Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00768:Gpr160'

11108

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr160

Ensembl Gene

ENSMUSG00000037661

Gene Name

G protein-coupled receptor 160

Synonyms

1700025D19Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00768

Quality Score

Status

Chromosome

Chromosomal Location

30910099-30951341 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 30950098 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 57 (Y57N)

Ref Sequence

ENSEMBL: ENSMUSP00000128666 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046624] [ENSMUST00000046748] [ENSMUST00000108258] [ENSMUST00000108259] [ENSMUST00000108261] [ENSMUST00000147697] [ENSMUST00000166278] [ENSMUST00000194979] [ENSMUST00000168645]

AlphaFold

Q3U3F9

Predicted Effect

probably benign
Transcript: ENSMUST00000046624

SMART Domains

Protein: ENSMUSP00000037862
Gene: ENSMUSG00000037652

Domain	Start	End	E-Value	Type
low complexity region	18	40	N/A	INTRINSIC
low complexity region	72	89	N/A	INTRINSIC
low complexity region	92	142	N/A	INTRINSIC
low complexity region	152	166	N/A	INTRINSIC
low complexity region	206	224	N/A	INTRINSIC
low complexity region	333	359	N/A	INTRINSIC
low complexity region	393	419	N/A	INTRINSIC
low complexity region	512	538	N/A	INTRINSIC
low complexity region	564	578	N/A	INTRINSIC
low complexity region	583	594	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000046748
AA Change: Y57N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000045165
Gene: ENSMUSG00000037661
AA Change: Y57N

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	54	76	N/A	INTRINSIC
transmembrane domain	96	118	N/A	INTRINSIC
transmembrane domain	138	160	N/A	INTRINSIC
transmembrane domain	185	207	N/A	INTRINSIC
transmembrane domain	240	262	N/A	INTRINSIC
transmembrane domain	277	294	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108258
AA Change: Y57N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000103893
Gene: ENSMUSG00000037661
AA Change: Y57N

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	54	76	N/A	INTRINSIC
transmembrane domain	96	118	N/A	INTRINSIC
transmembrane domain	138	160	N/A	INTRINSIC
transmembrane domain	185	207	N/A	INTRINSIC
transmembrane domain	240	262	N/A	INTRINSIC
transmembrane domain	277	294	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108259
AA Change: Y57N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000103894
Gene: ENSMUSG00000037661
AA Change: Y57N

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	54	76	N/A	INTRINSIC
transmembrane domain	96	118	N/A	INTRINSIC
transmembrane domain	138	160	N/A	INTRINSIC
transmembrane domain	185	207	N/A	INTRINSIC
transmembrane domain	240	262	N/A	INTRINSIC
transmembrane domain	277	294	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108261
AA Change: Y57N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000103896
Gene: ENSMUSG00000037661
AA Change: Y57N

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	54	76	N/A	INTRINSIC
transmembrane domain	96	118	N/A	INTRINSIC
transmembrane domain	138	160	N/A	INTRINSIC
transmembrane domain	185	207	N/A	INTRINSIC
transmembrane domain	240	262	N/A	INTRINSIC
transmembrane domain	277	294	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000147697

Predicted Effect

probably damaging
Transcript: ENSMUST00000166278
AA Change: Y57N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000128666
Gene: ENSMUSG00000037661
AA Change: Y57N

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	54	76	N/A	INTRINSIC
transmembrane domain	96	118	N/A	INTRINSIC
transmembrane domain	138	160	N/A	INTRINSIC
transmembrane domain	185	207	N/A	INTRINSIC
transmembrane domain	240	262	N/A	INTRINSIC
transmembrane domain	277	294	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000194979

