Incidental Mutation 'IGL00731:Igll1'
ID 11424
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igll1
Ensembl Gene ENSMUSG00000075370
Gene Name immunoglobulin lambda-like polypeptide 1
Synonyms Igll, Lambda 5, Igl-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL00731
Quality Score
Status
Chromosome 16
Chromosomal Location 16678535-16681849 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 16678783 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 176 (T176A)
Ref Sequence ENSEMBL: ENSMUSP00000097713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100136] [ENSMUST00000124890]
AlphaFold P20764
Predicted Effect probably benign
Transcript: ENSMUST00000100136
AA Change: T176A

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000097713
Gene: ENSMUSG00000075370
AA Change: T176A

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IGc1 126 200 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124649
Predicted Effect probably benign
Transcript: ENSMUST00000124890
AA Change: T152A

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000122045
Gene: ENSMUSG00000075370
AA Change: T152A

DomainStartEndE-ValueType
IGc1 102 176 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231439
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 A G 8: 111,771,501 (GRCm39) probably benign Het
Adcy10 T C 1: 165,400,183 (GRCm39) F1531L probably benign Het
Cgas G A 9: 78,342,770 (GRCm39) P344L probably damaging Het
Dab2 T C 15: 6,465,191 (GRCm39) S463P possibly damaging Het
Ehf C T 2: 103,097,185 (GRCm39) probably null Het
Fnbp4 G T 2: 90,598,987 (GRCm39) V704L probably benign Het
Gbp7 T C 3: 142,252,189 (GRCm39) S591P probably benign Het
Gpr155 A G 2: 73,192,957 (GRCm39) L498P probably damaging Het
Klk1b21 A G 7: 43,755,347 (GRCm39) E182G possibly damaging Het
Npat G A 9: 53,473,386 (GRCm39) E393K probably damaging Het
Npnt C T 3: 132,610,418 (GRCm39) probably null Het
Pde2a A G 7: 101,157,306 (GRCm39) Y693C probably benign Het
Ralgapa1 A G 12: 55,749,237 (GRCm39) S1269P possibly damaging Het
Rasal2 A C 1: 156,985,334 (GRCm39) D804E probably benign Het
Rdh10 A G 1: 16,178,099 (GRCm39) N124D probably benign Het
Slit3 G T 11: 35,512,981 (GRCm39) D536Y probably damaging Het
Snx24 C T 18: 53,517,681 (GRCm39) probably benign Het
Spink12 G A 18: 44,241,177 (GRCm39) probably benign Het
Other mutations in Igll1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03060:Igll1 APN 16 16,680,291 (GRCm39) critical splice donor site probably null
PIT4445001:Igll1 UTSW 16 16,678,783 (GRCm39) missense probably benign 0.04
R0058:Igll1 UTSW 16 16,681,740 (GRCm39) missense probably benign 0.02
R0058:Igll1 UTSW 16 16,681,740 (GRCm39) missense probably benign 0.02
R2014:Igll1 UTSW 16 16,681,639 (GRCm39) missense probably benign
R2015:Igll1 UTSW 16 16,681,639 (GRCm39) missense probably benign
R4242:Igll1 UTSW 16 16,681,564 (GRCm39) missense probably benign 0.15
R5024:Igll1 UTSW 16 16,681,657 (GRCm39) missense probably benign 0.05
R5453:Igll1 UTSW 16 16,681,558 (GRCm39) splice site probably null
R5855:Igll1 UTSW 16 16,678,921 (GRCm39) missense probably damaging 1.00
R6000:Igll1 UTSW 16 16,681,805 (GRCm39) start gained probably benign
R6946:Igll1 UTSW 16 16,678,920 (GRCm39) missense probably damaging 1.00
R7256:Igll1 UTSW 16 16,678,957 (GRCm39) missense probably damaging 1.00
R8904:Igll1 UTSW 16 16,681,576 (GRCm39) missense probably benign 0.00
Posted On 2012-12-06