Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02322:Ctrb1'

288308

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ctrb1

Ensembl Gene

ENSMUSG00000031957

Gene Name

chymotrypsinogen B1

Synonyms

2200008D09Rik, Prt-2

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.442) question?

Stock #

IGL02322

Quality Score

Status

Chromosome

Chromosomal Location

112413151-112417642 bp(-) (GRCm39)

Type of Mutation

splice site (6 bp from exon)

DNA Base Change (assembly)

A to C at 112415951 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000034435 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034435]

AlphaFold

Q9CR35

Predicted Effect

probably null
Transcript: ENSMUST00000034435

SMART Domains

Protein: ENSMUSP00000034435
Gene: ENSMUSG00000031957

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Tryp_SPc	33	256	2.69e-98	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183519

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(8) : Targeted(2) Gene trapped(6)

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acd	G	A	8: 106,425,268 (GRCm39)	A355V	probably benign	Het
Adam9	A	G	8: 25,445,990 (GRCm39)	V801A	probably damaging	Het
Ankrd36	T	A	11: 5,564,619 (GRCm39)	V479D	possibly damaging	Het
Arid5a	C	T	1: 36,358,497 (GRCm39)	P423L	probably benign	Het
Atp13a4	T	C	16: 29,258,920 (GRCm39)	I650V	probably benign	Het
B4gat1	C	A	19: 5,089,155 (GRCm39)	P51T	possibly damaging	Het
Caskin2	G	A	11: 115,695,303 (GRCm39)	T310M	probably damaging	Het
Ccdc121rt1	A	G	1: 181,337,999 (GRCm39)	S318P	possibly damaging	Het
Ccdc159	G	T	9: 21,840,669 (GRCm39)	V79L	possibly damaging	Het
Ccser2	A	T	14: 36,631,086 (GRCm39)	V18E	probably damaging	Het
Cct8l1	T	C	5: 25,722,581 (GRCm39)	V432A	probably benign	Het
Cdh11	A	T	8: 103,374,151 (GRCm39)	F529Y	probably benign	Het
Cep250	A	G	2: 155,832,248 (GRCm39)	E1370G	probably damaging	Het
Col22a1	C	A	15: 71,694,502 (GRCm39)	G717C	unknown	Het
Csmd2	T	C	4: 128,357,520 (GRCm39)		probably benign	Het
Cyp2b19	T	C	7: 26,461,803 (GRCm39)	S208P	possibly damaging	Het
Dnmt3l	T	A	10: 77,888,572 (GRCm39)	I158N	possibly damaging	Het
Evi5l	T	C	8: 4,237,236 (GRCm39)		probably benign	Het
Fkbpl	A	G	17: 34,864,298 (GRCm39)	E22G	probably benign	Het
Flnb	T	A	14: 7,894,676 (GRCm38)	F825I	probably damaging	Het
Gjb6	A	T	14: 57,361,732 (GRCm39)	N176K	probably damaging	Het
Gpc2	G	T	5: 138,274,499 (GRCm39)		probably null	Het
H1f7	T	C	15: 98,154,757 (GRCm39)	T131A	possibly damaging	Het
Il20	C	T	1: 130,837,313 (GRCm39)	C104Y	probably damaging	Het
Mgat5	A	G	1: 127,310,722 (GRCm39)	N212S	probably benign	Het
Olfm5	C	T	7: 103,803,608 (GRCm39)	G210D	probably damaging	Het
Olig2	T	C	16: 91,023,546 (GRCm39)	S87P	probably benign	Het
Or2y15	A	G	11: 49,350,784 (GRCm39)	S93G	probably benign	Het
Or4c121	T	A	2: 89,023,806 (GRCm39)	T191S	probably damaging	Het
Osbpl7	G	T	11: 96,946,950 (GRCm39)	A418S	probably benign	Het
Otog	G	T	7: 45,950,881 (GRCm39)	R2551L	probably benign	Het
Oxt	A	T	2: 130,418,200 (GRCm39)	N24I	probably damaging	Het
Pibf1	A	G	14: 99,448,419 (GRCm39)	Y626C	probably damaging	Het
Plekhh2	A	T	17: 84,896,894 (GRCm39)	K934*	probably null	Het
Pramel14	G	A	4: 143,718,591 (GRCm39)		probably benign	Het
Prdm9	A	T	17: 15,783,110 (GRCm39)	N57K	probably damaging	Het
Rapsn	A	G	2: 90,872,251 (GRCm39)	D195G	possibly damaging	Het
Rimbp3	T	G	16: 17,029,479 (GRCm39)	F968V	probably benign	Het
Rpgrip1	A	G	14: 52,387,499 (GRCm39)	N1047S	possibly damaging	Het
Slc35g1	C	T	19: 38,389,013 (GRCm39)	R107*	probably null	Het
Ssh2	A	C	11: 77,307,239 (GRCm39)		probably null	Het
Tiparp	C	A	3: 65,439,441 (GRCm39)	C70*	probably null	Het
Vmn2r110	A	G	17: 20,794,197 (GRCm39)	I824T	probably damaging	Het
Vmn2r78	T	C	7: 86,570,687 (GRCm39)	S402P	probably damaging	Het
Vps13c	A	G	9: 67,845,183 (GRCm39)	E2089G	probably benign	Het
Xirp2	A	T	2: 67,339,082 (GRCm39)	H441L	probably benign	Het
Zdhhc3	C	T	9: 122,929,542 (GRCm39)	G31D	probably benign	Het
Zfp330	A	G	8: 83,497,450 (GRCm39)	L64S	probably damaging	Het

Other mutations in Ctrb1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02348:Ctrb1	APN	8	112,413,762 (GRCm39)	missense	possibly damaging	0.93
R0066:Ctrb1	UTSW	8	112,413,269 (GRCm39)	nonsense	probably null
R0066:Ctrb1	UTSW	8	112,413,269 (GRCm39)	nonsense	probably null
R0371:Ctrb1	UTSW	8	112,413,783 (GRCm39)	missense	probably benign	0.43
R1468:Ctrb1	UTSW	8	112,416,041 (GRCm39)	splice site	probably benign
R1928:Ctrb1	UTSW	8	112,415,324 (GRCm39)	missense	probably benign	0.00
R1944:Ctrb1	UTSW	8	112,416,151 (GRCm39)	missense	probably damaging	1.00
R2026:Ctrb1	UTSW	8	112,415,317 (GRCm39)	missense	probably benign	0.09
R4898:Ctrb1	UTSW	8	112,413,783 (GRCm39)	missense	probably benign	0.43
R6323:Ctrb1	UTSW	8	112,416,223 (GRCm39)	missense	probably benign	0.22
R6791:Ctrb1	UTSW	8	112,415,981 (GRCm39)	missense	possibly damaging	0.76
R6868:Ctrb1	UTSW	8	112,416,035 (GRCm39)	missense	probably benign	0.03
R6954:Ctrb1	UTSW	8	112,413,296 (GRCm39)	missense	probably damaging	0.99
R7528:Ctrb1	UTSW	8	112,413,783 (GRCm39)	missense	probably benign	0.43
R8130:Ctrb1	UTSW	8	112,415,823 (GRCm39)	missense	possibly damaging	0.85
R9218:Ctrb1	UTSW	8	112,416,140 (GRCm39)	missense	probably damaging	1.00
Z1177:Ctrb1	UTSW	8	112,413,306 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16