Incidental Mutation 'IGL01674:Tmem92'
ID 103594
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem92
Ensembl Gene ENSMUSG00000075610
Gene Name transmembrane protein 92
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # IGL01674
Quality Score
Status
Chromosome 11
Chromosomal Location 94668043-94673529 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 94669519 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 148 (E148G)
Ref Sequence ENSEMBL: ENSMUSP00000125159 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100554] [ENSMUST00000143620] [ENSMUST00000162809]
AlphaFold B7ZWI3
Predicted Effect possibly damaging
Transcript: ENSMUST00000100554
AA Change: E100G

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000128300
Gene: ENSMUSG00000075610
AA Change: E100G

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 62 84 N/A INTRINSIC
low complexity region 87 102 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000143620
SMART Domains Protein: ENSMUSP00000129874
Gene: ENSMUSG00000075610

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000162809
AA Change: E148G

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000125159
Gene: ENSMUSG00000075610
AA Change: E148G

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 64 86 N/A INTRINSIC
low complexity region 135 150 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef39 A G 4: 43,497,590 (GRCm39) L222P probably damaging Het
Art3 T A 5: 92,551,473 (GRCm39) Y17* probably null Het
Cadps2 A G 6: 23,355,851 (GRCm39) L859P probably damaging Het
Celsr2 A G 3: 108,322,159 (GRCm39) Y218H probably damaging Het
Ces5a A G 8: 94,228,847 (GRCm39) V461A probably damaging Het
Clic4 C A 4: 134,966,204 (GRCm39) V51L probably benign Het
Col6a3 A G 1: 90,730,236 (GRCm39) L1083P probably damaging Het
Cul5 T C 9: 53,546,307 (GRCm39) E328G probably damaging Het
Erap1 T C 13: 74,812,350 (GRCm39) probably benign Het
Fn1 G A 1: 71,645,900 (GRCm39) P1527L probably damaging Het
Gm20547 T A 17: 35,100,631 (GRCm39) Q63L probably benign Het
Gm5089 T C 14: 122,673,575 (GRCm39) T49A unknown Het
Ippk T C 13: 49,602,740 (GRCm39) L362S probably damaging Het
Krt23 T C 11: 99,377,593 (GRCm39) M138V probably benign Het
Magi3 A G 3: 104,013,037 (GRCm39) probably benign Het
Mcc T A 18: 44,624,223 (GRCm39) I266F probably benign Het
Mcph1 A G 8: 18,681,535 (GRCm39) E224G probably damaging Het
Neurod4 A T 10: 130,106,887 (GRCm39) L129H probably damaging Het
Or14j5 T A 17: 37,920,853 (GRCm39) D263V probably damaging Het
Or4c123 T A 2: 89,127,014 (GRCm39) N200I probably damaging Het
Or5b24 T C 19: 12,912,926 (GRCm39) S275P probably damaging Het
Or8h7 T C 2: 86,721,093 (GRCm39) Y142C probably benign Het
Piezo2 A T 18: 63,160,630 (GRCm39) I2342N probably damaging Het
Pnpt1 A G 11: 29,105,787 (GRCm39) Q632R probably benign Het
Ppp2r2c T C 5: 37,097,570 (GRCm39) M252T possibly damaging Het
Ppp4r2 A G 6: 100,841,644 (GRCm39) N142D possibly damaging Het
Prex2 G T 1: 11,240,965 (GRCm39) K1024N probably damaging Het
Rimklb T A 6: 122,436,129 (GRCm39) I150F probably damaging Het
Slco4c1 T C 1: 96,770,218 (GRCm39) Q282R probably damaging Het
Traf7 T C 17: 24,729,349 (GRCm39) probably benign Het
Ubr5 G A 15: 37,998,623 (GRCm39) T1622M probably damaging Het
Vmn1r5 T A 6: 56,962,911 (GRCm39) S195R probably damaging Het
Vmn2r67 C T 7: 84,785,651 (GRCm39) V785I probably damaging Het
Ythdc2 G A 18: 44,993,471 (GRCm39) D839N probably benign Het
Zfp184 T C 13: 22,134,395 (GRCm39) probably benign Het
Zfp654 T C 16: 64,605,004 (GRCm39) N525S probably benign Het
Other mutations in Tmem92
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00972:Tmem92 APN 11 94,673,254 (GRCm39) missense possibly damaging 0.71
IGL02959:Tmem92 APN 11 94,669,504 (GRCm39) missense possibly damaging 0.72
R0028:Tmem92 UTSW 11 94,669,778 (GRCm39) missense possibly damaging 0.84
R1905:Tmem92 UTSW 11 94,669,501 (GRCm39) missense probably benign 0.04
R2396:Tmem92 UTSW 11 94,673,233 (GRCm39) missense probably damaging 0.99
R3056:Tmem92 UTSW 11 94,669,873 (GRCm39) missense probably benign
R3116:Tmem92 UTSW 11 94,673,254 (GRCm39) missense possibly damaging 0.71
R5096:Tmem92 UTSW 11 94,669,862 (GRCm39) missense probably benign 0.05
R5968:Tmem92 UTSW 11 94,669,564 (GRCm39) missense probably benign 0.09
R7570:Tmem92 UTSW 11 94,669,816 (GRCm39) missense probably benign 0.00
R7816:Tmem92 UTSW 11 94,669,784 (GRCm39) missense possibly damaging 0.93
Posted On 2014-01-21