Incidental Mutation 'R7326:Wdr91'
ID568896
Institutional Source Beutler Lab
Gene Symbol Wdr91
Ensembl Gene ENSMUSG00000058486
Gene NameWD repeat domain 91
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.161) question?
Stock #R7326 (G1)
Quality Score225.009
Status Not validated
Chromosome6
Chromosomal Location34880426-34910876 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 34904626 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 262 (F262Y)
Ref Sequence ENSEMBL: ENSMUSP00000079974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081214] [ENSMUST00000133336] [ENSMUST00000146968] [ENSMUST00000149448] [ENSMUST00000152488]
Predicted Effect probably damaging
Transcript: ENSMUST00000081214
AA Change: F262Y

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000079974
Gene: ENSMUSG00000058486
AA Change: F262Y

DomainStartEndE-ValueType
Blast:LisH 5 36 3e-6 BLAST
coiled coil region 179 228 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
WD40 393 437 6.34e-2 SMART
WD40 442 480 3.42e1 SMART
Blast:WD40 483 525 1e-19 BLAST
WD40 552 591 1.88e-4 SMART
WD40 594 633 3.96e-3 SMART
WD40 701 742 8.59e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000133336
Predicted Effect probably damaging
Transcript: ENSMUST00000146968
AA Change: F262Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138406
Gene: ENSMUSG00000058486
AA Change: F262Y

DomainStartEndE-ValueType
Blast:LisH 5 36 2e-6 BLAST
coiled coil region 179 228 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
WD40 393 437 6.34e-2 SMART
WD40 442 480 3.42e1 SMART
Blast:WD40 483 525 1e-19 BLAST
WD40 552 591 1.48e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149448
SMART Domains Protein: ENSMUSP00000120164
Gene: ENSMUSG00000058486

