Incidental Mutation 'R7465:Fsd1l'
ID |
578688 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fsd1l
|
Ensembl Gene |
ENSMUSG00000054752 |
Gene Name |
fibronectin type III and SPRY domain containing 1-like |
Synonyms |
Csdufd1, Fsd1nl, A230072O16Rik, Ccdc10 |
MMRRC Submission |
045539-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.683)
|
Stock # |
R7465 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
53631471-53707009 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 53647755 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 66
(I66T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000124002
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000129648]
[ENSMUST00000132151]
[ENSMUST00000159415]
[ENSMUST00000163067]
[ENSMUST00000180164]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000129648
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000132151
AA Change: I66T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000114931 Gene: ENSMUSG00000054752 AA Change: I66T
Domain | Start | End | E-Value | Type |
BBC
|
4 |
130 |
4.3e-8 |
SMART |
FN3
|
165 |
255 |
2.21e-3 |
SMART |
Pfam:SPRY
|
350 |
470 |
3.2e-17 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000159415
AA Change: I66T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000124002 Gene: ENSMUSG00000054752 AA Change: I66T
Domain | Start | End | E-Value | Type |
BBC
|
4 |
130 |
4.3e-8 |
SMART |
FN3
|
165 |
255 |
2.21e-3 |
SMART |
Pfam:SPRY
|
360 |
480 |
2e-16 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000163067
AA Change: I66T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000124613 Gene: ENSMUSG00000054752 AA Change: I66T
Domain | Start | End | E-Value | Type |
BBC
|
4 |
130 |
4.3e-8 |
SMART |
FN3
|
165 |
255 |
2.21e-3 |
SMART |
Pfam:SPRY
|
349 |
469 |
3.6e-17 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000180164
AA Change: I66T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000136184 Gene: ENSMUSG00000054752 AA Change: I66T
Domain | Start | End | E-Value | Type |
BBC
|
4 |
130 |
1.4e-7 |
SMART |
FN3
|
165 |
255 |
2.21e-3 |
SMART |
Pfam:SPRY
|
350 |
470 |
1.2e-16 |
PFAM |
|
Meta Mutation Damage Score |
0.0594 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
100% (59/59) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 56 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Agtr1a |
A |
T |
13: 30,565,964 (GRCm39) |
D343V |
probably benign |
Het |
Anks1 |
G |
A |
17: 28,273,297 (GRCm39) |
R972Q |
possibly damaging |
Het |
Atp2a2 |
T |
C |
5: 122,599,763 (GRCm39) |
K543E |
probably benign |
Het |
Atp8b5 |
G |
A |
4: 43,271,269 (GRCm39) |
V4I |
probably benign |
Het |
Bcar3 |
A |
T |
3: 122,316,879 (GRCm39) |
N617Y |
probably benign |
Het |
Blm |
A |
G |
7: 80,162,863 (GRCm39) |
S163P |
probably benign |
Het |
Cbx3 |
A |
G |
6: 51,455,510 (GRCm39) |
D87G |
probably benign |
Het |
Celsr1 |
A |
G |
15: 85,917,593 (GRCm39) |
S127P |
probably benign |
Het |
Cndp1 |
A |
T |
18: 84,637,666 (GRCm39) |
M356K |
probably damaging |
Het |
Cnn2 |
G |
A |
10: 79,828,361 (GRCm39) |
E113K |
probably damaging |
Het |
Col17a1 |
T |
A |
19: 47,656,544 (GRCm39) |
R573* |
probably null |
Het |
