Incidental Mutation 'IGL01340:Wdr91'
ID74815
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr91
Ensembl Gene ENSMUSG00000058486
Gene NameWD repeat domain 91
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.166) question?
Stock #IGL01340
Quality Score
Status
Chromosome6
Chromosomal Location34880426-34910876 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 34904579 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 278 (S278P)
Ref Sequence ENSEMBL: ENSMUSP00000079974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081214] [ENSMUST00000133336] [ENSMUST00000146968] [ENSMUST00000149448] [ENSMUST00000152488]
Predicted Effect probably benign
Transcript: ENSMUST00000081214
AA Change: S278P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000079974
Gene: ENSMUSG00000058486
AA Change: S278P

DomainStartEndE-ValueType
Blast:LisH 5 36 3e-6 BLAST
coiled coil region 179 228 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
WD40 393 437 6.34e-2 SMART
WD40 442 480 3.42e1 SMART
Blast:WD40 483 525 1e-19 BLAST
WD40 552 591 1.88e-4 SMART
WD40 594 633 3.96e-3 SMART
WD40 701 742 8.59e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000133336
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134830
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145765
Predicted Effect probably benign
Transcript: ENSMUST00000146968
AA Change: S278P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000138406
Gene: ENSMUSG00000058486
AA Change: S278P

DomainStartEndE-ValueType
Blast:LisH 5 36 2e-6 BLAST
coiled coil region 179 228 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
WD40 393 437 6.34e-2 SMART
WD40 442 480 3.42e1 SMART
Blast:WD40 483 525 1e-19 BLAST
WD40 552 591 1.48e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149448
SMART Domains Protein: ENSMUSP00000120164
Gene: ENSMUSG00000058486

DomainStartEndE-ValueType
coiled coil region 127 176 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000152488
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201569
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700022I11Rik A C 4: 42,971,984 E439A possibly damaging Het
Abca9 T A 11: 110,130,627 I1086L probably benign Het
Adam17 A T 12: 21,330,057 C630* probably null Het
Adgrg5 T C 8: 94,937,629 L289P probably damaging Het
Aplp1 G A 7: 30,444,418 T64I probably damaging Het
Bdh1 T A 16: 31,456,843 W261R probably damaging Het
Cadm2 A T 16: 66,784,785 I202N possibly damaging Het
Cd209c C T 8: 3,945,892 R6H probably benign Het
Cfap221 T A 1: 119,953,620 I371F possibly damaging Het
Cfap44 A G 16: 44,404,130 Y67C probably damaging Het
Cilp T C 9: 65,275,974 S387P probably damaging Het
Cnot1 T C 8: 95,760,537 D598G probably damaging Het
Col5a1 T C 2: 27,960,451 L520P unknown Het
Cpvl A T 6: 53,896,451 Y433* probably null Het
Cxcl1 G T 5: 90,891,575 C59F probably damaging Het
Cyth3 T A 5: 143,684,435 L33* probably null Het
Dnah2 T C 11: 69,493,184 K1069E probably damaging Het
Drosha T A 15: 12,834,023 probably benign Het
Fam83h T A 15: 76,004,036 D484V probably damaging Het
Igsf3 C A 3: 101,439,679 Y663* probably null Het
Kmt5c C T 7: 4,742,141 R44* probably null Het
Kxd1 T C 8: 70,515,443 probably null Het
Lars A G 18: 42,202,577 V1158A probably benign Het
Lmf2 A G 15: 89,352,872 F413S probably damaging Het
Mc4r C T 18: 66,859,158 A295T probably benign Het
Mrc1 T C 2: 14,310,084 probably null Het
Mtmr7 T C 8: 40,597,422 Y110C probably damaging Het
Myd88 A C 9: 119,337,352 probably benign Het
Ndc1 T C 4: 107,374,147 V95A probably damaging Het
Ntrk1 T A 3: 87,788,714 E163V possibly damaging Het
Olfr1208 T C 2: 88,896,977 T207A probably damaging Het
Pappa A T 4: 65,323,872 D1491V possibly damaging Het
Phc3 T A 3: 30,929,884 I673F possibly damaging Het
Pkhd1 A T 1: 20,522,977 N1637K probably benign Het
Relb T C 7: 19,616,373 I218V probably benign Het
Rgma T C 7: 73,417,330 F111S probably damaging Het
Slco1a6 A T 6: 142,109,383 N278K possibly damaging Het
Slfn9 A T 11: 82,981,751 F720I probably benign Het
Snd1 T A 6: 28,883,369 V741E probably benign Het
Snx6 C T 12: 54,754,309 R185Q probably damaging Het
Telo2 G A 17: 25,100,129 probably benign Het
Xab2 A T 8: 3,614,381 D277E probably damaging Het
Zbbx T C 3: 75,105,650 E158G possibly damaging Het
Other mutations in Wdr91
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01336:Wdr91 APN 6 34909543 splice site probably benign
IGL01402:Wdr91 APN 6 34889063 missense probably benign
IGL02632:Wdr91 APN 6 34889042 missense probably damaging 1.00
IGL03104:Wdr91 APN 6 34905556 missense probably benign 0.00
IGL03169:Wdr91 APN 6 34905491 missense possibly damaging 0.93
R0080:Wdr91 UTSW 6 34906685 missense possibly damaging 0.81
R0082:Wdr91 UTSW 6 34906685 missense possibly damaging 0.81
R0422:Wdr91 UTSW 6 34880846 missense probably damaging 1.00
R1738:Wdr91 UTSW 6 34884308 missense probably damaging 1.00
R1993:Wdr91 UTSW 6 34892362 missense probably damaging 1.00
R1994:Wdr91 UTSW 6 34892362 missense probably damaging 1.00
R3115:Wdr91 UTSW 6 34905587 missense probably damaging 0.98
R3116:Wdr91 UTSW 6 34905587 missense probably damaging 0.98
R4261:Wdr91 UTSW 6 34904522 missense possibly damaging 0.84
R4760:Wdr91 UTSW 6 34908299 missense probably damaging 0.96
R4977:Wdr91 UTSW 6 34910791 missense probably damaging 1.00
R5093:Wdr91 UTSW 6 34892353 missense probably damaging 1.00
R5910:Wdr91 UTSW 6 34891487 missense possibly damaging 0.93
R6788:Wdr91 UTSW 6 34886819 missense probably damaging 0.99
R7139:Wdr91 UTSW 6 34908263 missense possibly damaging 0.82
R7195:Wdr91 UTSW 6 34889274 missense possibly damaging 0.70
R7268:Wdr91 UTSW 6 34892440 missense probably benign
R7303:Wdr91 UTSW 6 34884323 missense probably benign 0.01
R7326:Wdr91 UTSW 6 34904626 missense probably damaging 0.99
R7341:Wdr91 UTSW 6 34891460 missense possibly damaging 0.49
R7362:Wdr91 UTSW 6 34889115 missense possibly damaging 0.50
X0026:Wdr91 UTSW 6 34909372 missense probably benign 0.03
Posted On2013-10-07