Incidental Mutation 'R7432:Fhod3'
| ID |
576601 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fhod3
|
| Ensembl Gene |
ENSMUSG00000034295 |
| Gene Name |
formin homology 2 domain containing 3 |
| Synonyms |
A930009H06Rik |
| MMRRC Submission |
045510-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7432 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
24841680-25266558 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 25134966 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 359
(D359G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000041361
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037097]
|
| AlphaFold |
Q76LL6 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000037097
AA Change: D359G
PolyPhen 2
Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000041361
Gene: ENSMUSG00000034295
AA Change: D359G
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:3DAD|B
|
1 |
327 |
1e-127 |
PDB |
|
Blast:Drf_GBD
|
73 |
204 |
3e-60 |
BLAST |
|
Blast:FH2
|
219 |
306 |
4e-25 |
BLAST |
|
low complexity region
|
399 |
420 |
N/A |
INTRINSIC |
|
low complexity region
|
428 |
446 |
N/A |
INTRINSIC |
|
low complexity region
|
553 |
583 |
N/A |
INTRINSIC |
|
coiled coil region
|
598 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
674 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
763 |
N/A |
INTRINSIC |
|
low complexity region
|
784 |
793 |
N/A |
INTRINSIC |
|
Blast:FH2
|
879 |
918 |
1e-9 |
BLAST |
|
Blast:FH2
|
931 |
964 |
1e-7 |
BLAST |
|
low complexity region
|
965 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
985 |
1023 |
N/A |
INTRINSIC |
|
FH2
|
1039 |
1492 |
3.96e-72 |
SMART |
|
Blast:FH2
|
1506 |
1570 |
9e-11 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mice homozygous for a knock-out reporter allele exhibit abnormal premyofibril maturation, impaired heart development, pericardial effusion and embryonic lethality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700093K21Rik |
T |
C |
11: 23,468,839 (GRCm39) |
I31V |
probably benign |
Het |
| Adamts17 |
A |
G |
7: 66,701,665 (GRCm39) |
K40E |
|
Het |
| Akr1c14 |
G |
A |
13: 4,138,952 (GRCm39) |
D312N |
probably benign |
Het |
| Alg6 |
T |
C |
4: 99,641,295 (GRCm39) |
V398A |
probably benign |
Het |
| Ankmy1 |
A |
T |
1: 92,823,801 (GRCm39) |
M155K |
probably benign |
Het |
| Arid5b |
C |
A |
10: 67,954,096 (GRCm39) |
R396L |
probably damaging |
Het |
| Armt1 |
C |
A |
10: 4,382,706 (GRCm39) |
D12E |
probably benign |
Het |
| Arrb2 |
T |
A |
11: 70,328,796 (GRCm39) |
N217K |
probably benign |
Het |
| Atg2b |
A |
T |
12: 105,627,463 (GRCm39) |
L508Q |
probably damaging |
Het |
| Atg2b |
A |
T |
12: 105,630,957 (GRCm39) |
S323T |
probably benign |
Het |
| Atp1a3 |
G |
A |
7: 24,705,300 (GRCm39) |
|
probably benign |
Het |
| Atp6v0e |
T |
C |
17: 26,901,672 (GRCm39) |
V42A |
probably benign |
Het |
| Atp9b |
A |
G |
18: 80,809,056 (GRCm39) |
V621A |
|
Het |
| Atrnl1 |
A |
C |
19: 57,743,956 (GRCm39) |
D1186A |
probably damaging |
Het |
| Atxn2l |
A |
T |
7: 126,093,046 (GRCm39) |
M821K |
possibly damaging |
Het |
| Blnk |
G |
A |
19: 40,948,301 (GRCm39) |
R123* |
probably null |
Het |
| Bud13 |
T |
A |
9: 46,198,372 (GRCm39) |
S98T |
probably benign |
Het |
| Ccdc183 |
T |
C |
2: 25,499,469 (GRCm39) |
M455V |
probably benign |
Het |
| Cd109 |
A |
G |
9: 78,622,225 (GRCm39) |
Y1405C |
possibly damaging |
Het |
| Cdan1 |
A |
T |
2: 120,553,236 (GRCm39) |
L989Q |
probably damaging |
Het |
| Clec16a |
T |
C |
16: 10,506,419 (GRCm39) |
I713T |
possibly damaging |
Het |
| Clta |
T |
A |
4: 44,032,419 (GRCm39) |
F168L |
possibly damaging |
Het |
