Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01394:Zfp811'

79360

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp811

Ensembl Gene

ENSMUSG00000055202

Gene Name

zinc finger protein 811

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL01394

Quality Score

Status

Chromosome

Chromosomal Location

33014650-33028905 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 33016794 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 414 (K414N)

Ref Sequence

ENSEMBL: ENSMUSP00000079709 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080905] [ENSMUST00000200914]

AlphaFold

A0A0J9YU71

Predicted Effect

probably damaging
Transcript: ENSMUST00000080905
AA Change: K414N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079709
Gene: ENSMUSG00000055202
AA Change: K414N

Domain	Start	End	E-Value	Type
KRAB	3	62	6.26e-16	SMART
ZnF_C2H2	192	215	1.25e-1	SMART
ZnF_C2H2	220	242	1.79e-2	SMART
ZnF_C2H2	248	270	9.08e-4	SMART
ZnF_C2H2	276	298	7.78e-3	SMART
ZnF_C2H2	304	326	3.69e-4	SMART
ZnF_C2H2	332	354	8.47e-4	SMART
ZnF_C2H2	360	382	1.45e-2	SMART
ZnF_C2H2	388	410	6.42e-4	SMART
ZnF_C2H2	416	438	5.9e-3	SMART
ZnF_C2H2	444	466	1.08e-1	SMART
ZnF_C2H2	472	494	2.75e-3	SMART
ZnF_C2H2	500	522	9.44e-2	SMART
ZnF_C2H2	528	551	3.89e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000104150

Predicted Effect

possibly damaging
Transcript: ENSMUST00000200914
AA Change: K415N

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000144038
Gene: ENSMUSG00000055202
AA Change: K415N

Domain	Start	End	E-Value	Type
KRAB	4	63	2.6e-18	SMART
ZnF_C2H2	193	216	5.4e-4	SMART
ZnF_C2H2	221	243	7.8e-5	SMART
ZnF_C2H2	249	271	3.8e-6	SMART
ZnF_C2H2	277	299	3.3e-5	SMART
ZnF_C2H2	305	327	1.6e-6	SMART
ZnF_C2H2	333	355	3.8e-6	SMART
ZnF_C2H2	361	383	6.1e-5	SMART
ZnF_C2H2	389	411	2.7e-6	SMART
ZnF_C2H2	417	439	2.5e-5	SMART
ZnF_C2H2	445	467	4.6e-4	SMART
ZnF_C2H2	473	495	1.2e-5	SMART
ZnF_C2H2	501	523	4e-4	SMART
ZnF_C2H2	529	552	1.7e-5	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402N03Rik	G	A	7: 130,747,960 (GRCm39)	Q11*	probably null	Het
Acot5	T	C	12: 84,122,262 (GRCm39)	I282T	probably benign	Het
Adcy2	A	G	13: 69,130,521 (GRCm39)	V122A	probably damaging	Het
Aldh16a1	A	C	7: 44,794,937 (GRCm39)	S511A	probably benign	Het
Arid3b	T	C	9: 57,702,317 (GRCm39)	E480G	probably damaging	Het
Baz2a	T	C	10: 127,954,514 (GRCm39)	V723A	possibly damaging	Het
Bmpr1b	A	G	3: 141,568,742 (GRCm39)		probably null	Het
Ccdc83	T	C	7: 89,873,209 (GRCm39)	E382G	probably damaging	Het
Cfap46	A	G	7: 139,246,895 (GRCm39)	Y349H	probably damaging	Het
Clpx	T	C	9: 65,217,495 (GRCm39)	V21A	probably damaging	Het
Clstn1	A	G	4: 149,719,239 (GRCm39)	N356S	possibly damaging	Het
Ctnnd1	A	G	2: 84,435,600 (GRCm39)		probably benign	Het
Dock1	A	G	7: 134,367,945 (GRCm39)	N505S	probably benign	Het
Eaf2	G	A	16: 36,630,928 (GRCm39)	P82S	probably damaging	Het
Fbxw26	T	C	9: 109,547,057 (GRCm39)	Y456C	probably benign	Het
Foxred2	T	C	15: 77,839,820 (GRCm39)	T157A	probably benign	Het
Fscb	A	T	12: 64,520,578 (GRCm39)	I296K	possibly damaging	Het
Gad1-ps	A	G	10: 99,281,424 (GRCm39)		noncoding transcript	Het
Golgb1	A	G	16: 36,751,926 (GRCm39)	E3120G	probably damaging	Het
Ift140	A	G	17: 25,313,676 (GRCm39)	D1369G	probably benign	Het
Kcnk13	T	C	12: 100,027,921 (GRCm39)	V332A	probably benign	Het
Lama3	T	A	18: 12,664,983 (GRCm39)	D661E	probably null	Het
Lum	A	T	10: 97,404,834 (GRCm39)	D243V	probably damaging	Het
Mgat4c	A	G	10: 102,220,975 (GRCm39)	T86A	possibly damaging	Het
Mpdz	A	T	4: 81,210,728 (GRCm39)	V1706D	possibly damaging	Het
Myrfl	T	C	10: 116,658,592 (GRCm39)	Q455R	probably benign	Het
Or6k2	T	C	1: 173,986,423 (GRCm39)	F28S	probably damaging	Het
Or8c20	T	A	9: 38,261,101 (GRCm39)	S241T	possibly damaging	Het
Papolg	G	A	11: 23,817,235 (GRCm39)	T654I	probably benign	Het
Pappa2	G	A	1: 158,592,674 (GRCm39)		probably benign	Het
Plekhh2	C	T	17: 84,864,858 (GRCm39)	T82I	probably benign	Het
Prrc2a	A	G	17: 35,372,080 (GRCm39)	V1773A	probably benign	Het
Psmb8	G	T	17: 34,419,703 (GRCm39)	V186L	probably damaging	Het
Rin3	T	C	12: 102,339,862 (GRCm39)	V604A	probably damaging	Het
Rtn1	T	C	12: 72,355,190 (GRCm39)	D252G	probably benign	Het
Sdk1	C	T	5: 141,598,970 (GRCm39)	H212Y	probably benign	Het
Slc5a5	G	T	8: 71,342,032 (GRCm39)	Y307*	probably null	Het
Slc9a9	T	A	9: 95,005,090 (GRCm39)	L499Q	probably benign	Het
Snx8	C	A	5: 140,337,934 (GRCm39)	G237V	probably benign	Het
Spata18	T	A	5: 73,836,688 (GRCm39)		probably null	Het
Stard9	A	G	2: 120,536,808 (GRCm39)	E417G	possibly damaging	Het
Ubr5	T	C	15: 38,009,875 (GRCm39)	D1034G	possibly damaging	Het
Upf2	A	G	2: 6,045,024 (GRCm39)		probably null	Het
Xrcc6	A	G	15: 81,909,862 (GRCm39)	K89R	possibly damaging	Het
Yeats2	T	C	16: 19,980,782 (GRCm39)	V237A	probably damaging	Het
Zdhhc6	A	G	19: 55,298,324 (GRCm39)	W178R	probably benign	Het
Zfp280b	C	A	10: 75,875,497 (GRCm39)	Q459K	probably damaging	Het

