
C |
T |
1: 111,789,303 (GRCm39) |
G411S |
probably damaging |
Het |
| Dynlrb2 |
T |
C |
8: 117,241,696 (GRCm39) |
V80A |
probably benign |
Het |
| Eif3a |
A |
T |
19: 60,755,082 (GRCm39) |
D1033E |
unknown |
Het |
| Enam |
C |
A |
5: 88,649,347 (GRCm39) |
H285Q |
possibly damaging |
Het |
| Ep400 |
T |
C |
5: 110,867,480 (GRCm39) |
D980G |
unknown |
Het |
| Epha7 |
C |
T |
4: 28,871,937 (GRCm39) |
S422L |
probably benign |
Het |
| Erc2 |
A |
C |
14: 27,762,346 (GRCm39) |
D703A |
probably damaging |
Het |
| Ezh2 |
G |
T |
6: 47,510,692 (GRCm39) |
S639* |
probably null |
Het |
| Fbn1 |
G |
A |
2: 125,193,969 (GRCm39) |
H1333Y |
probably damaging |
Het |
| Flad1 |
A |
G |
3: 89,315,972 (GRCm39) |
S197P |
possibly damaging |
Het |
| Foxl3 |
A |
G |
5: 138,806,736 (GRCm39) |
H82R |
probably damaging |
Het |
| Gfm2 |
G |
T |
13: 97,279,529 (GRCm39) |
C26F |
probably benign |
Het |
| Golga2 |
C |
T |
2: 32,193,013 (GRCm39) |
Q444* |
probably null |
Het |
| Gp5 |
A |
T |
16: 30,127,426 (GRCm39) |
V416D |
probably damaging |
Het |
| Gpat2 |
A |
G |
2: 127,268,901 (GRCm39) |
|
probably null |
Het |
| Gpr137c |
A |
G |
14: 45,516,471 (GRCm39) |
D353G |
probably damaging |
Het |
| Hoxa13 |
A |
C |
6: 52,236,862 (GRCm39) |
W133G |
probably damaging |
Het |
| Hydin |
A |
T |
8: 111,327,905 (GRCm39) |
K4804M |
probably damaging |
Het |
| Hydin |
A |
T |
8: 111,284,294 (GRCm39) |
I3189F |
probably damaging |
Het |
| Ice2 |
T |
C |
9: 69,307,794 (GRCm39) |
F26S |
probably damaging |
Het |
| Ints11 |
T |
C |
4: 155,956,687 (GRCm39) |
|
probably null |
Het |
| Ipo5 |
A |
G |
14: 121,157,497 (GRCm39) |
I112V |
probably benign |
Het |
| Itgax |
T |
A |
7: 127,734,481 (GRCm39) |
S346R |
probably damaging |
Het |
| Kcnj13 |
T |
A |
1: 87,316,739 (GRCm39) |
M125L |
probably damaging |
Het |
| Lmbrd1 |
T |
A |
1: 24,783,948 (GRCm39) |
V359E |
possibly damaging |
Het |
| Lrrc7 |
T |
G |
3: 157,903,798 (GRCm39) |
K287N |
probably damaging |
Het |
| Mau2 |
C |
T |
8: 70,481,884 (GRCm39) |
A191T |
possibly damaging |
Het |
| Mkx |
C |
A |
18: 7,000,747 (GRCm39) |
R65L |
possibly damaging |
Het |
| Mroh4 |
T |
A |
15: 74,482,220 (GRCm39) |
K746* |
probably null |
Het |
| Nlrp9c |
T |
A |
7: 26,070,822 (GRCm39) |
N920Y |
possibly damaging |
Het |
| Nr4a3 |
T |
G |
4: 48,051,290 (GRCm39) |
S15A |
possibly damaging |
Het |
| Ntn4 |
T |
C |
10: 93,480,666 (GRCm39) |
L130P |
probably damaging |
Het |
| Or2ag13 |
A |
G |
7: 106,313,171 (GRCm39) |
V239A |
probably benign |
Het |
| Or4a68 |
A |
G |
2: 89,270,542 (GRCm39) |
V27A |
probably benign |
Het |
| Or4f59 |
A |
T |
2: 111,873,359 (GRCm39) |
V6E |
possibly damaging |
Het |
| Or56a42-ps1 |
T |
A |
7: 104,777,552 (GRCm39) |
I21F |
probably benign |
Het |
| Or8d23 |
A |
T |
9: 38,842,072 (GRCm39) |
I202F |
probably damaging |
Het |
| Otog |
T |
C |
7: 45,947,732 (GRCm39) |
L110P |
probably damaging |
Het |
| Platr25 |
G |
A |
13: 62,848,719 (GRCm39) |
H48Y |
probably benign |
Het |
| Plcxd2 |
T |
C |
16: 45,800,789 (GRCm39) |
E145G |
probably damaging |
Het |
| Pltp |
A |
T |
2: 164,696,242 (GRCm39) |
N143K |
probably damaging |
Het |
| Pnpt1 |
T |
C |
11: 29,111,334 (GRCm39) |
Y735H |
probably damaging |
Het |
| Prom1 |
A |
G |
5: 44,178,173 (GRCm39) |
Y520H |
probably damaging |
Het |
| Rag2 |
A |
G |
2: 101,461,118 (GRCm39) |
Y476C |
probably damaging |
Het |
| Rdh16f2 |
A |
G |
10: 127,712,893 (GRCm39) |
Y297C |
probably damaging |
Het |
| Ryr1 |
T |
C |
7: 28,785,180 (GRCm39) |
E1844G |
probably benign |
Het |
| Ryr2 |
A |
G |
13: 11,655,161 (GRCm39) |
C3679R |
probably damaging |
Het |
| Sirt1 |
A |
G |
10: 63,157,782 (GRCm39) |
I544T |
probably benign |
Het |
| Slc26a10 |
A |
T |
10: 127,012,716 (GRCm39) |
I382N |
possibly damaging |
Het |
| Sox2 |
C |
A |
3: 34,705,121 (GRCm39) |
P186Q |
