Incidental Mutation 'IGL00586:Zfp120'
ID 7002
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp120
Ensembl Gene ENSMUSG00000068134
Gene Name zinc finger protein 120
Synonyms E030042N05Rik, MZF31
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # IGL00586
Quality Score
Status
Chromosome 2
Chromosomal Location 149956327-149978598 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 149961748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 67 (I67V)
Ref Sequence ENSEMBL: ENSMUSP00000114205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089207] [ENSMUST00000094538] [ENSMUST00000109931] [ENSMUST00000122859]
AlphaFold Q8BZW4
Predicted Effect probably benign
Transcript: ENSMUST00000089207
AA Change: I67V

PolyPhen 2 Score 0.246 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000086615
Gene: ENSMUSG00000068134
AA Change: I67V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
KRAB 28 91 1.7e-17 SMART
ZnF_C2H2 156 178 9.08e-4 SMART
ZnF_C2H2 184 206 3.44e-4 SMART
ZnF_C2H2 212 234 9.58e-3 SMART
ZnF_C2H2 240 262 1.95e-3 SMART
ZnF_C2H2 268 288 1.26e1 SMART
ZnF_C2H2 296 318 4.17e-3 SMART
ZnF_C2H2 324 346 5.29e-5 SMART
ZnF_C2H2 352 374 1.4e-4 SMART
ZnF_C2H2 408 430 2.71e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000094538
AA Change: I67V

PolyPhen 2 Score 0.799 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000092116
Gene: ENSMUSG00000068134
AA Change: I67V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
KRAB 28 89 1.01e-19 SMART
ZnF_C2H2 134 156 9.08e-4 SMART
ZnF_C2H2 162 184 3.44e-4 SMART
ZnF_C2H2 190 212 9.58e-3 SMART
ZnF_C2H2 218 240 1.95e-3 SMART
ZnF_C2H2 246 266 1.26e1 SMART
ZnF_C2H2 274 296 4.17e-3 SMART
ZnF_C2H2 302 324 5.29e-5 SMART
ZnF_C2H2 330 352 1.4e-4 SMART
ZnF_C2H2 386 408 2.71e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000109931
AA Change: I67V

PolyPhen 2 Score 0.698 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000105557
Gene: ENSMUSG00000068134
AA Change: I67V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
KRAB 28 89 1.01e-19 SMART
internal_repeat_1 96 130 3.31e-8 PROSPERO
Predicted Effect possibly damaging
Transcript: ENSMUST00000122859
AA Change: I67V

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000114205
Gene: ENSMUSG00000068134
AA Change: I67V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
KRAB 28 80 1.68e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142792
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl5b T C 2: 15,074,746 (GRCm39) S76P probably benign Het
Asap3 A C 4: 135,933,879 (GRCm39) D17A probably damaging Het
Ccdc24 C T 4: 117,729,243 (GRCm39) R78H probably damaging Het
Crp T C 1: 172,526,568 (GRCm39) F218L probably benign Het
Dab2 T C 15: 6,459,306 (GRCm39) L385P probably benign Het
Dip2c C A 13: 9,660,791 (GRCm39) T855N probably damaging Het
Dnai7 A T 6: 145,137,302 (GRCm39) F269I possibly damaging Het
Dync2i1 A T 12: 116,205,400 (GRCm39) D396E probably benign Het
Ep400 A G 5: 110,887,460 (GRCm39) V541A probably damaging Het
Gbgt1 A T 2: 28,392,207 (GRCm39) probably null Het
Gm6871 A T 7: 41,195,845 (GRCm39) D297E possibly damaging Het
Gpr107 T A 2: 31,062,006 (GRCm39) F145I probably benign Het
Itgb6 T G 2: 60,450,696 (GRCm39) D581A probably benign Het
Lce1a1 C T 3: 92,554,470 (GRCm39) M1I probably null Het
Lmbrd2 G A 15: 9,157,382 (GRCm39) V207M probably damaging Het
Muc5b T A 7: 141,395,129 (GRCm39) V45E unknown Het
Mybpc2 A G 7: 44,154,806 (GRCm39) V977A probably damaging Het
Oas1c T C 5: 120,946,744 (GRCm39) T29A probably benign Het
Pdzd2 G T 15: 12,365,853 (GRCm39) probably null Het
Plk2 T C 13: 110,532,912 (GRCm39) Y158H possibly damaging Het
Prss1l T C 6: 41,373,049 (GRCm39) I107T probably damaging Het
Ptprq A G 10: 107,443,983 (GRCm39) probably benign Het
Rnf17 C T 14: 56,658,539 (GRCm39) T76I probably damaging Het
Serpinb1c T C 13: 33,067,958 (GRCm39) K213E probably damaging Het
Sidt2 A G 9: 45,854,350 (GRCm39) V624A possibly damaging Het
Sin3b T C 8: 73,483,628 (GRCm39) V1005A probably benign Het
Ubr4 T C 4: 139,182,495 (GRCm39) V358A possibly damaging Het
Zfp942 A T 17: 22,147,605 (GRCm39) H341Q probably damaging Het
Other mutations in Zfp120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03033:Zfp120 APN 2 149,961,794 (GRCm39) missense probably benign 0.32
R0032:Zfp120 UTSW 2 149,959,512 (GRCm39) missense possibly damaging 0.94
R0032:Zfp120 UTSW 2 149,959,512 (GRCm39) missense possibly damaging 0.94
R1165:Zfp120 UTSW 2 149,961,849 (GRCm39) missense probably damaging 1.00
R1965:Zfp120 UTSW 2 149,959,318 (GRCm39) missense probably damaging 1.00
R1966:Zfp120 UTSW 2 149,959,318 (GRCm39) missense probably damaging 1.00
R4418:Zfp120 UTSW 2 149,960,105 (GRCm39) missense possibly damaging 0.79
R4902:Zfp120 UTSW 2 149,961,440 (GRCm39) utr 3 prime probably benign
R4910:Zfp120 UTSW 2 149,959,872 (GRCm39) missense probably damaging 0.96
R5108:Zfp120 UTSW 2 149,961,862 (GRCm39) missense probably damaging 0.98
R5521:Zfp120 UTSW 2 149,959,499 (GRCm39) nonsense probably null
R6280:Zfp120 UTSW 2 149,959,964 (GRCm39) missense possibly damaging 0.84
R8389:Zfp120 UTSW 2 149,959,327 (GRCm39) missense probably damaging 1.00
R8530:Zfp120 UTSW 2 149,959,168 (GRCm39) missense probably benign
R8871:Zfp120 UTSW 2 149,959,995 (GRCm39) missense probably benign 0.00
R9281:Zfp120 UTSW 2 149,959,615 (GRCm39) missense probably damaging 1.00
R9720:Zfp120 UTSW 2 149,959,197 (GRCm39) missense probably benign 0.00
Posted On 2012-04-20