Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01296:Or5b111'

73118

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5b111

Ensembl Gene

ENSMUSG00000062199

Gene Name

olfactory receptor family 5 subfamily B member 111

Synonyms

MOR202-28, GA_x6K02T2RE5P-3645346-3644423, Olfr1465

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

IGL01296

Quality Score

Status

Chromosome

Chromosomal Location

13290724-13291647 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 13291490 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 53 (L53P)

Ref Sequence

ENSEMBL: ENSMUSP00000146645 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080142] [ENSMUST00000207340]

AlphaFold

Q7TQR2

Predicted Effect

probably damaging
Transcript: ENSMUST00000080142
AA Change: L53P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079039
Gene: ENSMUSG00000062199
AA Change: L53P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	7.4e-47	PFAM
Pfam:7tm_1	39	288	3.7e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000207340
AA Change: L53P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadl	A	G	1: 66,880,864 (GRCm39)	S301P	probably damaging	Het
Adam34	A	G	8: 44,104,178 (GRCm39)	V489A	possibly damaging	Het
Adcy8	G	A	15: 64,655,628 (GRCm39)	T617I	probably damaging	Het
Aggf1	T	C	13: 95,490,479 (GRCm39)	D605G	probably damaging	Het
Atp10a	T	A	7: 58,463,373 (GRCm39)	F969I	probably benign	Het
Becn1	A	T	11: 101,182,277 (GRCm39)	N97K	probably damaging	Het
Cd4	G	A	6: 124,856,341 (GRCm39)	T50I	probably benign	Het
Crtac1	A	T	19: 42,272,652 (GRCm39)	C578S	probably damaging	Het
Dcp1b	A	G	6: 119,192,319 (GRCm39)	K412E	probably damaging	Het
Dlg2	T	A	7: 91,589,267 (GRCm39)	I327N	probably damaging	Het
Ehf	T	A	2: 103,098,500 (GRCm39)		probably null	Het
Elavl4	T	C	4: 110,063,809 (GRCm39)	N264S	probably benign	Het
Enpp2	A	T	15: 54,739,065 (GRCm39)	I406N	probably damaging	Het
F10	A	T	8: 13,105,383 (GRCm39)	Y316F	possibly damaging	Het
Fam20a	A	G	11: 109,576,177 (GRCm39)	I194T	possibly damaging	Het
Fcgbp	T	C	7: 27,789,072 (GRCm39)	V546A	probably benign	Het
Fras1	A	T	5: 96,821,557 (GRCm39)	Q1438L	probably null	Het
Gm43638	T	C	5: 87,608,451 (GRCm39)	I463V	probably benign	Het
H2-T10	T	C	17: 36,431,602 (GRCm39)	D84G	probably benign	Het
Itpr1	T	C	6: 108,376,322 (GRCm39)	F1262L	probably damaging	Het
Lama1	A	G	17: 68,052,046 (GRCm39)	N335D	probably benign	Het
Lasp1	T	C	11: 97,727,016 (GRCm39)	V246A	probably damaging	Het
Lrrk2	A	T	15: 91,567,345 (GRCm39)	I135L	probably benign	Het
Malrd1	G	A	2: 16,106,768 (GRCm39)		probably null	Het
Mctp2	T	C	7: 71,878,274 (GRCm39)	K268R	probably benign	Het
Nbea	A	T	3: 55,938,957 (GRCm39)	H710Q	probably benign	Het
Notch3	G	A	17: 32,385,731 (GRCm39)	R13C	unknown	Het
Ogfod1	A	T	8: 94,782,299 (GRCm39)		probably benign	Het
Or1j11	A	G	2: 36,311,716 (GRCm39)	Y102C	probably benign	Het
Or8d2	T	C	9: 38,759,548 (GRCm39)	I46T	probably damaging	Het
Pgm3	A	G	9: 86,443,932 (GRCm39)	V324A	probably damaging	Het
Ppfia2	A	T	10: 106,694,068 (GRCm39)	I681F	probably damaging	Het
Prss23	T	C	7: 89,159,095 (GRCm39)	K325E	possibly damaging	Het
Psmd7	T	A	8: 108,313,249 (GRCm39)		probably benign	Het
Rfx2	T	A	17: 57,115,317 (GRCm39)	M1L	possibly damaging	Het
Rpa1	T	C	11: 75,203,141 (GRCm39)	Y418C	probably damaging	Het
Rps6kc1	C	T	1: 190,505,875 (GRCm39)	R1029H	probably damaging	Het
Septin10	A	G	10: 59,002,422 (GRCm39)	V391A	probably benign	Het
Skint6	A	G	4: 113,093,637 (GRCm39)	F169L	probably benign	Het
Slc44a4	C	T	17: 35,140,674 (GRCm39)	T289I	probably benign	Het
Spata31e5	T	C	1: 28,816,137 (GRCm39)	I632V	probably benign	Het
Srl	T	C	16: 4,315,546 (GRCm39)	D32G	probably damaging	Het
Stxbp3-ps	T	A	19: 9,535,256 (GRCm39)		noncoding transcript	Het
Sult1b1	T	C	5: 87,662,815 (GRCm39)	D295G	probably benign	Het
Tmprss7	A	G	16: 45,504,937 (GRCm39)	V151A	probably damaging	Het
Trmo	A	G	4: 46,387,589 (GRCm39)	L84P	probably damaging	Het
Vmn2r98	T	A	17: 19,285,447 (GRCm39)	I89N	probably damaging	Het
Zcwpw1	G	A	5: 137,795,061 (GRCm39)	A86T	probably benign	Het
Zkscan16	A	G	4: 58,956,690 (GRCm39)	H324R	possibly damaging	Het

