Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02862:Ccdc163'

362207

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccdc163

Ensembl Gene

ENSMUSG00000028689

Gene Name

coiled-coil domain containing 163

Synonyms

4933430J04Rik, 0610037D15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02862

Quality Score

Status

Chromosome

Chromosomal Location

116565537-116572881 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 116569910 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030452] [ENSMUST00000030452] [ENSMUST00000030453] [ENSMUST00000106462] [ENSMUST00000106462] [ENSMUST00000106463] [ENSMUST00000106463] [ENSMUST00000106464] [ENSMUST00000106464] [ENSMUST00000125671] [ENSMUST00000155391] [ENSMUST00000135499] [ENSMUST00000130828] [ENSMUST00000138305]

AlphaFold

A2AGD7

Predicted Effect

probably null
Transcript: ENSMUST00000030452

SMART Domains

Protein: ENSMUSP00000030452
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
coiled coil region	112	144	N/A	INTRINSIC
coiled coil region	165	196	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000030452

SMART Domains

Protein: ENSMUSP00000030452
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
coiled coil region	112	144	N/A	INTRINSIC
coiled coil region	165	196	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000030453

SMART Domains

Protein: ENSMUSP00000030453
Gene: ENSMUSG00000028690

Domain	Start	End	E-Value	Type
Pfam:MMACHC	20	234	9.5e-102	PFAM
low complexity region	243	257	N/A	INTRINSIC
low complexity region	268	277	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106462

SMART Domains

Protein: ENSMUSP00000102070
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
coiled coil region	21	53	N/A	INTRINSIC
coiled coil region	74	105	N/A	INTRINSIC
low complexity region	171	186	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106462

SMART Domains

Protein: ENSMUSP00000102070
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
coiled coil region	21	53	N/A	INTRINSIC
coiled coil region	74	105	N/A	INTRINSIC
low complexity region	171	186	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106463

SMART Domains

Protein: ENSMUSP00000102071
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	50	60	N/A	INTRINSIC
coiled coil region	138	170	N/A	INTRINSIC
coiled coil region	191	222	N/A	INTRINSIC
low complexity region	288	303	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106463

SMART Domains

Protein: ENSMUSP00000102071
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	50	60	N/A	INTRINSIC
coiled coil region	138	170	N/A	INTRINSIC
coiled coil region	191	222	N/A	INTRINSIC
low complexity region	288	303	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106464

SMART Domains

Protein: ENSMUSP00000102072
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	50	60	N/A	INTRINSIC
coiled coil region	138	170	N/A	INTRINSIC
coiled coil region	191	222	N/A	INTRINSIC
low complexity region	288	303	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000106464

SMART Domains

Protein: ENSMUSP00000102072
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	50	60	N/A	INTRINSIC
coiled coil region	138	170	N/A	INTRINSIC
coiled coil region	191	222	N/A	INTRINSIC
low complexity region	288	303	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124628

Predicted Effect

probably benign
Transcript: ENSMUST00000125671

SMART Domains

Protein: ENSMUSP00000120954
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	50	60	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000155391

SMART Domains

Protein: ENSMUSP00000120050
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	49	59	N/A	INTRINSIC
coiled coil region	137	169	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134192

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126197

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143330

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129624

Predicted Effect

probably null
Transcript: ENSMUST00000156206

SMART Domains

Protein: ENSMUSP00000123645
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	32	42	N/A	INTRINSIC
low complexity region	58	73	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000135499

SMART Domains

Protein: ENSMUSP00000114263
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	63	73	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000130828

SMART Domains

Protein: ENSMUSP00000120572
Gene: ENSMUSG00000028689

Domain	Start	End	E-Value	Type
low complexity region	49	59	N/A	INTRINSIC
coiled coil region	137	169	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000138305

