Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02976:Or4d11'

406364

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4d11

Ensembl Gene

ENSMUSG00000067529

Gene Name

olfactory receptor family 4 subfamily D member 11

Synonyms

MOR239-3, GA_x6K02T2RE5P-2393361-2392429, Olfr1423

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.373) question?

Stock #

IGL02976

Quality Score

Status

Chromosome

Chromosomal Location

12013172-12014104 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 12013337 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 256 (Y256*)

Ref Sequence

ENSEMBL: ENSMUSP00000150649 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087831] [ENSMUST00000214472]

AlphaFold

Q8VFV0

Predicted Effect

probably null
Transcript: ENSMUST00000087831
AA Change: Y256*

SMART Domains

Protein: ENSMUSP00000085134
Gene: ENSMUSG00000067529
AA Change: Y256*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	304	2.7e-48	PFAM
Pfam:7tm_1	41	287	2.5e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207831

Predicted Effect

probably null
Transcript: ENSMUST00000214472
AA Change: Y256*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9630041A04Rik	A	G	9: 101,816,845 (GRCm39)	T84A	possibly damaging	Het
Adgrd1	T	A	5: 129,208,661 (GRCm39)	S288T	probably benign	Het
Ano7	T	A	1: 93,330,395 (GRCm39)	D806E	possibly damaging	Het
Arl6	A	G	16: 59,444,259 (GRCm39)	L79P	probably damaging	Het
Card6	A	T	15: 5,129,310 (GRCm39)	C695*	probably null	Het
Carmil1	T	C	13: 24,276,534 (GRCm39)	N610S	possibly damaging	Het
Cdc40	A	G	10: 40,758,917 (GRCm39)	V52A	probably benign	Het
Chd4	G	A	6: 125,098,331 (GRCm39)	R369H	probably damaging	Het
Clasp2	C	T	9: 113,735,204 (GRCm39)	P1031L	probably damaging	Het
Cldn34d	C	T	X: 75,626,690 (GRCm39)	A121T	probably benign	Het
Clmp	A	C	9: 40,692,520 (GRCm39)	Y263S	possibly damaging	Het
Cntn5	A	G	9: 10,419,104 (GRCm39)		probably benign	Het
Folh1	A	T	7: 86,412,126 (GRCm39)	M215K	probably benign	Het
Fut1	C	T	7: 45,268,744 (GRCm39)	R233C	probably damaging	Het
Gcdh	A	C	8: 85,615,207 (GRCm39)	Y398D	probably damaging	Het
Gm26741	T	G	10: 52,234,910 (GRCm39)	S16R	possibly damaging	Het
Jph3	T	A	8: 122,479,823 (GRCm39)	L167Q	probably damaging	Het
Jup	A	G	11: 100,269,192 (GRCm39)	V407A	probably benign	Het
Kif17	C	T	4: 137,996,374 (GRCm39)	A117V	probably damaging	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Magi2	C	T	5: 20,739,473 (GRCm39)	P349S	probably damaging	Het
Mlycd	T	C	8: 120,128,224 (GRCm39)	M177T	possibly damaging	Het
Mocos	A	G	18: 24,799,626 (GRCm39)	K287E	possibly damaging	Het
Morc2b	T	A	17: 33,356,497 (GRCm39)	H425L	possibly damaging	Het
Mrpl9	T	A	3: 94,355,084 (GRCm39)		probably benign	Het
Myo3a	G	A	2: 22,434,494 (GRCm39)	W825*	probably null	Het
Npas2	T	C	1: 39,326,565 (GRCm39)	S17P	probably damaging	Het
Nrk	A	G	X: 137,892,817 (GRCm39)	I1174V	probably benign	Het
Or1e32	A	G	11: 73,705,143 (GRCm39)	I255T	probably damaging	Het
Or4k2	G	A	14: 50,423,889 (GRCm39)	Q262*	probably null	Het
Parpbp	A	G	10: 87,947,456 (GRCm39)		probably null	Het
Pcdh10	T	C	3: 45,334,448 (GRCm39)	V254A	possibly damaging	Het
Plod1	C	T	4: 147,997,778 (GRCm39)	V644I	probably damaging	Het
Ptpn1	T	C	2: 167,813,704 (GRCm39)	V149A	probably benign	Het
Rassf4	T	C	6: 116,615,209 (GRCm39)	E320G	probably damaging	Het
Rgl2	T	A	17: 34,152,936 (GRCm39)	D448E	possibly damaging	Het
Rnf32	C	T	5: 29,411,710 (GRCm39)		probably null	Het
Rpa1	T	A	11: 75,203,628 (GRCm39)	D358V	probably damaging	Het
Sdk2	T	C	11: 113,742,668 (GRCm39)	N747S	probably damaging	Het
Slc17a4	A	C	13: 24,089,407 (GRCm39)	M170R	probably damaging	Het
Slc5a4a	G	A	10: 76,006,527 (GRCm39)	V310M	possibly damaging	Het
Spag9	G	A	11: 93,974,779 (GRCm39)	R463H	probably benign	Het
Spmip5	A	T	19: 58,777,552 (GRCm39)	V78E	probably benign	Het
Stxbp2	A	T	8: 3,691,971 (GRCm39)	I538F	probably benign	Het
Syt10	A	G	15: 89,698,682 (GRCm39)	S221P	probably benign	Het
Tlk1	T	A	2: 70,551,935 (GRCm39)	K579*	probably null	Het
Tubgcp3	T	C	8: 12,682,300 (GRCm39)	Y673C	probably damaging	Het
Vmn1r223	T	C	13: 23,434,165 (GRCm39)	F253S	probably damaging	Het
Vmn2r83	T	C	10: 79,304,832 (GRCm39)	M14T	probably benign	Het
Zfp59	A	G	7: 27,552,821 (GRCm39)	D91G	probably benign	Het