Other mutations in Zfp811

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02227:Zfp811	APN	17	33,017,616 (GRCm39)	nonsense	probably null
IGL02529:Zfp811	APN	17	33,016,789 (GRCm39)	missense	probably damaging	1.00
IGL03190:Zfp811	APN	17	33,017,855 (GRCm39)	splice site	probably benign
R0112:Zfp811	UTSW	17	33,016,738 (GRCm39)	missense	probably damaging	0.96
R1025:Zfp811	UTSW	17	33,017,618 (GRCm39)	missense	probably benign	0.00
R1522:Zfp811	UTSW	17	33,016,622 (GRCm39)	missense	probably damaging	1.00
R1829:Zfp811	UTSW	17	33,017,116 (GRCm39)	missense	possibly damaging	0.72
R1861:Zfp811	UTSW	17	33,016,399 (GRCm39)	missense	probably damaging	1.00
R2181:Zfp811	UTSW	17	33,016,695 (GRCm39)	missense	probably damaging	0.96
R4360:Zfp811	UTSW	17	33,017,432 (GRCm39)	missense	probably benign	0.01
R4425:Zfp811	UTSW	17	33,016,521 (GRCm39)	nonsense	probably null
R4657:Zfp811	UTSW	17	33,019,897 (GRCm39)	nonsense	probably null
R6066:Zfp811	UTSW	17	33,017,801 (GRCm39)	missense	possibly damaging	0.73
R6109:Zfp811	UTSW	17	33,016,348 (GRCm39)	splice site	probably null
R6702:Zfp811	UTSW	17	33,016,816 (GRCm39)	missense	probably damaging	1.00
R6714:Zfp811	UTSW	17	33,016,736 (GRCm39)	missense	probably damaging	1.00
R6826:Zfp811	UTSW	17	33,016,762 (GRCm39)	missense	probably damaging	1.00
R6983:Zfp811	UTSW	17	33,016,406 (GRCm39)	nonsense	probably null
R7276:Zfp811	UTSW	17	33,017,755 (GRCm39)	missense	probably benign	0.00
R7343:Zfp811	UTSW	17	33,016,487 (GRCm39)	missense	probably damaging	0.98
R7432:Zfp811	UTSW	17	33,017,733 (GRCm39)	missense	possibly damaging	0.73
R7523:Zfp811	UTSW	17	33,016,726 (GRCm39)	missense	probably benign	0.10
R7894:Zfp811	UTSW	17	33,017,821 (GRCm39)	missense	possibly damaging	0.85
R8737:Zfp811	UTSW	17	33,017,197 (GRCm39)	missense	possibly damaging	0.92
R8962:Zfp811	UTSW	17	33,017,622 (GRCm39)	missense	probably benign
R8987:Zfp811	UTSW	17	33,017,801 (GRCm39)	missense	possibly damaging	0.53
R9612:Zfp811	UTSW	17	33,017,740 (GRCm39)	missense	probably benign	0.33

Posted On

2013-11-05