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn4	A	G	7: 28,611,659 (GRCm39)		probably benign	Het
Adhfe1	T	C	1: 9,624,036 (GRCm39)	L170P	probably damaging	Het
Adprh	C	T	16: 38,266,396 (GRCm39)	V249I	probably benign	Het
Akr1e1	T	C	13: 4,659,092 (GRCm39)	T11A	possibly damaging	Het
Arhgap23	A	G	11: 97,347,306 (GRCm39)	E668G	probably damaging	Het
Egfr	A	T	11: 16,833,562 (GRCm39)	Y610F	probably benign	Het
Ercc3	T	C	18: 32,376,255 (GRCm39)		probably null	Het
Fasn	G	T	11: 120,709,805 (GRCm39)	H417Q	possibly damaging	Het
Gjd2	A	G	2: 113,843,624 (GRCm39)		probably benign	Het
Grip2	C	T	6: 91,765,085 (GRCm39)	R59H	probably damaging	Het
H2bc11	C	T	13: 22,227,515 (GRCm39)	S39L	possibly damaging	Het
Ighv1-43	A	G	12: 114,909,859 (GRCm39)	V21A	probably damaging	Het
Ltbp1	G	A	17: 75,697,466 (GRCm39)	G1368D	probably damaging	Het
Mogs	G	T	6: 83,092,871 (GRCm39)	G104C	probably damaging	Het
Nfix	T	A	8: 85,440,475 (GRCm39)	T472S	probably benign	Het
Or5m9	T	C	2: 85,877,648 (GRCm39)	V274A	probably benign	Het
Ovch2	A	T	7: 107,394,138 (GRCm39)	V105E	probably damaging	Het
Pex1	G	T	5: 3,655,424 (GRCm39)		probably benign	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Prl7a1	T	C	13: 27,823,872 (GRCm39)	T70A	probably benign	Het
Shmt2	C	T	10: 127,354,743 (GRCm39)	R311Q	probably benign	Het
St3gal4	A	G	9: 34,963,543 (GRCm39)	I255T	probably benign	Het
Taf8	C	T	17: 47,805,339 (GRCm39)	A187T	probably damaging	Het
Tm6sf1	T	A	7: 81,520,504 (GRCm39)	V62D	probably damaging	Het
Trpm5	A	T	7: 142,636,262 (GRCm39)	W537R	probably damaging	Het
Vmn2r101	T	A	17: 19,831,867 (GRCm39)	L621H	probably damaging	Het

Other mutations in Ccdc163

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00906:Ccdc163	APN	4	116,567,487 (GRCm39)	splice site	probably null
IGL01389:Ccdc163	APN	4	116,568,503 (GRCm39)	unclassified	probably benign
R0780:Ccdc163	UTSW	4	116,569,604 (GRCm39)	missense	probably benign
R2035:Ccdc163	UTSW	4	116,568,530 (GRCm39)	missense	probably damaging	1.00
R2870:Ccdc163	UTSW	4	116,599,058 (GRCm39)	synonymous	silent
R3105:Ccdc163	UTSW	4	116,566,697 (GRCm39)	missense	probably benign	0.27
R4728:Ccdc163	UTSW	4	116,566,209 (GRCm39)	unclassified	probably benign
R4925:Ccdc163	UTSW	4	116,568,528 (GRCm39)	missense	possibly damaging	0.82
R5749:Ccdc163	UTSW	4	116,571,309 (GRCm39)	nonsense	probably null
R6529:Ccdc163	UTSW	4	116,566,121 (GRCm39)	splice site	probably null
R6651:Ccdc163	UTSW	4	116,566,261 (GRCm39)	missense	possibly damaging	0.87
R8306:Ccdc163	UTSW	4	116,567,472 (GRCm39)	missense	probably damaging	1.00
R8700:Ccdc163	UTSW	4	116,571,348 (GRCm39)	critical splice donor site	probably null
R8840:Ccdc163	UTSW	4	116,567,483 (GRCm39)	critical splice donor site	probably null
R9723:Ccdc163	UTSW	4	116,569,595 (GRCm39)	nonsense	probably null

Posted On

2015-12-18