Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01025:Or6c205'

60181

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6c205

Ensembl Gene

ENSMUSG00000096220

Gene Name

olfactory receptor family 6 subfamily C member 205

Synonyms

Olfr1518, MOR111-6, MOR111-7, MOR111-7, GA_x6K02T2PULF-10936819-10937757, Olfr775

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01025

Quality Score

Status

Chromosome

Chromosomal Location

129086405-129087343 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 129086609 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 69 (I69F)

Ref Sequence

ENSEMBL: ENSMUSP00000150345 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097163] [ENSMUST00000214109]

AlphaFold

Q7TRI4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000097163
AA Change: I69F

PolyPhen 2 Score 0.791 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000132845
Gene: ENSMUSG00000096220
AA Change: I69F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	9.9e-52	PFAM
Pfam:7tm_1	39	288	9.1e-19	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000214109
AA Change: I69F

PolyPhen 2 Score 0.791 (Sensitivity: 0.85; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acap3	G	A	4: 155,986,676 (GRCm39)	V335M	probably damaging	Het
Apex1	C	T	14: 51,163,711 (GRCm39)	L113F	possibly damaging	Het
Bltp1	T	A	3: 37,100,429 (GRCm39)	H1218Q	possibly damaging	Het
Cd33	C	T	7: 43,182,329 (GRCm39)	V39M	probably damaging	Het
Chek2	A	G	5: 110,996,536 (GRCm39)	D166G	probably damaging	Het
Col2a1	T	C	15: 97,874,054 (GRCm39)	K1376R	unknown	Het
Cpd	C	T	11: 76,686,439 (GRCm39)	R963H	probably damaging	Het
Cracd	A	G	5: 76,805,921 (GRCm39)		probably benign	Het
Cyp2c67	A	C	19: 39,628,376 (GRCm39)	Y189*	probably null	Het
Dock6	T	C	9: 21,723,103 (GRCm39)	E1606G	possibly damaging	Het
Dusp4	A	T	8: 35,285,666 (GRCm39)	E309V	probably benign	Het
Dync2h1	A	G	9: 7,162,789 (GRCm39)	I600T	probably damaging	Het
Fer1l4	A	G	2: 155,894,105 (GRCm39)	V66A	probably benign	Het
Fktn	T	C	4: 53,737,568 (GRCm39)	L269P	possibly damaging	Het
Ftsj3	A	G	11: 106,141,185 (GRCm39)	I645T	probably damaging	Het
Fxr2	A	G	11: 69,534,713 (GRCm39)	H198R	probably damaging	Het
Fzd7	T	C	1: 59,523,539 (GRCm39)	V474A	probably damaging	Het
Gm10295	T	A	7: 71,000,406 (GRCm39)	D58V	unknown	Het
Hdlbp	T	C	1: 93,357,891 (GRCm39)	I337V	probably benign	Het
Hydin	T	C	8: 111,053,033 (GRCm39)	V235A	probably benign	Het
Igfbp4	C	T	11: 98,939,069 (GRCm39)	H30Y	probably damaging	Het
Kcna4	T	C	2: 107,126,736 (GRCm39)	V490A	probably damaging	Het
Kcnj13	T	G	1: 87,314,700 (GRCm39)	D174A	probably benign	Het
Krt7	T	A	15: 101,321,302 (GRCm39)	L373Q	probably benign	Het
Lama3	G	A	18: 12,614,094 (GRCm39)	V1288I	probably benign	Het
Mroh9	T	C	1: 162,875,435 (GRCm39)	D488G	possibly damaging	Het
Myh7	T	C	14: 55,216,994 (GRCm39)	E1121G	probably damaging	Het
Myom1	A	G	17: 71,384,912 (GRCm39)	N768D	probably damaging	Het
Naa16	T	C	14: 79,622,196 (GRCm39)	T48A	probably damaging	Het
Naglu	C	T	11: 100,964,773 (GRCm39)	P287S	probably benign	Het
Nipbl	A	G	15: 8,379,939 (GRCm39)	V951A	possibly damaging	Het
Nlrp3	T	A	11: 59,442,713 (GRCm39)	M755K	probably benign	Het
Nlrp4e	T	C	7: 23,052,586 (GRCm39)		probably benign	Het
Nt5dc1	C	T	10: 34,283,553 (GRCm39)	A79T	possibly damaging	Het
Or10aa3	T	C	1: 173,878,251 (GRCm39)	F104S	probably damaging	Het
Or8b47	A	G	9: 38,435,029 (GRCm39)		probably benign	Het
Otof	A	G	5: 30,541,597 (GRCm39)	L774P	possibly damaging	Het
Phf20l1	C	T	15: 66,484,981 (GRCm39)	R322C	probably damaging	Het
Pkhd1	C	T	1: 20,279,400 (GRCm39)	G2973R	probably benign	Het
Plekhg5	G	T	4: 152,192,983 (GRCm39)	D613Y	probably damaging	Het
Ppm1h	T	A	10: 122,714,534 (GRCm39)		probably null	Het
Pramel31	T	A	4: 144,089,947 (GRCm39)	L329Q	probably damaging	Het
Prpf39	T	C	12: 65,089,255 (GRCm39)		probably benign	Het
Rtn3	A	G	19: 7,460,406 (GRCm39)	S15P	unknown	Het
Slc22a28	G	T	19: 8,094,272 (GRCm39)		probably benign	Het
Slc4a5	T	A	6: 83,239,515 (GRCm39)	L143Q	probably damaging	Het
Sox17	T	C	1: 4,562,426 (GRCm39)	D130G	possibly damaging	Het
Stag1	A	G	9: 100,833,710 (GRCm39)	T1108A	possibly damaging	Het
Sugp2	G	A	8: 70,695,185 (GRCm39)	D53N	probably damaging	Het
Trim33	G	A	3: 103,261,234 (GRCm39)		probably benign	Het
Ttn	A	G	2: 76,629,568 (GRCm39)	I14291T	probably damaging	Het
Ttn	A	G	2: 76,619,869 (GRCm39)	V15933A	probably damaging	Het
Tulp3	A	C	6: 128,302,847 (GRCm39)	I324S	probably damaging	Het
Zfhx2	T	C	14: 55,301,717 (GRCm39)	E2089G	probably damaging	Het
Zhx1	T	C	15: 57,918,075 (GRCm39)	D57G	probably benign	Het