possibly damaging |
Het |
| Spata31e5 |
A |
T |
1: 28,819,233 (GRCm39) |
M16K |
probably benign |
Het |
| Tnpo3 |
A |
G |
6: 29,556,995 (GRCm39) |
L752P |
probably damaging |
Het |
| Top2b |
T |
A |
14: 16,416,649 (GRCm38) |
N1136K |
probably benign |
Het |
| Tpsg1 |
G |
T |
17: 25,592,184 (GRCm39) |
G86V |
probably damaging |
Het |
| Ttf2 |
C |
A |
3: 100,870,618 (GRCm39) |
D152Y |
possibly damaging |
Het |
| Txndc15 |
T |
C |
13: 55,862,601 (GRCm39) |
L4P |
unknown |
Het |
| Unc5a |
T |
C |
13: 55,144,386 (GRCm39) |
V237A |
possibly damaging |
Het |
| Urb1 |
CACTTAC |
CAC |
16: 90,569,461 (GRCm39) |
|
probably benign |
Het |
| Vav3 |
C |
A |
3: 109,535,415 (GRCm39) |
P616T |
possibly damaging |
Het |
| Vmn2r15 |
T |
A |
5: 109,441,105 (GRCm39) |
D251V |
probably benign |
Het |
| Vmn2r15 |
A |
G |
5: 109,445,388 (GRCm39) |
L12S |
probably benign |
Het |
| Wfs1 |
A |
C |
5: 37,125,076 (GRCm39) |
I605S |
probably benign |
Het |
| Wif1 |
G |
A |
10: 120,919,814 (GRCm39) |
R187Q |
possibly damaging |
Het |
| Yipf1 |
A |
G |
4: 107,207,738 (GRCm39) |
|
probably null |
Het |
| Zdhhc20 |
G |
T |
14: 58,111,377 (GRCm39) |
F74L |
possibly damaging |
Het |
| Zfp507 |
T |
C |
7: 35,475,843 (GRCm39) |
T303A |
unknown |
Het |
| Zfp763 |
A |
T |
17: 33,252,352 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Myh4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01471:Myh4
|
APN |
11 |
67,146,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01600:Myh4
|
APN |
11 |
67,151,015 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01737:Myh4
|
APN |
11 |
67,134,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL02208:Myh4
|
APN |
11 |
67,142,760 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02334:Myh4
|
APN |
11 |
67,136,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02376:Myh4
|
APN |
11 |
67,136,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Myh4
|
APN |
11 |
67,149,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02450:Myh4
|
APN |
11 |
67,142,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02524:Myh4
|
APN |
11 |
67,140,066 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02612:Myh4
|
APN |
11 |
67,147,305 (GRCm39) |
missense |
probably benign |
|
|
IGL03024:Myh4
|
APN |
11 |
67,139,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Myh4
|
APN |
11 |
67,149,982 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03084:Myh4
|
APN |
11 |
67,142,777 (GRCm39) |
splice site |
probably null |
|
|
IGL03188:Myh4
|
APN |
11 |
67,137,369 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03204:Myh4
|
APN |
11 |
67,141,122 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL03252:Myh4
|
APN |
11 |
67,143,042 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03345:Myh4
|
APN |
11 |
67,146,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mr_chicken
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
Mrs_muir
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Willies
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
F6893:Myh4
|
UTSW |
11 |
67,146,283 (GRCm39) |
missense |
probably null |
0.12 |
|
PIT1430001:Myh4
|
UTSW |
11 |
67,149,658 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4458001:Myh4
|
UTSW |
11 |
67,131,821 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0099:Myh4
|
UTSW |
11 |
67,150,173 (GRCm39) |
missense |
probably benign |
|
|
R0194:Myh4
|
UTSW |
11 |
67,143,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0346:Myh4
|
UTSW |
11 |
67,151,152 (GRCm39) |
missense |
probably benign |
|
|
R0427:Myh4
|
UTSW |
11 |
67,149,479 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0483:Myh4
|
UTSW |
11 |
67,143,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Myh4
|
UTSW |
11 |
67,141,157 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0854:Myh4
|
UTSW |
