Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01638:Prl5a1'

93143

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prl5a1

Ensembl Gene

ENSMUSG00000017064

Gene Name

prolactin family 5, subfamily a, member 1

Synonyms

1600013P04Rik, D13Wsu14e, Prlpl, PLP-L

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01638

Quality Score

Status

Chromosome

Chromosomal Location

28326467-28335578 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 28329422 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 34 (C34S)

Ref Sequence

ENSEMBL: ENSMUSP00000017208 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017208]

AlphaFold

Q9JII2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000017208
AA Change: C34S

PolyPhen 2 Score 0.770 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000017208
Gene: ENSMUSG00000017064
AA Change: C34S

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	230	4.8e-50	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts9	T	C	6: 92,849,409 (GRCm39)	T436A	probably benign	Het
Adgrb3	T	A	1: 25,598,832 (GRCm39)		probably benign	Het
Ajap1	A	G	4: 153,516,693 (GRCm39)	V216A	possibly damaging	Het
Akap7	T	A	10: 25,143,323 (GRCm39)	I124F	probably damaging	Het
Arfgef2	G	A	2: 166,715,865 (GRCm39)	V1385M	probably damaging	Het
Arhgap30	A	G	1: 171,225,138 (GRCm39)	K65E	probably damaging	Het
Bltp1	A	G	3: 37,028,460 (GRCm39)	N2377D	probably damaging	Het
Cacna1a	T	C	8: 85,298,456 (GRCm39)	F1260S	probably damaging	Het
Cad	T	A	5: 31,224,958 (GRCm39)	C954S	probably damaging	Het
Fcmr	A	T	1: 130,802,859 (GRCm39)	E157D	probably benign	Het
Gm4204	A	T	1: 135,160,873 (GRCm39)		noncoding transcript	Het
Gzmn	A	T	14: 56,406,476 (GRCm39)	D16E	probably benign	Het
Krt86	A	C	15: 101,373,353 (GRCm39)		probably benign	Het
Macc1	T	C	12: 119,410,246 (GRCm39)	L338P	probably benign	Het
Ms4a6d	A	T	19: 11,564,532 (GRCm39)	L113Q	probably damaging	Het
Myh15	T	C	16: 48,889,843 (GRCm39)	S145P	probably damaging	Het
Nav3	T	C	10: 109,688,724 (GRCm39)	K518E	probably damaging	Het
Or8d6	T	C	9: 39,853,816 (GRCm39)	S87P	probably benign	Het
Parp11	T	A	6: 127,468,492 (GRCm39)	F181I	probably benign	Het
Ppil1	C	A	17: 29,480,766 (GRCm39)	K52N	probably benign	Het
Prss55	A	G	14: 64,314,636 (GRCm39)	V178A	probably benign	Het
S100a7a	A	G	3: 90,562,837 (GRCm39)	D8G	probably benign	Het
Sh3glb2	A	G	2: 30,235,862 (GRCm39)	V310A	possibly damaging	Het
Slc22a7	T	C	17: 46,748,920 (GRCm39)		probably null	Het
Slc27a6	A	G	18: 58,740,885 (GRCm39)	D482G	probably damaging	Het
Smarcc2	T	A	10: 128,323,943 (GRCm39)		probably benign	Het
Specc1l	T	A	10: 75,082,039 (GRCm39)	Y478*	probably null	Het
Spryd3	A	G	15: 102,038,711 (GRCm39)		probably null	Het
Tcerg1l	G	A	7: 137,881,805 (GRCm39)	R295C	probably damaging	Het
Trpv1	T	C	11: 73,144,155 (GRCm39)	I637T	probably damaging	Het
Ttc7	A	C	17: 87,666,540 (GRCm39)		probably null	Het
Vmn1r6	C	T	6: 56,980,177 (GRCm39)	Q280*	probably null	Het

Other mutations in Prl5a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01820:Prl5a1	APN	13	28,332,683 (GRCm39)	missense	probably benign	0.34
IGL02682:Prl5a1	APN	13	28,329,403 (GRCm39)	missense	probably benign	0.32
R0266:Prl5a1	UTSW	13	28,333,970 (GRCm39)	missense	possibly damaging	0.77
R1022:Prl5a1	UTSW	13	28,333,880 (GRCm39)	missense	probably damaging	0.97
R1024:Prl5a1	UTSW	13	28,333,880 (GRCm39)	missense	probably damaging	0.97
R2098:Prl5a1	UTSW	13	28,329,488 (GRCm39)	missense	probably damaging	1.00
R5467:Prl5a1	UTSW	13	28,333,994 (GRCm39)	missense	possibly damaging	0.92
R6002:Prl5a1	UTSW	13	28,329,465 (GRCm39)	missense	probably benign	0.00
R6026:Prl5a1	UTSW	13	28,335,247 (GRCm39)	missense	probably benign	0.43
R6242:Prl5a1	UTSW	13	28,326,538 (GRCm39)	nonsense	probably null
R6616:Prl5a1	UTSW	13	28,333,839 (GRCm39)	missense	probably benign	0.00
R6733:Prl5a1	UTSW	13	28,333,919 (GRCm39)	missense	possibly damaging	0.81
R6979:Prl5a1	UTSW	13	28,335,189 (GRCm39)	missense	probably benign	0.32
R7692:Prl5a1	UTSW	13	28,333,997 (GRCm39)	missense	probably damaging	1.00
R9610:Prl5a1	UTSW	13	28,329,492 (GRCm39)	missense	possibly damaging	0.71
R9611:Prl5a1	UTSW	13	28,329,492 (GRCm39)	missense	possibly damaging	0.71

Posted On

2013-12-09