Other mutations in Or4d11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01333:Or4d11	APN	19	12,013,305 (GRCm39)	missense	probably benign	0.36
IGL01843:Or4d11	APN	19	12,014,041 (GRCm39)	missense	probably benign
IGL01915:Or4d11	APN	19	12,013,461 (GRCm39)	missense	probably damaging	1.00
IGL02283:Or4d11	APN	19	12,013,219 (GRCm39)	missense	possibly damaging	0.87
IGL02807:Or4d11	APN	19	12,013,648 (GRCm39)	missense	probably benign	0.12
IGL03142:Or4d11	APN	19	12,013,752 (GRCm39)	missense	probably damaging	1.00
R0326:Or4d11	UTSW	19	12,013,525 (GRCm39)	missense	probably benign	0.00
R0369:Or4d11	UTSW	19	12,013,765 (GRCm39)	missense	probably benign	0.01
R0614:Or4d11	UTSW	19	12,013,929 (GRCm39)	missense	possibly damaging	0.93
R1940:Or4d11	UTSW	19	12,013,275 (GRCm39)	missense	probably benign	0.06
R1978:Or4d11	UTSW	19	12,013,705 (GRCm39)	missense	probably benign	0.06
R2013:Or4d11	UTSW	19	12,013,518 (GRCm39)	missense	probably damaging	1.00
R2179:Or4d11	UTSW	19	12,013,452 (GRCm39)	missense	probably damaging	1.00
R3972:Or4d11	UTSW	19	12,013,383 (GRCm39)	missense	probably damaging	0.98
R5051:Or4d11	UTSW	19	12,013,288 (GRCm39)	missense	possibly damaging	0.88
R5484:Or4d11	UTSW	19	12,013,192 (GRCm39)	missense	probably benign	0.01
R5518:Or4d11	UTSW	19	12,013,429 (GRCm39)	missense	probably damaging	0.97
R5729:Or4d11	UTSW	19	12,013,272 (GRCm39)	missense	probably damaging	0.99
R6151:Or4d11	UTSW	19	12,014,100 (GRCm39)	missense	probably benign	0.00
R6708:Or4d11	UTSW	19	12,014,103 (GRCm39)	start codon destroyed	probably null	1.00
R6723:Or4d11	UTSW	19	12,013,639 (GRCm39)	missense	probably damaging	1.00
R7103:Or4d11	UTSW	19	12,013,752 (GRCm39)	missense	probably damaging	0.99
R7385:Or4d11	UTSW	19	12,013,363 (GRCm39)	missense	probably benign	0.39

Posted On

2016-08-02