Incidental Mutation 'IGL00226:Fbxw18'
ID2267
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw18
Ensembl Gene ENSMUSG00000074059
Gene NameF-box and WD-40 domain protein 18
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL00226
Quality Score
Status
Chromosome9
Chromosomal Location109676734-109702700 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 109693343 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 153 (T153S)
Ref Sequence ENSEMBL: ENSMUSP00000095962 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098359]
Predicted Effect probably benign
Transcript: ENSMUST00000098359
AA Change: T153S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000095962
Gene: ENSMUSG00000074059
AA Change: T153S

DomainStartEndE-ValueType
FBOX 8 48 4.13e-6 SMART
Blast:WD40 140 179 2e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810062G17Rik C A 3: 36,479,541 probably benign Het
5430419D17Rik T A 7: 131,238,094 probably null Het
Ankib1 G A 5: 3,727,573 S439L probably benign Het
Cpd G T 11: 76,797,789 H886N probably benign Het
Dhrs7 A G 12: 72,659,350 C94R probably damaging Het
Dmxl2 T A 9: 54,415,993 H1369L probably damaging Het
Dnah5 A G 15: 28,272,342 N1068S probably benign Het
Dopey1 T A 9: 86,551,679 D2329E possibly damaging Het
Eif1ad A G 19: 5,368,184 probably benign Het
Fam149a T C 8: 45,339,343 R693G probably damaging Het
Glg1 A T 8: 111,159,849 C1104S probably damaging Het
Jak3 T C 8: 71,681,697 probably benign Het
Kctd6 C T 14: 8,222,856 R233C possibly damaging Het
Kpna3 A G 14: 61,374,288 V300A possibly damaging Het
Msh5 A T 17: 35,029,881 Y725* probably null Het
Myh2 T C 11: 67,185,233 S749P possibly damaging Het
Olfr1215 A G 2: 89,001,339 probably benign Het
Olfr199 A T 16: 59,216,496 M39K probably damaging Het
Olfr27 T A 9: 39,144,757 I219N possibly damaging Het
Olfr697 T A 7: 106,741,701 T78S probably benign Het
Pdcd1 A G 1: 94,040,135 probably benign Het
Pde5a T A 3: 122,794,357 F391I probably damaging Het
Ptpn12 A C 5: 20,998,668 S371A probably damaging Het
Sec16b A G 1: 157,538,330 Y254C probably damaging Het
Slc2a10 G A 2: 165,514,780 C120Y probably damaging Het
Spink5 G A 18: 43,987,871 probably benign Het
Svil A G 18: 5,099,045 Q1250R probably benign Het
Tph1 G T 7: 46,656,870 N222K probably benign Het
Vmn2r83 A T 10: 79,478,971 D351V probably damaging Het
Zfp54 A G 17: 21,433,559 D105G possibly damaging Het
Zfp623 T C 15: 75,948,203 I336T probably damaging Het
Other mutations in Fbxw18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00820:Fbxw18 APN 9 109693369 missense probably damaging 1.00
IGL01447:Fbxw18 APN 9 109701607 missense probably damaging 1.00
IGL01511:Fbxw18 APN 9 109688821 missense possibly damaging 0.83
IGL01956:Fbxw18 APN 9 109693357 missense probably damaging 0.98
IGL02089:Fbxw18 APN 9 109701322 missense probably benign 0.00
PIT4810001:Fbxw18 UTSW 9 109676890 nonsense probably null
R0004:Fbxw18 UTSW 9 109701313 missense probably damaging 0.96
R0124:Fbxw18 UTSW 9 109691515 missense probably benign 0.00
R0375:Fbxw18 UTSW 9 109688839 missense possibly damaging 0.63
R1652:Fbxw18 UTSW 9 109690627 missense probably benign 0.35
R2153:Fbxw18 UTSW 9 109693370 missense probably damaging 1.00
R2294:Fbxw18 UTSW 9 109676797 missense probably damaging 1.00
R3738:Fbxw18 UTSW 9 109688913 missense possibly damaging 0.57
R4706:Fbxw18 UTSW 9 109690517 missense probably benign 0.00
R4982:Fbxw18 UTSW 9 109702651 start gained probably benign
R4990:Fbxw18 UTSW 9 109688393 missense probably damaging 0.99
R5314:Fbxw18 UTSW 9 109693178 missense possibly damaging 0.90
R5520:Fbxw18 UTSW 9 109691521 missense probably benign 0.00
R5634:Fbxw18 UTSW 9 109676803 missense possibly damaging 0.49
R5718:Fbxw18 UTSW 9 109691568 missense probably benign 0.01
R5894:Fbxw18 UTSW 9 109700167 missense possibly damaging 0.83
R5928:Fbxw18 UTSW 9 109700081 missense probably damaging 0.99
R6175:Fbxw18 UTSW 9 109676879 missense probably damaging 1.00
R6696:Fbxw18 UTSW 9 109688764 missense probably benign 0.09
R6944:Fbxw18 UTSW 9 109702587 missense probably damaging 1.00
R7396:Fbxw18 UTSW 9 109688886 missense probably benign 0.19
R7737:Fbxw18 UTSW 9 109701263 nonsense probably null
R7883:Fbxw18 UTSW 9 109688406 missense probably damaging 1.00
R7966:Fbxw18 UTSW 9 109688406 missense probably damaging 1.00
Posted On2011-12-09