Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01655:Aida'

102980

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Aida

Ensembl Gene

ENSMUSG00000042901

Gene Name

axin interactor, dorsalization associated

Synonyms

2610208M17Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.290) question?

Stock #

IGL01655

Quality Score

Status

Chromosome

Chromosomal Location

183078604-183105356 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 183094618 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 104 (Y104*)

Ref Sequence

ENSEMBL: ENSMUSP00000141649 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109166] [ENSMUST00000193625] [ENSMUST00000193959]

AlphaFold

Q8C4Q6

PDB Structure

Solution structure of four helical up-and-down bundle domain of the hypothetical protein 2610208M17Rik similar to the protein FLJ12806 [SOLUTION NMR]
Crystal Structure of the C-terminal domain of Aida [X-RAY DIFFRACTION]

Predicted Effect

probably null
Transcript: ENSMUST00000109166
AA Change: Y104*

SMART Domains

Protein: ENSMUSP00000104795
Gene: ENSMUSG00000042901
AA Change: Y104*

Domain	Start	End	E-Value	Type
Pfam:Aida_N	9	112	1.9e-43	PFAM
low complexity region	122	144	N/A	INTRINSIC
Pfam:Aida_C2	155	300	2.4e-68	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192293

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193359

Predicted Effect

probably null
Transcript: ENSMUST00000193625
AA Change: Y104*

SMART Domains

Protein: ENSMUSP00000141649
Gene: ENSMUSG00000042901
AA Change: Y104*

Domain	Start	End	E-Value	Type
Pfam:Aida_N	8	113	2.3e-49	PFAM
low complexity region	122	144	N/A	INTRINSIC
Pfam:Aida_C2	145	219	6.4e-36	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000193959