| Cnnm1 |
A |
T |
19: 43,456,710 (GRCm39) |
H583L |
probably benign |
Het |
| Cyp4f18 |
A |
G |
8: 72,749,906 (GRCm39) |
Y248H |
probably benign |
Het |
| Dsg4 |
G |
T |
18: 20,579,323 (GRCm39) |
G20* |
probably null |
Het |
| Dusp12 |
T |
A |
1: 170,707,345 (GRCm39) |
K248* |
probably null |
Het |
| Eeig2 |
C |
T |
3: 108,910,723 (GRCm39) |
A51T |
probably damaging |
Het |
| Elp1 |
C |
T |
4: 56,776,925 (GRCm39) |
G624D |
probably damaging |
Het |
| Frmpd2 |
C |
A |
14: 33,229,510 (GRCm39) |
F365L |
probably damaging |
Het |
| Gab1 |
A |
G |
8: 81,515,298 (GRCm39) |
I340T |
probably benign |
Het |
| Gabpa |
C |
T |
16: 84,654,408 (GRCm39) |
Q362* |
probably null |
Het |
| Gcnt2 |
A |
T |
13: 41,040,688 (GRCm39) |
|
probably benign |
Het |
| Gm12728 |
T |
A |
4: 105,651,486 (GRCm39) |
L32Q |
probably damaging |
Het |
| Gpatch4 |
A |
G |
3: 87,959,003 (GRCm39) |
N35D |
probably damaging |
Het |
| Grid2 |
G |
T |
6: 64,252,854 (GRCm39) |
V441L |
possibly damaging |
Het |
| H2-M2 |
A |
G |
17: 37,792,361 (GRCm39) |
|
probably null |
Het |
| Hip1r |
T |
C |
5: 124,129,829 (GRCm39) |
F180L |
probably benign |
Het |
| Il17re |
T |
C |
6: 113,439,332 (GRCm39) |
F81L |
probably benign |
Het |
| Il3ra |
T |
C |
14: 14,350,691 (GRCm38) |
V235A |
possibly damaging |
Het |
| Krtap6-2 |
C |
T |
16: 89,216,761 (GRCm39) |
G69S |
unknown |
Het |
| Lmln |
T |
C |
16: 32,909,738 (GRCm39) |
L373P |
probably damaging |
Het |
| Lmo7 |
C |
A |
14: 102,139,551 (GRCm39) |
Q945K |
probably benign |
Het |
| Loxhd1 |
G |
T |
18: 77,383,547 (GRCm39) |
V149L |
possibly damaging |
Het |
| Lrrc73 |
T |
C |
17: 46,566,709 (GRCm39) |
|
probably null |
Het |
| Mapkapk5 |
G |
A |
5: 121,675,234 (GRCm39) |
H112Y |
possibly damaging |
Het |
| Maz |
A |
G |
7: 126,622,220 (GRCm39) |
V467A |
probably benign |
Het |
| Med13l |
T |
G |
5: 118,890,003 (GRCm39) |
V1884G |
probably damaging |
Het |
| Nlrp12 |
A |
C |
7: 3,271,213 (GRCm39) |
N1033K |
probably benign |
Het |
| Nos3 |
T |
A |
5: 24,572,613 (GRCm39) |
V184E |
probably damaging |
Het |
| Npr2 |
T |
C |
4: 43,647,155 (GRCm39) |
V737A |
probably damaging |
Het |
| Nsd1 |
A |
G |
13: 55,361,187 (GRCm39) |
T52A |
probably benign |
Het |
| Obscn |
C |
T |
11: 58,919,733 (GRCm39) |
R108Q |
|
Het |
| Or4k50-ps1 |
A |
G |
2: 111,522,401 (GRCm39) |
*179W |
probably null |
Het |
| Or4x11 |
A |
T |
2: 89,867,528 (GRCm39) |
K88N |
probably damaging |
Het |
| Or5t5 |
G |
T |
2: 86,616,565 (GRCm39) |
G164* |
probably null |
Het |
| Or5w22 |
T |
C |
2: 87,362,784 (GRCm39) |
S136P |
probably damaging |
Het |
| Or6c70 |
T |
C |
10: 129,709,719 (GRCm39) |
I302M |
probably benign |
Het |
| Or9a4 |
C |
A |
6: 40,549,240 (GRCm39) |
R307S |
probably benign |
Het |
| Ovol2 |
A |
G |
2: 144,159,792 (GRCm39) |
V116A |
probably benign |
Het |
| Pcdha5 |
C |
A |
18: 37,095,379 (GRCm39) |
S629R |
probably benign |
Het |
| Pde4dip |
T |
A |
3: 97,602,408 (GRCm39) |
M2274L |
probably benign |
Het |
| Pdpk1 |
T |
C |
17: 24,320,643 (GRCm39) |
T185A |
probably benign |
Het |
| Pip5k1a |
T |
G |
3: 94,981,431 (GRCm39) |
T67P |
probably benign |
Het |
| Plat |
G |
T |
8: 23,263,667 (GRCm39) |
V189F |
probably damaging |
Het |
| Ppm1a |
C |
T |
12: 72,830,916 (GRCm39) |
S147L |
probably damaging |
Het |
| Prim1 |
T |
A |
10: 127,851,885 (GRCm39) |
D52E |
probably damaging |
Het |
| Prkab1 |
C |
G |
5: 116,162,221 (GRCm39) |
D30H |
possibly damaging |
Het |
| Psma6 |
A |
T |
12: 55,445,613 (GRCm39) |
|
probably benign |
Het |
| Psmd2 |
T |
A |
16: 20,473,675 (GRCm39) |
M196K |
probably damaging |
Het |
| Ralgapa2 |
G |
T |
2: 146,276,776 (GRCm39) |
T488K |
probably benign |
