Incidental Mutation 'IGL01473:Cylc1'
ID 88363
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cylc1
Ensembl Gene ENSMUSG00000073001
Gene Name cylicin, basic protein of sperm head cytoskeleton 1
Accession Numbers
Essential gene? Not available question?
Stock # IGL01473
Quality Score
Chromosome X
Chromosomal Location 111110418-111125854 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 111122680 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 243 (K243N)
Ref Sequence ENSEMBL: ENSMUSP00000147334 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000101282] [ENSMUST00000210720]
AlphaFold A0A1B0GR13
Predicted Effect unknown
Transcript: ENSMUST00000101282
AA Change: K243N
SMART Domains Protein: ENSMUSP00000098840
Gene: ENSMUSG00000073001
AA Change: K243N

Pfam:Cylicin_N 26 131 2.8e-42 PFAM
low complexity region 307 330 N/A INTRINSIC
low complexity region 334 371 N/A INTRINSIC
low complexity region 376 398 N/A INTRINSIC
low complexity region 402 420 N/A INTRINSIC
low complexity region 421 450 N/A INTRINSIC
low complexity region 467 491 N/A INTRINSIC
low complexity region 513 523 N/A INTRINSIC
low complexity region 532 542 N/A INTRINSIC
low complexity region 549 562 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000210720
AA Change: K243N
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp13a5 T C 16: 29,316,724 Y350C probably damaging Het
Ccdc151 C A 9: 21,995,379 probably null Het
Clca1 C T 3: 145,007,778 M697I probably benign Het
Clcn1 C A 6: 42,291,703 A181D probably damaging Het
Dsp A G 13: 38,167,571 Y122C probably damaging Het
Exoc5 A G 14: 49,014,294 V665A possibly damaging Het
Fcho1 G A 8: 71,712,138 P500S probably benign Het
Flg2 A G 3: 93,203,020 E785G unknown Het
Fpr1 A G 17: 17,877,692 S12P possibly damaging Het
Hydin A T 8: 110,312,160 M177L probably benign Het
Hydin G T 8: 110,354,953 G327V probably damaging Het
Itga10 G A 3: 96,647,641 G97E probably damaging Het
Khdc1c T A 1: 21,368,906 Y39N possibly damaging Het
Lrp1b T G 2: 40,611,486 T202P probably damaging Het
March10 T C 11: 105,389,605 K618R probably damaging Het
Mdc1 C A 17: 35,848,020 L431I probably benign Het
Mmp17 A G 5: 129,606,408 D536G probably benign Het
Myh8 G A 11: 67,301,825 probably null Het
Pop4 A G 7: 38,264,396 V154A probably benign Het
Ppp1r13l C T 7: 19,375,268 R608C probably damaging Het
Prss36 T C 7: 127,944,701 H166R probably damaging Het
Rab11fip3 C T 17: 26,068,735 R148Q possibly damaging Het
Rbm39 T A 2: 156,172,979 R49* probably null Het
S100a11 T C 3: 93,526,106 C86R probably damaging Het
Skint7 T C 4: 111,982,205 I232T probably damaging Het
Smchd1 G A 17: 71,389,750 T1210I probably benign Het
Speg C T 1: 75,428,285 T2907I possibly damaging Het
Spz1 A T 13: 92,575,256 C237* probably null Het
Sun3 G T 11: 9,029,394 D42E probably benign Het
Tgds C T 14: 118,128,214 probably benign Het
Tnxb G A 17: 34,685,701 D1270N probably damaging Het
Vmn2r78 A C 7: 86,920,312 T138P possibly damaging Het
Wdfy1 T C 1: 79,707,465 I351V probably benign Het
Other mutations in Cylc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01517:Cylc1 APN X 111119030 missense possibly damaging 0.71
IGL01656:Cylc1 APN X 111123716 missense probably benign 0.35
IGL02944:Cylc1 APN X 111123604 missense possibly damaging 0.91
IGL03029:Cylc1 APN X 111113338 splice site probably benign
IGL03057:Cylc1 APN X 111122601 missense unknown
R2060:Cylc1 UTSW X 111123123 missense unknown
Z1176:Cylc1 UTSW X 111123146 missense unknown
Z1177:Cylc1 UTSW X 111122279 missense probably benign 0.03
Posted On 2013-11-18