Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02486:Gpr108'

295424

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr108

Ensembl Gene

ENSMUSG00000005823

Gene Name

G protein-coupled receptor 108

Synonyms

1810015L19Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02486

Quality Score

Status

Chromosome

Chromosomal Location

57541635-57555446 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57542977 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 528 (N528S)

Ref Sequence

ENSEMBL: ENSMUSP00000005975 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000005975]

AlphaFold

Q91WD0

Predicted Effect

probably damaging
Transcript: ENSMUST00000005975
AA Change: N528S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000005975
Gene: ENSMUSG00000005823
AA Change: N528S

Domain	Start	End	E-Value	Type
low complexity region	61	75	N/A	INTRINSIC
low complexity region	86	103	N/A	INTRINSIC
Pfam:Lung_7-TM_R	240	529	2.3e-98	PFAM
low complexity region	535	547	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(3) : Targeted, other(2) Gene trapped(1)

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010106E10Rik	T	A	X: 111,424,955 (GRCm39)	N147K	probably benign	Het
Abtb3	C	A	10: 85,476,419 (GRCm39)	P900H	probably damaging	Het
Bcas1	T	C	2: 170,248,318 (GRCm39)	D201G	probably damaging	Het
Bmp1	T	A	14: 70,742,216 (GRCm39)	D333V	possibly damaging	Het
Capn6	T	C	X: 142,587,673 (GRCm39)	E535G	probably benign	Het
Cdin1	T	C	2: 115,607,487 (GRCm39)	V280A	possibly damaging	Het
Chac2	T	C	11: 30,927,625 (GRCm39)	D86G	probably damaging	Het
Col14a1	T	A	15: 55,252,092 (GRCm39)		probably benign	Het
Daam1	T	C	12: 71,993,919 (GRCm39)		probably benign	Het
Elapor2	T	A	5: 9,472,323 (GRCm39)	V340E	probably benign	Het
Eno4	A	G	19: 58,934,097 (GRCm39)		probably null	Het
Fat1	T	C	8: 45,478,109 (GRCm39)	V2385A	probably benign	Het
Ffar4	T	C	19: 38,102,208 (GRCm39)	I281T	possibly damaging	Het
Flcn	C	T	11: 59,691,869 (GRCm39)	W260*	probably null	Het
Fry	T	G	5: 150,414,642 (GRCm39)	S496A	probably damaging	Het
Gk	T	A	X: 84,759,274 (GRCm39)	I373F	possibly damaging	Het
Hey1	T	A	3: 8,731,579 (GRCm39)	R50W	probably damaging	Het
Hgf	A	G	5: 16,807,287 (GRCm39)	Y393C	probably damaging	Het
Hmcn2	A	T	2: 31,310,107 (GRCm39)	E3260D	probably damaging	Het
Ift172	A	G	5: 31,414,927 (GRCm39)	I1365T	probably damaging	Het
Letmd1	A	G	15: 100,372,992 (GRCm39)	R31G	probably damaging	Het
Mak16	T	C	8: 31,650,614 (GRCm39)		probably benign	Het
Mapkapk3	C	T	9: 107,166,467 (GRCm39)	G26D	probably damaging	Het
Mphosph8	T	C	14: 56,925,844 (GRCm39)	V603A	possibly damaging	Het
Myom1	G	T	17: 71,406,939 (GRCm39)		probably benign	Het
Neb	T	A	2: 52,172,615 (GRCm39)	N1564I	possibly damaging	Het
Nox1	C	T	X: 132,993,560 (GRCm39)	G433D	probably damaging	Het
Or11h6	T	C	14: 50,880,089 (GRCm39)	F111S	probably damaging	Het
Or2n1b	T	A	17: 38,460,112 (GRCm39)	L211Q	probably damaging	Het
Or51i2	T	C	7: 103,689,617 (GRCm39)	S205P	probably damaging	Het
Or52m1	A	T	7: 102,289,627 (GRCm39)	H58L	probably damaging	Het
Rcc2	T	C	4: 140,437,673 (GRCm39)	W135R	probably damaging	Het
Rgl2	A	G	17: 34,154,954 (GRCm39)	I205V	probably damaging	Het
Robo4	G	A	9: 37,319,670 (GRCm39)	G640E	probably damaging	Het
Slc26a5	A	G	5: 22,051,323 (GRCm39)	F64L	probably damaging	Het
Slc27a2	A	G	2: 126,395,270 (GRCm39)	T66A	probably benign	Het
St18	T	C	1: 6,890,307 (GRCm39)	S580P	probably damaging	Het
Syt15	G	A	14: 33,944,933 (GRCm39)	R160K	probably damaging	Het
Tmem63b	A	G	17: 45,984,909 (GRCm39)	S200P	probably damaging	Het
Tnks	T	A	8: 35,318,352 (GRCm39)	N841I	probably damaging	Het
Tnr	G	A	1: 159,679,664 (GRCm39)		probably null	Het
Unc13d	A	G	11: 115,960,632 (GRCm39)		probably benign	Het
Usp4	T	C	9: 108,228,228 (GRCm39)	L74P	probably damaging	Het