Cttnbp2 |
T |
A |
6: 18,501,991 (GRCm39) |
E49V |
probably damaging |
Het |
Dipk1a |
T |
C |
5: 108,057,550 (GRCm39) |
D336G |
probably damaging |
Het |
Dynlrb2 |
T |
A |
8: 117,241,696 (GRCm39) |
V80E |
possibly damaging |
Het |
Ehbp1 |
A |
G |
11: 22,088,001 (GRCm39) |
V386A |
probably benign |
Het |
Elfn1 |
C |
T |
5: 139,957,842 (GRCm39) |
P282L |
probably benign |
Het |
Fan1 |
G |
A |
7: 64,003,386 (GRCm39) |
T812I |
probably benign |
Het |
Fan1 |
T |
A |
7: 64,022,234 (GRCm39) |
N340Y |
probably damaging |
Het |
Fat1 |
G |
A |
8: 45,497,189 (GRCm39) |
V4225I |
probably benign |
Het |
Frem1 |
A |
G |
4: 82,833,072 (GRCm39) |
C1873R |
probably benign |
Het |
Gabrr1 |
C |
A |
4: 33,146,970 (GRCm39) |
D52E |
probably benign |
Het |
Il18rap |
T |
C |
1: 40,582,249 (GRCm39) |
L390P |
probably damaging |
Het |
Il27ra |
T |
A |
8: 84,766,241 (GRCm39) |
D181V |
probably benign |
Het |
Irgq |
C |
A |
7: 24,233,834 (GRCm39) |
H558Q |
probably damaging |
Het |
Itsn2 |
C |
T |
12: 4,756,983 (GRCm39) |
Q1358* |
probably null |
Het |
Kmt2c |
C |
T |
5: 25,507,847 (GRCm39) |
G3197S |
probably damaging |
Het |
Lrrk2 |
A |
G |
15: 91,651,543 (GRCm39) |
Y1733C |
probably damaging |
Het |
Mapk7 |
G |
A |
11: 61,381,279 (GRCm39) |
A510V |
probably damaging |
Het |
Mtch1 |
A |
T |
17: 29,551,698 (GRCm39) |
C385S |
probably benign |
Het |
Nfib |
A |
G |
4: 82,271,758 (GRCm39) |
|
probably null |
Het |
Nostrin |
C |
T |
2: 69,015,851 (GRCm39) |
T448M |
possibly damaging |
Het |
Or12j4 |
T |
A |
7: 140,046,711 (GRCm39) |
V199D |
probably damaging |
Het |
Or4c12b |
T |
C |
2: 89,646,880 (GRCm39) |
L64P |
probably damaging |
Het |
Or52e18 |
A |
G |
7: 104,609,124 (GRCm39) |
Y272H |
probably benign |
Het |
Or5a3 |
T |
A |
19: 12,400,509 (GRCm39) |
Y279N |
probably damaging |
Het |
Or5an10 |
T |
C |
19: 12,275,801 (GRCm39) |
I232V |
probably benign |
Het |
Or8k28 |
A |
G |
2: 86,286,150 (GRCm39) |
V155A |
probably benign |
Het |
Pcdha2 |
T |
C |
18: 37,073,383 (GRCm39) |
V338A |
probably damaging |
Het |
Pcdhgc3 |
A |
G |
18: 37,940,798 (GRCm39) |
T400A |
probably benign |
Het |
Piezo2 |
C |
T |
18: 63,145,794 (GRCm39) |
S2710N |
probably benign |
Het |
Ppp4r1 |
T |
A |
17: 66,138,015 (GRCm39) |
Y591* |
probably null |
Het |
Ptpn18 |
G |
A |
1: 34,512,445 (GRCm39) |
D417N |
possibly damaging |
Het |
Rab42 |
T |
C |
4: 132,029,925 (GRCm39) |
E99G |
possibly damaging |
Het |
Rd3l |
A |
T |
12: 111,945,916 (GRCm39) |
W188R |
probably damaging |
Het |
Sap30bp |
A |
G |
11: 115,842,794 (GRCm39) |
D89G |
probably benign |
Het |
Sptbn4 |
T |
C |
7: 27,066,114 (GRCm39) |
T1985A |
probably benign |
Het |
Tec |
T |
C |
5: 72,931,223 (GRCm39) |
Y247C |
probably damaging |
Het |
Tek |
G |
A |
4: 94,716,063 (GRCm39) |
|
probably null |
Het |
Tex14 |
T |
C |
11: 87,405,256 (GRCm39) |
S723P |
possibly damaging |
Het |
Thumpd3 |
T |
A |
6: 113,024,592 (GRCm39) |
L62Q |
probably damaging |
Het |
Tlr12 |
A |
T |
4: 128,509,963 (GRCm39) |
D762E |
probably damaging |
Het |
Tmem94 |
G |
T |
11: 115,677,082 (GRCm39) |
R118L |
possibly damaging |
Het |
Txndc16 |
T |
A |
14: 45,402,845 (GRCm39) |
I316F |
probably damaging |
Het |
Vamp1 |
T |
C |