Other mutations in Or6c205

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01310:Or6c205	APN	10	129,086,865 (GRCm39)	missense	possibly damaging	0.85
IGL02185:Or6c205	APN	10	129,086,904 (GRCm39)	missense	possibly damaging	0.60
IGL02887:Or6c205	APN	10	129,086,794 (GRCm39)	nonsense	probably null
R0584:Or6c205	UTSW	10	129,086,817 (GRCm39)	missense	probably benign	0.01
R1482:Or6c205	UTSW	10	129,087,012 (GRCm39)	missense	possibly damaging	0.80
R1845:Or6c205	UTSW	10	129,086,463 (GRCm39)	missense	probably benign	0.00
R2062:Or6c205	UTSW	10	129,087,001 (GRCm39)	nonsense	probably null
R2131:Or6c205	UTSW	10	129,086,943 (GRCm39)	missense	probably benign	0.05
R4975:Or6c205	UTSW	10	129,087,141 (GRCm39)	missense	probably damaging	1.00
R6714:Or6c205	UTSW	10	129,086,809 (GRCm39)	missense	possibly damaging	0.91
R7803:Or6c205	UTSW	10	129,086,864 (GRCm39)	missense	probably benign	0.04
R8060:Or6c205	UTSW	10	129,086,915 (GRCm39)	missense	possibly damaging	0.62
R8177:Or6c205	UTSW	10	129,086,790 (GRCm39)	missense	probably benign	0.05
R8878:Or6c205	UTSW	10	129,086,883 (GRCm39)	missense	probably benign	0.39
R9007:Or6c205	UTSW	10	129,086,669 (GRCm39)	missense	possibly damaging	0.94
R9332:Or6c205	UTSW	10	129,086,972 (GRCm39)	missense	probably damaging	0.99
R9571:Or6c205	UTSW	10	129,087,182 (GRCm39)	missense	possibly damaging	0.50

Posted On

2013-07-11