Mutagenetix > Incidental Mutation

Incidental Mutation 'R9007:Or6c205'

685372

Institutional Source

Beutler Lab

Gene Symbol

Or6c205

Ensembl Gene

ENSMUSG00000096220

Gene Name

olfactory receptor family 6 subfamily C member 205

Synonyms

Olfr1518, MOR111-6, MOR111-7, MOR111-7, GA_x6K02T2PULF-10936819-10937757, Olfr775

MMRRC Submission

068837-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R9007 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

129086405-129087343 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 129086669 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 89 (T89S)

Ref Sequence

ENSEMBL: ENSMUSP00000150345 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097163] [ENSMUST00000214109]

AlphaFold

Q7TRI4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000097163
AA Change: T89S

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000132845
Gene: ENSMUSG00000096220
AA Change: T89S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	9.9e-52	PFAM
Pfam:7tm_1	39	288	9.1e-19	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000214109
AA Change: T89S

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (60/60)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	A	17: 9,226,935 (GRCm39)	C497S	probably benign	Het
4930453N24Rik	A	T	16: 64,589,377 (GRCm39)	Y92*	probably null	Het
Adam3	A	G	8: 25,205,127 (GRCm39)	V117A	probably benign	Het
Amer2	G	C	14: 60,617,376 (GRCm39)	D524H	probably damaging	Het
Armh4	T	A	14: 50,011,695 (GRCm39)	D4V	probably damaging	Het
Atp6v0a4	T	C	6: 38,029,988 (GRCm39)	K692R	probably benign	Het
Atp8b1	A	G	18: 64,684,931 (GRCm39)	V730A	probably benign	Het
Bdh2	T	C	3: 134,991,309 (GRCm39)		probably benign	Het
Ccnd3	T	A	17: 47,905,332 (GRCm39)		probably null	Het
Chrm4	T	C	2: 91,758,075 (GRCm39)	V161A	possibly damaging	Het
Csmd3	T	C	15: 47,751,892 (GRCm39)		probably benign	Het
D430041D05Rik	A	G	2: 104,087,930 (GRCm39)	S349P	probably benign	Het
Ddx55	A	G	5: 124,697,370 (GRCm39)	N244S	probably damaging	Het
Dock1	A	G	7: 134,500,825 (GRCm39)		probably benign	Het
Dppa3	T	C	6: 122,605,724 (GRCm39)	S93P	probably damaging	Het
Echdc1	T	C	10: 29,220,426 (GRCm39)	I217T	probably damaging	Het
Fpr-rs4	T	A	17: 18,242,416 (GRCm39)	L141Q	probably damaging	Het
Galnt15	T	C	14: 31,771,935 (GRCm39)	F451L	probably damaging	Het
Galnt9	G	A	5: 110,692,665 (GRCm39)	R33H	probably benign	Het
Iah1	G	A	12: 21,367,402 (GRCm39)	G36D	probably damaging	Het
Jakmip1	A	G	5: 37,332,857 (GRCm39)	D1179G	probably benign	Het
Kcnh1	A	G	1: 192,188,055 (GRCm39)	T866A	probably benign	Het
Kcnq4	T	A	4: 120,555,150 (GRCm39)	I678F	probably benign	Het
Lars2	A	T	9: 123,260,980 (GRCm39)	R384*	probably null	Het
Lman2	T	C	13: 55,500,773 (GRCm39)	D142G	probably damaging	Het
Lrp1b	T	C	2: 40,587,564 (GRCm39)	D3897G		Het
Lrrn1	T	A	6: 107,544,820 (GRCm39)	I206N	probably damaging	Het
Mapkbp1	T	A	2: 119,850,143 (GRCm39)	L802H	probably damaging	Het
Meaf6	T	C	4: 125,001,450 (GRCm39)		probably benign	Het
Mier2	G	A	10: 79,384,274 (GRCm39)	R166W	probably damaging	Het
Mis18bp1	G	A	12: 65,180,616 (GRCm39)	S955L	probably benign	Het
Mocs1	T	A	17: 49,756,819 (GRCm39)	M267K	probably damaging	Het
Mroh3	T	A	1: 136,128,110 (GRCm39)	Y263F	probably damaging	Het
Ndufs1	A	T	1: 63,198,878 (GRCm39)		probably benign	Het
Nuak1	T	C	10: 84,210,492 (GRCm39)	Y532C	probably damaging	Het
Or51b6	A	G	7: 103,556,165 (GRCm39)	H170R		Het
Ost4	A	G	5: 31,064,866 (GRCm39)	V5A	possibly damaging	Het
P2rx1	T	A	11: 72,900,059 (GRCm39)	C159S	probably damaging	Het
Paqr8	T	C	1: 21,005,614 (GRCm39)	L256P	possibly damaging	Het
Pgls	T	A	8: 72,048,689 (GRCm39)		probably benign	Het
Pkd2l1	T	C	19: 44,140,864 (GRCm39)	E566G	possibly damaging	Het
Plau	A	T	14: 20,889,613 (GRCm39)	H226L	probably damaging	Het
Rps18-ps5	A	G	13: 28,441,872 (GRCm39)	N85S	probably damaging	Het
Rraga	T	C	4: 86,494,675 (GRCm39)	S174P	probably damaging	Het
Sacs	T	A	14: 61,445,185 (GRCm39)	D2410E	probably benign	Het
Sgms1	A	T	19: 32,137,227 (GRCm39)	M113K	probably benign	Het
Skint6	C	A	4: 113,095,347 (GRCm39)	G104V	probably damaging	Het
Spata31f1e	C	T	4: 42,792,546 (GRCm39)	G529S	probably benign	Het
Sqor	T	A	2: 122,649,876 (GRCm39)	Y373*	probably null	Het
Stra6l	T	A	4: 45,864,910 (GRCm39)	S79T	possibly damaging	Het
Svep1	T	C	4: 58,091,915 (GRCm39)	I1573M	possibly damaging	Het
Syne2	A	G	12: 76,146,224 (GRCm39)	D1674G	possibly damaging	Het
Tex26	C	A	5: 149,376,884 (GRCm39)	T91N	probably damaging	Het
Tigd2	T	G	6: 59,187,887 (GRCm39)	S251R	probably damaging	Het
Tmco1	C	T	1: 167,136,132 (GRCm39)		probably benign	Het
Tnks1bp1	T	A	2: 84,901,048 (GRCm39)	L1585Q	probably damaging	Het
Trmt10c	A	G	16: 55,855,542 (GRCm39)	V31A	probably benign	Het
Ttc41	T	C	10: 86,569,625 (GRCm39)	S668P	probably damaging	Het
Uggt2	A	T	14: 119,326,724 (GRCm39)	D162E	probably damaging	Het
Vmn1r125	G	C	7: 21,006,503 (GRCm39)	V134L	probably benign	Het
Vmn1r225	T	A	17: 20,723,449 (GRCm39)	F297I	probably damaging	Het
Vps13c	A	G	9: 67,845,006 (GRCm39)	D2030G	probably benign	Het