Het |
| Rapgefl1 |
A |
G |
11: 98,741,940 (GRCm39) |
K635E |
probably damaging |
Het |
| Rasgrp1 |
T |
C |
2: 117,118,424 (GRCm39) |
I522V |
probably damaging |
Het |
| Rcor3 |
C |
A |
1: 191,822,173 (GRCm39) |
G8V |
probably damaging |
Het |
| Rgs11 |
G |
A |
17: 26,426,734 (GRCm39) |
V289M |
probably damaging |
Het |
| Ro60 |
T |
C |
1: 143,641,548 (GRCm39) |
I304M |
probably benign |
Het |
| Scmh1 |
T |
C |
4: 120,386,353 (GRCm39) |
L631P |
probably damaging |
Het |
| Sema3e |
T |
G |
5: 14,274,404 (GRCm39) |
D218E |
probably damaging |
Het |
| Sh3rf2 |
T |
C |
18: 42,187,091 (GRCm39) |
V70A |
probably damaging |
Het |
| Slc12a1 |
G |
T |
2: 125,047,960 (GRCm39) |
V801L |
probably benign |
Het |
| Slc25a51 |
C |
G |
4: 45,399,765 (GRCm39) |
A142P |
possibly damaging |
Het |
| Slc41a1 |
C |
T |
1: 131,758,694 (GRCm39) |
T112I |
probably damaging |
Het |
| Slc44a2 |
T |
C |
9: 21,254,511 (GRCm39) |
M264T |
probably benign |
Het |
| Snapc1 |
T |
A |
12: 74,015,068 (GRCm39) |
M134K |
probably benign |
Het |
| Snrk |
T |
C |
9: 121,986,276 (GRCm39) |
F215S |
probably damaging |
Het |
| Stab2 |
T |
C |
10: 86,721,547 (GRCm39) |
E1526G |
probably damaging |
Het |
| Tbc1d10a |
C |
A |
11: 4,163,016 (GRCm39) |
Y260* |
probably null |
Het |
| Tdrd5 |
A |
T |
1: 156,130,002 (GRCm39) |
L56Q |
probably damaging |
Het |
| Tenm2 |
T |
C |
11: 36,755,768 (GRCm39) |
T77A |
probably benign |
Het |
| Tmprss11g |
T |
G |
5: 86,644,366 (GRCm39) |
R159S |
possibly damaging |
Het |
| Traj38 |
T |
A |
14: 54,418,034 (GRCm39) |
N1K |
|
Het |
| Ttn |
A |
G |
2: 76,596,631 (GRCm39) |
I20094T |
possibly damaging |
Het |
| Ubr4 |
T |
C |
4: 139,115,693 (GRCm39) |
L64P |
probably damaging |
Het |
| Utp20 |
C |
T |
10: 88,634,260 (GRCm39) |
R812Q |
probably benign |
Het |
| Vmn2r57 |
C |
A |
7: 41,076,148 (GRCm39) |
V455L |
probably benign |
Het |
| Wdcp |
T |
C |
12: 4,900,246 (GRCm39) |
V34A |
probably damaging |
Het |
| Zfp27 |
C |
T |
7: 29,594,784 (GRCm39) |
V394I |
probably benign |
Het |
| Zfp512b |
T |
C |
2: 181,231,649 (GRCm39) |
H177R |
probably benign |
Het |
| Zfp648 |
T |
A |
1: 154,080,783 (GRCm39) |
M314K |
possibly damaging |
Het |
| Zfp811 |
T |
C |
17: 33,017,733 (GRCm39) |
I102M |
possibly damaging |
Het |
| Zkscan6 |
A |
G |
11: 65,705,189 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Fhod3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00429:Fhod3
|
APN |
18 |
25,127,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01139:Fhod3
|
APN |
18 |
25,199,401 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01293:Fhod3
|
APN |
18 |
25,153,709 (GRCm39) |
splice site |
probably benign |
|
|
IGL01313:Fhod3
|
APN |
18 |
25,153,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01524:Fhod3
|
APN |
18 |
25,263,659 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01568:Fhod3
|
APN |
18 |
25,253,219 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01586:Fhod3
|
APN |
18 |
25,223,804 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01622:Fhod3
|
APN |
18 |
25,155,924 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL01623:Fhod3
|
APN |
18 |
25,155,924 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL01640:Fhod3
|
APN |
18 |
25,248,850 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01860:Fhod3
|
APN |
18 |
25,037,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01860:Fhod3
|
APN |
18 |
25,030,738 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02192:Fhod3
|
APN |
18 |
25,189,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02390:Fhod3
|
APN |
18 |
25,199,332 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02550:Fhod3