Other mutations in Gpr108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01982:Gpr108	APN	17	57,544,877 (GRCm39)	missense	probably damaging	1.00
IGL02810:Gpr108	APN	17	57,549,742 (GRCm39)	missense	probably benign	0.39
IGL03233:Gpr108	APN	17	57,552,042 (GRCm39)	missense	probably benign	0.00
1mM(1):Gpr108	UTSW	17	57,552,352 (GRCm39)	unclassified	probably benign
IGL02799:Gpr108	UTSW	17	57,544,482 (GRCm39)	missense	probably damaging	1.00
PIT4468001:Gpr108	UTSW	17	57,554,563 (GRCm39)	missense	probably null	0.09
R0391:Gpr108	UTSW	17	57,550,101 (GRCm39)	missense	probably benign	0.02
R0469:Gpr108	UTSW	17	57,542,358 (GRCm39)	missense	possibly damaging	0.65
R0510:Gpr108	UTSW	17	57,542,358 (GRCm39)	missense	possibly damaging	0.65
R0613:Gpr108	UTSW	17	57,545,174 (GRCm39)	splice site	probably benign
R1034:Gpr108	UTSW	17	57,542,995 (GRCm39)	missense	probably damaging	1.00
R1141:Gpr108	UTSW	17	57,544,219 (GRCm39)	missense	probably damaging	1.00
R1748:Gpr108	UTSW	17	57,543,217 (GRCm39)	missense	probably damaging	0.99
R2000:Gpr108	UTSW	17	57,543,712 (GRCm39)	missense	probably benign	0.03
R3036:Gpr108	UTSW	17	57,552,323 (GRCm39)	missense	probably benign	0.01
R4087:Gpr108	UTSW	17	57,544,925 (GRCm39)	missense	probably damaging	1.00
R4089:Gpr108	UTSW	17	57,544,925 (GRCm39)	missense	probably damaging	1.00
R5071:Gpr108	UTSW	17	57,542,335 (GRCm39)	missense	probably damaging	1.00
R5566:Gpr108	UTSW	17	57,543,919 (GRCm39)	missense	probably damaging	1.00
R6889:Gpr108	UTSW	17	57,543,990 (GRCm39)	missense	probably damaging	1.00
R7352:Gpr108	UTSW	17	57,543,944 (GRCm39)	missense	probably damaging	1.00
R7587:Gpr108	UTSW	17	57,543,732 (GRCm39)	missense	probably damaging	1.00
R7642:Gpr108	UTSW	17	57,543,228 (GRCm39)	nonsense	probably null
R9574:Gpr108	UTSW	17	57,545,039 (GRCm39)	missense	probably damaging	1.00
Z1177:Gpr108	UTSW	17	57,544,316 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16