Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01369:Ogfod1'

76079

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ogfod1

Ensembl Gene

ENSMUSG00000033009

Gene Name

2-oxoglutarate and iron-dependent oxygenase domain containing 1

Synonyms

4930415J21Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01369

Quality Score

Status

Chromosome

Chromosomal Location

94763826-94794549 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 94789719 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000105183 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034206] [ENSMUST00000060632] [ENSMUST00000093301] [ENSMUST00000109556]

AlphaFold

Q3U0K8

Predicted Effect

probably benign
Transcript: ENSMUST00000034206

SMART Domains

Protein: ENSMUSP00000034206
Gene: ENSMUSG00000031755

Domain	Start	End	E-Value	Type
Pfam:BBS2_N	20	161	1.4e-62	PFAM
Pfam:BBS2_Mid	162	272	6.9e-50	PFAM
Pfam:BBS2_C	276	715	2.6e-193	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000060632

SMART Domains

Protein: ENSMUSP00000051430
Gene: ENSMUSG00000033009

Domain	Start	End	E-Value	Type
P4Hc	46	223	4.87e-26	SMART
Pfam:Ofd1_CTDD	246	513	1.4e-50	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000093301

SMART Domains

Protein: ENSMUSP00000090991
Gene: ENSMUSG00000033009

Domain	Start	End	E-Value	Type
P4Hc	61	228	2.6e-12	SMART
low complexity region	328	353	N/A	INTRINSIC
low complexity region	375	389	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000109556

SMART Domains

Protein: ENSMUSP00000105183
Gene: ENSMUSG00000033009

Domain	Start	End	E-Value	Type
P4Hc	61	238	4.87e-26	SMART
Pfam:Ofd1_CTDD	261	528	7.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele are viable and fertile. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4fm4	T	C	4: 144,401,215 (GRCm39)	T90A	possibly damaging	Het
Abi2	A	G	1: 60,476,215 (GRCm39)	T96A	probably damaging	Het
Adam34	T	A	8: 44,104,094 (GRCm39)	K517M	probably benign	Het
Atm	A	T	9: 53,426,617 (GRCm39)	I547N	probably benign	Het
Cadm4	A	T	7: 24,198,947 (GRCm39)	D74V	possibly damaging	Het
Caprin1	G	A	2: 103,599,210 (GRCm39)	P46S	probably damaging	Het
Cbl	A	T	9: 44,112,358 (GRCm39)	Y112*	probably null	Het
Ccdc180	T	C	4: 45,900,256 (GRCm39)	V246A	probably benign	Het
Chd1	A	T	17: 15,975,259 (GRCm39)	E1103V	probably damaging	Het
Clock	G	A	5: 76,384,933 (GRCm39)	P428L	probably benign	Het
Cntn2	T	A	1: 132,443,843 (GRCm39)	I979F	probably benign	Het
Col2a1	A	G	15: 97,875,707 (GRCm39)	S1193P	unknown	Het
Fga	A	T	3: 82,937,507 (GRCm39)	Y128F	probably benign	Het
Glyr1	A	T	16: 4,838,152 (GRCm39)	D365E	probably benign	Het
Gmppb	G	A	9: 107,928,446 (GRCm39)		probably null	Het
Gmps	A	T	3: 63,909,013 (GRCm39)	H505L	probably benign	Het
Hexim2	A	G	11: 103,029,464 (GRCm39)	N172S	probably benign	Het
Hmgcr	T	C	13: 96,803,030 (GRCm39)	E65G	probably null	Het
Hsd17b4	T	C	18: 50,305,100 (GRCm39)	S446P	possibly damaging	Het
Kirrel3	C	T	9: 34,927,737 (GRCm39)	T382I	probably benign	Het
Klra7	A	T	6: 130,203,498 (GRCm39)	Y169*	probably null	Het
Lmbrd1	T	C	1: 24,745,055 (GRCm39)		probably benign	Het
Loxhd1	A	G	18: 77,416,897 (GRCm39)	E211G	possibly damaging	Het
Maf1	T	A	15: 76,236,892 (GRCm39)	F44I	probably damaging	Het
Mmd2	A	G	5: 142,560,984 (GRCm39)	S84P	probably damaging	Het
Morc2b	T	C	17: 33,357,139 (GRCm39)	E211G	probably benign	Het
Mov10l1	T	C	15: 88,909,040 (GRCm39)		probably benign	Het
Mycbp2	C	A	14: 103,392,946 (GRCm39)	C3205F	possibly damaging	Het
Myg1	G	A	15: 102,242,773 (GRCm39)	V155M	probably benign	Het
Ncam2	A	G	16: 81,258,459 (GRCm39)	N247S	probably benign	Het
Nek11	A	G	9: 105,177,259 (GRCm39)		probably null	Het
Nt5dc3	T	A	10: 86,656,139 (GRCm39)		probably benign	Het
Nudcd3	A	G	11: 6,100,551 (GRCm39)	Y134H	probably damaging	Het
Or5b99	A	T	19: 12,977,125 (GRCm39)	L258F	possibly damaging	Het
Orm2	T	C	4: 63,281,215 (GRCm39)	V51A	probably benign	Het
P2ry14	T	C	3: 59,022,756 (GRCm39)	I244V	probably damaging	Het
Poll	A	G	19: 45,542,115 (GRCm39)	V397A	probably damaging	Het
Ppdpf	C	A	2: 180,829,687 (GRCm39)		probably benign	Het
Ptch1	T	C	13: 63,659,495 (GRCm39)	E1249G	probably benign	Het
Rdh16f1	C	A	10: 127,595,844 (GRCm39)	T13K	probably benign	Het
Rrp1	G	A	10: 78,240,905 (GRCm39)		probably benign	Het
Sec14l2	A	G	11: 4,053,432 (GRCm39)	M346T	probably benign	Het
Sh2d2a	A	T	3: 87,759,136 (GRCm39)	Q246L	probably benign	Het
Slc44a1	G	A	4: 53,491,448 (GRCm39)	D62N	probably damaging	Het
Snx22	A	G	9: 65,976,060 (GRCm39)	Y58H	probably damaging	Het
Spata31f1a	T	C	4: 42,852,548 (GRCm39)		probably null	Het
Ttn	T	A	2: 76,599,779 (GRCm39)	D19104V	probably damaging	Het
Ugt2a3	T	C	5: 87,474,979 (GRCm39)	S422G	probably damaging	Het
Zfyve19	G	T	2: 119,041,094 (GRCm39)		probably benign	Het

