Incidental Mutation 'IGL00984:Syt16'
ID28793
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Syt16
Ensembl Gene ENSMUSG00000044912
Gene Namesynaptotagmin XVI
SynonymsStrep14, syt14r, Syt14l
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00984
Quality Score
Status
Chromosome12
Chromosomal Location73997661-74273267 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 74222830 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 148 (Q148*)
Ref Sequence ENSEMBL: ENSMUSP00000152623 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110451] [ENSMUST00000221220]
Predicted Effect probably benign
Transcript: ENSMUST00000110451
SMART Domains Protein: ENSMUSP00000106081
Gene: ENSMUSG00000044912

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
low complexity region 70 83 N/A INTRINSIC
C2 270 372 8.91e-4 SMART
low complexity region 386 407 N/A INTRINSIC
C2 425 541 7.07e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189898
Predicted Effect probably null
Transcript: ENSMUST00000221220
AA Change: Q148*
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b T A 8: 43,520,373 N531Y possibly damaging Het
Adamts12 G A 15: 11,215,610 R239K probably benign Het
Alppl2 T A 1: 87,088,812 H180L probably damaging Het
Atp10a T C 7: 58,658,741 V96A probably damaging Het
Atp2c1 T A 9: 105,418,579 I649F probably damaging Het
Atp6v1h A G 1: 5,095,682 Y125C probably damaging Het
Cds2 T C 2: 132,298,521 V213A probably benign Het
Csnk1a1 A G 18: 61,575,553 probably benign Het
Ctdspl2 C T 2: 121,969,286 probably benign Het
Dohh G A 10: 81,387,922 probably null Het
Dst A T 1: 34,256,320 D5971V probably damaging Het
Fam71e2 C T 7: 4,757,527 V729M probably damaging Het
Focad G T 4: 88,344,785 M1006I unknown Het
Iqgap1 T C 7: 80,726,798 D1322G probably damaging Het
Mcm3ap G T 10: 76,499,566 S1274I probably damaging Het
Mrpl42 C T 10: 95,490,340 V97I probably benign Het
Olfr1182 A T 2: 88,446,195 F248I probably damaging Het
Pabpc6 A T 17: 9,668,689 L311H probably damaging Het
Pdzrn3 A T 6: 101,354,486 S276T probably benign Het
Pi4ka A T 16: 17,358,932 C383* probably null Het
Pik3r6 A G 11: 68,533,619 D350G probably benign Het
Ptcd1 C T 5: 145,165,429 V27I probably benign Het
Ranbp2 A T 10: 58,461,964 R398* probably null Het
Rpl3l T C 17: 24,735,471 C336R probably damaging Het
Rxfp2 T C 5: 150,067,132 S443P probably benign Het
Sec24b T C 3: 130,020,646 probably benign Het
Sept11 T C 5: 93,162,184 M282T possibly damaging Het
Timm23 A G 14: 32,180,655 I177T probably benign Het
Treh A G 9: 44,682,967 probably benign Het
Vmn1r71 A G 7: 10,748,119 V214A probably damaging Het
Zfp715 G A 7: 43,299,784 P251S probably benign Het
Other mutations in Syt16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Syt16 APN 12 74266739 missense probably damaging 1.00
IGL01401:Syt16 APN 12 74222663 missense possibly damaging 0.66
IGL01780:Syt16 APN 12 74266842 missense probably benign 0.15
IGL02350:Syt16 APN 12 74266842 missense probably benign 0.15
IGL02353:Syt16 APN 12 74129471 missense probably damaging 1.00
IGL02357:Syt16 APN 12 74266842 missense probably benign 0.15
IGL02360:Syt16 APN 12 74129471 missense probably damaging 1.00
IGL02558:Syt16 APN 12 74235058 nonsense probably null
IGL02696:Syt16 APN 12 74129411 missense possibly damaging 0.90
R0701:Syt16 UTSW 12 74235112 missense probably benign 0.01
R1103:Syt16 UTSW 12 74266898 missense probably damaging 1.00
R2002:Syt16 UTSW 12 74235203 missense possibly damaging 0.77
R2079:Syt16 UTSW 12 74238299 missense probably damaging 1.00
R2124:Syt16 UTSW 12 74238235 missense probably damaging 1.00
R3806:Syt16 UTSW 12 74229398 missense possibly damaging 0.93
R3807:Syt16 UTSW 12 74229398 missense possibly damaging 0.93
R4887:Syt16 UTSW 12 74129386 missense probably damaging 0.96
R4889:Syt16 UTSW 12 74129495 missense probably damaging 0.98
R5153:Syt16 UTSW 12 74222768 missense possibly damaging 0.60
R6038:Syt16 UTSW 12 74222535 splice site probably null
R6042:Syt16 UTSW 12 74266730 missense probably damaging 1.00
R6328:Syt16 UTSW 12 74266693 nonsense probably null
R6752:Syt16 UTSW 12 74229213 critical splice acceptor site probably null
R7248:Syt16 UTSW 12 74266709 missense probably damaging 1.00
R7275:Syt16 UTSW 12 74266709 missense probably damaging 1.00
R7276:Syt16 UTSW 12 74266709 missense probably damaging 1.00
Z1177:Syt16 UTSW 12 74222789 missense possibly damaging 0.92
Posted On2013-04-17