Incidental Mutation 'R5855:Igll1'
ID 454884
Institutional Source Beutler Lab
Gene Symbol Igll1
Ensembl Gene ENSMUSG00000075370
Gene Name immunoglobulin lambda-like polypeptide 1
Synonyms Igll, Lambda 5, Igl-5
MMRRC Submission 043229-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R5855 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 16678535-16681849 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 16678921 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 130 (V130M)
Ref Sequence ENSEMBL: ENSMUSP00000097713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100136] [ENSMUST00000124890]
AlphaFold P20764
Predicted Effect probably damaging
Transcript: ENSMUST00000100136
AA Change: V130M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097713
Gene: ENSMUSG00000075370
AA Change: V130M

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IGc1 126 200 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124649
Predicted Effect probably damaging
Transcript: ENSMUST00000124890
AA Change: V106M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000122045
Gene: ENSMUSG00000075370
AA Change: V106M

DomainStartEndE-ValueType
IGc1 102 176 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231439
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 96.8%
  • 20x: 89.3%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadsb T G 7: 131,026,328 (GRCm39) L57R probably damaging Het
Bmpr1b G A 3: 141,577,146 (GRCm39) T55M possibly damaging Het
Cep350 G A 1: 155,829,508 (GRCm39) T132I probably benign Het
Cops4 A T 5: 100,695,280 (GRCm39) M400L probably benign Het
Cul1 G A 6: 47,500,147 (GRCm39) D653N probably benign Het
Cyp3a13 C G 5: 137,917,318 (GRCm39) L36F probably damaging Het
Dcaf10 T C 4: 45,342,558 (GRCm39) F131L probably benign Het
Dgkh T C 14: 78,861,944 (GRCm39) probably null Het
Kif2c C T 4: 117,039,739 (GRCm39) probably benign Het
Klra7 T C 6: 130,195,921 (GRCm39) D262G possibly damaging Het
Lrrc27 T C 7: 138,798,251 (GRCm39) probably benign Het
Maf A G 8: 116,432,531 (GRCm39) S358P probably benign Het
Map1a A G 2: 121,134,155 (GRCm39) D1419G possibly damaging Het
Map3k1 G A 13: 111,892,513 (GRCm39) A914V probably benign Het
Naa25 T G 5: 121,561,755 (GRCm39) L436R possibly damaging Het
Ndc1 T C 4: 107,240,904 (GRCm39) I294T probably damaging Het
Nek1 A C 8: 61,469,306 (GRCm39) D121A probably damaging Het
Nfil3 C T 13: 53,122,746 (GRCm39) G53R probably benign Het
Or10h28 T C 17: 33,488,310 (GRCm39) V204A possibly damaging Het
Parp14 A T 16: 35,661,297 (GRCm39) Y1550* probably null Het
Patl1 A G 19: 11,898,880 (GRCm39) I192V probably damaging Het
Pax3 G A 1: 78,098,288 (GRCm39) T367I probably damaging Het
Pla2g4a C T 1: 149,755,814 (GRCm39) V208M probably damaging Het
Prdm10 A T 9: 31,248,619 (GRCm39) K347M probably damaging Het
Prkd1 A T 12: 50,439,699 (GRCm39) M376K probably benign Het
Prkg1 C T 19: 30,872,094 (GRCm39) V219I possibly damaging Het
Rictor G A 15: 6,823,487 (GRCm39) E1555K probably benign Het
Scn3a T C 2: 65,295,074 (GRCm39) I1550V possibly damaging Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Sox4 T C 13: 29,136,979 (GRCm39) E9G probably damaging Het
Spon1 T A 7: 113,628,307 (GRCm39) D354E probably damaging Het
Stat2 T A 10: 128,119,363 (GRCm39) L450H probably damaging Het
Tek T A 4: 94,741,790 (GRCm39) M849K probably damaging Het
Tmem63c G A 12: 87,122,500 (GRCm39) D433N probably damaging Het
Tnpo3 G A 6: 29,589,032 (GRCm39) T106I probably damaging Het
Tns1 G T 1: 73,957,192 (GRCm39) A1674D possibly damaging Het
Trim8 T C 19: 46,503,849 (GRCm39) V467A possibly damaging Het
Trmo T A 4: 46,382,568 (GRCm39) H183L probably benign Het
Trpm1 C A 7: 63,918,710 (GRCm39) C683* probably null Het
Vsig10 T G 5: 117,476,335 (GRCm39) L263R probably damaging Het
Zfp874a A T 13: 67,590,812 (GRCm39) Y291N probably benign Het
Other mutations in Igll1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00731:Igll1 APN 16 16,678,783 (GRCm39) missense probably benign 0.04
IGL03060:Igll1 APN 16 16,680,291 (GRCm39) critical splice donor site probably null
PIT4445001:Igll1 UTSW 16 16,678,783 (GRCm39) missense probably benign 0.04
R0058:Igll1 UTSW 16 16,681,740 (GRCm39) missense probably benign 0.02
R0058:Igll1 UTSW 16 16,681,740 (GRCm39) missense probably benign 0.02
R2014:Igll1 UTSW 16 16,681,639 (GRCm39) missense probably benign
R2015:Igll1 UTSW 16 16,681,639 (GRCm39) missense probably benign
R4242:Igll1 UTSW 16 16,681,564 (GRCm39) missense probably benign 0.15
R5024:Igll1 UTSW 16 16,681,657 (GRCm39) missense probably benign 0.05
R5453:Igll1 UTSW 16 16,681,558 (GRCm39) splice site probably null
R6000:Igll1 UTSW 16 16,681,805 (GRCm39) start gained probably benign
R6946:Igll1 UTSW 16 16,678,920 (GRCm39) missense probably damaging 1.00
R7256:Igll1 UTSW 16 16,678,957 (GRCm39) missense probably damaging 1.00
R8904:Igll1 UTSW 16 16,681,576 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTCCTTCATGAGTGACCCGG -3'
(R):5'- ATCCCTGGATGGAAGACTGATG -3'

Sequencing Primer
(F):5'- CAGCTGTATCTACTGTGAGGCATC -3'
(R):5'- ATGCTGTAGTGAATGGCCAC -3'
Posted On 2017-02-10