Incidental Mutation 'IGL03154:Olfr549'
ID411197
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr549
Ensembl Gene ENSMUSG00000073977
Gene Nameolfactory receptor 549
SynonymsMOR31-3, GA_x6K02T2PBJ9-5274337-5275287
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL03154
Quality Score
Status
Chromosome7
Chromosomal Location102549870-102555842 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 102554706 bp
ZygosityHeterozygous
Amino Acid Change Valine to Leucine at position 141 (V141L)
Ref Sequence ENSEMBL: ENSMUSP00000150373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033264] [ENSMUST00000098227] [ENSMUST00000106913] [ENSMUST00000217478]
Predicted Effect probably benign
Transcript: ENSMUST00000033264
SMART Domains Protein: ENSMUSP00000033264
Gene: ENSMUSG00000030966

DomainStartEndE-ValueType
RING 12 50 6e-8 SMART
BBOX 83 124 2.71e-15 SMART
coiled coil region 184 242 N/A INTRINSIC
PRY 282 334 1.08e-23 SMART
SPRY 335 461 8.9e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000098227
AA Change: V141L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000095829
Gene: ENSMUSG00000073977
AA Change: V141L

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 1.7e-105 PFAM
Pfam:7TM_GPCR_Srsx 37 225 1.2e-11 PFAM
Pfam:7tm_1 43 294 1e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106913
SMART Domains Protein: ENSMUSP00000102526
Gene: ENSMUSG00000030966

DomainStartEndE-ValueType
RING 12 50 6e-8 SMART
BBOX 83 124 2.71e-15 SMART
coiled coil region 184 242 N/A INTRINSIC
PRY 282 334 1.08e-23 SMART
SPRY 335 461 8.9e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000217478
AA Change: V141L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a1 A G 19: 20,630,768 E318G probably benign Het
Alpi A T 1: 87,100,088 W257R probably damaging Het
Arap2 T C 5: 62,642,925 E1253G probably damaging Het
Fam208b A T 13: 3,575,255 M1565K possibly damaging Het
Fbxw13 G T 9: 109,181,465 F368L probably damaging Het
Gm7030 T A 17: 36,127,875 N208I probably benign Het
Herc2 T A 7: 56,202,159 D3655E probably damaging Het
Hkdc1 T A 10: 62,385,705 D858V probably damaging Het
Ifi205 A C 1: 174,017,666 probably benign Het
Ighv10-3 T A 12: 114,523,887 M1L probably benign Het
Igkv4-90 C T 6: 68,807,272 G87R probably damaging Het
Insc G A 7: 114,842,189 G413S probably null Het
Iqch T A 9: 63,454,682 T850S probably damaging Het
Kcnd2 A G 6: 21,216,708 Y137C probably damaging Het
Lhx6 A T 2: 36,094,443 probably null Het
Lrp2 A G 2: 69,549,042 S109P probably damaging Het
Mroh1 T C 15: 76,452,838 L1617P probably damaging Het
Olfr346 A T 2: 36,688,643 I214F possibly damaging Het
Olfr464 A T 11: 87,914,246 V220D possibly damaging Het
Olfr739 A T 14: 50,424,623 I35F probably benign Het
Prex2 T C 1: 11,153,633 V727A possibly damaging Het
Ralgapb A G 2: 158,432,866 H229R probably damaging Het
Rusc2 G A 4: 43,425,806 G1304S probably benign Het
Sbsn A G 7: 30,751,728 N56S possibly damaging Het
Skint8 T A 4: 111,939,510 probably null Het
Uso1 C A 5: 92,180,618 S358* probably null Het
Other mutations in Olfr549
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Olfr549 APN 7 102554891 missense probably damaging 1.00
IGL02048:Olfr549 APN 7 102554883 missense probably damaging 1.00
IGL02314:Olfr549 APN 7 102555111 missense probably damaging 1.00
R0783:Olfr549 UTSW 7 102554439 missense probably benign 0.01
R2009:Olfr549 UTSW 7 102554944 missense probably damaging 1.00
R2145:Olfr549 UTSW 7 102555060 splice site probably null
R3547:Olfr549 UTSW 7 102554470 missense probably damaging 1.00
R6843:Olfr549 UTSW 7 102554721 missense probably benign
R7294:Olfr549 UTSW 7 102554953 missense probably damaging 1.00
R7533:Olfr549 UTSW 7 102554511 missense probably damaging 1.00
X0018:Olfr549 UTSW 7 102554728 missense probably benign 0.00
Z1177:Olfr549 UTSW 7 102554971 missense probably benign
Posted On2016-08-02