Incidental Mutation 'IGL02976:Olfr1423'
ID406364
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1423
Ensembl Gene ENSMUSG00000067529
Gene Nameolfactory receptor 1423
SynonymsMOR239-3, GA_x6K02T2RE5P-2393361-2392429
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.349) question?
Stock #IGL02976
Quality Score
Status
Chromosome19
Chromosomal Location12031787-12041317 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 12035973 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 256 (Y256*)
Ref Sequence ENSEMBL: ENSMUSP00000150649 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087831] [ENSMUST00000214472]
Predicted Effect probably null
Transcript: ENSMUST00000087831
AA Change: Y256*
SMART Domains Protein: ENSMUSP00000085134
Gene: ENSMUSG00000067529
AA Change: Y256*

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 2.7e-48 PFAM
Pfam:7tm_1 41 287 2.5e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207831
Predicted Effect probably null
Transcript: ENSMUST00000214472
AA Change: Y256*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019N19Rik A T 19: 58,789,120 V78E probably benign Het
9630041A04Rik A G 9: 101,939,646 T84A possibly damaging Het
Adgrd1 T A 5: 129,131,597 S288T probably benign Het
Ano7 T A 1: 93,402,673 D806E possibly damaging Het
Arl6 A G 16: 59,623,896 L79P probably damaging Het
Card6 A T 15: 5,099,828 C695* probably null Het
Carmil1 T C 13: 24,092,551 N610S possibly damaging Het
Cdc40 A G 10: 40,882,921 V52A probably benign Het
Chd4 G A 6: 125,121,368 R369H probably damaging Het
Clasp2 C T 9: 113,906,136 P1031L probably damaging Het
Cldn34d C T X: 76,583,084 A121T probably benign Het
Clmp A C 9: 40,781,224 Y263S possibly damaging Het
Cntn5 A G 9: 10,419,099 probably benign Het
Folh1 A T 7: 86,762,918 M215K probably benign Het
Fut1 C T 7: 45,619,320 R233C probably damaging Het
Gcdh A C 8: 84,888,578 Y398D probably damaging Het
Gm26741 T G 10: 52,358,814 S16R possibly damaging Het
Jph3 T A 8: 121,753,084 L167Q probably damaging Het
Jup A G 11: 100,378,366 V407A probably benign Het
Kif17 C T 4: 138,269,063 A117V probably damaging Het
Lyl1 C T 8: 84,702,671 P3L possibly damaging Het
Magi2 C T 5: 20,534,475 P349S probably damaging Het
Mlycd T C 8: 119,401,485 M177T possibly damaging Het
Mocos A G 18: 24,666,569 K287E possibly damaging Het
Morc2b T A 17: 33,137,523 H425L possibly damaging Het
Mrpl9 T A 3: 94,447,777 probably benign Het
Myo3a G A 2: 22,542,452 W825* probably null Het
Npas2 T C 1: 39,287,484 S17P probably damaging Het
Nrk A G X: 138,992,068 I1174V probably benign Het
Olfr392 A G 11: 73,814,317 I255T probably damaging Het
Olfr730 G A 14: 50,186,432 Q262* probably null Het
Parpbp A G 10: 88,111,594 probably null Het
Pcdh10 T C 3: 45,380,013 V254A possibly damaging Het
Plod1 C T 4: 147,913,321 V644I probably damaging Het
Ptpn1 T C 2: 167,971,784 V149A probably benign Het
Rassf4 T C 6: 116,638,248 E320G probably damaging Het
Rgl2 T A 17: 33,933,962 D448E possibly damaging Het
Rnf32 C T 5: 29,206,712 probably null Het
Rpa1 T A 11: 75,312,802 D358V probably damaging Het
Sdk2 T C 11: 113,851,842 N747S probably damaging Het
Slc17a4 A C 13: 23,905,424 M170R probably damaging Het
Slc5a4a G A 10: 76,170,693 V310M possibly damaging Het
Spag9 G A 11: 94,083,953 R463H probably benign Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Syt10 A G 15: 89,814,479 S221P probably benign Het
Tlk1 T A 2: 70,721,591 K579* probably null Het
Tubgcp3 T C 8: 12,632,300 Y673C probably damaging Het
Vmn1r223 T C 13: 23,249,995 F253S probably damaging Het
Vmn2r83 T C 10: 79,468,998 M14T probably benign Het
Zfp59 A G 7: 27,853,396 D91G probably benign Het
Other mutations in Olfr1423
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01333:Olfr1423 APN 19 12035941 missense probably benign 0.36
IGL01843:Olfr1423 APN 19 12036677 missense probably benign
IGL01915:Olfr1423 APN 19 12036097 missense probably damaging 1.00
IGL02283:Olfr1423 APN 19 12035855 missense possibly damaging 0.87
IGL02807:Olfr1423 APN 19 12036284 missense probably benign 0.12
IGL03142:Olfr1423 APN 19 12036388 missense probably damaging 1.00
R0326:Olfr1423 UTSW 19 12036161 missense probably benign 0.00
R0369:Olfr1423 UTSW 19 12036401 missense probably benign 0.01
R0614:Olfr1423 UTSW 19 12036565 missense possibly damaging 0.93
R1940:Olfr1423 UTSW 19 12035911 missense probably benign 0.06
R1978:Olfr1423 UTSW 19 12036341 missense probably benign 0.06
R2013:Olfr1423 UTSW 19 12036154 missense probably damaging 1.00
R2179:Olfr1423 UTSW 19 12036088 missense probably damaging 1.00
R3972:Olfr1423 UTSW 19 12036019 missense probably damaging 0.98
R5051:Olfr1423 UTSW 19 12035924 missense possibly damaging 0.88
R5484:Olfr1423 UTSW 19 12035828 missense probably benign 0.01
R5518:Olfr1423 UTSW 19 12036065 missense probably damaging 0.97
R5729:Olfr1423 UTSW 19 12035908 missense probably damaging 0.99
R6151:Olfr1423 UTSW 19 12036736 missense probably benign 0.00
R6708:Olfr1423 UTSW 19 12036739 start codon destroyed probably null 1.00
R6723:Olfr1423 UTSW 19 12036275 missense probably damaging 1.00
R7103:Olfr1423 UTSW 19 12036388 missense probably damaging 0.99
R7385:Olfr1423 UTSW 19 12035999 missense probably benign 0.39
Posted On2016-08-02