Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01655:Acp6'

102984

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Acp6

Ensembl Gene

ENSMUSG00000028093

Gene Name

acid phosphatase 6, lysophosphatidic

Synonyms

5730559A09Rik, ACPL1, mPACPL1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL01655

Quality Score

Status

Chromosome

Chromosomal Location

97066070-97083892 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 97073288 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000088263 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090759]

AlphaFold

Q8BP40

Predicted Effect

probably null
Transcript: ENSMUST00000090759

SMART Domains

Protein: ENSMUSP00000088263
Gene: ENSMUSG00000028093

Domain	Start	End	E-Value	Type
Pfam:His_Phos_2	42	228	4.6e-20	PFAM
Pfam:His_Phos_2	245	371	8e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126438

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133965

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146143

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149900

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]
PHENOTYPE: Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aida	T	A	1: 183,094,618 (GRCm39)	Y104*	probably null	Het
Cd300lg	T	C	11: 101,937,901 (GRCm39)	S244P	probably benign	Het
Ces4a	T	A	8: 105,873,806 (GRCm39)	L425Q	probably damaging	Het
Chrnb3	T	C	8: 27,884,202 (GRCm39)	V298A	probably damaging	Het
Cnot6	A	C	11: 49,568,131 (GRCm39)	F486C	probably damaging	Het
Ctnna3	A	G	10: 64,708,949 (GRCm39)	T663A	probably benign	Het
Cyp2j12	T	A	4: 96,003,814 (GRCm39)	K267N	possibly damaging	Het
Dclre1a	A	T	19: 56,535,489 (GRCm39)	Y32N	probably damaging	Het
Ddx21	A	G	10: 62,423,270 (GRCm39)	I644T	probably damaging	Het
Epha6	A	C	16: 59,659,666 (GRCm39)	N817K	probably benign	Het
Ercc6l2	T	A	13: 63,967,566 (GRCm39)	Y55*	probably null	Het
Esyt1	A	G	10: 128,358,181 (GRCm39)	I183T	possibly damaging	Het
Exoc8	T	C	8: 125,622,967 (GRCm39)	T467A	probably benign	Het
Fance	T	C	17: 28,541,753 (GRCm39)		probably benign	Het
Fbxo46	C	T	7: 18,870,235 (GRCm39)	R285W	probably damaging	Het
Ffar2	A	T	7: 30,519,012 (GRCm39)	V176E	probably damaging	Het
Fnbp1l	T	C	3: 122,362,398 (GRCm39)		probably null	Het
Gm10288	T	C	3: 146,544,565 (GRCm39)		noncoding transcript	Het
Gm12588	T	A	11: 121,798,777 (GRCm39)			Het
Gm9755	G	A	8: 67,967,885 (GRCm39)		noncoding transcript	Het
Gpr33	A	T	12: 52,070,343 (GRCm39)	M232K	probably damaging	Het
Haus5	A	T	7: 30,362,719 (GRCm39)		probably benign	Het
Ilvbl	A	G	10: 78,413,167 (GRCm39)		probably benign	Het
Kifap3	G	A	1: 163,623,618 (GRCm39)		probably benign	Het
Klhl26	T	C	8: 70,904,533 (GRCm39)	Y378C	probably damaging	Het
Lama4	G	A	10: 38,936,209 (GRCm39)	S628N	probably benign	Het
Lamc3	G	A	2: 31,788,290 (GRCm39)	R150H	probably damaging	Het
Mrgprx2	A	T	7: 48,132,439 (GRCm39)	C126*	probably null	Het
Myo3a	A	T	2: 22,428,137 (GRCm39)	D798V	probably damaging	Het
Ndufs1	A	T	1: 63,190,716 (GRCm39)	L44Q	probably damaging	Het
Nfrkb	G	T	9: 31,314,755 (GRCm39)	R525L	probably benign	Het
Or10ag58	T	A	2: 87,265,229 (GRCm39)	C133S	probably damaging	Het
Or1e34	T	C	11: 73,778,753 (GRCm39)	I148M	probably benign	Het
Or2p2	T	C	13: 21,257,075 (GRCm39)	Y132C	probably damaging	Het
Or2r11	T	C	6: 42,437,474 (GRCm39)	T160A	probably benign	Het
Or4k41	T	C	2: 111,280,234 (GRCm39)	F250L	probably benign	Het
Or4q3	A	G	14: 50,583,641 (GRCm39)	M86T	probably benign	Het
Or5w1	A	G	2: 87,486,773 (GRCm39)	F164S	probably damaging	Het
Or8g17	T	A	9: 38,930,214 (GRCm39)	I208F	probably benign	Het
Or9r7	G	T	10: 129,962,860 (GRCm39)	T22K	probably benign	Het
Pias4	T	C	10: 80,991,492 (GRCm39)	K352E	probably benign	Het
Pkhd1	G	A	1: 20,604,857 (GRCm39)	Q1153*	probably null	Het
Pon1	C	A	6: 5,175,760 (GRCm39)	W254C	probably damaging	Het
Prr14	A	G	7: 127,074,939 (GRCm39)	T447A	probably benign	Het
Serpinb9g	T	A	13: 33,679,088 (GRCm39)	C319*	probably null	Het
Slc9c1	A	T	16: 45,403,335 (GRCm39)	M801L	probably benign	Het
Tenm4	C	T	7: 96,202,931 (GRCm39)	T182M	probably damaging	Het
Ubr4	T	A	4: 139,135,107 (GRCm39)	L813Q	probably damaging	Het
Uimc1	T	C	13: 55,176,517 (GRCm39)	E667G	probably benign	Het
Unc79	A	G	12: 103,134,546 (GRCm39)	T2173A	probably benign	Het
Unkl	T	C	17: 25,429,822 (GRCm39)	S142P	probably benign	Het
Vezt	A	G	10: 93,832,859 (GRCm39)	V204A	probably benign	Het
Vps53	A	T	11: 75,953,860 (GRCm39)	I402N	probably damaging	Het
Zfyve9	T	C	4: 108,499,289 (GRCm39)	D1343G	probably damaging	Het