Predicted Effect

probably benign
Transcript: ENSMUST00000168645

SMART Domains

Protein: ENSMUSP00000130142
Gene: ENSMUSG00000037652

Domain	Start	End	E-Value	Type
low complexity region	6	28	N/A	INTRINSIC
low complexity region	60	77	N/A	INTRINSIC
low complexity region	80	130	N/A	INTRINSIC
low complexity region	140	154	N/A	INTRINSIC
low complexity region	194	212	N/A	INTRINSIC
low complexity region	321	347	N/A	INTRINSIC
low complexity region	381	407	N/A	INTRINSIC
low complexity region	500	526	N/A	INTRINSIC
low complexity region	552	566	N/A	INTRINSIC
low complexity region	571	601	N/A	INTRINSIC
low complexity region	640	648	N/A	INTRINSIC
low complexity region	658	686	N/A	INTRINSIC
PDB:2L8E\|A	775	811	7e-9	PDB
low complexity region	879	898	N/A	INTRINSIC
SAM	914	980	1.6e-11	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 13 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	C	T	14: 118,766,409 (GRCm39)	V888I	probably benign	Het
Apob	A	T	12: 8,052,107 (GRCm39)	N1170Y	probably damaging	Het
Clca3a1	T	C	3: 144,461,012 (GRCm39)	D213G	probably damaging	Het
Col6a6	T	C	9: 105,659,611 (GRCm39)	S445G	probably benign	Het
Dgkb	A	C	12: 38,477,478 (GRCm39)	E629D	probably benign	Het
Gabra3	T	C	X: 71,519,903 (GRCm39)	H188R	probably benign	Het
Gak	G	T	5: 108,724,520 (GRCm39)	H1063Q	probably benign	Het
Gm382	C	T	X: 125,968,366 (GRCm39)	Q184*	probably null	Het
Gucy1a2	T	C	9: 3,635,111 (GRCm39)	V385A	possibly damaging	Het
Khdc1b	A	T	1: 21,454,405 (GRCm39)	D36V	probably benign	Het
Tmem67	A	G	4: 12,055,029 (GRCm39)		probably null	Het
Tmpo	G	A	10: 91,000,068 (GRCm39)		probably benign	Het
Triml1	A	G	8: 43,593,998 (GRCm39)		probably benign	Het

Other mutations in Gpr160

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01505:Gpr160	APN	3	30,950,002 (GRCm39)	missense	possibly damaging	0.90
IGL02952:Gpr160	APN	3	30,950,443 (GRCm39)	missense	probably benign	0.00
R2259:Gpr160	UTSW	3	30,950,444 (GRCm39)	missense	probably damaging	0.99
R2416:Gpr160	UTSW	3	30,950,158 (GRCm39)	missense	probably benign	0.00
R4191:Gpr160	UTSW	3	30,950,863 (GRCm39)	missense	possibly damaging	0.65
R4688:Gpr160	UTSW	3	30,950,835 (GRCm39)	missense	probably benign	0.28
R5987:Gpr160	UTSW	3	30,950,612 (GRCm39)	missense	probably benign
R6209:Gpr160	UTSW	3	30,950,141 (GRCm39)	missense	possibly damaging	0.56
R6353:Gpr160	UTSW	3	30,950,171 (GRCm39)	missense	probably damaging	1.00
R7075:Gpr160	UTSW	3	30,950,926 (GRCm39)	missense	possibly damaging	0.52
R8261:Gpr160	UTSW	3	30,950,096 (GRCm39)	missense	probably benign	0.08
R8381:Gpr160	UTSW	3	30,949,930 (GRCm39)	start codon destroyed	probably null	0.99
R8785:Gpr160	UTSW	3	30,950,923 (GRCm39)	missense	probably damaging	1.00
R9273:Gpr160	UTSW	3	30,950,038 (GRCm39)	missense	probably benign	0.45
R9487:Gpr160	UTSW	3	30,950,914 (GRCm39)	missense	probably benign	0.44
R9728:Gpr160	UTSW	3	30,950,144 (GRCm39)	missense	probably damaging	0.96

Posted On

2012-12-06