Incidental Mutation 'P0043:Cxcl5'
ID 7765
Institutional Source Beutler Lab
Gene Symbol Cxcl5
Ensembl Gene ENSMUSG00000029371
Gene Name C-X-C motif chemokine ligand 5
Synonyms Scyb6, GCP-2, granulocyte chemotactic protein-2, Cxcl6, AMCF-II, ENA-78, Scyb5, LIX
MMRRC Submission 038291-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # P0043 (G1)
Quality Score
Status Validated
Chromosome 5
Chromosomal Location 90907219-90909483 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 90907826 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 85 (I85M)
Ref Sequence ENSEMBL: ENSMUSP00000031318 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031318]
AlphaFold P50228
Predicted Effect probably damaging
Transcript: ENSMUST00000031318
AA Change: I85M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031318
Gene: ENSMUSG00000029371
AA Change: I85M

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
SCY 50 110 1.83e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202380
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 81.5%
  • 3x: 74.1%
  • 10x: 50.1%
  • 20x: 26.7%
Validation Efficiency 74% (145/195)
MGI Phenotype FUNCTION: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased chemokine scavenging, decrease suscetibility to bacterial infection, and altered neutrophil physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Chn1 A T 2: 73,454,509 (GRCm39) V247E probably damaging Het
Col28a1 T A 6: 8,168,152 (GRCm39) probably benign Het
Fnip1 A G 11: 54,394,051 (GRCm39) E829G probably benign Het
Kctd18 G A 1: 58,006,722 (GRCm39) R43C probably damaging Het
Kidins220 T A 12: 25,058,155 (GRCm39) F629I probably damaging Het
Lamb1 T C 12: 31,328,620 (GRCm39) S195P probably damaging Het
Lrrc74b A T 16: 17,376,023 (GRCm39) probably benign Het
Mrpl30 A G 1: 37,937,259 (GRCm39) T133A probably benign Het
Mrps27 A G 13: 99,548,754 (GRCm39) T297A probably benign Het
Per1 G T 11: 68,992,869 (GRCm39) probably benign Het
Ptprq C A 10: 107,416,086 (GRCm39) M1737I probably benign Het
Ropn1l A C 15: 31,457,447 (GRCm39) probably benign Het
Sfrp4 A G 13: 19,807,765 (GRCm39) I55V probably benign Het
Spata31 G A 13: 65,068,820 (GRCm39) probably null Het
Trpm6 T A 19: 18,855,129 (GRCm39) D1929E probably damaging Het
Ttn A G 2: 76,628,358 (GRCm39) S12855P probably damaging Het
Zscan10 C T 17: 23,828,594 (GRCm39) R302* probably null Het
Other mutations in Cxcl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Cxcl5 APN 5 90,908,382 (GRCm39) utr 3 prime probably benign
R1902:Cxcl5 UTSW 5 90,907,644 (GRCm39) missense probably damaging 1.00
R6148:Cxcl5 UTSW 5 90,907,565 (GRCm39) missense probably benign 0.00
R6558:Cxcl5 UTSW 5 90,907,677 (GRCm39) missense probably damaging 1.00
R7664:Cxcl5 UTSW 5 90,907,890 (GRCm39) missense probably damaging 1.00
Posted On 2012-10-29