DomainStartEndE-ValueType
coiled coil region 127 176 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000152488
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 112 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430531B16Rik A T 7: 139,978,545 probably null Het
Abcb4 T C 5: 8,934,226 V652A probably benign Het
Acvrl1 G T 15: 101,141,072 V417L probably damaging Het
Add1 A G 5: 34,619,371 R479G probably benign Het
Adgb A T 10: 10,400,574 L350Q possibly damaging Het
Adgrl2 A T 3: 148,846,870 S666T probably benign Het
Akap9 T A 5: 4,045,930 D2268E possibly damaging Het
Amigo3 C A 9: 108,054,066 H229Q probably benign Het
Ano6 G C 15: 95,864,244 Q31H possibly damaging Het
Ap4m1 G A 5: 138,175,019 D180N probably damaging Het
Apc2 A T 10: 80,311,740 D876V probably damaging Het
Apcdd1 T A 18: 62,952,188 Y485* probably null Het
Aqp1 G T 6: 55,336,851 D121Y probably benign Het
Bicd2 C A 13: 49,369,609 R141S probably benign Het
Brpf3 C A 17: 28,806,293 H113Q probably benign Het
Cacng2 A T 15: 78,013,320 Y96* probably null Het
Catsperg1 G T 7: 29,210,759 N52K possibly damaging Het
Celsr2 A C 3: 108,394,995 F2606V possibly damaging Het
Cerkl A T 2: 79,332,605 N516K probably benign Het
Ciita G A 16: 10,512,288 R812H probably damaging Het
Cldn3 T A 5: 134,986,983 L180Q probably damaging Het
Cnot6l T C 5: 96,077,299 I512V probably benign Het
Col5a2 A T 1: 45,442,867 D32E unknown Het
Coro7 A G 16: 4,632,048 V616A probably damaging Het
Cyp4f18 T C 8: 71,988,654 D494G probably benign Het
Ddx39 T A 8: 83,722,471 V296E probably benign Het
Dgkg A T 16: 22,548,690 H593Q probably damaging Het
Dhx16 T C 17: 35,886,160 L645P probably damaging Het
Dnah14 A G 1: 181,598,403 M171V probably benign Het
Dnhd1 G A 7: 105,720,930 V4521I probably damaging Het
Dok7 A T 5: 35,064,522 M60L probably benign Het
Donson A T 16: 91,688,711 M1K probably null Het
Dsp C T 13: 38,192,883 T1548M probably benign Het
Dyrk1a A G 16: 94,692,043 T712A probably damaging Het
Eef2 A G 10: 81,181,282 T708A probably benign Het
Epn3 G A 11: 94,493,780 T289I probably benign Het
Fam171a1 C T 2: 3,226,472 R881* probably null Het
Fam71a G A 1: 191,164,353 T31M probably benign Het
Fat2 T A 11: 55,282,304 R2528W probably damaging Het
Fgfr1 T G 8: 25,573,839 F707C probably damaging Het
Frem2 G C 3: 53,654,753 P778A probably damaging Het
Ganc A G 2: 120,430,599 Y255C probably damaging Het
Ginm1 A T 10: 7,777,850 Y65* probably null Het
Gm11559 T A 11: 99,864,881 C119S unknown Het
Gnai1 T A 5: 18,289,551 H188L Het
H6pd C T 4: 149,996,350 A13T probably benign Het
Hist1h2be T C 13: 23,585,923 K12E probably benign Het
Hoxd12 A T 2: 74,675,246 T54S possibly damaging Het
Hs3st5 T A 10: 36,833,194 L242M probably damaging Het
Il9r C A 11: 32,194,389 V139L possibly damaging Het
Immt A G 6: 71,846,369 D68G probably damaging Het
Itsn2 A G 12: 4,632,985 I304V unknown Het
Lgr4 G A 2: 109,996,629 W159* probably null Het
Lin52 G A 12: 84,457,954 G38S probably damaging Het
Lpgat1 A T 1: 191,719,453 M64L probably benign Het
Lrrc10b G T 19: 10,456,778 R180S possibly damaging Het
Lrrc29 T C 8: 105,312,898 D127G probably damaging Het
Lrrc36 A T 8: 105,449,769 L258F possibly damaging Het
Ltbp4 T A 7: 27,329,755 Q235L unknown Het
Maml2 A G 9: 13,621,607 M706V Het
Mc5r G T 18: 68,339,668 C366F probably damaging Het
Mlip T C 9: 77,164,842 R244G probably benign Het
Muc16 T A 9: 18,585,013 R6658S probably benign Het
Mup4 G T 4: 59,960,046 H73N possibly damaging Het
Nf1 A G 11: 79,564,943 M565V probably benign Het
Nphp1 G A 2: 127,761,217 T382I possibly damaging Het
Nrcam C T 12: 44,564,026 T503I possibly damaging Het
Nwd2 A T 5: 63,800,409 N361Y probably damaging Het
Olfr1045 A G 2: 86,198,573 Y60H probably damaging Het
Olfr1309 A T 2: 111,983,327 L249* probably null Het
Olfr308 A G 7: 86,321,574 I126T probably damaging Het
Olfr461 G T 6: 40,544,895 A28E probably damaging Het
