Incidental Mutation 'IGL03241:Zfp114'
ID414291
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp114
Ensembl Gene ENSMUSG00000068962
Gene Namezinc finger protein 114
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL03241
Quality Score
Status
Chromosome7
Chromosomal Location24175060-24183188 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 24181012 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 261 (T261I)
Ref Sequence ENSEMBL: ENSMUSP00000145971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086010] [ENSMUST00000205309] [ENSMUST00000206547]
Predicted Effect probably benign
Transcript: ENSMUST00000086010
AA Change: T262I

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000083173
Gene: ENSMUSG00000068962
AA Change: T262I

DomainStartEndE-ValueType
KRAB 8 68 1.38e-17 SMART
low complexity region 158 168 N/A INTRINSIC
ZnF_C2H2 306 328 6.57e-1 SMART
ZnF_C2H2 334 356 1.95e-3 SMART
ZnF_C2H2 362 384 2.36e-2 SMART
ZnF_C2H2 390 412 3.16e-3 SMART
ZnF_C2H2 418 440 2.84e-5 SMART
ZnF_C2H2 446 468 4.87e-4 SMART
ZnF_C2H2 474 496 2.24e-3 SMART
ZnF_C2H2 502 524 7.37e-4 SMART
ZnF_C2H2 530 552 1.6e-4 SMART
ZnF_C2H2 558 580 2.36e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205309
AA Change: T261I

PolyPhen 2 Score 0.144 (Sensitivity: 0.92; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000206547
AA Change: T261I

PolyPhen 2 Score 0.132 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933417A18Rik G T 13: 34,944,330 A177S probably damaging Het
Abcc12 T A 8: 86,509,807 E1126V possibly damaging Het
Acnat1 A G 4: 49,447,702 V275A probably benign Het
Adamts15 G A 9: 30,904,485 P692S probably damaging Het
Aqp7 A T 4: 41,045,270 probably benign Het
Arhgap26 A T 18: 39,229,917 I413F probably damaging Het
Cdc25a T C 9: 109,884,199 probably null Het
Cdh18 C T 15: 23,226,933 T160I probably benign Het
Cfap206 T C 4: 34,711,553 Y448C probably damaging Het
Clec4a4 T C 6: 122,990,373 S3P probably damaging Het
Dhx38 A T 8: 109,562,656 H37Q possibly damaging Het
F7 A T 8: 13,028,779 E70V probably damaging Het
Nbeal1 G A 1: 60,234,869 E419K probably benign Het
Nbeal1 A T 1: 60,234,868 Q418H possibly damaging Het
Nebl A G 2: 17,393,164 probably null Het
Olfr725 T A 14: 50,035,068 M112L possibly damaging Het
Pfkm T C 15: 98,123,180 V293A probably benign Het
Slc36a3 A G 11: 55,125,108 S407P possibly damaging Het
Slc5a1 T C 5: 33,133,405 V111A probably benign Het
St6galnac5 G T 3: 152,846,586 Q115K probably benign Het
Timmdc1 G A 16: 38,510,709 probably benign Het
Trim34b T C 7: 104,334,613 probably benign Het
Trim75 A T 8: 64,982,706 I364N probably damaging Het
Vmn1r27 T A 6: 58,215,141 N293Y probably benign Het
Vmn2r88 A G 14: 51,418,373 T689A probably benign Het
Vmn2r97 T C 17: 18,928,176 V111A probably benign Het
Zfp516 A G 18: 82,987,520 T850A probably benign Het
Other mutations in Zfp114
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0139:Zfp114 UTSW 7 24181260 missense possibly damaging 0.69
R1443:Zfp114 UTSW 7 24177769 missense probably damaging 1.00
R1793:Zfp114 UTSW 7 24177739 splice site probably null
R2169:Zfp114 UTSW 7 24181084 missense probably benign 0.04
R3928:Zfp114 UTSW 7 24181042 missense possibly damaging 0.93
R4915:Zfp114 UTSW 7 24177865 missense probably damaging 1.00
R6468:Zfp114 UTSW 7 24177781 missense possibly damaging 0.94
R7102:Zfp114 UTSW 7 24180658 missense possibly damaging 0.84
R7480:Zfp114 UTSW 7 24181882 missense probably damaging 1.00
R7847:Zfp114 UTSW 7 24181035 missense possibly damaging 0.67
X0026:Zfp114 UTSW 7 24180405 missense possibly damaging 0.92
X0061:Zfp114 UTSW 7 24180460 missense probably benign 0.02
Posted On2016-08-02