|
APN |
18 |
25,156,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02987:Fhod3
|
APN |
18 |
25,246,610 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0328:Fhod3
|
UTSW |
18 |
25,246,657 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0362:Fhod3
|
UTSW |
18 |
25,223,133 (GRCm39) |
nonsense |
probably null |
|
|
R0373:Fhod3
|
UTSW |
18 |
25,223,161 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0483:Fhod3
|
UTSW |
18 |
24,842,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Fhod3
|
UTSW |
18 |
25,245,640 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0617:Fhod3
|
UTSW |
18 |
25,245,736 (GRCm39) |
splice site |
probably benign |
|
|
R0834:Fhod3
|
UTSW |
18 |
25,248,862 (GRCm39) |
nonsense |
probably null |
|
|
R0836:Fhod3
|
UTSW |
18 |
25,199,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1132:Fhod3
|
UTSW |
18 |
25,153,722 (GRCm39) |
small deletion |
probably benign |
|
|
R1157:Fhod3
|
UTSW |
18 |
25,118,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1158:Fhod3
|
UTSW |
18 |
25,118,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1160:Fhod3
|
UTSW |
18 |
25,118,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Fhod3
|
UTSW |
18 |
25,223,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1533:Fhod3
|
UTSW |
18 |
25,248,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1621:Fhod3
|
UTSW |
18 |
25,155,924 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1748:Fhod3
|
UTSW |
18 |
24,903,550 (GRCm39) |
nonsense |
probably null |
|
|
R1757:Fhod3
|
UTSW |
18 |
25,199,335 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1758:Fhod3
|
UTSW |
18 |
25,253,367 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1872:Fhod3
|
UTSW |
18 |
25,263,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1911:Fhod3
|
UTSW |
18 |
25,245,643 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1917:Fhod3
|
UTSW |
18 |
25,218,658 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1917:Fhod3
|
UTSW |
18 |
25,123,022 (GRCm39) |
splice site |
probably benign |
|
|
R1934:Fhod3
|
UTSW |
18 |
25,223,335 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1958:Fhod3
|
UTSW |
18 |
25,223,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1997:Fhod3
|
UTSW |
18 |
25,223,473 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3618:Fhod3
|
UTSW |
18 |
25,153,722 (GRCm39) |
small deletion |
probably benign |
|
|
R3709:Fhod3
|
UTSW |
18 |
25,223,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3937:Fhod3
|
UTSW |
18 |
25,223,818 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4246:Fhod3
|
UTSW |
18 |
25,123,123 (GRCm39) |
missense |
probably null |
1.00 |
|
R4248:Fhod3
|
UTSW |
18 |
25,123,123 (GRCm39) |
missense |
probably null |
1.00 |
|
R4249:Fhod3
|
UTSW |
18 |
25,123,123 (GRCm39) |
missense |
probably null |
1.00 |
|
R4497:Fhod3
|
UTSW |
18 |
25,243,296 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4498:Fhod3
|
UTSW |
18 |
25,243,296 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4532:Fhod3
|
UTSW |
18 |
25,243,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4596:Fhod3
|
UTSW |
18 |
25,248,775 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4628:Fhod3
|
UTSW |
18 |
25,253,186 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4667:Fhod3
|
UTSW |
18 |
25,199,395 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4668:Fhod3
|
UTSW |
18 |
25,199,395 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Fhod3
|
UTSW |
18 |
25,161,192 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4753:Fhod3
|
UTSW |
18 |
25,223,382 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4796:Fhod3