Olfr518 A T 7: 108,880,816 H263Q probably damaging Het
Olfr836 A G 9: 19,121,669 Y235C probably benign Het
Olfr993 A T 2: 85,414,444 V145E probably damaging Het
Orc5 A G 5: 22,523,584 F308L probably benign Het
Padi1 T A 4: 140,832,404 Y54F probably benign Het
Parp1 A G 1: 180,569,100 K23E possibly damaging Het
Pate1 A T 9: 35,685,972 V79D possibly damaging Het
Pcdh18 T C 3: 49,756,860 H2R probably benign Het
Pcnx2 G A 8: 125,887,083 S543F probably damaging Het
Pcp4l1 G A 1: 171,174,465 A42V possibly damaging Het
Pnkp T A 7: 44,859,734 F169L probably damaging Het
Ppp6r3 A T 19: 3,507,325 N254K probably damaging Het
Psd A G 19: 46,324,454 L159P probably benign Het
Ptprf A G 4: 118,231,669 Y646H probably damaging Het
Rab3ip A T 10: 116,937,633 S92T probably benign Het
Rabgef1 A G 5: 130,187,351 probably benign Het
Ralgapa1 C A 12: 55,709,004 W1129L probably damaging Het
Rhpn2 T A 7: 35,385,463 L594Q probably benign Het
Rnf38 C A 4: 44,158,989 probably benign Het
Ryr2 T A 13: 11,738,194 H1747L possibly damaging Het
Sec16a A G 2: 26,439,717 L13P unknown Het
Sppl3 C A 5: 115,082,335 T102K probably damaging Het
Srgap2 A T 1: 131,291,613 Y264* probably null Het
Stxbp2 T C 8: 3,641,151 M465T Het
Sumf2 A G 5: 129,862,710 K305R probably benign Het
Susd2 T A 10: 75,642,565 Y59F probably benign Het
Taco1 T C 11: 106,072,617 V198A probably benign Het
Tas2r136 A T 6: 132,777,906 M86K possibly damaging Het
Tbc1d10c T C 19: 4,184,898 E388G possibly damaging Het
Tmem132c C T 5: 127,564,059 T1098I possibly damaging Het
Trim3 G T 7: 105,617,800 Y457* probably null Het
Ttc38 A G 15: 85,852,861 T316A probably benign Het
Ubqln4 T A 3: 88,555,910 N127K probably benign Het
Zdhhc6 A T 19: 55,302,755 C343S possibly damaging Het
Zfp248 A G 6: 118,430,209 C140R probably damaging Het
Zfp266 T C 9: 20,502,095 T90A probably benign Het
Zfp407 A T 18: 84,559,042 D1315E possibly damaging Het
Zfp644 T C 5: 106,638,277 S135G probably benign Het
Zscan29 A T 2: 121,160,988 I773N probably damaging Het
Zswim5 T A 4: 116,980,834 V787E possibly damaging Het
Other mutations in Wdr91
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01336:Wdr91 APN 6 34909543 splice site probably benign
IGL01340:Wdr91 APN 6 34904579 missense probably benign 0.00
IGL01402:Wdr91 APN 6 34889063 missense probably benign
IGL02632:Wdr91 APN 6 34889042 missense probably damaging 1.00
IGL03104:Wdr91 APN 6 34905556 missense probably benign 0.00
IGL03169:Wdr91 APN 6 34905491 missense possibly damaging 0.93
R0080:Wdr91 UTSW 6 34906685 missense possibly damaging 0.81
R0082:Wdr91 UTSW 6 34906685 missense possibly damaging 0.81
R0422:Wdr91 UTSW 6 34880846 missense probably damaging 1.00
R1738:Wdr91 UTSW 6 34884308 missense probably damaging 1.00
R1993:Wdr91 UTSW 6 34892362 missense probably damaging 1.00
R1994:Wdr91 UTSW 6 34892362 missense probably damaging 1.00
R3115:Wdr91 UTSW 6 34905587 missense probably damaging 0.98
R3116:Wdr91 UTSW 6 34905587 missense probably damaging 0.98
R4261:Wdr91 UTSW 6 34904522 missense possibly damaging 0.84
R4760:Wdr91 UTSW 6 34908299 missense probably damaging 0.96
R4977:Wdr91 UTSW 6 34910791 missense probably damaging 1.00
R5093:Wdr91 UTSW 6 34892353 missense probably damaging 1.00
R5910:Wdr91 UTSW 6 34891487 missense possibly damaging 0.93
R6788:Wdr91 UTSW 6 34886819 missense probably damaging 0.99
R7139:Wdr91 UTSW 6 34908263 missense possibly damaging 0.82
R7195:Wdr91 UTSW 6 34889274 missense possibly damaging 0.70
R7268:Wdr91 UTSW 6 34892440 missense probably benign
R7303:Wdr91 UTSW 6 34884323 missense probably benign 0.01
R7341:Wdr91 UTSW 6 34891460 missense possibly damaging 0.49
R7362:Wdr91 UTSW 6 34889115 missense possibly damaging 0.50
X0026:Wdr91 UTSW 6 34909372 missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TGAGAAGATGACCCACAAGC -3'
(R):5'- CTTTCAAACTCGGGTCTCGG -3'

Sequencing Primer
(F):5'- ACAAGCCCATGAGTGACCGG -3'
(R):5'- AAACTCGGGTCTCGGAACCTAG -3'
Posted On2019-09-13