Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01539:Trim66'

90092

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim66

Ensembl Gene

ENSMUSG00000031026

Gene Name

tripartite motif-containing 66

Synonyms

Tif1d, D7H11orf29

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.169) question?

Stock #

IGL01539

Quality Score

Status

Chromosome

Chromosomal Location

109048213-109107341 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 109054273 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 1312 (M1312I)

Ref Sequence

ENSEMBL: ENSMUSP00000102352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033339] [ENSMUST00000106739] [ENSMUST00000106741]

AlphaFold

Q924W6

Predicted Effect

probably benign
Transcript: ENSMUST00000033339
AA Change: M1210I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000033339
Gene: ENSMUSG00000031026
AA Change: M1210I

Domain	Start	End	E-Value	Type
PHD	4	69	7.77e0	SMART
BBC	108	234	1.61e-39	SMART
low complexity region	318	333	N/A	INTRINSIC
low complexity region	452	486	N/A	INTRINSIC
low complexity region	517	530	N/A	INTRINSIC
low complexity region	568	581	N/A	INTRINSIC
PHD	998	1041	4.09e-10	SMART
BROMO	1069	1175	8.22e-27	SMART
low complexity region	1185	1199	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000106739
AA Change: M1210I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000102350
Gene: ENSMUSG00000031026
AA Change: M1210I

Domain	Start	End	E-Value	Type
PHD	4	69	7.77e0	SMART
BBC	108	234	1.61e-39	SMART
low complexity region	318	333	N/A	INTRINSIC
low complexity region	452	486	N/A	INTRINSIC
low complexity region	517	530	N/A	INTRINSIC
low complexity region	568	581	N/A	INTRINSIC
PHD	998	1041	4.09e-10	SMART
BROMO	1069	1175	8.22e-27	SMART
low complexity region	1185	1199	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000106741
AA Change: M1312I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000102352
Gene: ENSMUSG00000031026
AA Change: M1312I

Domain	Start	End	E-Value	Type
RING	28	78	2.38e-2	SMART
BBOX	102	140	1.48e0	SMART
PHD	106	171	7.77e0	SMART
RING	107	170	4.38e0	SMART
BBOX	162	203	4.21e-3	SMART
BBC	210	336	1.61e-39	SMART
low complexity region	420	435	N/A	INTRINSIC
low complexity region	554	588	N/A	INTRINSIC
low complexity region	619	632	N/A	INTRINSIC
low complexity region	670	683	N/A	INTRINSIC
PHD	1100	1143	4.09e-10	SMART
BROMO	1171	1277	8.22e-27	SMART
low complexity region	1287	1301	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Clca4b	T	A	3: 144,631,918 (GRCm39)	M196L	probably benign	Het
Cyp4a14	T	C	4: 115,344,374 (GRCm39)	N497S	possibly damaging	Het
Eif3b	T	C	5: 140,416,008 (GRCm39)		probably benign	Het
Grin2c	T	C	11: 115,140,932 (GRCm39)	Q1062R	probably benign	Het
Ina	A	G	19: 47,003,903 (GRCm39)	E237G	probably damaging	Het
Lmx1b	T	C	2: 33,529,510 (GRCm39)	D83G	possibly damaging	Het
Macf1	A	G	4: 123,289,701 (GRCm39)		probably benign	Het
Muc6	T	A	7: 141,236,306 (GRCm39)	M406L	probably benign	Het
Myo15b	T	C	11: 115,754,299 (GRCm39)	I933T	probably benign	Het
Or4c121	A	G	2: 89,023,836 (GRCm39)	F181L	possibly damaging	Het
Or6c204	T	C	10: 129,022,804 (GRCm39)	N162S	probably benign	Het
Pde1b	A	T	15: 103,433,772 (GRCm39)		probably benign	Het
Rab29	G	A	1: 131,798,445 (GRCm39)	R75Q	probably damaging	Het
Scn10a	A	T	9: 119,467,764 (GRCm39)	I792N	probably damaging	Het
Serpinb6a	A	T	13: 34,114,117 (GRCm39)	V70D	probably damaging	Het
Slco1a7	A	G	6: 141,673,333 (GRCm39)	S402P	possibly damaging	Het
Spart	A	G	3: 55,024,723 (GRCm39)	D106G	possibly damaging	Het
Sucla2	A	G	14: 73,828,561 (GRCm39)	E359G	probably damaging	Het
Sycp2	T	C	2: 178,016,488 (GRCm39)	Y658C	probably damaging	Het
Tenm2	T	A	11: 35,997,654 (GRCm39)	T811S	possibly damaging	Het
Tspan18	A	G	2: 93,041,198 (GRCm39)	S135P	probably damaging	Het
Ube2j1	T	C	4: 33,043,993 (GRCm39)		probably benign	Het
Ubr1	A	C	2: 120,756,494 (GRCm39)	V711G	possibly damaging	Het
Veph1	T	C	3: 66,065,496 (GRCm39)	T524A	probably benign	Het
Vmn1r222	A	T	13: 23,417,059 (GRCm39)	F51L	probably benign	Het
Vwf	G	T	6: 125,567,225 (GRCm39)	V338L	possibly damaging	Het
Zfp770	G	T	2: 114,027,574 (GRCm39)	A165E	probably damaging	Het

Other mutations in Trim66

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01758:Trim66	APN	7	109,085,252 (GRCm39)	critical splice donor site	probably null
IGL01982:Trim66	APN	7	109,057,970 (GRCm39)	missense	probably benign	0.00
IGL01983:Trim66	APN	7	109,057,458 (GRCm39)	nonsense	probably null
IGL02149:Trim66	APN	7	109,060,109 (GRCm39)	missense	possibly damaging	0.66
IGL02392:Trim66	APN	7	109,059,481 (GRCm39)	missense	probably benign	0.01
IGL02483:Trim66	APN	7	109,076,837 (GRCm39)	splice site	probably benign
IGL02832:Trim66	APN	7	109,059,704 (GRCm39)	missense	probably damaging	1.00
IGL02945:Trim66	APN	7	109,059,383 (GRCm39)	nonsense	probably null
IGL03085:Trim66	APN	7	109,057,952 (GRCm39)	missense	probably benign	0.17
PIT1430001:Trim66	UTSW	7	109,074,454 (GRCm39)	missense	probably damaging	0.99
R0326:Trim66	UTSW	7	109,059,379 (GRCm39)	missense	probably benign	0.00
R0358:Trim66	UTSW	7	109,059,383 (GRCm39)	nonsense	probably null
R0401:Trim66	UTSW	7	109,074,471 (GRCm39)	missense	probably damaging	0.98
R0470:Trim66	UTSW	7	109,056,749 (GRCm39)	splice site	probably benign
R0568:Trim66	UTSW	7	109,059,902 (GRCm39)	missense	probably benign	0.00
R0669:Trim66	UTSW	7	109,054,199 (GRCm39)	intron	probably benign
R0980:Trim66	UTSW	7	109,054,877 (GRCm39)	missense	probably damaging	1.00
R1015:Trim66	UTSW	7	109,054,440 (GRCm39)	missense	probably damaging	1.00
R1078:Trim66	UTSW	7	109,071,526 (GRCm39)	missense	probably damaging	1.00
R1099:Trim66	UTSW	7	109,074,661 (GRCm39)	missense	probably benign	0.34
R1181:Trim66	UTSW	7	109,083,784 (GRCm39)	critical splice donor site	probably null
R1497:Trim66	UTSW	7	109,083,826 (GRCm39)	missense	probably benign	0.00
R1583:Trim66	UTSW	7	109,054,287 (GRCm39)	missense	probably damaging	1.00
R1843:Trim66	UTSW	7	109,075,046 (GRCm39)	missense	probably damaging	0.99
R1998:Trim66	UTSW	7	109,083,784 (GRCm39)	critical splice donor site	probably null
R2016:Trim66	UTSW	7	109,071,439 (GRCm39)	critical splice donor site	probably null
R2143:Trim66	UTSW	7	109,074,320 (GRCm39)	missense	probably damaging	0.98
R2144:Trim66	UTSW	7	109,074,320 (GRCm39)	missense	probably damaging	0.98
R2145:Trim66	UTSW	7	109,074,320 (GRCm39)	missense	probably damaging	0.98
R3945:Trim66	UTSW	7	109,071,475 (GRCm39)	missense	possibly damaging	0.94
R4012:Trim66	UTSW	7	109,057,338 (GRCm39)	missense	probably damaging	0.98
R4464:Trim66	UTSW	7	109,076,897 (GRCm39)	missense	possibly damaging	0.51
R4473:Trim66	UTSW	7	109,081,202 (GRCm39)	missense	probably damaging	1.00
R4729:Trim66	UTSW	7	109,055,267 (GRCm39)	critical splice donor site	probably null
R4730:Trim66	UTSW	7	109,082,276 (GRCm39)	missense	probably damaging	1.00
R4775:Trim66	UTSW	7	109,056,796 (GRCm39)	nonsense	probably null
R4819:Trim66	UTSW	7	109,056,793 (GRCm39)	missense	probably damaging	1.00
R5269:Trim66	UTSW	7	109,056,797 (GRCm39)	missense	probably benign	0.00
R5557:Trim66	UTSW	7	109,082,944 (GRCm39)	missense	probably benign	0.06
R5832:Trim66	UTSW	7	109,054,409 (GRCm39)	missense	probably damaging	1.00
R6220:Trim66	UTSW	7	109,082,300 (GRCm39)	missense	probably damaging	0.97
R6243:Trim66	UTSW	7	109,059,481 (GRCm39)	missense	probably benign	0.01
R6374:Trim66	UTSW	7	109,085,269 (GRCm39)	missense	probably benign
R6450:Trim66	UTSW	7	109,059,945 (GRCm39)	missense	probably benign	0.09
R6543:Trim66	UTSW	7	109,075,086 (GRCm39)	missense	probably benign	0.01
R6788:Trim66	UTSW	7	109,076,961 (GRCm39)	missense	probably damaging	1.00
R6842:Trim66	UTSW	7	109,059,983 (GRCm39)	missense	probably benign	0.00
R7169:Trim66	UTSW	7	109,054,328 (GRCm39)	missense	probably benign	0.25
R7257:Trim66	UTSW	7	109,059,451 (GRCm39)	missense	probably damaging	1.00
R7328:Trim66	UTSW	7	109,056,958 (GRCm39)	missense	probably damaging	0.99
R7616:Trim66	UTSW	7	109,082,956 (GRCm39)	missense	probably damaging	0.99
R8423:Trim66	UTSW	7	109,074,599 (GRCm39)	missense	possibly damaging	0.77
R8855:Trim66	UTSW	7	109,081,188 (GRCm39)	missense	probably damaging	1.00
R9130:Trim66	UTSW	7	109,076,896 (GRCm39)	missense	possibly damaging	0.90
R9137:Trim66	UTSW	7	109,074,330 (GRCm39)	missense	probably damaging	0.99
R9640:Trim66	UTSW	7	109,074,825 (GRCm39)	missense	probably damaging	1.00
RF013:Trim66	UTSW	7	109,059,960 (GRCm39)	missense	probably damaging	0.99
RF024:Trim66	UTSW	7	109,059,947 (GRCm39)	missense	possibly damaging	0.62

Posted On

2013-12-03