Incidental Mutation 'IGL02320:Fpr2'
| ID |
288185 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fpr2
|
| Ensembl Gene |
ENSMUSG00000052270 |
| Gene Name |
formyl peptide receptor 2 |
| Synonyms |
Fpr-rs2, E330010I07Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.090)
|
| Stock # |
IGL02320
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
18108086-18114214 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 18113608 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 201
(R201S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000065799
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054871]
[ENSMUST00000064068]
[ENSMUST00000149944]
|
| AlphaFold |
O88536 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054871
|
| SMART Domains |
Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
43 |
302 |
2.2e-43 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064068
AA Change: R201S
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000065799
Gene: ENSMUSG00000052270
AA Change: R201S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
43 |
302 |
4.3e-36 |
PFAM |
|
low complexity region
|
326 |
341 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149944
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a targeted reporter allele exhibit altered leukocyte responses and experimentally induced inflammation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb1 |
T |
C |
15: 74,445,961 (GRCm39) |
S146P |
probably damaging |
Het |
| Ap1m2 |
A |
T |
9: 21,210,620 (GRCm39) |
Y336* |
probably null |
Het |
| Arap1 |
T |
C |
7: 101,034,236 (GRCm39) |
L226P |
probably benign |
Het |
| Cacna1c |
T |
A |
6: 118,614,753 (GRCm39) |
N1150Y |
probably damaging |
Het |
| Ccsap |
G |
T |
8: 124,569,177 (GRCm39) |
H221Q |
probably damaging |
Het |
| Ceacam3 |
T |
A |
7: 16,895,865 (GRCm39) |
Y612N |
probably benign |
Het |
| Col12a1 |
A |
G |
9: 79,523,303 (GRCm39) |
|
probably null |
Het |
| Ddx23 |
T |
C |
15: 98,548,819 (GRCm39) |
T328A |
possibly damaging |
Het |
| Depdc1a |
T |
A |
3: 159,222,570 (GRCm39) |
M252K |
probably damaging |
Het |
| Ighv1-20 |
A |
G |
12: 114,687,463 (GRCm39) |
S94P |
probably damaging |
Het |
| Itgb7 |
A |
C |
15: 102,132,772 (GRCm39) |
V180G |
probably benign |
Het |
| Mmp13 |
G |
T |
9: 7,278,941 (GRCm39) |
R344L |
probably benign |
Het |
| Mucl3 |
A |
T |
17: 35,948,332 (GRCm39) |
N422K |
probably benign |
Het |
| Ncam2 |
C |
T |
16: 81,231,725 (GRCm39) |
S63L |
probably damaging |
Het |
| Or5p52 |
C |
T |
7: 107,502,038 (GRCm39) |
T38I |
possibly damaging |
Het |
| Pde9a |
G |
A |
17: 31,678,059 (GRCm39) |
C187Y |
probably damaging |
Het |
| Sh2b1 |
A |
G |
7: 126,068,341 (GRCm39) |
L490P |
probably benign |
Het |
| Shank2 |
A |
G |
7: 143,974,681 (GRCm39) |
T1193A |
probably damaging |
Het |
| Shisa2 |
T |
A |
14: 59,867,246 (GRCm39) |
M166K |
probably damaging |
Het |
| Smg7 |
A |
T |
1: 152,744,088 (GRCm39) |
S40T |
possibly damaging |
Het |
| Spef2 |
A |
C |
15: 9,717,662 (GRCm39) |
S285A |
probably damaging |
Het |
| Tlcd3a |
A |
G |
11: 76,096,231 (GRCm39) |
M120V |
probably damaging |
Het |
| Trgv7 |
C |
A |
13: 19,362,249 (GRCm39) |
P13Q |
unknown |
Het |
| Ttn |
A |
G |
2: 76,769,656 (GRCm39) |
|
probably benign |
Het |
| Tyw5 |
A |
G |
1: 57,435,884 (GRCm39) |
|
probably null |
Het |
| Vars2 |
A |
G |
17: 35,971,346 (GRCm39) |
V212A |
probably benign |
Het |
| Vmn2r1 |
T |
C |
3: 63,989,180 (GRCm39) |
S40P |
possibly damaging |
Het |
| Wwc2 |
A |
G |
8: 48,316,882 (GRCm39) |
|
probably null |
Het |
| Zbed6 |
T |
C |
1: 133,585,411 (GRCm39) |
N642S |
probably damaging |
Het |
| Zfp423 |
A |
T |
8: 88,508,230 (GRCm39) |
C580S |
probably damaging |
Het |
| Zfp64 |
A |
G |
2: 168,768,118 (GRCm39) |
V498A |
probably damaging |
Het |
|
| Other mutations in Fpr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00508:Fpr2
|
APN |
17 |
18,113,034 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01481:Fpr2
|
APN |
17 |
18,113,025 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02479:Fpr2
|
APN |
17 |
18,113,074 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1553:Fpr2
|
UTSW |
17 |
18,113,856 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3906:Fpr2
|
UTSW |
17 |
18,113,811 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4424:Fpr2
|
UTSW |
17 |
18,113,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4480:Fpr2
|
UTSW |
17 |
18,114,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4521:Fpr2
|
UTSW |
17 |
18,113,509 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4718:Fpr2
|
UTSW |
17 |
18,113,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5385:Fpr2
|
UTSW |
17 |
18,113,309 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7184:Fpr2
|
UTSW |
17 |
18,113,533 (GRCm39) |
missense |
unknown |
|
|
R7233:Fpr2
|
UTSW |
17 |
18,113,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Fpr2
|
UTSW |
17 |
18,113,190 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8927:Fpr2
|
UTSW |
17 |
18,113,724 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8928:Fpr2
|
UTSW |
17 |
18,113,724 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8939:Fpr2
|
UTSW |
17 |
18,113,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9410:Fpr2
|
UTSW |
17 |
18,113,604 (GRCm39) |
missense |
probably benign |
|
|
R9651:Fpr2
|
UTSW |
17 |
18,113,484 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation