Incidental Mutation 'R1110:Or9r7'
ID 96664
Institutional Source Beutler Lab
Gene Symbol Or9r7
Ensembl Gene ENSMUSG00000095804
Gene Name olfactory receptor family 9 subfamily R member 7
Synonyms Olfr824, GA_x6K02T2PULF-11797746-11796799, MOR210-3
MMRRC Submission 039183-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R1110 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129961977-129962924 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129962522 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 135 (Y135H)
Ref Sequence ENSEMBL: ENSMUSP00000150662 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074161] [ENSMUST00000214192] [ENSMUST00000215217]
AlphaFold Q8VFU4
Predicted Effect probably damaging
Transcript: ENSMUST00000074161
AA Change: Y135H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073794
Gene: ENSMUSG00000095804
AA Change: Y135H

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 4.6e-54 PFAM
Pfam:7tm_1 44 293 3e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214192
AA Change: Y135H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215217
AA Change: Y135H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 94.3%
Validation Efficiency 97% (63/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap3 T A 4: 155,989,856 (GRCm39) probably null Het
Acp2 A G 2: 91,038,767 (GRCm39) probably null Het
Akap13 T G 7: 75,261,125 (GRCm39) S447A possibly damaging Het
Alk G A 17: 72,291,740 (GRCm39) probably benign Het
Arhgef39 T C 4: 43,496,834 (GRCm39) T327A probably benign Het
Calhm5 T G 10: 33,972,013 (GRCm39) I141L probably benign Het
Cdan1 G A 2: 120,551,083 (GRCm39) A1103V probably damaging Het
Cdh18 A G 15: 23,474,403 (GRCm39) T758A probably benign Het
Cdk17 T A 10: 93,074,895 (GRCm39) Y3* probably null Het
Cdon T C 9: 35,367,733 (GRCm39) probably benign Het
Cntn3 T A 6: 102,222,119 (GRCm39) N460I probably benign Het
Cntrl T A 2: 35,050,639 (GRCm39) C985S possibly damaging Het
Col6a2 T C 10: 76,443,574 (GRCm39) E497G probably benign Het
Crybg1 A G 10: 43,875,089 (GRCm39) M673T possibly damaging Het
Cyp2u1 A G 3: 131,087,258 (GRCm39) I441T possibly damaging Het
Disp2 T C 2: 118,620,920 (GRCm39) S551P probably damaging Het
Dock2 A T 11: 34,206,535 (GRCm39) F1354I possibly damaging Het
Dstyk A G 1: 132,381,063 (GRCm39) probably benign Het
Dzip1 T C 14: 119,126,717 (GRCm39) N527S probably benign Het
Eomes A G 9: 118,313,667 (GRCm39) I571V probably benign Het
Fbxl13 T C 5: 21,689,034 (GRCm39) D758G probably benign Het
Frem1 T C 4: 82,868,557 (GRCm39) S1457G probably damaging Het
Gabbr2 C T 4: 46,718,838 (GRCm39) C613Y probably damaging Het
Gm9755 A T 8: 67,967,710 (GRCm39) noncoding transcript Het
Hnrnpul2 A G 19: 8,804,110 (GRCm39) R570G probably damaging Het
Ift70a1 A T 2: 75,810,320 (GRCm39) C588S probably damaging Het
Igdcc4 A G 9: 65,034,208 (GRCm39) H674R possibly damaging Het
Kdm5d T A Y: 910,539 (GRCm39) L250H probably damaging Het
Kif1a T C 1: 92,951,175 (GRCm39) probably benign Het
Kmt2c T C 5: 25,519,360 (GRCm39) N2250S probably benign Het
Kmt2e C T 5: 23,707,653 (GRCm39) H1739Y probably damaging Het
Lmtk3 T A 7: 45,444,427 (GRCm39) probably benign Het
Lpin3 A G 2: 160,735,999 (GRCm39) D93G probably benign Het