Other mutations in Ogfod1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01074:Ogfod1	APN	8	94,789,634 (GRCm39)	missense	probably damaging	1.00
IGL01296:Ogfod1	APN	8	94,782,299 (GRCm39)	splice site	probably benign
IGL02113:Ogfod1	APN	8	94,790,841 (GRCm39)	missense	probably damaging	1.00
IGL02228:Ogfod1	APN	8	94,789,615 (GRCm39)	missense	probably benign	0.00
IGL03057:Ogfod1	APN	8	94,782,766 (GRCm39)	missense	possibly damaging	0.78
IGL03071:Ogfod1	APN	8	94,784,395 (GRCm39)	missense	probably damaging	1.00
R0391:Ogfod1	UTSW	8	94,789,651 (GRCm39)	missense	probably damaging	1.00
R0395:Ogfod1	UTSW	8	94,790,156 (GRCm39)	critical splice donor site	probably null
R0518:Ogfod1	UTSW	8	94,781,876 (GRCm39)	splice site	probably null
R0605:Ogfod1	UTSW	8	94,773,895 (GRCm39)	splice site	probably benign
R0708:Ogfod1	UTSW	8	94,765,673 (GRCm39)	missense	possibly damaging	0.89
R0763:Ogfod1	UTSW	8	94,782,264 (GRCm39)	missense	probably benign	0.03
R1101:Ogfod1	UTSW	8	94,790,932 (GRCm39)	missense	probably benign
R1244:Ogfod1	UTSW	8	94,763,999 (GRCm39)	missense	probably benign
R1332:Ogfod1	UTSW	8	94,784,727 (GRCm39)	missense	probably damaging	1.00
R1336:Ogfod1	UTSW	8	94,784,727 (GRCm39)	missense	probably damaging	1.00
R2301:Ogfod1	UTSW	8	94,763,996 (GRCm39)	missense	probably damaging	0.99
R3025:Ogfod1	UTSW	8	94,789,680 (GRCm39)	missense	probably damaging	1.00
R3710:Ogfod1	UTSW	8	94,784,380 (GRCm39)	nonsense	probably null
R4612:Ogfod1	UTSW	8	94,763,975 (GRCm39)	missense	possibly damaging	0.66
R5349:Ogfod1	UTSW	8	94,781,876 (GRCm39)	splice site	probably benign
R5495:Ogfod1	UTSW	8	94,790,906 (GRCm39)	missense	probably benign	0.30
R5690:Ogfod1	UTSW	8	94,784,769 (GRCm39)	missense	probably damaging	0.99
R6355:Ogfod1	UTSW	8	94,789,610 (GRCm39)	missense	probably benign
R7282:Ogfod1	UTSW	8	94,764,067 (GRCm39)	missense	possibly damaging	0.47
R7396:Ogfod1	UTSW	8	94,765,615 (GRCm39)	missense	probably benign	0.00
R7651:Ogfod1	UTSW	8	94,763,981 (GRCm39)	missense	probably benign	0.04
R8868:Ogfod1	UTSW	8	94,773,906 (GRCm39)	missense	probably damaging	1.00
X0027:Ogfod1	UTSW	8	94,764,032 (GRCm39)	missense	probably benign	0.08
Z1177:Ogfod1	UTSW	8	94,763,937 (GRCm39)	unclassified	probably benign

Posted On

2013-10-07