Other mutations in Or5b111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01548:Or5b111	APN	19	13,291,350 (GRCm39)	missense	possibly damaging	0.95
IGL02548:Or5b111	APN	19	13,291,302 (GRCm39)	missense	probably damaging	0.98
IGL02663:Or5b111	APN	19	13,290,743 (GRCm39)	missense	probably benign	0.01
BB010:Or5b111	UTSW	19	13,291,569 (GRCm39)	missense	probably benign
BB020:Or5b111	UTSW	19	13,291,569 (GRCm39)	missense	probably benign
PIT4651001:Or5b111	UTSW	19	13,291,556 (GRCm39)	missense	probably benign	0.12
R0563:Or5b111	UTSW	19	13,291,112 (GRCm39)	missense	probably benign	0.28
R1803:Or5b111	UTSW	19	13,291,535 (GRCm39)	missense	possibly damaging	0.90
R2146:Or5b111	UTSW	19	13,291,485 (GRCm39)	missense	probably benign	0.23
R4674:Or5b111	UTSW	19	13,291,178 (GRCm39)	missense	probably benign	0.17
R4697:Or5b111	UTSW	19	13,291,081 (GRCm39)	missense	probably benign	0.39
R4825:Or5b111	UTSW	19	13,291,684 (GRCm39)	splice site	probably null
R4884:Or5b111	UTSW	19	13,291,034 (GRCm39)	missense	probably benign	0.28
R5647:Or5b111	UTSW	19	13,291,553 (GRCm39)	missense	probably damaging	1.00
R6401:Or5b111	UTSW	19	13,290,878 (GRCm39)	missense	probably damaging	1.00
R6913:Or5b111	UTSW	19	13,290,998 (GRCm39)	missense	probably benign	0.01
R6996:Or5b111	UTSW	19	13,291,036 (GRCm39)	missense	probably benign	0.15
R7933:Or5b111	UTSW	19	13,291,569 (GRCm39)	missense	probably benign
R8946:Or5b111	UTSW	19	13,291,502 (GRCm39)	missense	probably damaging	0.97
R8966:Or5b111	UTSW	19	13,291,196 (GRCm39)	missense	probably damaging	1.00
R9641:Or5b111	UTSW	19	13,291,100 (GRCm39)	missense	probably damaging	0.98

Posted On

2013-10-07