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194652

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp6	G	A	3: 97,073,288 (GRCm39)		probably null	Het
Cd300lg	T	C	11: 101,937,901 (GRCm39)	S244P	probably benign	Het
Ces4a	T	A	8: 105,873,806 (GRCm39)	L425Q	probably damaging	Het
Chrnb3	T	C	8: 27,884,202 (GRCm39)	V298A	probably damaging	Het
Cnot6	A	C	11: 49,568,131 (GRCm39)	F486C	probably damaging	Het
Ctnna3	A	G	10: 64,708,949 (GRCm39)	T663A	probably benign	Het
Cyp2j12	T	A	4: 96,003,814 (GRCm39)	K267N	possibly damaging	Het
Dclre1a	A	T	19: 56,535,489 (GRCm39)	Y32N	probably damaging	Het
Ddx21	A	G	10: 62,423,270 (GRCm39)	I644T	probably damaging	Het
Epha6	A	C	16: 59,659,666 (GRCm39)	N817K	probably benign	Het
Ercc6l2	T	A	13: 63,967,566 (GRCm39)	Y55*	probably null	Het
Esyt1	A	G	10: 128,358,181 (GRCm39)	I183T	possibly damaging	Het
Exoc8	T	C	8: 125,622,967 (GRCm39)	T467A	probably benign	Het
Fance	T	C	17: 28,541,753 (GRCm39)		probably benign	Het
Fbxo46	C	T	7: 18,870,235 (GRCm39)	R285W	probably damaging	Het
Ffar2	A	T	7: 30,519,012 (GRCm39)	V176E	probably damaging	Het
Fnbp1l	T	C	3: 122,362,398 (GRCm39)		probably null	Het
Gm10288	T	C	3: 146,544,565 (GRCm39)		noncoding transcript	Het
Gm12588	T	A	11: 121,798,777 (GRCm39)			Het
Gm9755	G	A	8: 67,967,885 (GRCm39)		noncoding transcript	Het
Gpr33	A	T	12: 52,070,343 (GRCm39)	M232K	probably damaging	Het
Haus5	A	T	7: 30,362,719 (GRCm39)		probably benign	Het
Ilvbl	A	G	10: 78,413,167 (GRCm39)		probably benign	Het
Kifap3	G	A	1: 163,623,618 (GRCm39)		probably benign	Het
Klhl26	T	C	8: 70,904,533 (GRCm39)	Y378C	probably damaging	Het
Lama4	G	A	10: 38,936,209 (GRCm39)	S628N	probably benign	Het
Lamc3	G	A	2: 31,788,290 (GRCm39)	R150H	probably damaging	Het
Mrgprx2	A	T	7: 48,132,439 (GRCm39)	C126*	probably null	Het
Myo3a	A	T	2: 22,428,137 (GRCm39)	D798V	probably damaging	Het
Ndufs1	A	T	1: 63,190,716 (GRCm39)	L44Q	probably damaging	Het
Nfrkb	G	T	9: 31,314,755 (GRCm39)	R525L	probably benign	Het
Or10ag58	T	A	2: 87,265,229 (GRCm39)	C133S	probably damaging	Het
Or1e34	T	C	11: 73,778,753 (GRCm39)	I148M	probably benign	Het
Or2p2	T	C	13: 21,257,075 (GRCm39)	Y132C	probably damaging	Het
Or2r11	T	C	6: 42,437,474 (GRCm39)	T160A	probably benign	Het
Or4k41	T	C	2: 111,280,234 (GRCm39)	F250L	probably benign	Het
Or4q3	A	G	14: 50,583,641 (GRCm39)	M86T	probably benign	Het
Or5w1	A	G	2: 87,486,773 (GRCm39)	F164S	probably damaging	Het
Or8g17	T	A	9: 38,930,214 (GRCm39)	I208F	probably benign	Het
Or9r7	G	T	10: 129,962,860 (GRCm39)	T22K	probably benign	Het
Pias4	T	C	10: 80,991,492 (GRCm39)	K352E	probably benign	Het
Pkhd1	G	A	1: 20,604,857 (GRCm39)	Q1153*	probably null	Het
Pon1	C	A	6: 5,175,760 (GRCm39)	W254C	probably damaging	Het
Prr14	A	G	7: 127,074,939 (GRCm39)	T447A	probably benign	Het
Serpinb9g	T	A	13: 33,679,088 (GRCm39)	C319*	probably null	Het
Slc9c1	A	T	16: 45,403,335 (GRCm39)	M801L	probably benign	Het
Tenm4	C	T	7: 96,202,931 (GRCm39)	T182M	probably damaging	Het
Ubr4	T	A	4: 139,135,107 (GRCm39)	L813Q	probably damaging	Het
Uimc1	T	C	13: 55,176,517 (GRCm39)	E667G	probably benign	Het
Unc79	A	G	12: 103,134,546 (GRCm39)	T2173A	probably benign	Het
Unkl	T	C	17: 25,429,822 (GRCm39)	S142P	probably benign	Het
Vezt	A	G	10: 93,832,859 (GRCm39)	V204A	probably benign	Het
Vps53	A	T	11: 75,953,860 (GRCm39)	I402N	probably damaging	Het
Zfyve9	T	C	4: 108,499,289 (GRCm39)	D1343G	probably damaging	Het

Other mutations in Aida

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
billowing	UTSW	1	183,103,346 (GRCm39)	missense	probably damaging	1.00
omentum	UTSW	1	183,085,610 (GRCm39)	splice site	probably null
R1660:Aida	UTSW	1	183,079,127 (GRCm39)	missense	probably damaging	1.00
R1853:Aida	UTSW	1	183,087,380 (GRCm39)	missense	probably benign
R1991:Aida	UTSW	1	183,094,627 (GRCm39)	missense	probably benign
R2103:Aida	UTSW	1	183,094,627 (GRCm39)	missense	probably benign
R2159:Aida	UTSW	1	183,103,234 (GRCm39)	missense	probably benign	0.02
R3709:Aida	UTSW	1	183,085,610 (GRCm39)	splice site	probably null
R3710:Aida	UTSW	1	183,085,610 (GRCm39)	splice site	probably null
R5425:Aida	UTSW	1	183,103,201 (GRCm39)	missense	possibly damaging	0.78
R6281:Aida	UTSW	1	183,103,145 (GRCm39)	missense	probably damaging	0.99
R6784:Aida	UTSW	1	183,103,346 (GRCm39)	missense	probably damaging	1.00
R7409:Aida	UTSW	1	183,099,809 (GRCm39)	missense	probably benign	0.01
R7805:Aida	UTSW	1	183,085,633 (GRCm39)	missense	probably damaging	0.98
R9045:Aida	UTSW	1	183,094,940 (GRCm39)	missense	possibly damaging	0.93
R9594:Aida	UTSW	1	183,095,012 (GRCm39)	missense	possibly damaging	0.71

Posted On

2014-01-21