|
UTSW |
18 |
25,118,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Fhod3
|
UTSW |
18 |
25,223,305 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5338:Fhod3
|
UTSW |
18 |
25,161,138 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5832:Fhod3
|
UTSW |
18 |
25,223,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5863:Fhod3
|
UTSW |
18 |
25,258,810 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6362:Fhod3
|
UTSW |
18 |
24,887,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6414:Fhod3
|
UTSW |
18 |
25,223,935 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7099:Fhod3
|
UTSW |
18 |
25,223,219 (GRCm39) |
missense |
probably benign |
|
|
R7172:Fhod3
|
UTSW |
18 |
25,218,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7190:Fhod3
|
UTSW |
18 |
25,223,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7241:Fhod3
|
UTSW |
18 |
25,193,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7294:Fhod3
|
UTSW |
18 |
25,266,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7348:Fhod3
|
UTSW |
18 |
25,223,524 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7588:Fhod3
|
UTSW |
18 |
25,223,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7629:Fhod3
|
UTSW |
18 |
24,887,374 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7667:Fhod3
|
UTSW |
18 |
25,135,001 (GRCm39) |
missense |
probably benign |
|
|
R7681:Fhod3
|
UTSW |
18 |
25,123,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7829:Fhod3
|
UTSW |
18 |
25,248,947 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7889:Fhod3
|
UTSW |
18 |
24,903,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8072:Fhod3
|
UTSW |
18 |
25,153,722 (GRCm39) |
small deletion |
probably benign |
|
|
R8117:Fhod3
|
UTSW |
18 |
25,248,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Fhod3
|
UTSW |
18 |
25,246,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8511:Fhod3
|
UTSW |
18 |
25,265,994 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8518:Fhod3
|
UTSW |
18 |
25,189,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8845:Fhod3
|
UTSW |
18 |
25,265,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8889:Fhod3
|
UTSW |
18 |
25,189,452 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8892:Fhod3
|
UTSW |
18 |
25,189,452 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9016:Fhod3
|
UTSW |
18 |
25,243,136 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9035:Fhod3
|
UTSW |
18 |
25,161,140 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9063:Fhod3
|
UTSW |
18 |
25,153,772 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9157:Fhod3
|
UTSW |
18 |
25,218,651 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9201:Fhod3
|
UTSW |
18 |
25,127,613 (GRCm39) |
nonsense |
probably null |
|
|
R9244:Fhod3
|
UTSW |
18 |
25,248,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9268:Fhod3
|
UTSW |
18 |
24,842,832 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9272:Fhod3
|
UTSW |
18 |
25,030,681 (GRCm39) |
splice site |
probably benign |
|
|
R9415:Fhod3
|
UTSW |
18 |
25,102,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Fhod3
|
UTSW |
18 |
25,248,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9596:Fhod3
|
UTSW |
18 |
25,193,392 (GRCm39) |
nonsense |
probably null |
|
|
R9739:Fhod3
|
UTSW |
18 |
24,903,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Fhod3
|
UTSW |
18 |
25,153,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGTGGCCTGCAATGTAGG -3'
(R):5'- CGTGGTCAGTACACATGACC -3'
Sequencing Primer
(F):5'- AGTCACAATCAAGGCCTGAG -3'
(R):5'- GTGGTCAGTACACATGACCTTTCATC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation