Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02139:Rbm42'

281454

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rbm42

Ensembl Gene

ENSMUSG00000036733

Gene Name

RNA binding motif protein 42

Synonyms

1700003D06Rik, 3100004P22Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.936) question?

Stock #

IGL02139

Quality Score

Status

Chromosome

Chromosomal Location

30340420-30349653 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 30345130 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 185 (P185S)

Ref Sequence

ENSEMBL: ENSMUSP00000103776 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042726] [ENSMUST00000108141]

AlphaFold

Q91V81

Predicted Effect

unknown
Transcript: ENSMUST00000042726
AA Change: P214S

SMART Domains

Protein: ENSMUSP00000040005
Gene: ENSMUSG00000036733
AA Change: P214S

Domain	Start	End	E-Value	Type
low complexity region	6	31	N/A	INTRINSIC
low complexity region	75	86	N/A	INTRINSIC
low complexity region	101	126	N/A	INTRINSIC
low complexity region	192	217	N/A	INTRINSIC
low complexity region	220	243	N/A	INTRINSIC
low complexity region	247	277	N/A	INTRINSIC
low complexity region	279	333	N/A	INTRINSIC
low complexity region	339	355	N/A	INTRINSIC
RRM	380	453	1.11e-21	SMART
low complexity region	467	474	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000108141
AA Change: P185S

SMART Domains

Protein: ENSMUSP00000103776
Gene: ENSMUSG00000036733
AA Change: P185S

Domain	Start	End	E-Value	Type
low complexity region	6	31	N/A	INTRINSIC
low complexity region	75	86	N/A	INTRINSIC
low complexity region	101	126	N/A	INTRINSIC
low complexity region	163	188	N/A	INTRINSIC
low complexity region	191	214	N/A	INTRINSIC
low complexity region	218	248	N/A	INTRINSIC
low complexity region	250	304	N/A	INTRINSIC
low complexity region	310	326	N/A	INTRINSIC
RRM	351	424	1.11e-21	SMART
low complexity region	438	445	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140550

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146232

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181529

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3100002H09Rik	G	A	4: 124,504,369 (GRCm39)	T61M	unknown	Het
Adam34l	T	A	8: 44,078,615 (GRCm39)	R536S	probably benign	Het
Ambn	T	C	5: 88,613,149 (GRCm39)	F217L	probably benign	Het
Cast	T	C	13: 74,876,484 (GRCm39)	D121G	possibly damaging	Het
Clmn	T	C	12: 104,747,358 (GRCm39)	I730V	probably benign	Het
Cryzl1	T	C	16: 91,509,139 (GRCm39)	K54R	possibly damaging	Het
Cyp3a16	A	G	5: 145,392,290 (GRCm39)	S222P	probably benign	Het
Dcstamp	T	C	15: 39,617,854 (GRCm39)	S88P	probably damaging	Het
F5	A	G	1: 164,020,243 (GRCm39)	D906G	possibly damaging	Het
Fam193a	A	G	5: 34,602,081 (GRCm39)	T428A	probably benign	Het
Fbxw16	T	G	9: 109,265,754 (GRCm39)	D355A	probably benign	Het
Focad	T	C	4: 88,047,291 (GRCm39)		probably null	Het
Ftsj3	G	A	11: 106,145,489 (GRCm39)	P82S	possibly damaging	Het
Grwd1	A	T	7: 45,476,667 (GRCm39)	H307Q	probably damaging	Het
Hip1r	T	C	5: 124,134,307 (GRCm39)	F289S	probably damaging	Het
Igkc	C	T	6: 70,703,559 (GRCm39)	R47*	probably null	Het
Lcn3	T	C	2: 25,656,646 (GRCm39)	F100S	possibly damaging	Het
Lmnb1	T	C	18: 56,882,871 (GRCm39)	F572S	probably benign	Het
Mrps17	T	A	5: 129,793,860 (GRCm39)	I18N	probably damaging	Het
Myo9a	G	A	9: 59,687,275 (GRCm39)	V127I	probably benign	Het
Or2l13b	T	C	16: 19,349,640 (GRCm39)	D10G	probably benign	Het
Or4c35	T	C	2: 89,808,773 (GRCm39)	V217A	possibly damaging	Het
Or5g23	T	A	2: 85,438,574 (GRCm39)	K227*	probably null	Het
Pcdhb21	A	G	18: 37,648,299 (GRCm39)	D476G	probably damaging	Het
Pkd2l2	T	A	18: 34,545,768 (GRCm39)	Y56*	probably null	Het
Pld1	C	A	3: 28,174,961 (GRCm39)	D86E	probably damaging	Het
Plpp1	A	G	13: 112,993,433 (GRCm39)	T122A	probably benign	Het
Prkag3	A	G	1: 74,779,883 (GRCm39)	I484T	probably benign	Het
Prl7d1	T	A	13: 27,896,066 (GRCm39)	I104F	probably damaging	Het
Prr14l	A	G	5: 32,984,876 (GRCm39)	S1540P	probably damaging	Het
Pyroxd1	T	G	6: 142,300,457 (GRCm39)	S196A	probably benign	Het
Ror2	T	A	13: 53,265,200 (GRCm39)	I619F	probably damaging	Het
Slitrk4	T	G	X: 63,314,555 (GRCm39)	E704A	probably benign	Het
Sycp1	A	G	3: 102,772,430 (GRCm39)	V626A	probably benign	Het
Trmt44	T	A	5: 35,726,143 (GRCm39)	K345*	probably null	Het
Ugt1a6b	T	A	1: 88,035,527 (GRCm39)		probably benign	Het
Ulk4	T	A	9: 120,970,897 (GRCm39)		probably null	Het
Zfp618	G	T	4: 63,051,773 (GRCm39)	K758N	probably damaging	Het
Zfp819	G	T	7: 43,261,534 (GRCm39)		probably null	Het

Other mutations in Rbm42

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0115:Rbm42	UTSW	7	30,347,200 (GRCm39)	missense	probably damaging	1.00
R0285:Rbm42	UTSW	7	30,345,265 (GRCm39)	missense	possibly damaging	0.93
R2144:Rbm42	UTSW	7	30,340,535 (GRCm39)	makesense	probably null
R3122:Rbm42	UTSW	7	30,349,152 (GRCm39)	unclassified	probably benign
R6369:Rbm42	UTSW	7	30,340,738 (GRCm39)	missense	unknown
R8080:Rbm42	UTSW	7	30,345,136 (GRCm39)	missense	unknown
R8329:Rbm42	UTSW	7	30,344,582 (GRCm39)	missense	unknown
R8372:Rbm42	UTSW	7	30,340,631 (GRCm39)	missense	unknown
R9567:Rbm42	UTSW	7	30,345,395 (GRCm39)	missense	possibly damaging	0.95
Z1186:Rbm42	UTSW	7	30,349,578 (GRCm39)	unclassified	probably benign

Posted On

2015-04-16