Incidental Mutation 'IGL02389:Vmn1r34'
ID291659
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r34
Ensembl Gene ENSMUSG00000091012
Gene Namevomeronasal 1 receptor 34
SynonymsGm5991
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02389
Quality Score
Status
Chromosome6
Chromosomal Location66635936-66643879 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 66637058 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 232 (L232Q)
Ref Sequence ENSEMBL: ENSMUSP00000153720 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074381] [ENSMUST00000226262] [ENSMUST00000226910] [ENSMUST00000226999] [ENSMUST00000227332] [ENSMUST00000228498] [ENSMUST00000228647]
Predicted Effect probably damaging
Transcript: ENSMUST00000074381
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132900
Gene: ENSMUSG00000091012
AA Change: L232Q

DomainStartEndE-ValueType
Pfam:V1R 28 293 2.2e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226262
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226910
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226999
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227332
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228498
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228647
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G A 5: 63,896,483 S11N probably null Het
Aqp9 T C 9: 71,122,906 I200V possibly damaging Het
BC100530 C A 16: 36,367,486 V6F possibly damaging Het
Cntn2 T C 1: 132,525,321 E411G probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dennd3 A G 15: 73,567,056 D1091G probably damaging Het
Dock2 T C 11: 34,698,740 probably benign Het
Dscam T A 16: 96,640,897 I1577F probably benign Het
Egflam A T 15: 7,250,078 N482K probably benign Het
Fam216a T C 5: 122,367,511 T129A probably damaging Het
Fbxo40 T C 16: 36,969,774 M325V probably benign Het
Fbxw8 C T 5: 118,128,955 V148M possibly damaging Het
Fcgbp C T 7: 28,075,171 R57C probably damaging Het
Gnpnat1 A G 14: 45,380,931 probably null Het
Gria2 T C 3: 80,709,422 T408A probably benign Het
H2-T3 A G 17: 36,186,608 M59T probably benign Het
Jakmip1 C T 5: 37,100,843 Q278* probably null Het
Krtap21-1 C T 16: 89,403,424 G110D unknown Het
Myo7a C T 7: 98,106,991 probably null Het
Nlrp9c T A 7: 26,394,207 Q11L probably benign Het
Olfr1442 A T 19: 12,674,535 D110V probably benign Het
Olfr298 A G 7: 86,489,128 L141P probably damaging Het
Olfr767 A C 10: 129,079,230 I244M probably damaging Het
Olfr790 T A 10: 129,501,070 M62K probably benign Het
Pdzd8 A G 19: 59,301,393 I525T probably benign Het
Pign A T 1: 105,646,781 L280* probably null Het
Pik3r4 T G 9: 105,650,331 I294M possibly damaging Het
Pkhd1 T A 1: 20,117,720 I3455F probably damaging Het
Prmt3 C T 7: 49,848,758 Q471* probably null Het
Prrc2c A G 1: 162,692,870 F2006L probably damaging Het
Ptger3 C T 3: 157,567,171 R52C probably damaging Het
Rfx2 T C 17: 56,808,325 probably benign Het
Sh3bp4 T C 1: 89,145,148 F573L probably damaging Het
Slc18a2 G T 19: 59,263,301 probably benign Het
Slc26a8 T A 17: 28,638,650 I840F probably benign Het
Slc5a4b A T 10: 76,072,465 Y364* probably null Het
Slitrk1 A G 14: 108,912,322 I319T probably benign Het
Stxbp5l C T 16: 37,208,205 A499T probably benign Het
Tnks2 T A 19: 36,884,103 S951R probably benign Het
Trim30c A G 7: 104,382,174 F478S probably benign Het
Tyro3 C T 2: 119,804,864 probably benign Het
Zfp148 T A 16: 33,495,446 C215S probably damaging Het
Zzef1 T A 11: 72,899,538 V2106D possibly damaging Het
Zzef1 C T 11: 72,891,217 P1995S probably benign Het
Other mutations in Vmn1r34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00974:Vmn1r34 APN 6 66637655 missense possibly damaging 0.64
IGL01322:Vmn1r34 APN 6 66636915 nonsense probably null
IGL01866:Vmn1r34 APN 6 66637389 missense probably benign 0.03
IGL03356:Vmn1r34 APN 6 66636986 missense probably benign 0.00
R0508:Vmn1r34 UTSW 6 66637408 missense probably benign 0.19
R0601:Vmn1r34 UTSW 6 66637664 missense possibly damaging 0.94
R1381:Vmn1r34 UTSW 6 66636938 missense probably damaging 1.00
R1605:Vmn1r34 UTSW 6 66636948 missense probably benign 0.01
R1765:Vmn1r34 UTSW 6 66637496 missense probably damaging 0.99
R2022:Vmn1r34 UTSW 6 66637401 missense possibly damaging 0.90
R3878:Vmn1r34 UTSW 6 66637568 missense possibly damaging 0.82
R4023:Vmn1r34 UTSW 6 66637704 missense probably benign
R4024:Vmn1r34 UTSW 6 66637704 missense probably benign
R4025:Vmn1r34 UTSW 6 66637704 missense probably benign
R4026:Vmn1r34 UTSW 6 66637704 missense probably benign
R4385:Vmn1r34 UTSW 6 66637139 missense probably damaging 0.99
R5274:Vmn1r34 UTSW 6 66637139 missense probably damaging 1.00
R6182:Vmn1r34 UTSW 6 66637328 missense probably damaging 0.97
R6629:Vmn1r34 UTSW 6 66637515 missense probably benign 0.00
R7143:Vmn1r34 UTSW 6 66637664 missense probably benign 0.12
R7689:Vmn1r34 UTSW 6 66637010 nonsense probably null
R7956:Vmn1r34 UTSW 6 66637793 start gained probably benign
R8031:Vmn1r34 UTSW 6 66637181 missense probably damaging 1.00
X0066:Vmn1r34 UTSW 6 66637475 missense probably benign 0.02
Z1176:Vmn1r34 UTSW 6 66637125 nonsense probably null
Posted On2015-04-16