11 |
67,149,973 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0940:Myh4
|
UTSW |
11 |
67,133,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0946:Myh4
|
UTSW |
11 |
67,142,577 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1108:Myh4
|
UTSW |
11 |
67,146,532 (GRCm39) |
missense |
probably null |
0.01 |
|
R1162:Myh4
|
UTSW |
11 |
67,149,439 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1194:Myh4
|
UTSW |
11 |
67,146,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1347:Myh4
|
UTSW |
11 |
67,135,567 (GRCm39) |
splice site |
probably benign |
|
|
R1457:Myh4
|
UTSW |
11 |
67,139,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1531:Myh4
|
UTSW |
11 |
67,141,366 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1716:Myh4
|
UTSW |
11 |
67,141,135 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1766:Myh4
|
UTSW |
11 |
67,147,121 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1796:Myh4
|
UTSW |
11 |
67,151,150 (GRCm39) |
missense |
probably benign |
|
|
R1856:Myh4
|
UTSW |
11 |
67,146,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1873:Myh4
|
UTSW |
11 |
67,145,569 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2069:Myh4
|
UTSW |
11 |
67,137,192 (GRCm39) |
splice site |
probably benign |
|
|
R2370:Myh4
|
UTSW |
11 |
67,146,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2406:Myh4
|
UTSW |
11 |
67,150,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2414:Myh4
|
UTSW |
11 |
67,141,594 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2848:Myh4
|
UTSW |
11 |
67,139,459 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3111:Myh4
|
UTSW |
11 |
67,137,276 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3744:Myh4
|
UTSW |
11 |
67,146,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Myh4
|
UTSW |
11 |
67,149,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3877:Myh4
|
UTSW |
11 |
67,148,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4498:Myh4
|
UTSW |
11 |
67,142,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4514:Myh4
|
UTSW |
11 |
67,146,395 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4601:Myh4
|
UTSW |
11 |
67,141,136 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4673:Myh4
|
UTSW |
11 |
67,137,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4684:Myh4
|
UTSW |
11 |
67,136,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4736:Myh4
|
UTSW |
11 |
67,131,746 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4837:Myh4
|
UTSW |
11 |
67,149,818 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4866:Myh4
|
UTSW |
11 |
67,139,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4869:Myh4
|
UTSW |
11 |
67,143,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Myh4
|
UTSW |
11 |
67,131,880 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4921:Myh4
|
UTSW |
11 |
67,144,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Myh4
|
UTSW |
11 |
67,144,241 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5008:Myh4
|
UTSW |
11 |
67,144,358 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5011:Myh4
|
UTSW |
11 |
67,147,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5087:Myh4
|
UTSW |
11 |
67,146,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Myh4
|
UTSW |
11 |
67,143,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Myh4
|
UTSW |
11 |
67,150,017 (GRCm39) |
splice site |
probably null |
|
|
R5354:Myh4
|
UTSW |
11 |
67,146,551 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5371:Myh4
|
UTSW |
11 |
67,150,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Myh4
|
UTSW |
11 |
67,142,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5774:Myh4
|
UTSW |
11 |
67,144,034 (GRCm39) |
nonsense |
probably null |
|
|
R5902:Myh4
|
UTSW |
11 |
67,141,733 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5941:Myh4
|
UTSW |
11 |
67,150,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6045:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6156:Myh4
|
UTSW |
11 |
67,141,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6301:Myh4
|
UTSW |
11 |
67,146,159 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6318:Myh4
|
UTSW |
11 |
67,134,268 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6352:Myh4
|
UTSW |
11 |
67,143,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6385:Myh4
|
UTSW |
11 |
67,146,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6493:Myh4
|
UTSW |
11 |
67,149,455 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6666:Myh4
|
UTSW |
11 |
67,142,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6826:Myh4
|
UTSW |
11 |
67,137,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Myh4
|
UTSW |
11 |
67,143,794 (GRCm39) |
splice site |
probably null |
|
|
R6857:Myh4
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7029:Myh4
|
UTSW |
11 |
67,137,251 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7076:Myh4
|
UTSW |
11 |
67,143,999 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7145:Myh4
|
UTSW |
11 |
67,151,054 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7179:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7514:Myh4
|
UTSW |
11 |
67,134,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7553:Myh4
|
UTSW |
11 |
67,147,221 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Myh4
|
UTSW |
11 |
67,147,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7673:Myh4
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7685:Myh4
|
UTSW |
11 |
67,131,756 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8154:Myh4
|
UTSW |
11 |
67,144,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8343:Myh4
|
UTSW |
11 |
67,143,390 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R8446:Myh4
|
UTSW |
11 |
67,144,347 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8534:Myh4
|
UTSW |
11 |
67,134,335 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8710:Myh4
|
UTSW |
11 |
67,143,158 (GRCm39) |
missense |
probably benign |
|
|
R8775:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8775-TAIL:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8852:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Myh4
|
UTSW |
11 |
67,137,362 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8954:Myh4
|
UTSW |
11 |
67,143,806 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8957:Myh4
|
UTSW |
11 |
67,141,780 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9065:Myh4
|
UTSW |
11 |
67,139,573 (GRCm39) |
missense |
probably benign |
|
|
R9280:Myh4
|
UTSW |
11 |
67,146,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9296:Myh4
|
UTSW |
11 |
67,146,130 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9310:Myh4
|
UTSW |
11 |
67,145,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9314:Myh4
|
UTSW |
11 |
67,151,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Myh4
|
UTSW |
11 |
67,141,811 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9516:Myh4
|
UTSW |
11 |
67,141,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Myh4
|
UTSW |
11 |
67,139,290 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9773:Myh4
|
UTSW |
11 |
67,137,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Myh4
|
UTSW |
11 |
67,137,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,147,097 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Myh4
|
UTSW |
11 |
67,144,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,139,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGCTACAGGGTGTGACCAAGG -3'
(R):5'- ATCTGCAGAGGCCAGTTTGC -3'
Sequencing Primer
(F):5'- CCAAGGGTAGGGGGTCTG -3'
(R):5'- CTGTGGCACCGAAATGGATTC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation