Incidental Mutation 'IGL00586:Zfp942'
| ID |
332713 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp942
|
| Ensembl Gene |
ENSMUSG00000071267 |
| Gene Name |
zinc finger protein 942 |
| Synonyms |
3110048L19Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
IGL00586
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
22145941-22181445 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 22147605 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 341
(H341Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000089494
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074295]
[ENSMUST00000091879]
|
| AlphaFold |
B8JJA7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000074295
AA Change: H341Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000073907
Gene: ENSMUSG00000071267
AA Change: H341Q
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
69 |
6.55e-19 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.32e-1 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.99e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000091879
AA Change: H341Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000089494
Gene: ENSMUSG00000071267
AA Change: H341Q
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
69 |
6.55e-19 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.32e-1 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.99e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arl5b |
T |
C |
2: 15,074,746 (GRCm39) |
S76P |
probably benign |
Het |
| Asap3 |
A |
C |
4: 135,933,879 (GRCm39) |
D17A |
probably damaging |
Het |
| Ccdc24 |
C |
T |
4: 117,729,243 (GRCm39) |
R78H |
probably damaging |
Het |
| Crp |
T |
C |
1: 172,526,568 (GRCm39) |
F218L |
probably benign |
Het |
| Dab2 |
T |
C |
15: 6,459,306 (GRCm39) |
L385P |
probably benign |
Het |
| Dip2c |
C |
A |
13: 9,660,791 (GRCm39) |
T855N |
probably damaging |
Het |
| Dnai7 |
A |
T |
6: 145,137,302 (GRCm39) |
F269I |
possibly damaging |
Het |
| Dync2i1 |
A |
T |
12: 116,205,400 (GRCm39) |
D396E |
probably benign |
Het |
| Ep400 |
A |
G |
5: 110,887,460 (GRCm39) |
V541A |
probably damaging |
Het |
| Gbgt1 |
A |
T |
2: 28,392,207 (GRCm39) |
|
probably null |
Het |
| Gm6871 |
A |
T |
7: 41,195,845 (GRCm39) |
D297E |
possibly damaging |
Het |
| Gpr107 |
T |
A |
2: 31,062,006 (GRCm39) |
F145I |
probably benign |
Het |
| Itgb6 |
T |
G |
2: 60,450,696 (GRCm39) |
D581A |
probably benign |
Het |
| Lce1a1 |
C |
T |
3: 92,554,470 (GRCm39) |
M1I |
probably null |
Het |
| Lmbrd2 |
G |
A |
15: 9,157,382 (GRCm39) |
V207M |
probably damaging |
Het |
| Muc5b |
T |
A |
7: 141,395,129 (GRCm39) |
V45E |
unknown |
Het |
| Mybpc2 |
A |
G |
7: 44,154,806 (GRCm39) |
V977A |
probably damaging |
Het |
| Oas1c |
T |
C |
5: 120,946,744 (GRCm39) |
T29A |
probably benign |
Het |
| Pdzd2 |
G |
T |
15: 12,365,853 (GRCm39) |
|
probably null |
Het |
| Plk2 |
T |
C |
13: 110,532,912 (GRCm39) |
Y158H |
possibly damaging |
Het |
| Prss1l |
T |
C |
6: 41,373,049 (GRCm39) |
I107T |
probably damaging |
Het |
| Ptprq |
A |
G |
10: 107,443,983 (GRCm39) |
|
probably benign |
Het |
| Rnf17 |
C |
T |
14: 56,658,539 (GRCm39) |
T76I |
probably damaging |
Het |
| Serpinb1c |
T |
C |
13: 33,067,958 (GRCm39) |
K213E |
probably damaging |
Het |
| Sidt2 |
A |
G |
9: 45,854,350 (GRCm39) |
V624A |
possibly damaging |
Het |
| Sin3b |
T |
C |
8: 73,483,628 (GRCm39) |
V1005A |
probably benign |
Het |
| Ubr4 |
T |
C |
4: 139,182,495 (GRCm39) |
V358A |
possibly damaging |
Het |
| Zfp120 |
T |
C |
2: 149,961,748 (GRCm39) |
I67V |
possibly damaging |
Het |
|
| Other mutations in Zfp942 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Zfp942
|
APN |
17 |
22,148,042 (GRCm39) |
missense |
probably benign |
|
|
IGL02973:Zfp942
|
APN |
17 |
22,151,972 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03212:Zfp942
|
APN |
17 |
22,148,445 (GRCm39) |
nonsense |
probably null |
|
|
IGL03382:Zfp942
|
APN |
17 |
22,148,083 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0008:Zfp942
|
UTSW |
17 |
22,147,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0113:Zfp942
|
UTSW |
17 |
22,148,066 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0244:Zfp942
|
UTSW |
17 |
22,147,553 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0369:Zfp942
|
UTSW |
17 |
22,148,017 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1664:Zfp942
|
UTSW |
17 |
22,147,420 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1824:Zfp942
|
UTSW |
17 |
22,147,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4545:Zfp942
|
UTSW |
17 |
22,147,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4785:Zfp942
|
UTSW |
17 |
22,148,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5493:Zfp942
|
UTSW |
17 |
22,151,985 (GRCm39) |
missense |
probably null |
0.66 |
|
R6568:Zfp942
|
UTSW |
17 |
22,148,043 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6733:Zfp942
|
UTSW |
17 |
22,147,733 (GRCm39) |
nonsense |
probably null |
|
|
R7650:Zfp942
|
UTSW |
17 |
22,147,818 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7935:Zfp942
|
UTSW |
17 |
22,148,208 (GRCm39) |
nonsense |
probably null |
|
|
R8065:Zfp942
|
UTSW |
17 |
22,149,391 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8067:Zfp942
|
UTSW |
17 |
22,149,391 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8237:Zfp942
|
UTSW |
17 |
22,147,226 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8513:Zfp942
|
UTSW |
17 |
22,147,282 (GRCm39) |
missense |
probably benign |
|
|
R9468:Zfp942
|
UTSW |
17 |
22,148,422 (GRCm39) |
missense |
probably benign |
0.24 |
|
R9539:Zfp942
|
UTSW |
17 |
22,148,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Zfp942
|
UTSW |
17 |
22,147,463 (GRCm39) |
missense |
probably benign |
0.05 |
|
X0025:Zfp942
|
UTSW |
17 |
22,148,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-08-05 |
Incidental Mutation