Myh10 T C 11: 68,682,676 (GRCm39) probably benign Het
Myom2 G A 8: 15,172,413 (GRCm39) E1171K probably benign Het
Ncoa6 A T 2: 155,253,440 (GRCm39) probably benign Het
Nup160 A G 2: 90,563,563 (GRCm39) probably benign Het
Oit3 G A 10: 59,264,016 (GRCm39) R373C probably damaging Het
Olfml2a A T 2: 38,849,765 (GRCm39) I494L probably damaging Het
Or11g27 T C 14: 50,771,159 (GRCm39) S97P possibly damaging Het
Parp6 G T 9: 59,556,847 (GRCm39) C584F probably damaging Het
Pcgf2 A G 11: 97,582,676 (GRCm39) probably benign Het
Pde3a T C 6: 141,405,042 (GRCm39) probably benign Het
Pibf1 C T 14: 99,350,409 (GRCm39) R186C probably damaging Het
Pitrm1 A G 13: 6,608,280 (GRCm39) D335G probably benign Het
Pkp4 T C 2: 59,169,109 (GRCm39) L752P probably damaging Het
Plcb3 C A 19: 6,939,281 (GRCm39) E566* probably null Het
Prune2 T C 19: 17,102,586 (GRCm39) S2582P probably benign Het
Reln A T 5: 22,239,773 (GRCm39) D831E probably benign Het
Samd9l T A 6: 3,374,267 (GRCm39) D998V probably benign Het
Sardh G A 2: 27,081,931 (GRCm39) T865I possibly damaging Het
Setbp1 G A 18: 78,901,075 (GRCm39) T864I probably damaging Het
Slc9a1 T A 4: 133,097,859 (GRCm39) M2K probably benign Het
Sorbs2 A G 8: 46,248,767 (GRCm39) T593A probably benign Het
Spata31e3 A T 13: 50,402,296 (GRCm39) D83E possibly damaging Het
Svs5 A T 2: 164,175,507 (GRCm39) I120L probably benign Het
Tcl1b1 G T 12: 105,126,074 (GRCm39) V19F probably damaging Het
Urgcp T C 11: 5,666,004 (GRCm39) N778S probably benign Het
Vnn1 A T 10: 23,775,499 (GRCm39) I250F possibly damaging Het
Xntrpc A G 7: 101,732,181 (GRCm39) R365G possibly damaging Het
Zfp84 T A 7: 29,470,797 (GRCm39) M1K probably null Het
Zfyve26 G A 12: 79,326,841 (GRCm39) R761C probably damaging Het
Zp3r A G 1: 130,505,621 (GRCm39) probably null Het
Other mutations in Or9r7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Or9r7 APN 10 129,962,860 (GRCm39) missense probably benign 0.45
IGL02391:Or9r7 APN 10 129,962,773 (GRCm39) missense possibly damaging 0.75
IGL03247:Or9r7 APN 10 129,962,584 (GRCm39) missense probably damaging 1.00
R0781:Or9r7 UTSW 10 129,962,522 (GRCm39) missense probably damaging 1.00
R1694:Or9r7 UTSW 10 129,962,123 (GRCm39) missense possibly damaging 0.93
R2069:Or9r7 UTSW 10 129,962,074 (GRCm39) missense possibly damaging 0.94
R2173:Or9r7 UTSW 10 129,962,372 (GRCm39) missense probably benign 0.10
R4078:Or9r7 UTSW 10 129,962,587 (GRCm39) missense probably damaging 1.00
R4864:Or9r7 UTSW 10 129,962,756 (GRCm39) nonsense probably null
R5556:Or9r7 UTSW 10 129,962,728 (GRCm39) missense probably damaging 1.00
R6704:Or9r7 UTSW 10 129,962,024 (GRCm39) nonsense probably null
R7624:Or9r7 UTSW 10 129,962,455 (GRCm39) missense probably damaging 0.98
R8013:Or9r7 UTSW 10 129,962,647 (GRCm39) missense probably damaging 1.00
R8049:Or9r7 UTSW 10 129,962,469 (GRCm39) nonsense probably null
R8932:Or9r7 UTSW 10 129,962,631 (GRCm39) missense probably benign 0.29
R9256:Or9r7 UTSW 10 129,962,335 (GRCm39) missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- CCCAGGCTGAGCATACATGAAGAAC -3'
(R):5'- GCAGAGCAGGAACTATACTGAGCTG -3'

Sequencing Primer
(F):5'- CCACATGTAGAGAAGGTTTTACTCC -3'
(R):5'- ACTGAGCTGACAGACTTTATCCTG -3'
Posted On 2014-01-05