Other mutations in Or6c205

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01025:Or6c205	APN	10	129,086,609 (GRCm39)	missense	possibly damaging	0.79
IGL01310:Or6c205	APN	10	129,086,865 (GRCm39)	missense	possibly damaging	0.85
IGL02185:Or6c205	APN	10	129,086,904 (GRCm39)	missense	possibly damaging	0.60
IGL02887:Or6c205	APN	10	129,086,794 (GRCm39)	nonsense	probably null
R0584:Or6c205	UTSW	10	129,086,817 (GRCm39)	missense	probably benign	0.01
R1482:Or6c205	UTSW	10	129,087,012 (GRCm39)	missense	possibly damaging	0.80
R1845:Or6c205	UTSW	10	129,086,463 (GRCm39)	missense	probably benign	0.00
R2062:Or6c205	UTSW	10	129,087,001 (GRCm39)	nonsense	probably null
R2131:Or6c205	UTSW	10	129,086,943 (GRCm39)	missense	probably benign	0.05
R4975:Or6c205	UTSW	10	129,087,141 (GRCm39)	missense	probably damaging	1.00
R6714:Or6c205	UTSW	10	129,086,809 (GRCm39)	missense	possibly damaging	0.91
R7803:Or6c205	UTSW	10	129,086,864 (GRCm39)	missense	probably benign	0.04
R8060:Or6c205	UTSW	10	129,086,915 (GRCm39)	missense	possibly damaging	0.62
R8177:Or6c205	UTSW	10	129,086,790 (GRCm39)	missense	probably benign	0.05
R8878:Or6c205	UTSW	10	129,086,883 (GRCm39)	missense	probably benign	0.39
R9332:Or6c205	UTSW	10	129,086,972 (GRCm39)	missense	probably damaging	0.99
R9571:Or6c205	UTSW	10	129,087,182 (GRCm39)	missense	possibly damaging	0.50

Predicted Primers

PCR Primer
(F):5'- ACACCAGAAGTCCAGGTTGTG -3'
(R):5'- AATCCTATCAGCCATGAGGTG -3'

Sequencing Primer
(F):5'- AGAAGTCCAGGTTGTGATTTTTATCC -3'
(R):5'- GCCATGAGGTGAGGACAAG -3'

Posted On

2021-10-11