Incidental Mutation 'IGL03133:Eno1'
ID410420
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Eno1
Ensembl Gene ENSMUSG00000063524
Gene Nameenolase 1, alpha non-neuron
Synonymsalpha-enolase, 2-phospho-D-glycerate hydrolase, Eno-1, MBP-1, c-Myc promoter binding protein
Accession Numbers

Genbank: NM_023119

Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL03133
Quality Score
Status
Chromosome4
Chromosomal Location150236721-150248879 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to G at 150245344 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000123695 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080149] [ENSMUST00000080926] [ENSMUST00000133839] [ENSMUST00000141931] [ENSMUST00000150175]
Predicted Effect probably benign
Transcript: ENSMUST00000080149
SMART Domains Protein: ENSMUSP00000079045
Gene: ENSMUSG00000063524

DomainStartEndE-ValueType
Enolase_N 1 66 2.91e-6 SMART
Enolase_C 74 363 1.22e-207 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000080926
SMART Domains Protein: ENSMUSP00000079727
Gene: ENSMUSG00000063524

DomainStartEndE-ValueType
Enolase_N 3 134 4.75e-91 SMART
Enolase_C 142 431 1.22e-207 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130632
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133789
Predicted Effect probably benign
Transcript: ENSMUST00000133839
SMART Domains Protein: ENSMUSP00000114361
Gene: ENSMUSG00000063524

DomainStartEndE-ValueType
Enolase_N 3 134 7.66e-86 SMART
Enolase_C 142 221 2e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135063
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136310
Predicted Effect probably benign
Transcript: ENSMUST00000141931
SMART Domains Protein: ENSMUSP00000120059
Gene: ENSMUSG00000063524

DomainStartEndE-ValueType
Enolase_N 3 67 6.31e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150175
SMART Domains Protein: ENSMUSP00000123695
Gene: ENSMUSG00000063524

DomainStartEndE-ValueType
Enolase_N 3 119 2.31e-71 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151057
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous animals exhibit growth arrest and embryonic lethality at approximately E6.5. [provided by MGI curators]
Allele List at MGI

All alleles(59) : Targeted, knock-out(1) Gene trapped(58)

Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adarb1 T C 10: 77,325,896 probably benign Het
Ano5 C T 7: 51,576,512 R505* probably null Het
Asphd1 A G 7: 126,948,280 C284R possibly damaging Het
Cep192 T A 18: 67,810,105 W158R probably benign Het
Ces2h T A 8: 105,016,779 D188E probably damaging Het
Dab1 G A 4: 104,727,580 V306I probably benign Het
Dcc A G 18: 71,262,955 probably benign Het
Dennd6b T A 15: 89,188,523 probably null Het
Dmwd T A 7: 19,076,637 V123D probably damaging Het
Fat2 G A 11: 55,286,043 T1542I probably benign Het
Fcrl1 T C 3: 87,389,392 S274P probably benign Het
Gmpr T C 13: 45,517,018 V72A probably benign Het
Kank2 T C 9: 21,795,641 E27G probably null Het
Mtor G T 4: 148,484,319 A1099S probably benign Het
Ofcc1 T C 13: 40,072,768 I763V probably benign Het
Olfr1023 G T 2: 85,887,134 E111D probably damaging Het
Olfr1065 A G 2: 86,445,658 I108T probably damaging Het
Olfr487 G T 7: 108,212,387 S47R possibly damaging Het
Olfr870 T A 9: 20,170,713 N286I probably damaging Het
Piwil1 C A 5: 128,742,029 H201N probably benign Het
Slc26a7 C T 4: 14,532,576 V433M possibly damaging Het
Spata31d1c T C 13: 65,034,985 Y114H probably benign Het
Stx7 A T 10: 24,185,038 N221I probably damaging Het
Tbc1d31 A T 15: 57,942,459 probably benign Het
Ubxn7 T G 16: 32,381,781 L393R probably damaging Het
Vit A T 17: 78,566,071 M59L probably benign Het
Vmn1r5 T A 6: 56,985,615 C92S probably benign Het
Other mutations in Eno1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01767:Eno1 APN 4 150246710 missense probably benign 0.03
IGL01992:Eno1 APN 4 150239536 missense probably damaging 1.00
IGL03114:Eno1 APN 4 150241126 missense probably benign 0.01
B5639:Eno1 UTSW 4 150245112 unclassified probably benign
R1387:Eno1 UTSW 4 150248133 unclassified probably benign
R1957:Eno1 UTSW 4 150246775 splice site probably null
R3835:Eno1 UTSW 4 150246662 missense probably benign 0.08
R3925:Eno1 UTSW 4 150239568 critical splice donor site probably null
R4178:Eno1 UTSW 4 150244033 missense possibly damaging 0.94
R5577:Eno1 UTSW 4 150246610 nonsense probably null
R5790:Eno1 UTSW 4 150245253 missense probably benign 0.01
R6369:Eno1 UTSW 4 150239568 critical splice donor site probably null
R6377:Eno1 UTSW 4 150248552 missense possibly damaging 0.78
R7305:Eno1 UTSW 4 150245339 critical splice donor site probably null
R8116:Eno1 UTSW 4 150241069 missense probably damaging 0.97
R8342:Eno1 UTSW 4 150245236 missense probably damaging 1.00
Posted On2016-08-02