6: 125,195,538 (GRCm39) |
S2P |
unknown |
Het |
Vmn1r211 |
T |
A |
13: 23,036,086 (GRCm39) |
M194L |
probably benign |
Het |
Zfp874a |
T |
A |
13: 67,590,376 (GRCm39) |
Q436L |
probably damaging |
Het |
|
Other mutations in Fsd1l |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00975:Fsd1l
|
APN |
4 |
53,682,187 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01019:Fsd1l
|
APN |
4 |
53,694,742 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01154:Fsd1l
|
APN |
4 |
53,701,074 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01359:Fsd1l
|
APN |
4 |
53,659,601 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL01996:Fsd1l
|
APN |
4 |
53,647,760 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02192:Fsd1l
|
APN |
4 |
53,647,754 (GRCm39) |
missense |
probably benign |
|
IGL02629:Fsd1l
|
APN |
4 |
53,686,417 (GRCm39) |
missense |
probably damaging |
1.00 |
R0009:Fsd1l
|
UTSW |
4 |
53,687,209 (GRCm39) |
missense |
probably benign |
0.01 |
R0166:Fsd1l
|
UTSW |
4 |
53,647,664 (GRCm39) |
splice site |
probably null |
|
R0255:Fsd1l
|
UTSW |
4 |
53,694,727 (GRCm39) |
missense |
probably damaging |
1.00 |
R0349:Fsd1l
|
UTSW |
4 |
53,679,854 (GRCm39) |
missense |
probably damaging |
0.97 |
R0409:Fsd1l
|
UTSW |
4 |
53,679,932 (GRCm39) |
missense |
probably benign |
0.00 |
R1886:Fsd1l
|
UTSW |
4 |
53,696,984 (GRCm39) |
splice site |
probably null |
|
R1887:Fsd1l
|
UTSW |
4 |
53,696,984 (GRCm39) |
splice site |
probably null |
|
R2039:Fsd1l
|
UTSW |
4 |
53,679,972 (GRCm39) |
missense |
probably benign |
0.02 |
R2289:Fsd1l
|
UTSW |
4 |
53,696,931 (GRCm39) |
missense |
possibly damaging |
0.64 |
R4577:Fsd1l
|
UTSW |
4 |
53,686,397 (GRCm39) |
missense |
probably damaging |
1.00 |
R5134:Fsd1l
|
UTSW |
4 |
53,647,766 (GRCm39) |
missense |
probably benign |
0.43 |
R6073:Fsd1l
|
UTSW |
4 |
53,679,994 (GRCm39) |
missense |
probably damaging |
1.00 |
R6216:Fsd1l
|
UTSW |
4 |
53,694,742 (GRCm39) |
missense |
probably damaging |
1.00 |
R7184:Fsd1l
|
UTSW |
4 |
53,694,054 (GRCm39) |
missense |
probably damaging |
1.00 |
R7285:Fsd1l
|
UTSW |
4 |
53,682,200 (GRCm39) |
critical splice donor site |
probably null |
|
R7423:Fsd1l
|
UTSW |
4 |
53,686,406 (GRCm39) |
missense |
probably damaging |
1.00 |
R8723:Fsd1l
|
UTSW |
4 |
53,647,001 (GRCm39) |
missense |
unknown |
|
R8926:Fsd1l
|
UTSW |
4 |
53,686,493 (GRCm39) |
missense |
probably benign |
|
R9131:Fsd1l
|
UTSW |
4 |
53,694,756 (GRCm39) |
missense |
probably damaging |
0.98 |
R9220:Fsd1l
|
UTSW |
4 |
53,679,799 (GRCm39) |
nonsense |
probably null |
|
R9313:Fsd1l
|
UTSW |
4 |
53,701,093 (GRCm39) |
missense |
possibly damaging |
0.64 |
R9313:Fsd1l
|
UTSW |
4 |
53,694,760 (GRCm39) |
missense |
probably damaging |
1.00 |
R9380:Fsd1l
|
UTSW |
4 |
53,693,991 (GRCm39) |
missense |
possibly damaging |
0.69 |
R9448:Fsd1l
|
UTSW |
4 |
53,694,826 (GRCm39) |
nonsense |
probably null |
|
R9712:Fsd1l
|
UTSW |
4 |
53,679,972 (GRCm39) |
missense |
probably benign |
0.02 |
|
Predicted Primers |
PCR Primer
(F):5'- CTGTACATGTGAGGCAGATGC -3'
(R):5'- GCCTGAAAAGAGCAAACAGTAAATTTC -3'
Sequencing Primer
(F):5'- TTGAGAACCACTCCGTTAGGG -3'
(R):5'- CCCTGACAAGACTTATCTCTG -3'
|
Posted On |
2019-10-07 |