Incidental Mutation 'IGL01544:Cry1'
| ID |
90251 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cry1
|
| Ensembl Gene |
ENSMUSG00000020038 |
| Gene Name |
cryptochrome circadian regulator 1 |
| Synonyms |
Phll1 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01544
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
84967564-85020918 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 84982360 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 329
(K329*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020227
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020227]
|
| AlphaFold |
P97784 |
| PDB Structure |
Crystal Structure of Mouse Cryptochrome1 in Complex with Period2 [X-RAY DIFFRACTION]
Crystal structure of mouse Cryptochrome 1 [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000020227
AA Change: K329*
|
| SMART Domains |
Protein: ENSMUSP00000020227
Gene: ENSMUSG00000020038
AA Change: K329*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DNA_photolyase
|
5 |
168 |
1.4e-47 |
PFAM |
|
Pfam:FAD_binding_7
|
213 |
486 |
6.9e-91 |
PFAM |
|
internal_repeat_1
|
502 |
523 |
3.57e-8 |
PROSPERO |
|
internal_repeat_1
|
521 |
543 |
3.57e-8 |
PROSPERO |
|
low complexity region
|
544 |
555 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214248
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214675
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214805
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]
PHENOTYPE: Homozygotes for targeted null mutations exhibit a one-hour shorter circadian period under constant darkness and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arap3 |
G |
A |
18: 38,123,889 (GRCm39) |
R377C |
probably damaging |
Het |
| Bbx |
C |
A |
16: 50,095,140 (GRCm39) |
E59* |
probably null |
Het |
| Cep120 |
C |
T |
18: 53,819,033 (GRCm39) |
R886H |
probably benign |
Het |
| Cep350 |
C |
A |
1: 155,828,933 (GRCm39) |
V324L |
probably damaging |
Het |
| Dhtkd1 |
T |
C |
2: 5,918,342 (GRCm39) |
N627S |
probably benign |
Het |
| Dpp8 |
A |
T |
9: 64,962,270 (GRCm39) |
T437S |
probably benign |
Het |
| Elovl1 |
G |
A |
4: 118,288,107 (GRCm39) |
|
probably null |
Het |
| Heca |
A |
G |
10: 17,791,715 (GRCm39) |
Y114H |
probably damaging |
Het |
| Hrh4 |
A |
G |
18: 13,148,950 (GRCm39) |
N104S |
probably benign |
Het |
| Ift80 |
T |
A |
3: 68,898,115 (GRCm39) |
K73N |
probably benign |
Het |
| Ina |
T |
C |
19: 47,003,948 (GRCm39) |
V252A |
possibly damaging |
Het |
| Klhl36 |
A |
G |
8: 120,596,755 (GRCm39) |
E152G |
possibly damaging |
Het |
| Lamp5 |
T |
A |
2: 135,910,990 (GRCm39) |
L241Q |
probably damaging |
Het |
| Lrp4 |
G |
A |
2: 91,307,896 (GRCm39) |
R447H |
probably damaging |
Het |
| Mmp24 |
G |
A |
2: 155,641,807 (GRCm39) |
G212R |
probably damaging |
Het |
| Mpp3 |
A |
G |
11: 101,909,485 (GRCm39) |
V191A |
possibly damaging |
Het |
| Mtmr4 |
A |
G |
11: 87,488,437 (GRCm39) |
|
probably benign |
Het |
| Mynn |
C |
A |
3: 30,661,854 (GRCm39) |
S312* |
probably null |
Het |
| Neb |
T |
A |
2: 52,182,917 (GRCm39) |
I1010F |
possibly damaging |
Het |
| Nes |
T |
C |
3: 87,885,271 (GRCm39) |
S1177P |
possibly damaging |
Het |
| Noct |
T |
C |
3: 51,155,469 (GRCm39) |
V79A |
probably damaging |
Het |
| Rad1 |
A |
G |
15: 10,490,465 (GRCm39) |
D114G |
probably damaging |
Het |
| Slc26a9 |
T |
C |
1: 131,687,233 (GRCm39) |
|
probably null |
Het |
| Sqor |
G |
A |
2: 122,634,266 (GRCm39) |
|
probably benign |
Het |
| Sspo |
G |
T |
6: 48,467,953 (GRCm39) |
W4309L |
probably damaging |
Het |
| Thoc7 |
A |
C |
14: 13,953,435 (GRCm38) |
Y72D |
probably damaging |
Het |
| Thra |
A |
G |
11: 98,647,754 (GRCm39) |
I43V |
possibly damaging |
Het |
| Timm44 |
G |
T |
8: 4,325,888 (GRCm39) |
|
probably benign |
Het |
| Trmo |
C |
T |
4: 46,386,169 (GRCm39) |
G119R |
probably damaging |
Het |
| Trpc4 |
T |
C |
3: 54,209,567 (GRCm39) |
M644T |
probably damaging |
Het |
| Wdr72 |
C |
T |
9: 74,056,007 (GRCm39) |
L300F |
probably damaging |
Het |
| Wrn |
T |
C |
8: 33,814,554 (GRCm39) |
T54A |
probably benign |
Het |
|
| Other mutations in Cry1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00234:Cry1
|
APN |
10 |
84,982,698 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL00737:Cry1
|
APN |
10 |
84,978,904 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01349:Cry1
|
APN |
10 |
84,984,603 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01545:Cry1
|
APN |
10 |
85,020,226 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01767:Cry1
|
APN |
10 |
84,982,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03392:Cry1
|
APN |
10 |
84,992,993 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0119:Cry1
|
UTSW |
10 |
84,969,104 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0605:Cry1
|
UTSW |
10 |
85,020,223 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1618:Cry1
|
UTSW |
10 |
84,982,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1955:Cry1
|
UTSW |
10 |
84,980,042 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2209:Cry1
|
UTSW |
10 |
84,982,619 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2221:Cry1
|
UTSW |
10 |
84,979,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2223:Cry1
|
UTSW |
10 |
84,979,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2314:Cry1
|
UTSW |
10 |
84,969,175 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3851:Cry1
|
UTSW |
10 |
84,982,363 (GRCm39) |
missense |
probably benign |
0.15 |
|
R3872:Cry1
|
UTSW |
10 |
84,969,024 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3981:Cry1
|
UTSW |
10 |
84,982,456 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4856:Cry1
|
UTSW |
10 |
84,984,634 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5162:Cry1
|
UTSW |
10 |
84,969,150 (GRCm39) |
missense |
probably benign |
|
|
R5404:Cry1
|
UTSW |
10 |
85,020,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5449:Cry1
|
UTSW |
10 |
84,968,999 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5484:Cry1
|
UTSW |
10 |
84,982,588 (GRCm39) |
splice site |
probably null |
|
|
R5599:Cry1
|
UTSW |
10 |
84,980,114 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5717:Cry1
|
UTSW |
10 |
84,982,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7031:Cry1
|
UTSW |
10 |
84,984,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7371:Cry1
|
UTSW |
10 |
84,983,783 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7943:Cry1
|
UTSW |
10 |
84,978,984 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8022:Cry1
|
UTSW |
10 |
84,982,266 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8290:Cry1
|
UTSW |
10 |
84,978,977 (GRCm39) |
nonsense |
probably null |
|
|
R8805:Cry1
|
UTSW |
10 |
84,992,969 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1176:Cry1
|
UTSW |
10 |
84,980,061 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2013-12-03 |
Incidental Mutation