Other mutations in Acp6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Acp6	APN	3	97,083,737 (GRCm39)	missense	possibly damaging	0.94
IGL01610:Acp6	APN	3	97,083,036 (GRCm39)	missense	possibly damaging	0.81
IGL01788:Acp6	APN	3	97,073,198 (GRCm39)	missense	probably damaging	1.00
IGL01845:Acp6	APN	3	97,081,123 (GRCm39)	missense	probably benign	0.00
IGL02978:Acp6	APN	3	97,073,875 (GRCm39)	missense	probably benign	0.30
IGL03180:Acp6	APN	3	97,082,951 (GRCm39)	missense	probably benign	0.15
R0144:Acp6	UTSW	3	97,073,145 (GRCm39)	splice site	probably benign
R0471:Acp6	UTSW	3	97,075,891 (GRCm39)	critical splice donor site	probably null
R1458:Acp6	UTSW	3	97,081,104 (GRCm39)	splice site	probably benign
R1889:Acp6	UTSW	3	97,073,201 (GRCm39)	missense	probably damaging	0.98
R1990:Acp6	UTSW	3	97,083,054 (GRCm39)	missense	probably damaging	1.00
R2051:Acp6	UTSW	3	97,075,333 (GRCm39)	missense	probably benign	0.00
R3786:Acp6	UTSW	3	97,066,605 (GRCm39)	missense	probably damaging	0.98
R3933:Acp6	UTSW	3	97,073,499 (GRCm39)	missense	probably benign	0.00
R4271:Acp6	UTSW	3	97,073,934 (GRCm39)	critical splice donor site	probably null
R4604:Acp6	UTSW	3	97,083,075 (GRCm39)	missense	probably benign	0.23
R4864:Acp6	UTSW	3	97,066,683 (GRCm39)	critical splice donor site	probably null
R4935:Acp6	UTSW	3	97,079,060 (GRCm39)	critical splice donor site	probably null
R5076:Acp6	UTSW	3	97,075,305 (GRCm39)	missense	probably benign	0.01
R5255:Acp6	UTSW	3	97,075,312 (GRCm39)	missense	probably benign	0.11
R5896:Acp6	UTSW	3	97,075,810 (GRCm39)	missense	probably benign	0.03
R5959:Acp6	UTSW	3	97,073,888 (GRCm39)	missense	probably damaging	1.00
R6004:Acp6	UTSW	3	97,082,997 (GRCm39)	missense	probably benign	0.11
R6938:Acp6	UTSW	3	97,082,949 (GRCm39)	missense	probably benign	0.04
R7593:Acp6	UTSW	3	97,073,266 (GRCm39)	missense	probably benign	0.30
R8485:Acp6	UTSW	3	97,066,302 (GRCm39)	start gained	probably benign
R8796:Acp6	UTSW	3	97,066,509 (GRCm39)	missense	probably benign	0.01
R8971:Acp6	UTSW	3	97,078,961 (GRCm39)	missense	probably damaging	1.00
X0067:Acp6	UTSW	3	97,073,273 (GRCm39)	nonsense	probably null

Posted On

2014-01-21